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Chimps have more adaptive genetic changes than humans

According to new research, chimpanzee genes have shown more adaptive changes than those of humans. The media widely reported the results as evidence that chimps are ‘more evolved’ than humans. But as I discuss here, these headlines are putting words into the researchers’ mouths.

Chimps have more adaptive genetic changes than humansSince the time when humans and chimps evolved from our common ancestor, our species appears to have come on by leaps and bounds. We walk on two legs, we speak using languages and while there is no doubt that chimps are intelligent, there is even less doubt that our brainpower outclasses theirs.

For years, scientists have assumed that our advanced abilities must be reflected in our genetics. After all, traits like intelligence and language give us great adaptive advantages. They should therefore be mirrored by similarly large changes in the human genome, compared to the chimp one.

Not so. Researchers at the University of Michigan sifted through the human and chimp genomes for signs of positive selection – the process where natural selection firmly embeds new mutations because of the advantages they provide. They found that the chimp genome contains 50% more positively-selected genes than the human one.

While earlier studies have compared individual human and chimp genes, this is the first to do a proper census. Margaret Bakewell and colleagues looked at almost 14,000 genes in both species.

The project was given a valuable push by the recent publication of the fully-sequenced rhesus macaque genome. The macaque – a type of monkey – is an evolutionary cousin of both humans and chimps, and provides a useful comparison.

Humans may have fewer adaptive changes than chimps because our population sizes have traditionally been smaller.If the team found a difference in the human and chimp genes, the macaque version can tell them which version is closest to the ancestral one. Previously, scientists had to make do with the mouse, a much more distantly related animal. The macaque’s presence gives the analysis greater accuracy.

Bakewell failed to find any noticeable differences in the function of positively-selected genes in humans and chimps. Both species even had similar proportions of positive changes among the genes that control the brain and nervous systems.

The reasons for this surprising result are unclear, but Bakewell feels that population sizes may hold the answer. For most of their evolution, chimpanzees have enjoyed a larger population size than humans have. It’s only recently that our numbers have ballooned to unfeasible proportions.

According to evolutionary theory, beneficial genetic changes are more quickly established in a population if it is larger. But in smaller groups, random genetic changes can trickle down through generations without being properly weeded out. This ‘genetic drift’ could explain why humans have fewer positively-selected genes than chimps do.

An alternative theory is that many of the human genetic changes that provide us with the greatest advantages may be relatively new developments. It is only recently in our history that we spread around the world from our origins in Africa, and as such, new genetic innovations may not have become established in the population as a whole.

A third theory, which I’m putting forward myself, is that the genetic changes responsible for our most human traits, may lie among stretches of DNA missed by this study. Recently, a study showed that one of the most important ‘genes’ in human evolution lies within our so-called junk DNA and controls the development of our brains. Clearly, we still have much to learn.

Evolution is not about progress.Nonetheless, the study helpfully shows that evolution is not necessarily about progress. It’s not an inexorable march toward some gleaming future. It’s about change, regardless of direction or result.

Somewhere along the line, the word ‘evolved’ started to gain a false value. It became an indicator of positive progress, so that claiming to be ‘more evolved’ than a peer is to claim superiority.

A huge number of newspapers and magazines reported this story under the headline of ‘Chimps more evolved than humans’. And while that may be technically reasonable, the inferences made were anything but.

The inherent values placed upon the phrase ‘more evolved’ clearly emerged in the reaction to the story. Some suggested that humans were obviously ‘less evolved’ given for reasons ranging from pollution to capitalism. Meanwhile, creationists and ID-supporters smelled blood in the water, and claimed that such as blatantly preposterous conclusion proved that evolution was nonsense.

Of course, no such conclusions were actually made by the study itself. In the light of the proper progress-free meaning of the word ‘evolution’, hese results are not preposterous, but fascinating. We should use them to drive a nail in the coffin of phrases like ‘evolutionary race’ or ‘more evolved’, at least in its value-laden non-scientific sense.

Reference: Bakewell, Shi & Zhang. 2007. More genes underwent positive selection in chimpanzee evolution than in human evolution. PNAS 104: 7489-7494.

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Non-coding DNA drove human brain evolution by making nerve cells stickier

Most of our genome is made up of the poorly named ‘junk DNA’. New research shows that these sequences may have been vital in the evolution of human brains, by allowing our neurons to make better contacts with each other.

DNA, and little of it is 'junk'.Two months ago, a group of scientists found that the gene that has evolved fastest since our evolutionary split from chimpanzees is found in our so-called ‘junk DNA’. DNA is a code that tells our cells how to build their molecular workforce – proteins.

But the vast majority of our DNA sequence is never translated into proteins. While some considered this ‘junk’ DNA to be meaningless, recent research has shown that it makes important contributions to our most human of organs – our brains.

Now, Shyam Prabhakar and James Noonan at the Lawrence Berkeley National Laboratory have found further proof of the link between non-coding DNA and our mental evolution.

They studied over 110,000 stretches of DNA called ‘conserved non-coding sequences’ (CNSs), that are largely similar in a wide variety of animals. Of these sequences, 992 showed large numbers of changes that were specific to humans.

This number is much higher than would be expected if these DNA regions were drifting aimlessly in the evolutionary river. Their frequency is the mark of natural selection – these sequences must have changed for a reason.

To discover what this reason might have been, Prabhakar and Noonan looked at which genes these CNSs were in, and what they do in the body. They found that a large proportion of the genes in question were involved in the adhesion of neurons (nerve cells).

These genes are vital for the growth and development of our brains and allow neurons to make connections with each other, and with their surrounding framework of supportive cells.

The duo found a similar number of CNSs with chimpanzee-specific changes and many of these were also involved in nerve cell adhesion. But there was hardly any overlap between the chimp-specific and human-specific sequences.

Both lineages have developed nerve cells that make better contacts with each other, but have done so in separate ways using different genes.

It is possible that human and chimp brains have evolved different mental abilities to satisfy different evolutionary pressures. Identifying the precise role of the human-specific CNSs will help to test this possibility and it is the next big challenge facing Prabhakar and Noonan.

In the meantime, this research once again shows that non-coding DNA, far from being useless junk, was vitally important for the evolution of the human brain and its many unique abilities. Subtle changes in these sequences separate us from even our closest animal relatives.

Prabhakar, Noonan, Paabo & Rubin. 2006. Science 314: 786.
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Hidden ‘junk’ gene separates human brains from chimpanzees




Humans and chimps share over 98.5% of our DNA.




Hidden gems

98.5% of our DNA is apparently junk








Related posts on DNA and chimp/human evolution:
Non-coding DNA drove brain evolution by making nerve cells stickier
Chimps have more adaptive genetic changes than humans
Chimps show that actions spoke louder than words in language evolution



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