Do embryos and the uterus talk to each other?

blastocyst-embryo-pivfWe know that in normal fertile couples it takes an average of 3 months to conceive.  We also know that in successful IVF programs, most embryos will never implant.  Even when genetic testing is performed on the embryos to eliminate the most common cause of IVF failure, 30% of embryos will still not stick. So, is the embryo sending some sort of message to the uterus that is OK to allow implantation or not? Researchers from the UK, discovered that embryos produce an enzyme called trypsin that facilitates the implantation process, but that embryos which are genetically abnormal produce less trypsin. This may be a way that embryos tells the uterus whether it ok to allow implantation. Perhaps a better understanding of this process may help develop ways to make IVF more successful.