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DNA Mismatch Repair Introduces Mutations in Non-Dividing Cells

Yoke Wah Kow, Ph.D., Gray F. Crouse, Ph.D.
Emory University
NIEHS Grant P01ES011163


NIEHS grantees report a role for DNA mismatch repair in creating mutations in non-dividing cells. These mutations can lead to cancer or create beneficial new phenotypes.

DNA mismatch repair removes replication errors by removing mismatched nucleotides. It is a strand-specific process, meaning the process removes only nucleotides on the newly replicated strand of DNA. How eukaryotic cells distinguish the strands is not fully understood, but the cells likely lose the ability to distinguish the strands as replication proceeds.



Citation: Rodriguez GP, Romanova NV, Bao G, Rouf NC, Kow YW, Crouse GF. 2012. Mismatch repair-dependent mutagenesis in nondividing cells. Proc Natl Acad Sci U S A 109(16):6153-6158.

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