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Definition of Gram-negative


The Gram-negative bacteria include most of the bacteria normally found in the gastrointestinal tract that can be responsible for disease as well as gonococci (venereal disease) and meningococci (bacterial meningitis). The organisms responsible for cholera and bubonic plague are Gram-negative.

The Danish bacteriologist J.M.C. Gram (1853-1938) devised this method of staining bacteria using a dye called crystal (gentian) violet. Gram's method helps distinguish between different types of bacteria. The gram-staining characteristics of bacteria are denoted as positive or negative, depending upon whether the bacteria take up and retain the crystal violet stain or not.

Reviewed on 5/13/2016

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