Monday, August 11, 2014

Treat ALS with Anti-Inflammatory Drugs

This is the dirty little secret that Big Pharma and the corrupt ALS therapy development industry do not want you to know. Most ALS (amyotrophic lateral sclerosis or Lou Gehrig's disease) patients can be treated with cheap, off the shelf, non-proprietary anti-inflammatory drugs. Here is a partial list of ALS patients who have seen major improvements and reversal of symptoms after being given anti-inflammatory drugs:
  1. Ted harada. Drugs: anesthetics, basiliximab, methylprednisolone, prednisone, tacrolimus, mycophenolate mofetil.
  2. Ernie Schmid. Drugs: various glucocorticoids.
  3. Paul Aiken. Drugs: local anesthetics, Kenalog, dexamethasone.
  4. Louis Savain's wife. Drugs: anesthetics, dexamethasone.
There are more, I am sure. Some patients are reporting improvements from anti-inflammatory supplements such as Lunasin (a peptide) and zinc gluconate. Other people have reported sudden improvements in speech and swallowing ability after a trip to the dentist where they are injected with dexamethasone and lidocaine. Please, feel free to add more items to the list if you know of other examples.
Important: There are several ALS variants caused by different mutations. Not every ALS patient will see improvements from dexamethasone or prednisone or any one drug. But I believe that many will. Those who don't see any improvements should not despair. The immune system is vast and complex. It is likely that their particular form of ALS affects a different part of the immune system. Other types of anti-inflammatory drugs or a complex cocktail of drugs may do the trick.

Another reason that some PALS may not respond successfully to anti-inflammatory drugs has to do with drug penetration. Inflammation and other factors may prevent the drugs from reaching areas of the CNS where there are needed the most. Such patients may require direct injections into their brainstem and/or spine.
See Also:

Anesthetics and Glucocorticoids for ALS

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