Pronunciation: ES tra MUS teen

Brand: Emcyt

What is the most important information I should know about estramustine?

You should not use this medicine if you have a blood clot, swelling of a vein caused by a blood clot, or if you have ever had an allergic reaction to estradiol or nitrogen mustard.

What is estramustine?


Estramustine is used to treat metastatic or progressive prostate cancer.

Estramustine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking estramustine?

You should not use estramustine if you are allergic to it, or if you have:

  • a blood clot;
  • swelling of a vein caused by a blood clot; or
  • if you have ever had an allergic reaction to estradiol or nitrogen mustard.

To make sure estramustine is safe for you, tell your doctor if you have:

  • a history of blood clot, stroke, or heart attack;
  • diabetes;
  • high blood pressure (hypertension);
  • heart disease or coronary artery disease (atherosclerosis);
  • congestive heart failure;
  • migraine headaches;
  • epilepsy or other seizure disorder;
  • liver disease;
  • kidney disease; or
  • a metabolic bone disease (such as Paget's disease).

If a man fathers a baby while using estramustine, the baby may have birth defects. Use condoms to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.

How should I take estramustine?


Take estramustine on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take this medicine with water, not with milk or other dairy products.

It may take up to 90 days before you receive the full benefit of taking estramustine. Your doctor will determine how long to treat you with estramustine.

While using estramustine, you may need frequent blood tests. Your blood pressure will also need to be checked often.


Store in the refrigerator, do not freeze.

What happens if I miss a dose?


What happens if I overdose?


What should I avoid while taking estramustine?

Do not take this medication with milk, milk products, calcium supplements, or calcium-rich foods such as ice cream, yogurt, broccoli, and others.

Avoid using antacids or vitamin/mineral supplements that contain calcium. Calcium can make it harder for your body to absorb estramustine.


What are the possible side effects of estramustine?


Stop using estramustine and call your doctor at once if you have:

  • heart problems --shortness of breath (even with mild exertion), swelling, rapid weight gain, chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

Common side effects may include:

  • breast swelling or tenderness;
  • impotence;
  • nausea, diarrhea, upset stomach;
  • swelling, trouble breathing;
  • leg cramps; or
  • abnormal liver function tests.


What other drugs will affect estramustine?


Where can I get more information?

Your doctor or pharmacist can provide more information about estramustine.



Copyright 1996-2015 Cerner Multum, Inc. Version: 5.05. Revision date: 9/29/2015.
