Nicotine Addiction: Introduction

The use of tobacco leaf to create and satisfy nicotine addiction was introduced to Columbus by Native Americans and spread rapidly to Europe. The use of tobacco as cigarettes, however, is predominantly a twentieth century phenomenon, as is the epidemic of disease caused by this form of tobacco.

Nicotine is the principal constituent of tobacco responsible for its addictive character. Addicted smokers regulate their nicotine intake and blood levels by adjusting the frequency and intensity of their tobacco use both to obtain the desired psychoactive effects and avoid withdrawal.

Unburned cured tobacco contains nicotine, carcinogens, and other toxins capable of causing gum disease and oral cancer. When tobacco is burned, the resultant smoke contains, in addition to nicotine, carbon monoxide and 4000 other compounds that result from volatilization, pyrolysis, and pyrosynthesis of tobacco and various chemical additives used in making different tobacco products. The smoke is composed of a fine aerosol, with a particle size distribution predominantly in the range to deposit in the airways and alveolar surfaces of the lungs, and a vapor phase.

The bulk of the toxicity and carcinogenicity of the smoke resides in the aerosolized particulate phase, which contains a large number of toxic constituents and carcinogenic compounds. The aggregate of particulate matter, after subtracting nicotine and moisture, is referred to as tar. The vapor phase contains carbon monoxide, respiratory irritants, and ciliotoxins as well as many of the volatile compounds responsible for the distinctive smell of cigarette smoke.


Genetic Considerations
Several genes have been associated with nicotine addiction. Some reduce the clearance of nicotine, and others have been associated with an increased likelihood of becoming dependent on tobacco and other drugs as well as a higher incidence of depression. It is unlikely that genetic factors are the principal determinants of addiction. Rates of smoking initiation among males, and corresponding rates of nicotine addiction, have dropped by almost 50% since the mid-1950s, suggesting that factors other than genetics are important. It is more likely that genetic susceptibility influences the probability that experimentation with tobacco as an adolescent will lead to addiction as an adult.

Nicotine Addiction

Provided by ArmMed Media
Revision date: July 3, 2011
Last revised: by Jorge P. Ribeiro, MD