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Who Is at Risk for Pernicious Anemia?



Pernicious anemia also can occur in younger people and other populations. You're at higher risk for pernicious anemia if you:

  • Have a family history of the condition.
  • Have had part or all of your stomach surgically removed. The stomach makes intrinsic factor. This protein helps your body absorb vitamin B12.
  • Have an autoimmune disorder that involves the endocrine glands, such as Addison's disease, type 1 diabetes, Graves' disease, or vitiligo. Research suggests a link may exist between these autoimmune disorders and pernicious anemia that's caused by an autoimmune response.
  • Have had part or all of your small intestine surgically removed. The small intestine is where vitamin B12 is absorbed.
  • Have certain intestinal diseases or other disorders that may prevent your body from properly absorbing vitamin B12. Examples include Crohn's disease, intestinal infections, and HIV.
  • Take medicines that prevent your body from properly absorbing vitamin B12. Examples of such medicines include antibiotics and certain seizure medicines.
  • Are a strict vegetarian who doesn't eat any animal or dairy products and doesn't take a vitamin B12 supplement, or if you eat poorly overall.
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April 1, 2011