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Indirect Antiglobulin

Indirect Antiglobulin

Does this test have other names?


What is this test?

This test looks for antibodies circulating in your bloodstream. Antibodies are proteins that your immune system makes in response to a possible foreign invader. If you receive a blood transfusion, these antibodies could attach to donated red blood cells and damage them.

Why do I need this test?

You may have this blood test before you get a blood transfusion. Doctors need to know if your blood has antibodies that aren't compatible with a donor's red blood cells.

If you do not have antibodies to the donor's red blood cells, the transfusion can proceed safely.

If you do have incompatible antibodies, the blood will agglutinate (clump) and can't be used.  


In this case, your body will make antibodies against the D antigen that could cause baby to develop a severe type of anemia called hemolytic disease. This usually happens with a second child, not the firstborn.


What other tests might I have along with this test?

Your doctor may also order a direct Coombs test. This test might be needed if antibodies are found in the indirect Coombs test or if you have a reaction to a transfusion.

What do my test results mean?


A normal finding is negative. This means you do not have antibodies to donor red blood cells, and the blood is not clumping.

A positive test result could indicate your blood and the donor's blood are incompatible. A positive test result during pregnancy could mean your baby has hemolytic disease.

How is this test done?


Does this test pose any risks?


What might affect my test results?

Some drugs, including insulin and penicillin, could interfere with your test results. Other medications that can affect your results include drugs to treat tuberculosis and drugs to control heart rhythm, blood pressure, or seizures.

How do I get ready for this test?

You don't need to prepare for this test.  In addition to the specific medications mentioned above, be sure your doctor knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.