mesangial cell

Also found in: Wikipedia.

mes·an·gi·al cell

a phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft.


of the nature of or pertaining to mesangium.

mesangial cell
connective tissue cells of the glomerulus; occur singly or in pairs in a thin matrix.
mesangial sclerosis
increased mesangial matrix.
References in periodicals archive ?
Cutting edge: calcium/calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis," The Journal of Immunology, vol.
Microsco-pic examination showed mild focal mesangial cell pro-liferation.
Membranoproliferative glomerulonephritis (MPGN) is characterized by profound hypocomplementemia, mesangial cell proliferation, mesangial interposition, and the deposition of immunoglobulins and complements in the peripheral portion of the nodules (fringe) formed by merging of glomerular capillaries.
26] Heparan sulphate proteoglycan also strongly inhibits mesangial cell growth, and loss of heparan sulphate has been shown to be an inducer of the mesangial expansion.
Development of albuminuria and glomerular lesions in normoglycemic B6 recipients of db/db mice bone marrow: the role of mesangial cell progenitors.
miR-451 negatively regulated the expression of its target gene Ywhaz , which was required for the activation of p38 MAPK signaling, and inhibited glomerular mesangial cell proliferation in early DN, thus preventing mesangial hypertrophy.
DN is a complex syndrome whose pathogenesis includes loss of podocytes, mesangial cell hypertrophy, thickening of glomerular basement membrane (GBM) and renal fibrosis (Brosius et al.
Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.
It also modulates mesangial cell growth and stimulates the production of fibronectin, types I and IV collagen, and laminin (Ziyadeh, Sharma, Ericksen, & Wolf, 1994).
Glomerular uptake of nucleosomes: evidence for receptor-mediated mesangial cell binding.
4,44) Another effect of amyloid deposition is enhancement of apoptosis, which explains why in the advanced stages of the disease there is significant mesangial cell deletion, to the point where these cells essentially disappear and only amyloid remains in the mesangium.