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Generic Name: bexarotene (topical) (beks AIR oh teen)
Brand Name: Targretin Topical

What is bexarotene topical?

Bexarotene topical is a cancer medication that interferes with the growth and spread of cancer cells in the body.


Bexarotene topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about bexarotene topical?

Bexarotene topical can harm an unborn baby or cause birth defects. Do not use if you are pregnant, or if you are a man and your sexual partner is pregnant. Use at least 2 reliable forms of birth control while either sexual partner is using bexarotene topical, and for at least 30 days after treatment ends.



What should I discuss with my healthcare provider before using bexarotene topical?

You should not use bexarotene topical if you are allergic to it, or if you are pregnant.

To make sure bexarotene topical is safe for you, tell your doctor if you have:

  • liver disease; or

  • kidney disease.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use bexarotene topical if you are pregnant, or if you are a man and your sexual partner is pregnant.

  • If you are a woman, you must have a negative pregnancy test within 7 days before you start using bexarotene topical. A pregnancy test is also required every month during treatment with bexarotene topical.



  • Use at least 2 reliable forms of birth control while either sexual partner is using bexarotene topical. Keep using 2 forms of birth control for at least 30 days after you stop using bexarotene topical.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using bexarotene topical.

It is not known whether bexarotene topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using bexarotene topical.

How should I use bexarotene topical?


Bexarotene topical is usually applied once every other day for the first week. Your doctor may gradually increase your dose each week, until you are applying the medication 2 or more times every day. Follow your doctor's dosing instructions very carefully.

Women who use bexarotene topical should start the medication on the second or third day of a normal menstrual period.

Wash your hands before and after using bexarotene topical, unless you are using the medication to treat the skin on your hands.

Apply enough gel to cover each lesion. Allow the gel to dry before covering with clothing. Do not cover the treated skin with a bandage.




What happens if I miss a dose?


What happens if I overdose?


What should I avoid while using bexarotene topical?

Avoid getting this medication in your eyes, mouth, or nose. If this does happen, rinse with water.




Avoid using other medications on the areas you treat with bexarotene topical unless your doctor tells you to.

Do not use insect repellents or other products that contain DEET (N,N-diethyl-m-toluamide) while using bexarotene topical. Bexarotene may increase DEET toxicity, which could be dangerous.

Bexarotene topical side effects


Stop using bexarotene topical and call your doctor at once if you have:


  • severe skin rash or redness; or

  • swelling, bleeding, or tearing of treated skin.

Common side effects may include:

  • mild burning, stinging, or itching;

  • mild pain, redness, or irritation; or

  • skin dryness or peeling.


See also: Side effects (in more detail)

Bexarotene dosing information

Usual Adult Dose for Cutaneous T-cell Lymphoma:


What other drugs will affect bexarotene topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied bexarotene topical. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about bexarotene topical.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.02. Revision Date: 2013-07-01, 12:13:03 PM.