YuezhiWade-Giles romanization Yüeh-chih, also called Indo-Scythancient people who ruled in Bactria and India from about 128 BC BCE to about AD 450 CE. The Yuezhi are first mentioned in Chinese sources at the beginning of the 2nd century BC BCE as nomads living in the western part of Gansu province, northwest northwestern China. When Lao Shang (reigned c. 174–161 BC BCE), ruler of the Xiongnu (a powerful people of North China), defeated them and killed their king, the main body of the Yuezhi moved westward into Sogdiana and Bactria, putting an end to Greek rule therein both regions. They and related tribes are the Asi (Asiani) and Tocharians (Tochari) of Western sources. About 128 BC BCE the Yuezhi were recorded living north of the Oxus River (Amu Darya), ruling Bactria as a dependency, but a little later the Great Yuezhi kingdom was in Bactria, and Sogdiana was occupied by the Ta-yuan Dayuan (Tocharians). The remnant in Gansu were called Little Yuezhi.

A new dynasty, the KushānKushan, was subsequently founded by one of the five chieftains among whom Bactria was divided. The Kushān Kushan kingdom extended its power southward and eastward into India and northward into Central Asia. From the 3rd century, however, Kushān Kushan power declined, and about AD 400 CE the Kidara dynasty arose in GandhāraGandhara; it the latter survived only to about AD 450 CE, when it was overwhelmed by the Hephthalites (originally a Yuezhi tribe).

Missionaries from the Great Yuezhi played an important part in the propagation of Buddhism in China. The spread of Indian culture into Central Asia as far as the borders of China probably also resulted from Kushān Kushan influence.