Protein-histidine tele-kinase

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protein histidine tele-kinase
EC number
CAS number 99283-67-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a protein-histidine tele-kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + protein L-histidine \rightleftharpoons ADP + protein Nτ-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Ntau-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Ntau-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-tele-phosphotransferase, histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK3.


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  • Huebner VD, Matthews HR (1985). "Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia". J. Biol. Chem. 260 (30): 16106–13. PMID 4066704.