Addison’s disease (also known as primary adrenal insufficiency or hypoadrenalism) is a rare disorder of the adrenal glands. It affects the production of two essential hormones called cortisol and aldosterone.

The adrenal glands are two small glands that sit on top of the kidneys.

About 8,400 people in the UK have Addison's disease. It can affect people of any age, although it's most common between the ages of 30 and 50. It is also more common in women than men.

Early stages symptoms of Addison’s disease are similar to other more common health conditions such as depression or flu. You may experience:

  • fatigue (lack of energy or motivation)
  • muscle weakness
  • low mood
  • loss of appetite and unintentional weight loss
  • increased thirst

Over time, these problems may become more severe and you may experience further symptoms, such as dizziness, faintingcramps and exhaustion. You may also develop small areas of darkened skin.

Although these symptoms aren’t always caused by Addison’s disease, you should see your GP if you have them so they can be investigated.

Read more about the symptoms of Addison’s disease and diagnosing Addison’s disease.

Why it happens

The condition is usually the result of a problem with the immune system, which causes it to attack the outer later of the adrenal gland (the adrenal cortex), disrupting production of steroid hormones aldosterone and cortisol. It is not clear why this happens, but it is responsible for 70-90% of cases in the UK.


Read more about the causes of Addison’s disease.

Treating Addison's disease

Addison’s disease is treated with medication to replace the missing hormones. You will need to take the medication for the rest of your life.

With treatment, symptoms of Addison's disease can largely be controlled and most people with the condition live a normal, healthy life.

However, there is a risk of a sudden worsening of symptoms called an adrenal crisis. This can happen when the levels of cortisol in your body fall significantly. 

An adrenal crisis is a medical emergency. If left untreated it can be fatal. If you or someone you know has Addison’s disease and is experiencing severe symptoms, dial 999 to request an ambulance.

Read more about treating Addison's disease.

Fatigue and low mood are common symptoms of Addison's disease 

The adrenal glands

The adrenal glands are two small, pyramid-shaped glands that sit on top of the kidneys. Each gland has inner and outer layers, which have separate functions:

  • the inner area (medulla) produces the hormone adrenaline
  • the outer layer (cortex) produces the hormones cortisol and aldosterone

In Addison's disease, the adrenal cortex is damaged and not enough cortisol and aldosterone are produced.

Page last reviewed: 08/07/2013

Next review due: 08/07/2015