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New veterinary vaccinology network will help tackle threat of animal diseases, including those spreading to humans

New veterinary vaccinology network will help tackle threat of animal diseases, including those spreading to humans - 12 August 2014. Copyright: iStock

BBSRC has funded a new multidisciplinary network of veterinary vaccinology experts to help in the fight against animal diseases, some of which have the potential to spread to humans. The UK Veterinary Vaccinology Network will draw together major UK research players to enhance the uptake of new technologies in order to design, develop and deliver safe and effective next-generation vaccines against new and (re)-emerging diseases.

Vaccines represent one of the most cost effective ways of preventing and eradicating diseases and they are an important tool in the armoury against infectious diseases. With approximately 60% of animal diseases having the potential to cause human infections, these vaccines protect public health as well as enhancing animal welfare and sustainably improving livestock production to meet growing food demands.

While vaccination campaigns have had success, such as the eradication of rinderpest and reducing the usage of antibiotics and other drugs (e.g. aquaculture), new diseases (e.g. schmallenberg), exotic (e.g. avian influenza) and re-emerging diseases (e.g. Porcine Respiratory and Reproductive Syndrome), have highlighted the need to re-think the current methods for developing vaccines.

Building on the UK strength in veterinary science, advances in biotechnology, and the biological revolution in new technologies (such as next generation DNA sequencing and synthetic biology), there are opportunities for researchers to create new veterinary vaccines and increase efficient development pathways for them.

Dr Bryan Charleston, head of the Livestock Viral Diseases Programme at The Pirbright Institute, and Network Coordinator, said: "There is huge potential to improve animal welfare, human health, and the economic performance of the UK livestock industries by developing new vaccines for widespread infectious diseases caused by parasites, bacteria and viruses. The network will facilitate and promote coordination of research in this important field to generate the scientific knowledge and discoveries needed for a step change in veterinary vaccinology."

BBSRC has fostered the multi-disciplinary community in order to form a coherent research agenda in this area. With the UK livestock industry (including cows, pigs, sheep, poultry and fish) estimated to have an annual value of over £14bn in 2013, the research will have direct benefits for the UK economy.

Copyright: Dr Maya Wardeh, LUCINDA team
The relationship between diseases of domestic animal and humans. Circle size represents the number of pathogen species found for each host; the arrows linking these circles represent the number of pathogen species shared by each pair of hosts (the thicker the arrow, the greater the number of pathogen species they share). The colour of the circles is related to the type of host (humans, other mammals, birds, rodents). Copyright: Dr Maya Wardeh, Liverpool University Climate and Infectious Diseases of Animals team. Data from EID2.

Professor Melanie Welham, BBSRC's Science Director, said: "We have an excellent breadth of skills in this area across the UK but a strategic, concerted effort is required to improve animal health, ensure global food security and reduce the impact of animal diseases on public health. The network will advance the field by sharing resources, encouraging collaboration between experts in veterinary and medical sciences, and establishing links with industry."

The network includes experts from the Animal Health and Veterinary Laboratories Agency, Cambridge Veterinary School, Edinburgh University, Global Alliance for Livestock Veterinary Medicines, London School of Hygiene and Tropical Medicine, Moredun Research Institute, Oxford University, The Pirbright Institute, The Roslin Institute, The Royal Veterinary College and the University of Stirling. The Network has funding for 5 years (£300k) and they will report to BBSRC and provide input into developing the future research agenda.





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