Screening Scheme Description

DNA test - PFK
Phosphofructokinase Deficiency

Details about the disease

PFK leads to a lack of the phosphofructokinase enzyme, without which muscle cells and red blood cells are unable to produce enough adequate energy for their needs.

Clinical signs

Intermittent clinical signs include weakness, lethargy (lack of energy), exercise intolerance, poor performance, muscle cramps, anaemia (reduced number of red blood cells), jaundice (yellowing of the skin or whites of the eyes) and dark-coloured urine. Dark-coloured urine, a hallmark of this disorder, usually appears after strenuous exercise or after excessive barking, panting or heat exposure.

How it is inherited


Which laboratories test for this condition?


How to responsibly breed from your DNA tested dog


How to find out if a potential mate has been DNA tested


