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Clomipramine Brand names, Clomipramine Analogs

Clomipramine Brand Names Mixture

  • No information avaliable

Clomipramine Chemical_Formula


Clomipramine RX_link


Clomipramine fda sheet

Clomipramine FDA

Clomipramine msds (material safety sheet)

Clomipramine Synthesis Reference

No information avaliable

Clomipramine Molecular Weight

314.852 g/mol

Clomipramine Melting Point

189.5 oC

Clomipramine H2O Solubility

0.294 mg/L

Clomipramine State


Clomipramine LogP


Clomipramine Dosage Forms


Clomipramine Indication

For the treatment of depression, obsessive compulsive disorder (OCD), panic attacks with or without agoraphobia, narcolepsy, chronic pain, and enuresis.

Clomipramine Pharmacology

Clomipramine, a tricyclic antidepressant, is the 3-chloro derivative of Imipramine. It was thought that tricylic antidepressants work exclusively by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: alpha-1 and beta-1 receptors are sensitized, alpha-2 receptors are desensitized (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain.

Clomipramine Absorption

Bioavailability is approximately 50% orally.

Clomipramine side effects and Toxicity

Signs and symptoms vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the time elapsed since drug ingestion. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with Anafranil either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7000 mg. The second death involved a patient suspected of ingesting a dose of 5750 mg.

Clomipramine Patient Information

Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with clomipramine hydrochloride and should counsel them in its appropriate use. A patient Medication Guide About Using Antidepressants in Children and Teenagers is available for clomipramine hydrochloride. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have.

Clomipramine Organisms Affected

Humans and other mammals