OpGen > What is Whole Genome Mapping?

What is Whole Genome Mapping?

What if you could study any genome using a high zoom viewer like Google Earth–with OpGen’s Whole Genome Mapping (WGM) technology you can do just that and much more.  

Current technologies break DNA into thousands of pieces to be sequenced and then reassembled, comparing the pieces to a published reference. But this process is time-consuming and costly. And comparing the small pieces to a reference genome presents challenges–the known high rate of misassembly and gaps in published reference sequences. OpGen’s technology provides a complete structural view that enables rapid assembly, and highly accurate order and orientation of the sequence contigs.

Whole Genome Maps–A More Accurate Approach

Long, intact single molecule DNA is analyzed in high definition, while maintaining the genome’s integrity (Figure 1). This novel  approach gives you a complete blueprint of the genome– accurate visual information, including  important positional changes that sequencing alone cannot detect.

Figure 1. DNA molecules are stretched out in a reaction card and processed. The single molecule are imaged, analyzed and represented as a barcode. 
Whole Genome Mapping technology is validated and widely adopted for microbial applications including sequence assembly, comparative genomics and strain typing. A new software suite called Genome-Builder™ provides a game changing approach for whole genome assembly and comparative analysis of larger genomes. Combining Single Molecule Maps  with sequence scaffolds enables completed assembly in weeks, compared to months or years using traditional methods.

You can take advantage of OpGen’s powerful technologies by contacting MapIt® Services or bring the Argus® Whole Genome Mapping System into your lab. Learn more about Whole Genome Mapping technology–and how you can get faster, more accurate data for sequence assembly and public health epidemiology applications today.


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