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What is the AHCY Mutation?

  4 years, 2 months ago

The AHCY (Adenosylhomocysteine Hydrolase) Mutation activates Homocysteine.
This defect is a prime example of just how challenging nutrigenomics medicine is, particularly when trying to sort through methylation’s domino effect. This zone activates SAM into Homocysteine, which is then utilized within the system or eliminated through the CBS enzyme. When AHCY defects are present, one could have the MTHFR C677T enzyme mutation yet still have normal homocysteine levels. And, if a coexisting CBS upregulation is present, homocysteine levels may be even lower, despite having complete C677T and/or BHMT defects. Furthermore, when such AHCY defects are present, there is less ... ..more
