Genome Property Definition Page

Nametrehalose biosynthesis, OtsAB pathway
DescriptionTrehalose is compatible solute, an osmolyte that protects cells against osmotic stress. It is built from two glucose molecules in an alpha,alpha linkage and can be made by at least three different pathways. In the OtsAB pathway (ots stands for osmotically regulated trehalose synthesis), OtsA (EC makes trehalose-6-phosphate from UDP-glucose and D-glucose 6-phosphate. OtsB (EC removes the phosphate.
JCVI RoleAdaptations to atypical conditions
Parent PropertyGenProp0267: osmolyte biosynthesis
Literature References
[ 1 ]Wolf A, Kramer R, Morbach S  Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stress.  Mol Microbiol 2003 Aug;49(4):1119-34.  PMID 12890033
[ 2 ]Kaasen I, McDougall J, Strom AR  Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex.  Gene 1994 Jul 22;145(1):9-15.  PMID 8045430
Gene Ontology TermGO:0005992: trehalose biosynthetic process (biological_process)
GO:0006970: response to osmotic stress (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Trehalose-6-phosphate synthaseotsAYESTIGR02400 (HMM): alpha,alpha-trehalose-phosphate synthase (UDP-forming)GO:0005992: trehalose biosynthetic process
GO:0006970: response to osmotic stress
trehalose-phosphataseotsBYESTIGR00685 (HMM): trehalose-phosphataseGO:0005992: trehalose biosynthetic process
GO:0006970: response to osmotic stress

Parent Properties
GenProp0267osmolyte biosynthesis

Sibling Properties
GenProp0147glycine betaine biosynthesis from choline
GenProp0264glucosylglycerol biosynthesis
GenProp0266trehalose biosynthesis, TreYZ pathway
GenProp0268ectoine biosynthesis
GenProp0281mannosylglycerate biosynthesis
GenProp0878N(epsilon)-acetyl-beta-lysine biosynthesis
GenProp1070beta-glutamate biosynthesis