Consider the following cell: it has a plasma membrane with surface area of 5000 �m2; there are 106 phospholipid molecules per �m2 in each leaflet of the membrane; there are 3000 molecules of flippase enzyme associated with the plasma membrane; each flippase enzyme molecule can catalyze 100 flips per second (we�ll ignore enzyme specificity for the moment).
What is the maximum rate of inappropriate spontaneous phospholipid flips, in flips/sec for the whole plasma membrane, that can be reversed by the action of the flippases?

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