





It may also act as a mild stimulant and antidepressant.

Benefits and Effects


  • Improved Overall Brain Function – Centrophenoxine is considered a neuro energizer because it stimulates glucose uptake, oxygen consumption, and carbon dioxide production. The additional oxygen and glucose add to its nootropic effects, making learning easier, thought clearer, and all of the brain’s functions more efficient.

How it Works

Centrophenoxine is a combination of PCPA (paracholrphenoxyacetic) and a synthetic version of DMAE (dimethylaminoethanol) that has been modified to improve absorption and enhance its ability to cross the blood-brain barrier. It is a fat-soluble compound that is metabolized in the liver.

Though centrophenoxine has been the subject of decades of research, it’s precise mechanisms of action are still not entirely clear. While is known to cross the blood-brain barrier and ultimately increase the amount of acetylcholine in the synaptic vesicles, the exact method by which the process takes place remains a matter of speculation. Some researchers theorize that it works by converting into an intermediary phospholipid which is then used to make acetylcholine, while others believe it breaks down into choline in the brain and then is converted to acetylcholine.

But though the exact mechanism of action is not known, it is clear that centrophenoxine is a net cholinergic that increases production of acetylcholine, the neurotransmitter most strongly associated with memory and general cognitive acuity. This function is the primary means by which centrophenoxine acts as a nootropic, but it enhances cognition in other ways as well.

In addition to increasing acetylcholine production, centrophenoxine also stimulates brain activity. This brain state leads to increased oxygen uptake and better glucose absorption which result in many benefits, cognitive and otherwise. The increased oxygen and nutrient absorption energizes the brain and makes it function more efficiently, which improves focus, concentration, and clarity of thought.

Better oxygen and nutrient absorption is also an important factor in the improved fluid intelligence and problem-solving ability that many users report, and is believed to be largely responsible for the improved mood and enhanced energy associated with centrophenoxine.

Centrophenoxine has proven anti-aging as well as nootropic properties. It is an effective antioxidant capable of flushing out toxins that build up in cells as we age. It has been shown to reduce or even eliminate the buildup of lipofuscin, a waste material present in aging cells, and it is believed to halt and perhaps even reverse the cellular potassium buildup that is associated with age-related cognitive decline.






Centrophenoxine is an outstanding choline source that works extremely well with other nootropics, particularly the racetams. Review our beginner’s guide to stacking for detailed information on basic combinations and ratios to help you design your own nootropic stack.

Side Effects

Centrophenoxine is safe and nontoxic at every level of dosage and is very well tolerated. However, some users have experienced mild and minor side effects, including nausea, headache, gastrointestinal issues, and sleeplessness. In most cases, the side effects were associated with high doses and reducing the cumulative daily dosage eliminated the unwanted side effects.

Where to Buy

Centrophenoxine can be purchased online via Amazon or specialized nootropics vendors.

Buying from Amazon is convenient and available in capsule form such as Double Wood Centrophenoxine Capsules.

Alternatively, you can buy centrophenoxine from a specialized nootropic vendor such as

Closing Thoughts

Centrophenoxine is a safe, effective nootropic supplement that can significantly boost memory, learning ability, fluid intelligence, and concentration. It is also a known anti-aging supplement capable of flushing toxins from cells and halting, or perhaps even reversing, age-related cellular damage.

For nootropic users, centrophenoxine is an outstanding source of choline that works exceptionally well with other supplements like the racetams, which put heavy demand on the brain’s choline supplies.

Centrophenoxine is an affordable, readily available supplement with a long track record of success. Whether you’re interested in a powerful memory booster, an anti-aging supplement, or a high-quality choline source to combine with other nootropics, this could be the one you’re looking for.