Unit Three

Whole-Genome Perspective

Chapter 7: Genomic Circuits in Single Genes

Section 7.1 Dissecting a Gene's Circuitry

  • How do genomes control individual genes?
  • How does a gene control location, timing, and quantity of transcription?
  • What does module G do?
  • Can we apply engineering and computer science concepts to genes?

Section 7.2 Intergrating Single-Gene Circuits

  • How can we describe to others what we know about a genome circuit?
  • Can we visualize circuits for protein interaction and DNA binding?

Chapter 8: Integrated Genomic Circuits


Section 8.1 Simple Integrated Circuits

  • Can genes form toggle switches and make choices?
  • Can humans engineer a genetic toggle switch?
  • Can humans build a synthetic circadian clock from a toggle switch design?
  • If switches are so noisy, how can multi-cellular organisms develop?
  • Redundancy: is it really beneficial to have more than one copy of a gene?

Math Minutes:

8.1 How are stochastic models applied to cellular processes?


Section 8.2 Complex Integrated Circuits

  • Are circuits the key to learning?
  • Can we understand cancer better by understanding its circuitry?
  • If circuits are interconnected, does gene order matter?

Math Minutes:

8.2 Is it possible to predict steady-state behavior?


Chpater 9: Modeling Whole-Genome Circuits

Section 9.1 Is genomics a new perspective?

  • The people involved: Who is doing systems biology?
  • The quality of the message: What questions do systems biologists ask?

Section 9.2 Can we model entire eukaryotes with a systems approach?

  • How do yeast adapt to new food sources?
  • Genomics vs. Proteomics
  • Building a systems model
  • Context of the message

Section 9.3 Will systems biology go systemic?

Methods for Genomic Circuits

15 Second Biographies of Genomic Circuit Researchers

Cell Web Front Page

Genomics Course Outline and Syllabus

Genomics Schedule

Molecular Biology Course

Biology Course Materials

Biology Home Page

College Home Page search

Send comments, questions, and suggestions to: macampbell@davidson.edu