From T to B: Understanding immune cells in MS


Blood cells in circulation


Lymphocyte (b cell)


Current knowledge

Gaps in knowledge

Therapies that selectively deplete B cells lead to dramatic decreases in new MS relapses Identification of “good” B cells vs. “bad” B cells is needed to develop therapies that target the correct cells
B cells in people with MS can abnormally produce molecules that promote inflammation The method by which B cells enter the central nervous system to cause damage to myelin and surrounding tissues
B cells in people with MS can trigger abnormal T cell responses Clarification on the role of B cells in progressive MS
B cells are sometimes found in inflamed brain tissue of people with progressive MS, which suggests they may contribute to disease progression and subsequent worsening of disability The details behind B cell and T cell interaction, and how this interaction influences MS


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