Brittle Bone Disease – Brittle bone disease, or osteogenesis imperfecta, is a congenital defect that causes abnormalities in the genes that produce collagen. The degree of severity of osteogenesis imperfecta is determined by which gene is affected. A person has about a 50 percent chance of passing it on to her children. Bones that fracture easily characterize brittle bone disease.



Paget’s Disease - Paget’s disease is a bone disorder characterized by inflammation in the bone. It causes the bones to become enlarged and soft, weakening them and sometimes causing them to break. Almost any bone in the body can be affected including the femur, pelvis and skull.Unlike osteoporosis, which usually affects women, Paget’s is more often found in men older than 40 years of age.



Cancer of the Bone – Bone cancer starts in the bone. It is uncommon, but can begin in almost any bone in the body. Most cases of bone canceroriginate in the long bones of the body. Osteosarcoma begins in the osteoid part of the bone, while chondrosarcoma begins in the cartilage. Primary bone cancer is cancer that originates in the bone itself. Metastastic cancer starts in other areas of the body such as the lungs or breasts and metastasizes to the bone tissue.


Hyperparathyroidism- Hyperparathyroidism occurs when the parathyroid glands produce too much hormone. Excessive amounts of parathyroid hormone will cause the bones to release too much calcium, according to the University of Maryland Medicine. This causes the bones to become weak and can cause fractures. It can also lead to osteoporosis and other disorders that affect the bones.