SAN FRANCISCO — Scientists have known for years that when vampire bats tear through an animal’s skin with their razor-sharp teeth, their noses guide them to the best spots — where a precise bite will strike a vein and spill forth nourishing blood. But nobody knew exactly how bats knew where to bite.

By investigating wild vampire bats in South America, researchers at the University of California, San Francisco and Instituto Venezolano de Investigaciones Científicas in Caracas, Venezuela, have discovered their secret: a sensitive, heat-detecting molecule covering nerve endings on their noses called TRPV1. A number of pharmaceutical and biotech companies are working on developing new pain medications that target molecules like TRPV1.

“Vampire bats feed on blood, and it’s useful for them to have an infrared detector to be able to find the circulation,” said David Julius, the Morris Herzstein Chair in Molecular Biology & Medicine at UCSF, who led the research.

Similar TRPV1 molecules can be found on pain-sensing nerve fibers in the human tongue, skin or eyes. They allow people to detect the chemical capsaicin in chili peppers and experience the burning tinge of spicy food.

Described this week in the journal Nature, the discovery highlights how small changes to genes in the genome of a species can contribute to major evolutionary adaptations over time — in this case, allowing the vampire bat to detect infrared heat from their prey, helping them efficiently find and feed on blood.


“There is a double-edged sword with pain,” Julius said. “Pain is necessary as a warning system to let us know when we are in danger of injury but, at the same time, pain can outlive its usefulness as a warning system when it fails to resolve and becomes chronic and debilitating.”
Sensory nerves: how the brain experiences the world

The human brain does not connect directly with the world but instead floats secluded in a protective bubble of cerebrospinal fluid within the skull. All the information the brain receives about earthly sights, smells, textures, and tastes comes through long nerve fibers that make up the body’s sensory system, which connect the brain with our eyes, noses, fingers and tongues.

At the ends of these nerve fibers, cues that give life to our perception of the world are collected. Tiny molecular channels covering these nerve endings can alternatively open or close if they perceive the proper stimulus from a chemical, heat, cold or the pressure of touch. When they do, and when the right balance of openings and closings occurs all over a nerve ending, that nerve will fire, sending a signal to the brain that says “hot” or “cold” or “hard” or “bitter” or “pretty,” depending on the type of stimulus.


“There is a lot of stuff in our environment that we want to stay away from,” Julius said.

TRPV1, one of these sensory system channels, does belong to a large family of similar molecules common to many types of animals; but they differ slightly from animal to animal, both in terms of their DNA and in terms of where they appear in the body.

Vampire bats run like horses, feed on cows





Within minutes of sinking its teeth in an animal’s flesh, an adult vampire bat can drink half its body weight in blood. But first they must find a vein, helped by its major adaptations: heat-sensing ability, which allows them to “see” a vein at night.

Researchers have known for years that pits on vampire bats’ noses allow them to detect blood vessels because they radiate heat. But no one knew exactly how this occurred.

Working with three researchers in South America, Julius’ postdoctoral fellows Elena Gracheva and Julio Cordero-Morales, together with UCSF colleagues Nicholas Ingolia and Jonathan Weissman, sequenced genes from samples of nose tissue from wild vampire bats in Venezuela, determining that TRPV1 is the molecule responsible for their ability to detect heat.

They also determined that it was not just TRPV1 but an evolutionary genetic variation of it that allows vampire bats to detect low temperature heat. Through a mechanism known as “alternative splicing,” a special form of the molecule emerged in the noses of the bats, becoming a sensitive detector for finding the hottest spots.

The article “Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats” is authored by Elena O. Gracheva, Julio F. Cordero-Morales, José A. González-Carcacía, Nicholas T. Ingolia, Carlo Manno, Carla I. Aranguren, Jonathan S. Weissman, and David Julius and appears in the journal Nature on Aug. 4, 2011. Online:

This work was supported by funding from the National Institutes of Health and the Howard Hughes Medical Institute. Additional support was provided by a Ruth L. Kirschstein National Research Service Award and a Pathway to Independence Fellowship from the UCSF Cardiovascular Research Institute. David Julius is on the advisory board of Hydra Biosciences, Inc., which is investigating potential drugs that target molecules like TRPV1.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. Follow UCSF on Twitter: @ucsf/@ucsfscience