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Medications and Drugs

Brand Names: Xyralid RC

Generic Name: hydrocortisone and lidocaine topical with psyllium (Pronunciation: HYE droe KORT i sone, LYE doe kane TOP ik al, SIL ee um)

What is hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?



Psyllium is a type of soluble fiber used as a bulk-forming stool softener. Psyllium is not a laxative.

The combination of hydrocortisone and lidocaine topical (for the skin) is used to relieve itching, pain or other discomforts caused by conditions such as hemorrhoids or anal fissures (tiny tears in the tissues surrounding the anus). Psyllium is provided as a medication you take by mouth to help soften your stools, making them easier and less painful to pass while your rectal condition is being treated.


What are the possible side effects of hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?


Stop using this medication and call your doctor at once if you have severe irritation or burning of the treated area, or if you show signs of absorbing hydrocortisone topical through your skin, such as:

  • blurred vision, or seeing halos around lights;
  • mood changes;
  • sleep problems (insomnia);
  • weight gain, puffiness in your face; or
  • muscle weakness, feeling tired.

Less serious side effects may include:

  • mild stinging, burning, or redness where the medication is applied;
  • thinning of your skin;
  • numbness in places where the medicine is accidentally applied.


What is the most important information I should know about hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?

You should not use this medication if you are allergic to hydrocortisone, lidocaine (or any other type of numbing medicine), or psyllium, or if you have severe liver disease, a fungal infection, smallpox, chickenpox, herpes, or tuberculosis.

Before using hydrocortisone and lidocaine topical with psyllium, tell your doctor if you have liver or kidney disease, a heart rhythm problem, congestive heart failure, stomach or intestinal conditions, diabetes, or any type of infection.


Do not cover the treated rectal areas with a bandage, plastic pants or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Your body may also absorb more of this medication if you use too much.


Do not use this medication in a child without a doctor's advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

Report Problems to the Food and Drug Administration


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