Vitamin D Blog: D's Role in Weight Loss

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"Blind dosing" has several issues. First, deficient Ss typically need a large temporary loading doe to get up to a serum target (if the new blind dose isn't greater than the body's D usage, then the dose doesn't raise serum levels). Second, dose effect likely varies as a function of body size. Third, D serum level distributions are typically on a bell curve, so giving dose X simply raises the bell curve, potentially still leaving a deficient/insufficient population (therefore diluting/masking the effect). Finally, the assumption that a serum level of XX ng/ml is sufficient for the studied outcome may or may not be the same as the level for bone effects. Folks should always graph their serum level distribution vice their outcome variables; there may be effects at other serum levels. Obviously, folks with liver/kidney diseases and some drugs may be excluded since their 25(OH)D levels may not reflect their 1,25 serum levels. Or Ss who do not respond to the intervention may need magnesium or other co-factor levels checked..

mary c

I found taking large doses of D3 for several years and avoiding sunlight caused high cholesterol. Every month my labs would show a rise. I read an article that said sunlight actually lowers blood pressure and I began thinking... Vitamin D is made from sunlight and it USES cholesterol to do that! I stopped supplementing with D3 and began to get 20 minutes a week of sunlight. It was winter and that was about all I could get due to the cold weather...brrrr. My total dropped from 250 to 205 in one month... within 3 months I was down to a total of 166 with an ldl of 98. My triglycerides are still a bit higher than I like and my hdl dropped to around 50 which I was not happy about. I had raised it to 77 previously with coconut/mct oils. Anyway, sunlight is the better way to go. In moderation, naturally. BTW, anyone taking D3 should also be taking K2. K2 is not a clotting factor like K1, rather it directs the calcium into hard tissue such as bones and teeth an keeps the calcium out of soft tissue, such as arteries, hearts, etc. The D3 tells the body to absorb calcium, unfortunately it does not tell it what to do with it. K2 directs the calcium to the proper place. Taking D3 without K2 is not really healthy. (K2 is difficult to get enough of through food, unless you happen to like nato...yuck!) Nato is a common Japanese food, but not generally something westerners would enjoy. It is a very high source of K2 and probably has something to do with Japanese heart health, in my opinion..


