Medical Research Report
The effects of Rose Placenta Extract (Rosaceae family flowers) in the Top Pet Pro Product (Top Intelligence) against the central nervous system in Human and Animal

- by Dr. Marcel Gisain


Roses are best known as ornamental plants grown for their attractive or scented foliage. Besides possessing perfuming effect, it also possesses useful rose placenta extract, which can affect the central nervous system function such as being antihypnotic, anticonvulsant, stress adjustment, mental relaxation and also improve the cognition function and memory. This article will review the effects of rose placenta extract. Online literature searches were performed to identify the studies about the Rosaceae family flowers especially Rosa damascena spesies.



The Rose Placenta Extract is derived from Rosaceae family flowers where the most commonly used is the species Rosa damascene. Historical records show roses were planted and consumed for medical purposes by the ancient Chinese and Egyptians nearly 5,000 years ago, as well as in ancient Greece and the Roman Empire (1).

Various products and constit­uents isolated from the flowers, petals, and hips of this plant have been studied in vivo and in vitro, and have been shown to have antihypnotic, anticonvulsive, anti-Human immunodefi­ciency Virus, antidiabetic, antibacterial, and anti-inflammatory effects (2). This review article will highlight the findings of previous studies on the effects of the Rosa damascena against the central nervous system.


The effects of R. damascena against the central nervous system

The consumption of Rosa damascena had shown that it contributes to stress adjustment, relaxation and suppression of hypothalamus-pituitary activity (3) (4) (5).

Previous study also revealed that R. demascena  has some effects on central nervous system including hypnotic, anticonvulsant, anti-depressant, antianxiety, analgesic, and neuroprotective effects (5)(6)(7)(8)(9)(10)(11) .

It has been previously suggested that the flavonoids compound present in R. damascene has acted as anticonvulsant and antioxidant that may have interaction with GABAergic system in the brain (8) (12)(13)(14). These findings had been supported when flavonoids were successfully isolated from R.damascena by other previous study (18).

The flavonoids from plant based source have been studied in animal dietary supplementation and result shown that the cognition function has improved suggesting due to its protective effect on vulnerable neurons, enhancing existing neuronal function or by stimulating neuronal regeneration (15).

In addition, flavonoids may also participate in the beneficial effects on memory and preventing cognitive losses that caused by ageing and reversing certain age-related declines (16) (17).



The extract yielded from rose placenta as having beneficial compound such as flavonoids is contributive to the healthiness of central nervous system particularly for the intelligence, behavior and well-being of pets when fed as a dietary supplement.



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2. Bani S, Hasanpour S, Mousavi Z, et al. The effect of rosa damascena extract on primary dysmenorrhea: a double-blind cross-over clinical trial. Iran Red Crescent Med J 2014;16: e14643.

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