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Vitamin C and Iron

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  • Stroke is the fourth leading cause of death in the United States
  • Up to 80 percent of all strokes are preventable through lifestyle factors such as diet, exercise, maintaining a healthy weight, normalizing your blood sugar levels and blood pressure, and quitting smoking
  • Recent research shows that those with vitamin C deficiency are at an increased risk for hemorrhagic stroke. In an earlier study, people with high blood levels of vitamin C reduced their stroke risk by 42 percent
  • Research also suggests that iron deficiency can increase your risk of ischemic stroke if you have hereditary hemorrhagic telangiectasia, a hereditary disease that causes enlarged blood vessels in your lungs
  • Sun exposure can reduce your stroke risk both by elevating your vitamin D levels, and by inducing nitric oxide in your skin, which helps normalize your blood pressure

How Vitamin C and Iron Can Help Reduce Your Risk of Stroke

March 03, 2014 | 284,185 views
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By Dr. Mercola

Stroke, which is akin to a heart attack in your brain, is the fourth leading cause of death in the United States.1 Obstructed blood flow to your brain is known as an ischemic stroke, which represent about 75 percent of all strokes. When an artery that feeds your brain with blood actually ruptures, it's called a hemorrhagic stroke, and this is a far more lethal situation.

Fortunately, up to 80 percent of all strokes are preventable through lifestyle factors2 such as diet, exercise,3, 4 maintaining a healthy weight, normalizing your blood sugar levels and blood pressure, and quitting smoking.


Recent studies also highlight the importance of getting sufficient amounts of vitamin C and iron in your diet. Interestingly, certain weather conditions have also been linked to increased rates of stroke, and getting appropriate amounts of sun exposure can help protect against it, in more ways than one.

Getting Enough Vitamin C May Help Reduce Risk of Hemorrhagic Stroke

The first featured article6 reports the preliminary findings of a French study, which found that those with vitamin C deficiency are at an increased risk for a lethal hemorrhagic stroke. According to the article:

"'Our results show that vitamin C deficiency should be considered a risk factor for this severe type of stroke, as were high blood pressure, drinking alcohol and being overweight in our study,'" study researcher Dr. Stéphane Vannier, M.D., of Pontchaillou University Hospital in France, said in a statement.

'More research is needed to explore specifically how vitamin C may help to reduce stroke risk. For example, the vitamin may regulate blood pressure.' ...[P]ast studies have also linked vitamin C with reduced stroke risk.


What's the Best Way to Optimize Your Vitamin C?

The ideal way to optimize your vitamin C stores is by eating a wide variety of fresh whole foods. A number of people, primarily with the naturopathic perspective, believe that in order to be truly effective, ascorbic acid alone is not enough.

They believe the combination of the ascorbic acid with its associated micronutrients, such as bioflavonoids and other components. Eating a colorful diet (i.e. plenty of vegetables) helps ensure you're naturally getting the phytonutrient synergism needed.




Iron Deficiency Can Raise Stroke Risk in Certain Individuals

Recent research also suggests that iron deficiency can increase your risk of ischemic stroke if you have hereditary hemorrhagic telangiectasia, a hereditary disease that causes enlarged blood vessels in your lungs. Iron deficiency increases the stickiness of your blood, which increases your risk of blood clots, and in those with this genetic abnormality, such clots can travel through your lungs and into your brain.

According to the study in question, published in the journal PLOS One,7 even having moderately low iron levels can double your stroke risk if you have this condition. According to the researchers, other health conditions may also permit blood clots to bypass the filtration system of your lungs. Study author Dr. Claire Shovlin stated that:


Sun Exposure Also Plays Multiple Roles in Stroke Prevention

Another nutrient that is very important for stroke prevention is vitamin D. According to research presented at the American Heart Association's (AHA) Annual Scientific Sessions in 2010,8 low levels of vitamin D—the essential nutrient obtained from sun exposure—doubles the risk of stroke in Caucasians. 

While many opt for vitamin D3 supplements to raise their vitamin D level, I strongly recommend optimizing your levels through appropriate sun exposure or by using a safe tanning bed (i.e. one with electronic ballasts rather than magnetic ballasts, to avoid unnecessary exposure to EMF fields). Ideally, you'll want to maintain your vitamin D level within the range of 50-70 ng/ml year-round.

Vitamin D3 supplements are best used as a last resort, as they will not provide you with any of the other health benefits associated with sun exposure... If you do opt for a supplement, the most recent research suggests the average adult needs to take about 8,000 IUs of vitamin D per day in order to elevate their levels above 40 ng/ml, which is the absolute minimum for disease prevention.

