Generic Name: Maprotiline

  • What is Maprotiline?

    Maprotiline is a medicine used to treat depression and anxiety associated with depression.

  • What is the most important information I should know about Maprotiline?


    Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. People with bipolar disorder, or who have a family history of bipolar disorder, are at greater risk.

    Call your doctor right away if you experience new or sudden changes in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression/anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior.

  • Who should not take Maprotiline?

    Do not take maprotiline if you are allergic to any of its components.

    Do not take maprotiline if you are currently taking or have taken monoamine oxidase inhibitors (MAOIs), a class of medicine used to treat depression and other psychiatric conditions, or within 14 days after discontinuing an MAOI.

    Do not take maprotiline if you have recently had a heart attack.

  • What should I tell my doctor before I take the first dose of Maprotiline?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with maprotiline. Also, talk to your doctor about your complete medical history, especially if you have past or current heart problems, seizures, history of depression or suicidality, history or family history of psychiatric illness such as bipolar disorder, or have glaucoma (increased pressure in the eye), an enlarged prostate, bladder problems, or an overactive thyroid.

    Also, tell your doctor if you are planning to have surgery, or if you will have it while taking maprotiline.

  • What is the usual dosage?


    Adults: The usual starting dose for mild to moderate depression is 75 milligrams (mg) once a day. You doctor may increase your dose as appropriate.

  • How should I take Maprotiline?

    Take maprotiline exactly as prescribed by your doctor.

  • What should I avoid while taking Maprotiline?

    Maprotiline may cause you to become drowsy or less alert. Do not drive or operate dangerous machinery or participate in any hazardous activity that requires full mental alertness until you know how this medication affects you.

    Do not drink alcohol or take medications that cause drowsiness (such as sedatives) while you are taking maprotiline.

  • What are possible food and drug interactions associated with Maprotiline?

    If maprotiline is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining maprotiline with the following: barbiturates (such as phenobarbital), benzodiazepines (such as alprazolam and diazepam), cimetidine, electroshock therapy, fluoxetine, phenytoin, or thyroid medications.

  • What are the possible side effects of Maprotiline?


    Side effects may include: decreased urination, dizziness, drowsiness, dry mouth, fluctuations in blood pressure, insomnia, nausea, nervousness, nightmares, sexual dysfunction, shortness of breath

  • Can I receive Maprotiline if I am pregnant or breastfeeding?

    The effects of maprotiline during pregnancy are not known and it passes into your breast milk. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Maprotiline?


  • How should I store Maprotiline?

    Store at room temperature.