Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Eylea


Aflibercept injection is used to treat neovascular (wet) age-related macular degeneration (AMD). AMD is a disorder of the retina in the eye that causes blurred vision or blindness. Aflibercept works by changing the amount of blood that gets to the retina.

Aflibercept injection is also used to treat macular edema after retinal vein occlusion. It is also used to treat diabetic macular edema (DME) and diabetic retinopathy in patients with DME. Macular edema is swelling in the back of the eye and may cause vision loss. Retinal vein occlusion is a blockage of a blood vessel in the eye. Swelling can occur when the blood vessel is blocked.


This product is available in the following dosage forms:

  • Solution

Before Using








Drug Interactions


Other Interactions


Other Medical Problems


  • Detached retina (eye disorder) or
  • Endophthalmitis (inflammation of the eye) or

Proper Use




Serious eye problems may occur with this medicine. Check with your eye doctor right away if your eye becomes red, sensitive to light, or painful, or if you see flashes or sparks of light, have a change in vision, or feel increased pressure in the eye several days after the injection.

This medicine may increase your risk of blood clots. Check with your doctor right away if you have pain in your chest, groin, or legs, especially the calves, difficulty with breathing, a severe, sudden headache, slurred speech, a sudden loss of coordination, severe weakness or numbness in your arm or leg, or vision changes.


Side Effects



More common

  1. Blindness
  2. bloody eye
  3. blurred vision
  4. eye or eyelid redness
  5. eye pain
  7. seeing floating spots before the eyes
  8. vision changes

Less common

  1. Bleeding or pain at the injection site
  2. swelling of the eyelid


  1. Fast heartbeat
  2. fever
  3. headache
  4. hives, itching, rash, or skin redness
  5. hoarseness
  6. joint pain, stiffness, or swelling
  8. troubled breathing or swallowing

Incidence not known

  2. severe, sudden headache
  3. slurred speech
  4. sudden loss of coordination
  6. sudden, unexplained shortness of breath


Less common

  1. Feeling like something is in the eye
  2. watery eyes

