Stephen J. Schueler, M.D.

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Gastrin Hypersecretion Overview

Another name for Gastrin Hypersecretion is Zollinger-Ellison Syndrome.

What is Zollinger-Ellison syndrome?
A person with Zollinger-Ellison syndrome has a tumor in the pancreas, stomach, or intestine that stimulates the stomach to produce more acid than usual. The increased acid can destroy the cells that line the stomach and intestine. Zollinger-Ellison syndrome can lead to peptic ulcer disease and malabsorption.

What are the symptoms of Zollinger-Ellison syndrome?
Symptoms of Zollinger-Ellison syndrome include upper abdominal pain. The pain may be worse on an empty stomach, and may be relieved with antacids. Additional symptoms of Zollinger-Ellison syndrome include heartburn, hiccups, indigestion, nausea, vomiting, and weight loss.

How does the doctor treat Zollinger-Ellison syndrome?
Treatment for Zollinger-Ellison syndrome includes medications that block acid production in the stomach, or surgery. Severe Zollinger-Ellison syndrome may require chemotherapy.

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Last Updated: Aug 23, 2010 References

PubMed Gastrin Hypersecretion References
  1. Desir B, Poitras P. Oral pantoprazole for acid suppression in the treatment of patients with Zollinger-Ellison syndrome. Can J Gastroenterol. 2001 Dec;15(12):795-8. [11773945]
  2. Gibril F, Jensen RT. Advances in evaluation and management of gastrinoma in patients with Zollinger-Ellison syndrome. Curr Gastroenterol Rep. 2005 May;7(2):114-21. [15802099]
  3. Gibril F, Jensen RT. Zollinger-Ellison syndrome revisited: diagnosis, biologic markers, associated inherited disorders, and acid hypersecretion. Curr Gastroenterol Rep. 2004 Dec;6(6):454-63. [15527675]
  4. Roy PK, Venzon DJ, Shojamanesh H, Abou-Saif A, Peghini P, Doppman JL, Gibril F, Jensen RT. Zollinger-Ellison syndrome. Clinical presentation in 261 patients. Medicine (Baltimore). 2000 Nov;79(6):379-411. [11144036]