Bacterial Ribosome Inhibitors

  • The bacterial ribosomes are sufficiently different from mammalian ribosomes that they can be selectively inhibited by pharmacological agents. Bacterial Ribosome Inhibitors are a class of antibiotics whose common mode of action is through inhibition of the bacterial ribosome which thus prevents bacterial protein synthesis and consequently growth. However, these drugs are structurally diverse and target different steps of ribosomal translation and different parts of the ribosome. One notable aspect of the ribosome inhibitor class of antimicrobials is that they potently reduce synthesis of exotoxins and are especially effective when exotoxin release is a significant source of pathogenesis.
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