

PRD Class
Families List  Genes List
Alx Family
There are three human genes, originally called ALX3, ALX4 and CART1, in the Alx gene family. The clear relationship between these genes, and their duplication on the vertebrate lineage, led to CART1 being renamed ALX1 (Holland et al. 2007). There is no ALX2 gene in humans. Mouse has the same complement of Alx genes as human, although intriguingly the Alx3 genes were lost independently in chicken, Xenopus and anole lizard (McGonnell et al 2011). Amphioxus has a single gene in this family. Drosophila lacks the gene family; this is secondary loss, because the gene family is present in the cnidarian Nematostella vectensis.

McGonnell IM et al (2011) Evol Devel 13: 343-351.
Families List of Class PRD :
Loci in Alx of Frog back to top..
alx1ALX homeobox 1 AlxFrog 
alx4ALX homeobox 4 AlxFrog