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Secondary Adrenal Insufficiency


Secondary adrenal insufficiency (SAI) is a condition that develops when your adrenal glands do not make enough adrenal hormones. The adrenal glands are controlled by the pituitary gland in the brain. SAI develops when the pituitary gland does not make enough of a chemical called ACTH to control adrenal hormone production. Adrenal hormones such as cortisol help your body handle stress, keep blood pressure normal, and balance salt and fluids. They also control how your body uses sugars, fats, and proteins. An adrenal crisis may happen if your adrenal hormone level becomes too low. This condition is life-threatening and needs immediate treatment.



  • Steroid medicine: Steroids are given to balance the steroid hormones levels your adrenals naturally make. You may need to take this medicine for the rest of your life. You may need to change the amount you take when you are ill or have increased stress. Your primary healthcare provider will order medicine that can be given as a shot if you have an adrenal crisis. Ask your primary healthcare provider to show you and a friend or family member how to do this. Do not stop taking this medicine before you talk to your primary healthcare provider. You can trigger an adrenal crisis if you stop taking steroids suddenly.


Follow up with your primary healthcare provider or endocrinologist as directed:

You may need to have blood tests and your bone density checked often. Your endocrinologist may have you check your blood pressure and blood sugar level on a regular basis. He will tell you when and how often to do this. Write down your questions so you remember to ask them during your visits.

Medical alert identification:

Wear medical alert jewelry or carry a card that says you have adrenal disease. You may get one from your local drugstore or ask your primary healthcare provider where to get this.

Contact your primary healthcare provider or endocrinologist if:

  • You have a fever.

  • You have nausea, vomiting, diarrhea, or abdominal pain.

  • You sweat or urinate more than usual.

  • You do not have any more medicine, or you stopped taking it.

  • You have questions about your condition or care.

Seek help immediately or call 911 if:

  • You always feel dizzy when you stand up.

  • You have very bad pain in your stomach, waist, or back.

  • You have very dry skin, dry mouth and tongue, or feel very thirsty.

  • Your symptoms become worse even after you take your medicines.



Learn more about Secondary Adrenal Insufficiency (Discharge Care)