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Autoimmune Hepatatis

Autoimmune hepatitis is a rare form of chronic hepatitis of unknown cause and is associated with various autoimmune phenomena. The disease usually affects women and is more common in individuals of northern European descent (see epidemiology). The major histologic finding in the liver is piecemeal necrosis, in which there is necrosis of hepatocytes in the periportal region, disruption of the limiting plate of the portal tract, and local infiltration of lymphoid cells.