If you opt for a supplement, you also need to make sure you're getting sufficient amounts of vitamin K2, as it works synergistically with vitamin D and activates matrix GLA protein, which inhibits arterial calcification. That said, exposing your skin to sunlight will also suppress your risk of stroke by altering the level of nitric oxide in your skin, which dilates your blood vessels and normalizes your blood pressure.9

Previous research10, 11 has shown that reducing your systolic blood pressure by 20 millimeters (regardless of how high your blood pressure currently is) decreases your risk of stroke by 50 percent. Reduce it by another 20 mm, and you cut your individual risk in half yet again. One way to naturally reduce your blood pressure is through exercise. Another is by making sure you're getting enough sun exposure. According to Martin Feelisch, a professor of experimental medicine at the University of Southampton in southern England:12


Interestingly, previous research13 also suggests that inducing nitric oxide (NO) actually helps protect your skin against UV damage... Another crucial element in the normalization of blood pressure is to address insulin and leptin resistance, which is present in about 80 percent of the population from eating far too many carbohydrates and not getting enough exercise. If you have high blood pressure and are overweight, your first step would be to eliminate all grains, sugars, and processed foods, and increase healthy fats, like avocado, coconut oil, butter, and nuts.

Weather Changes Influence Stroke Rates

In related news, yet another recent study claims there's a link between weather conditions and stroke hospitalization rates. The researchers speculate that meteorological factors such as fluctuations in temperature and humidity may act as stressors. As reported by Medical News Today:14

"Lichtman and her team analyzed the medical records of 134,510 patients hospitalized in 2009-10 with ischemic stroke, which is caused by a blood clot blocking the blood flow to the brain. They then cross-referenced this data with meteorological records of temperature and dew point data from this period.

The team found that large daily temperature changes and higher-than-average air moisture were linked to higher hospitalization rates from stroke. Lower-than-average annual temperatures were also associated with death and hospitalization from stroke. [Lichtman says] 'People at risk for stroke may want to avoid being exposed to significant temperature changes and high dew point and, as always, be prepared to act quickly if they or someone they know experiences stroke signs and symptoms.'"

Don't Depend on Your Cholesterol Level to Assess Your Stroke Risk

High cholesterol is an oft-cited risk factor for stroke, but total cholesterol alone will tell you virtually nothing about your disease risk, unless it's exceptionally elevated (above 330 or so, which would be suggestive of familial hypercholesterolemia, and is, in my view, about the only time a cholesterol-lowering drug would be appropriate). It's also well worth noting that cholesterol-lowering drugs known as statins have been found to increase your stroke risk, and previous research also suggests that having too little cholesterol in your blood may increase your risk of stroke.

According to research published in 1999,15, 16 individuals with cholesterol levels above 230 milligrams per deciliter of blood (mg/dL) had an elevated risk of ischemic stroke. For example, a person with a cholesterol level of 280 mg/dL had twice the risk of ischemic stroke as a person with 230 mg/dL. But they also found that as cholesterol dropped, the risk of more lethal hemorrhagic stroke increased significantly instead. A person with a cholesterol level below 180 mg/dL had twice the risk of that type of stroke compared with someone at 230 mg/dL.

So, with regards to cholesterol, what you want is proper balance between your HDL, LDL, and total cholesterol. This is best achieved through a healthy diet, as outlined in my Nutrition Plan, and exercise. Two ratios that are far better indicators of heart disease risk are:

  2. Your triglyceride/HDL ratios: This ratio should ideally be below 2

Lifesaving Information: How to Recognize a Stroke

A stroke doesn't advertise its pending arrival, which makes prevention all the more important. That said, getting medical help quickly can mean the difference between life and death or permanent disability, should you or someone you love suffer a stroke. This is an area where conventional medicine excels, so please do NOT delay in getting medical attention.

In the case of ischemic stroke, there are emergency medications that can dissolve a blood clot that is blocking blood flow to your brain. If done quickly enough, emergency medicine can prevent or reverse permanent neurological damage—but you typically need treatment within one hour, which means the faster you recognize the signs, the better the prognosis. The National Stroke Association recommends using the FAST acronym to help remember the warning signs of stroke:17





Other Stroke-Prevention Guidelines

It's important to realize that the vast majority—up to 80 percent, according to the National Stroke Association—of strokes are preventable, so your lifestyle plays a major role in whether or not you're going to become a statistic here. Besides the specific nutritional factors discussed above, other lifestyle factors that can have a direct impact on your stroke risk include:

  • Exercise will go a long way toward improving your insulin and leptin receptor signaling, thereby normalizing your blood pressure and reducing your stroke risk. I recommend a comprehensive program that includes Peak Fitness exercises along with super slow strength training, Active Isolated Stretching and core work. If you've had a stroke, exercise is also very important, as research shows it can significantly improve both your mental and physical recovery.18
  • My favorite overall tool to manage stress is EFT (Emotional Freedom Technique). Other common stress-reduction tools with a high success rate include prayer, meditation, laughter and yoga, for example. For more tips, see my article "10 Simple Steps to Help De-Stress."


  • Grounding. Walking barefoot, aka "grounding," has a potent antioxidant effect that helps alleviate inflammation throughout your body. The human body appears to be finely tuned to "work" with the Earth in the sense that there's a constant flow of energy between our bodies and the Earth. When you put your feet on the ground, you absorb large amounts of negative electrons through the soles of your feet.
  • High-sugar diets, smoking, radiofrequencies, and other toxic electromagnetic forces, emotional stress, high cholesterol, and high uric acid levels are examples of factors that make your blood hypercoagulable, meaning it makes it thick and slow-moving, which increases your risk of having a blood clot or stroke.


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