Orimeten (discontinued in the UK - February 2005)

Aminoglutethimide prevents the production of steroid hormones in the adrenal cortex

What is it used for?

How does it work?

Aminoglutethimide prevents the production of steroid hormones in the adrenal cortex. This occurs at an early stage in the process. Aminoglutethimide may also suppress the production of oestrogens elsewhere in the body.

Some types of cancer, especially breast cancer, will grow in the presence of oestrogens. Reduction of oestrogen levels will limit the growth of this type of cancer. Aminoglutethimide can be used for this purpose.As aminoglutethimide also inhibits production of cortisone, it can also be used in the treatment of Cushing's syndrome.



  • People taking this medicine should have regular blood tests.
  • It is recommended that blood tests are performed every six months to check the levels of thyroid hormones in the blood (thyroid function tests).
  • Blood pressure should be monitored regularly during treatment with this medicine.

Use with caution in


Not to be used in

  • Breastfeeding
  • Known sensitivity or allergy to any ingredient
  • Pregnancy



Pregnancy and Breastfeeding



Label warnings


Side effects


  • Rash
  • Drowsiness
  • Nausea
  • Blood disorders
  • Decreased functioning of the adrenal gland (adrenal suppression)
  • Dizziness
  • Tiredness (lethargy)
  • An extreme allergic reaction (anaphylaxis)
  • Shaky movements and unsteady walk (ataxia)



How can this medicine affect other medicines?

Aminoglutethimide increase the breakdown of the following medicines and therefore may reduce their effects:

blood-thinning / anti-clotting medicines (e.g. nicoumalone and warfarin).oral anti-diabetic medicinesdexamethasoneLast updated

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