Our Location

      9220 James Ave S.,

      Bloomington, MN 55431

      Immunotherapy - LDI/LDA Therapy in Bloomington, MN


      Low dose immunotherapy (LDI) and Low dose allergen (LDA)

      Low dose immunotherapy, (LDI), is a revolutionary treatment that has been shown to provide dramatic relief of symptoms and improvement in health for patients with a wide range of chronic illnesses, including Lyme disease, chronic fatigue syndrome, fibromyalgia, Hashimoto's, multiple sclerosis, Crohn's disease, ulcerative colitis, interstitial cystitis and lupus. It is effective and originally used for chronic allergies, where the treatment is called Low Dose Allergen.

      How does LDI work?


      With a number of infections, the body's immune system is able to kill the majority of pathogens, but a small amount of pathogens are able to evade the immune system. The small amount of remaining pathogens continue to stimulate a maladaptive inflammatory response that leads to chronic illness, including chronic Lyme disease, chronic fatigue syndrome, fibromyalgia and a wide variety of autoimmune diseases.

      We know that Lyme-related bacteria can be difficult to completely eliminate from the body due to the bacteria's ability to mutate and hide within the body. But even if the bacteria are almost completely destroyed by antibiotic therapy, this may not turn off the immune response that is causing most of the symptoms. In this case, chronic Lyme is more like an autoimmune disease.

      Most autoimmune diseases are triggered by an initial infection. As the immune system fights the infection, it may begin to confuse the body's own proteins with proteins made by foreign invaders such as bacteria and viruses. Even after the bacteria have been eliminated, the immune system remains activated, and an autoimmune reaction triggered by the bacteria has been launched.

      What is in an LDI dose?

      LDI combines specific antigens (bacteria, toxins, or other foreign substances that induce an immune response in the body) with an enzyme called beta-glucuronidase. This enzyme attracts T cells, which are specialized white blood cells involved in the immune response and tells the T cells to pay attention to whatever antigens are included with the enzyme. Then the enzyme causes the down-regulation, or desensitization of TH2, the part of the immune system that was over-reacting to the included antigens. When the over-activated TH2 portion of the immune system is reduced, the depressed TH1 immunity is enhanced, which can effectively destroy intracellular infections.


      How is LDI Administered?

      LDI can be administered by intradermal injection or by sublingual dosing.  At One Agora, we utilize sublingual dosing with great success.  Doses given sublingually are placed under the tongue and held for a short period of time, typically about 30 seconds. In sublingual dosing, the treatment is absorbed through the mucus membranes in the mouth.

      There are a wide range of LDI antigens for numerous conditions along with a wide range of doses of LDI. After the initial dose, it is generally given once per week until an effect is seen, then it is dosed once every seven to eight weeks, though a booster dose can be given if a patient's improvement diminishes and symptoms return before the seven-week mark.

      What Results Can You Expect?



      As patients progress through each dose, symptom relief lasts longer. Often by the 4th or 5th exposure to the LDI/LDA, patients will see significant relief from symptoms for the full seven weeks between treatments. At this point, the interval between treatments is typically stretched out - waiting until symptoms return before giving the next dose. After a period of time, patients may need injections/sublingual dosing only one or twice per year to stay in remission.

      What Can be Treated with LDI?


      • Fibromyalgia
      • Chronic Fatigue Syndrome
      • Lyme Disease
      • Multiple Sclerosis
      • Autoimmune Arthritis
      • Crohn's Disease
      • Ulcerative Colitis
      • Endometriosis
      • Sarcoidosis
      • Myositis
      • Psoriasis (some forms)
      • Autism
      • Sarcoidosis
      • Interstitial cystitis
      • and other inflammatory type diseases

      Want to know more? Call or book an appointment online.


      Our Location

      One Agora Integrative Health Clinic
      9220 James Ave S.
      Bloomington, MN 55431
      Phone: (952) 234-5898

      Integrative medicine clinic serving patients in Bloomington, Richfield, Edina, Eden Prairie and the surrounding Hennepin County, Minnesota communities.


      Our Location

      One Agora Integrative Health Clinic
      9220 James Ave S.
      Bloomington, MN 55431
      Phone: (952) 234-5898


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