



Many people who report having a penicillin allergy don't have a true allergy. They may have had a reaction to penicillin, such as certain types of rash, but not all reactions are allergies. Penicillin allergy symptoms include:

  • Hives
  • Rash
  • Itchy skin
  • Wheezing
  • Swollen lips, tongue or face (angioedema)

Anaphylactic reactions

The most serious allergic reaction to penicillin is an anaphylactic (an-uh-fuh-LAK-tik) response, which can be life-threatening. Anaphylactic reactions develop immediately after penicillin exposure in highly sensitive people. Signs and symptoms include:

  • Difficulty breathing
  • Wheezing
  • Drop in blood pressure
  • Swelling of the throat or tongue
  • Dizziness
  • Loss of consciousness
  • Rapid or weak pulse

When to see a doctor

Seek emergency medical care if you think you or someone else is having an anaphylactic reaction.

If you have less severe reactions after taking penicillin, talk to your doctor. If possible, see your doctor when the allergic reaction is occurring. This will aid in making a diagnosis.

Penicillin allergy occurs when your immune system responds to the drug as if it were a harmful substance instead of a helpful remedy. Your immune system triggers certain cells to produce immunoglobulin E (IgE) antibodies to fight the component of penicillin to which you're allergic (allergen). Chemicals released by your immune cells can cause the signs and symptoms associated with an allergic reaction. Exactly why this happens isn't clear.

Penicillin belongs to a family of drugs called beta-lactam antibiotics. These drugs include penicillin and amoxicillin, which are relatively inexpensive and effective at treating many common bacterial infections. Such infections include skin, ear, sinus and upper respiratory infections.

Taken orally or injected, penicillin works by stopping the growth of bacteria in your body. Several varieties of penicillin exist, and each targets a different infection in a different part of your body. You may have heard of some of the other drugs in the penicillin family, including:

  • Amoxicillin
  • Ampicillin
  • Dicloxacillin
  • Oxacillin
  • Penicillin V
  • Piperacillin
  • Piperacillin and tazobactam combined (Zosyn)

If you're allergic to one type of penicillin, you're at risk of being allergic to all penicillin-related antibiotics. Some people allergic to penicillin may also be allergic to cephalosporins, a class of antibiotics related to penicillin.

It isn't clear why some people develop penicillin allergies, while others don't. However, certain people seem to be at greater risk of developing a penicillin allergy than others are.

You may be at higher risk if:

  • You're between the ages of 20 and 49
  • You've taken penicillin frequently
  • You have HIV/AIDS
  • You have cystic fibrosis
  • You've had allergic reactions to penicillin or another drug in the past

You're likely to start by seeing your family doctor or a general practitioner. However, in some cases when you call to set up an appointment, you may be referred immediately to an allergist, a doctor who specializes in allergies.


What you can do

  • Document any exposure to penicillin, when it occurred and what type of reaction you had.
  • If you develop a rash after taking penicillin, take a photograph of the rash to show your doctor. A photo can be helpful in making a diagnosis.
  • Write down questions to ask your doctor.

Preparing a list of questions before your appointment will help you make the most of your time with your doctor. List your questions from most important to least important. For penicillin allergy, some basic questions to ask your doctor include:

  • What's the most likely cause for my symptoms?
  • Are there other possible causes for my symptoms?
  • How is a penicillin allergy treated?
  • How can I avoid penicillin and what alternatives are there?


What to expect from your doctor


  • When did you first begin experiencing symptoms?
  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • What was your dose of penicillin and how did you take it (by mouth or by injection)?
  • Is there a history of allergies in your family?
  • If you had symptoms after taking penicillin, how long did it take for the symptoms to develop?

What you can do in the meantime

If you suspect you have a penicillin allergy, don't take penicillin or related antibiotics. Your doctor can determine whether it's safe for you to take penicillin.

Your doctor will want to know about your past reactions to penicillin and may examine you to identify or exclude other medical problems. Unless you require penicillin — either because it's the only effective antibiotic for a life-threatening condition or because you're allergic to other antibiotics and have few treatment options — your doctor may prescribe another antibiotic.

Your doctor may recommend you be tested for penicillin allergy if:

  • You were allergic to penicillin in the past, but possibly are no longer sensitive to the drug
  • You require penicillin for treatment
  • Your doctor wants to keep you from taking a stronger antibiotic than your condition requires

Because of the risk of anaphylaxis, testing for penicillin allergy should only be done by an allergist in a hospital or doctor's office.

Skin test

This test, which can determine your sensitivity to the drug, involves the following:

  • A small amount of penicillin is injected into the skin of your forearm or back.
  • If you're allergic to the particular substance being tested, you develop a red, raised bump or reaction.

If the skin tests to penicillin are negative, your doctor may recommend penicillin or a related antibiotic. If the skin test to penicillin is positive, most likely your doctor will recommend that you continue to avoid penicillin and related antibiotics.

Blood test

Although blood tests are available for some types of allergic reaction, there aren't currently any reliable blood tests to diagnose a penicillin allergy.

If you have an allergic reaction after taking an antibiotic in the penicillin family, you should:

  • Stop taking the medication and ask your doctor about another antibiotic
  • Avoid using penicillin in the future

Treatment for signs and symptoms you develop during an allergic reaction to penicillin depends on what kind of reaction you have.

  • Anaphylaxis is the most rare and serious allergic drug reaction. It can be life-threatening and requires an injection of epinephrine (adrenaline) and emergency care to maintain blood pressure and support breathing.
  • Rashes or hives may improve when treated with an antihistamine, such as diphenhydramine (Benadryl, others). More severe reactions may require treatment with oral or injected corticosteroids.

If you think you've had reactions to penicillin in the past, be sure to tell your doctor and other medical professionals, including your dentist. Let your doctor know about any new reactions you notice when taking your medication.

If your doctor determines that you're allergic to penicillin, it's a good idea to wear a medical alert bracelet that describes your allergy. You might also want to carry an alert card in your wallet or purse. These items are available over-the-counter at most drugstores or can be purchased on the Internet.

The best way to avoid an allergic reaction to penicillin is to avoid penicillin and similar antibiotics altogether. If you require an antibiotic, your doctor will work with you to find one you can tolerate. When a doctor or other medical professional prescribes an antibiotic, be sure to double-check that it's not in the penicillin family.

Penicillin desensitization

For some infections, it may be necessary for you to take penicillin. In these cases, and if you previously experienced a reaction to penicillin, an allergy skin test may be important. If the skin test reveals that you're sensitive to penicillin, your doctor may recommend desensitization.

During the desensitization process, you receive small but gradually increasing doses of penicillin orally or intravenously. Because desensitization can trigger an allergic reaction, it's attempted only in a controlled setting, usually a hospital, by a doctor trained in the technique, and only when penicillin is absolutely necessary. Your desensitization lasts only as long as you continue taking penicillin. If you stop and then need to take penicillin again later, you'll need to go through the desensitization process again.

Dec. 15, 2011