II. Indications: Malaria Prophylaxis

  1. Areas without Chloroquine resistance

III. Safety

  1. Safe in all trimesters of pregnancy
  2. Safe for children of all ages

IV. Dose: Prophylaxis

  1. Protocol
    1. Start 1-2 weeks before travel
    2. Continue through 4 weeks after return
  2. Adult: 300 mg base (500 mg salt) PO once weekly
  3. Child: Dose: 5 mg/kg base (8.3 mg/kg salt) up to 300 mg base orally once weekly

V. Directions

  1. Taking with food decreases gastric irritation

VI. Adverse Effects

  1. Blurred vision
  2. Tinnitus
  3. Hearing Loss

VII. Efficacy

  1. Most world regions exhibit high Chloroquine resistance in Plasmodium falciparum

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Cost: Medications

chloroquine (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
CHLOROQUINE PH 500 MG TABLET Generic $11.13 each

Ontology: Chloroquine (C0008269)

Definition (NCI) A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.
Definition (MSH) The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
Definition (CSP) antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002738
SnomedCT 330034001, 324890009, 14728000, 373468005
LNC LP16070-2, MTHU014870
English Chingamin, Chlorochin, Chloroquine, Khingamin, chloroquine, 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Chloroquine [anti-malarial], Chloroquine [musculo-skeletal], chloroquine (medication), Chloroquine [Chemical/Ingredient], chloroquine products, Chloroquine [musculo-skeletal] (product), Chloroquine [anti-malarial] (product), CHLOROQUINE, Chloroquine (product), Chloroquine (substance), Chloroquine [anti-malarial] (substance), Chloroquine [musculo-skeletal] (substance)
Swedish Klorokin
Czech chlorochin, chloroquin
Finnish Klorokiini
Japanese リン酸クロロキン, クロロキン
Polish Arechina, Resochina, Chlorochina
Spanish cloroquina [antipalúdico] (producto), cloroquina [uso musculoesquelético] (producto), cloroquina [antipalúdico], cloroquina [uso musculoesquelético], cloroquina (producto), cloroquina (sustancia), cloroquina, Cloroquina
Croatian Klorokin
French Chloroquine
German Chlorochin
Italian Clorochina
Portuguese Cloroquina

Ontology: Aralen Phosphate (C0718643)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Aralen Phosphate