I had a tumor on my leg that popped out quickly in July 2007. By November I was having radiation treatments for lymphoma, 27 in all. The biopsy was positive for LCA, CD43, CD30 and CD3 immunostains. Cells were negative for S100, wide spectrum pancytokeratin, CD20, CD4 and CD8 immunostains. I still have unexplained fevers , enlarged neck lymph nodes and occasional groin node swelling and chronic anemia . Have you ever heard of this type of lymphoma being just in the skin but still having an ill patient and not being able to find a reason for it? Does this type of lymphoma hide itself at all? Just looking for some kind of answer; the doctors are all just bewildered. Thanks in advance for the information. 

In addition to knowing what stains were positive, it is also important to know what the lymphoma looked like under the microscope and what the pathologists determined the final diagnosis to be. An accurate diagnosis of the subtype of lymphoma (particularly for the T-cell lymphomas, which are rare and can be difficult to diagnose) is critical. (The term “CD” in the results you mentioned above refers to “cluster of differentiation,” the unique molecules that sit on the surface of lymphocytes.)

A review by an expert hematopathologist, a pathologist who specializes in the study of cells involved in the formation of blood, may be necessary. It sounds like you need further studies, including scans and possibly a lymph node and/or bone marrow biopsy to evaluate for the extent of disease. It would be very unusual for a lymphoma in the skin only to cause such a constellation of symptoms.