Pronunciation: DEX lan SOE pra zol

Brand: Dexilant

What is the most important information I should know about dexlansoprazole?


What is dexlansoprazole?

Dexlansoprazole is in a group of drugs called proton pump inhibitors. Dexlansoprazole decreases the amount of acid produced in the stomach.

Dexlansoprazole is used to treat heartburn caused by gastroesophageal reflux disease (GERD), and to heal erosive esophagitis (damage to the esophagus from stomach acid).

Dexlansoprazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dexlansoprazole?


You should not take dexlansoprazole if you are allergic to it.

To make sure you can safely take dexlansoprazole, tell your doctor if you have liver disease or low levels of magnesium in your blood.

Taking a proton pump inhibitor such as dexlansoprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether dexlansoprazole is the actual cause of an increased risk of fracture. Before you take this medication, tell your doctor if you have osteoporosis or osteopenia (low bone mineral density).


It is not known whether dexlansoprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take dexlansoprazole?


Take this medicine with a full glass of water.

Dexlansoprazole may be taken with or without food.



When treating heartburn, dexlansoprazole is usually given for 4 weeks. To best heal erosive esophagitis, you may need to take dexlansoprazole for several months. Follow your doctor's instructions.


Call your doctor if your symptoms do not improve, or if they get worse while using dexlansoprazole.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?


What happens if I overdose?


What should I avoid while taking dexlansoprazole?

This medication can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking dexlansoprazole and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What are the possible side effects of dexlansoprazole?


Call your doctor at once if you have:

  • chest pain, fast or pounding heartbeats;
  • severe stomach pain;
  • diarrhea that is watery or bloody;
  • worsening heartburn; or

Common side effects may include:

  • nausea, vomiting, stomach pain, gas;
  • mild diarrhea; or
  • stuffy nose, sneezing, or other cold symptoms.


What other drugs will affect dexlansoprazole?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with dexlansoprazole, especially:

  • ampicillin, digoxin, iron, ketoconazole, methotrexate, tacrolimus; or
  • a blood thinner --warfarin, Coumadin; a diuretic or "water pill"; or HIV/AIDS medications --atazanavir, nelfinavir, rilpivirine, ritonavir, saquinavir, and others.

This list is not complete. Other drugs may interact with dexlansoprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about dexlansoprazole.



Copyright 1996-2015 Cerner Multum, Inc. Version: 10.02. Revision date: 6/21/2013.
