Obesity treatment drugs, Causes and Research Medication

Latest Obesity treatment drugs, research medication options along with what causes fatness and which food supplements can help you lose weight.

WHO fact files on obesity reveals that the condition has gone to epidemic proportions worldwide, with around 2.8 million deaths associated with being overweight or obese.


Obesity or Excessive Weight is associated with various diseases, particularly e.g Cardiovascular Diseases, Diabetes Mellitus type 2, Obstructive Sleep apnea, Certain Types of Cancer and Osteoarthritis.

As a result, obesity has been found to reduce life expectancy. The primary treatment for obesity is dieting and physical exercise. If this fails, anti-obesity drugs and (in severe cases) bariatric surgery can be tried Obesity, in absolute terms, is an increase of body adipose tissue (fat tissue) mass. In a practical setting it is difficult to determine this directly. Therefore, obesity is typically assessed by BMI (body mass index)

Obesity treatment drugs, Causes and Research Medication

Obesity Treatment Drugs, Causes and Research Medication









What are the Causes of Obesity and Fatness?

Most researchers agree that a combination of excessive calorie consumption and a sedentary lifestyle are the primary causes of obesity. In a minority of cases, increased food consumption can be attributed to genetic, medical, or psychiatric A 2006 review identifies ten other possible contributors to the recent increase of obesity.

  1. Insufficient sleep
  2. Endocrine disruptors—food substances that interfere with lipid metabolism
  3. Decreased variability in ambient temperature
  4. Decreased rates of smoking as smoking suppresses appetite
  5. Increased use of medication that leads to weight gain
  6. Increased distribution of ethnic and age groups that tend to be heavier
  7. Pregnancy at a later age
  8. Positive natural selection of people with a higher BMI
  9. Genetic factors
  10. Lack of Physical activity
  11. Intake of Weight gaining substances like creatin

Causes of Obesity and Fatness

Anti-obesity or weight loss programs contains two main constituents as given below:

  • Obesity treatment without drugs using non therapeutic obesity treatment programs
  • Obesity treatment with drugs using therapeutic obesity treatment programs

Anti-Obesity Programs

Obesity Treatment without Supplements, Drugs or Medications

Obesity treatment without drugs using non therapeutic obesity treatment programs includes weight loss techniques without using medications:

  1. Exercise for Obesity treatment
    Regular exercise is very important for diabetic as well as obesity patient. Actually exercise works as calorie burner as well as metabolism booster. Both of these effects play very important role in reducing body fat by consuming excessive storage depots of fats.
  2. Diet for Obesity treatment
    Diet is another non therapeutic way to reduce body weight and to treat obesity. Actually by restricting your diet from fatty food and  constituents that contains high amount of calorie like sugar will help you to limit your body fat reservoirs.

Obesity Treatment with Drugs

For hard to treat patient, obesity treatment with drugs using therapeutic obesity treatment programs. Therapeutic treatment includes Obesity treatment drugs, medications and supplements that specifically target obesity by different mechanisms. These medications are given below:

  1. Sibutramine for Obesity Treatment


  2. Metformin for Obesity Treatment


  3. Byetta for Obesity Treatment


  4. Symlin for Obesity Treatment


  5. Rimonabant for Obesity Treatment


Orlistat: Obesity Treatment Research Medications

Orlistat is the only non-controlled anti-obesity prescription drug approved by FDA. Obesity refers to an excessive amount of body fat. Most health care professionals agree that men with more than 25 percent body fat and women with more than 30 percent body fat are obese.

Most available weight-loss medications approved by the Food and Drug Administration (FDA) are appetite-suppressant medications. However, Orlistat is one drug that works in a different way. Orlistat works by reducing the body’s ability to absorb dietary fat by about one third. It does this by blocking the enzyme lipase, which is responsible for breaking down dietary fat. When fat is not broken down, the body cannot absorb it, so fewer calories are taken in.

Prescription weight-loss medications should be used only by patients who are at increased medical risk because of their weight. They should not be used for “cosmetic” weight loss. Prescription weight loss drugs are approved only for those with a body mass index (BMI) of 30 and above, or 27 and above if they have obesity-related conditions, such as high blood pressure, dyslipidemia (abnormal amounts of fat in the blood), or type 2 diabetes. BMI is a measure of weight in relation to height. A BMI of 18.5 to 24.9 is considered healthy.

Orlistat Dosage and Administration

The recommended dose of orlistat is one 120 mg capsule three times a day with each main meal (during or up to one hour after the meal). Orlistat is currently approved for use in teens age 12 or above.

Orlistat Mechanism for Weight Loss

Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorb-able free fatty acids and are excreted undigested. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.

Orlistat Trials Results for Obesity Treatment


For further learning please watch our video on Obesity Causes,Types,Treatment, and Symptoms!

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