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PEG MGF – IGF-1Ec Explained

PEG-MGF (Pegylated Mechano Growth Factor) is one of my personal favorite peptides.  In fact, it's the best variant of IGF on the market today when it comes to site growth.  Specifically, it's a IGF-1Ec splice that's responsible for both damaged muscle recovery and satellite cell growth.

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Base MGF which is produced in liver and secreted into the blood stream, only lasts for about 5-7 minutes before it breaks down.  This is the regular “base” MGF version that's not widely used due to the short half-life.  Just as IGF-1 was modified to be IGF-1LR3 (the longer acting version), the same has been done with MGF.    The additive polyethylene glycol was added to the MGF chain in order to give it a half life of several days!

mgf igf-1

Fig 1. MGF and IGF-1

PEG MGF Explained


How does MGF work?

If you have been training with weights, then you have already been using your own MGF that your body creates.  IGF-1 is spliced due to its response to broken down muscle tissue and one of the splices produced is IGF-1Ec, better known as mechano growth factor.  Basically, MGF is a version of IGF, specifically IGF-1Ec.  MGF is an amazing variant that directly helps with the up-regulation of protein synthesis and nitrogen retention.   This is why I think that PEG MGF is the best variant of the IGF-1 series.  After you have broken down muscle tissue (post training), you can use the peptide PEG MGF and reap the benefit of its response to damaged muscle tissue.  In addition, it will help you signal growth in nearby undamaged muscled cells. This gives it the unique ability to grow lagging body parts in areas where muscle growth is desired.

mgf vs IGF-IEa

Fig 2. MGF vs. IGF-IEa

Doses and Usage







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