How do action potentials travel along the axon?

1 Answer
Jul 16, 2014

An action potential is generated in 4 steps:

  1. Depolarization to threshold.

  2. Activation of sodium channels and rapid depolarization: the sodium ions rush into the cytoplasm and the inner membrane surface changes from negative to positive.

  3. Inactivation of sodium channels and activation of potassium channels:
    at +30 mV, inactivation gates of sodium channels close (sodium channel inactivation), and potassium channels open, beginning repolarization

  4. Return to normal permeability:
    The potassium channels begin to close when the membrane reaches normal resting potential (-70 mV) and when potassium channels finish closing, the membrane is hyperpolarized to -90 mV

The transmembrane potential then returns to resting level, and the action potential is over.

Action potentials move along an unmyelinated axon by continuous propagation , in which the moving action potential affects one segment of the axon at a time. A local current depolarizes the next segment to threshold, and the cycle repeats, propagating the action potential along the axon in 1 direction only, at a speed of about 1 meter/sec.

An action potential moves along a myelinated axon by saltatory propagation , which is faster and uses less energy.

In saltatory propagation, the local current produced by the action potential “jumps” from node of Ranvier to the next.

References from Hole's A&P

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