25135122330_d883904d7e_k NASA HQ PHOTO

After reaching the International Space Station last year on March 27, NASA astronaut Scott Kelly embarked on a mission that has pushed the boundaries of American spaceflight.

And on Tuesday evening at about 11:26 p.m. ET, part of that mission came to an end.

After spending 340 days in space — longer than any American before him — Kelly arrived back on Earth safely, packed inside a snug Soyuz capsule with cosmonauts Sergey Aleksandrovich Volkov and Mikhail Korniyenko, who also just completed 340 days in space.

Kelly's trip back to solid ground marks an end to his epic life in space.

Now, the real work begins.

Sending an astronaut into space to live for nearly a year on the ISS is one of the most ambitious missions NASA has launched in its efforts to eventually send humans to Mars.

But there are many questions that need answering before NASA is ready for the red planet.

Now that Kelly is back on Earth, scientists can begin to answer some of those questions. They'll start by analyzing, in detail, how Kelly's 340-day stay in space has affected his body.

Life in space

25062739349_f15c80dd8c_k Soyuz capsule on its way to Earth. NASA HQ PHOTO

Unfortunately for humans, one of the most entertaining aspects about space is also the most harmful to the human body: microgravity.

Somersaulting in midair looks like great fun, but over time microgravity has a bizarre and potentially dangerous impact on physical performance.

For example, astronauts in the past have experienced impaired vision, changes in their sense of taste, and an increased flow of fluid to the brain.

Increased fluid flow to the brain is particularly concerning, because when astronauts return to Earth their blood pressure must readjust to Earth's gravity. But this takes time, and as a result some recently arrived astronauts can't stand up for more than 10 minutes without fainting.

Other concerns about prolonged spaceflight include a loss of bone and muscle mass, a weakened immune system, and fatigue.

Kelly conducted numerous experiments during his time in space to help address these concerns, but now that he's back scientists can get a closer look at him.

They'll also observe how quickly he recovers. Recovery rate is important in predicting how much future astronauts — who land on Mars for brief periods — will be capable of doing, both physically and mentally, after spending 8 1/2 months in space, about the time it takes to get to Mars.