pharm T2, L20 Adrenergic antagonists.txt

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  1. What are the three classes of alpha receptors antagonists?
    • Reversible
    • irreversible
    • Alpha 2 selective
  2. two alpha receptor blockers?
    • Phentolamine: competitive, reversible
    • Phenoxybenzamine: non-competitive, irreversible
  3. Four alpha 1 selective blockers?
    • Prazosin
    • Terazosin
    • Doxazosin
    • Tamsulosin
  4. What are the three classes of Beta receptor antagonists?
    • Non-selective
    • Beta-1 selective
    • Intrinsic (partial agonist)
  5. What receptors do Epi and NE mainly act on ?
    • Epi = Beta 2
    • NE = Beta 1
  6. Affect of alpha 2 blockage on BP?
    increase sympathetic output & inc BP
  7. receptor constricts arterial & venous sm mm to maintain PR?
    Alpha 1
  8. R contracts bladder, sphinctors, prostate
    Alpha 1
  9. Adrenergic receptor causing mydriasis
    Alpha 1
  10. Adrenergic receptor causing ejaculation
    Alpha 1
  11. Adrenergic receptor causing nasal decongestion
    Alpha 1
  12. Adrenergic receptor decreasing NE release
    Alpha 2
  13. Adrenergic receptor contracting some vascular sm mm
    Alpha 2
  14. AR increasing HR and contraction
    Beta 1
  15. AR increasing Heart automaticity
  16. AR increasing Renin & BP
  17. AR relaxing bronchioles
  18. AR dilating some blood vessels
  19. AR increasing glyocogenolysis
  20. AR receptor increasing lipolysis
  21. AR increasing aqueous humor, intraocular pressure
  22. Common ending for Alpha antagonists
    -osin or -alol
  23. Phenoxybenzamine
    only irreversible alpha antagonist, can't overcome w/ excessive NE
  24. What happens w/ HR after Alpha blockade?
    HR and BP decrease but then there is reflex tachycardia from Baroreceptors and increased NE on B1 receptors
  25. What happens when you stand up and are taking an alpha blockage?
    Postural hypotension = possible passing out
  26. What receptors does Phentolamine work on? Reversible or irreversible?
    A1 & A2, reversible
  27. What happens if A2 is blocked?
    Block NE release = harder to raise BP but baroreflex can cover
  28. Phentolamine side effects?
    • Tachycardia
    • Miosis
    • Myocardial ischemia
    • hyptotension
    • increased urination
    • stuffiness
    • ** increased gastric acid (unusual)
  29. Althought not used often, when would you use phentolamine? (3)
    • 1) Hypertensive crisis
    • 2) Patients with MAO inhibition that ingest Tyramine (= large NE release)
    • 3) Prevent necrosis of digits after alpha agonist or NE
  30. Most common use for Phenoxybenzamine?
    Pheochromocytoma: tumor increasing release of NE and Epi (high HTN, tachycardia, arrhythmia)
  31. Prazosin receptor?
    Alpha 1 blocker
  32. Principle functions of Prazosin?
    • CO does not increase
    • Less tachycardia (b/c Alpha 2 not blocked)
    • baroreceptor reflex inhibited
    • Hypotension
  33. Prazosin effect on lipids?
    Decrease LDL and increase HDL
  34. Half life of Prazosin?
    7-10 hours, problem b/c needs to be taken 2x a day
  35. What is the first dose phenomenon of Prazosin, Terazosin & Doxazosin?
    postural hypotension = must take at bedtime so the person does not collapse
  36. T/F Prazosin, Terazosin & Doxazosin should be taken w/ Viagra?
    F, they both decrease tone and would cause immense hypotension w/o a baro receptor effect
  37. Why should Terazosin and/or Doxazosin be used over Prazosin?
    • Longer half life = 1 pill a day
    • ** same side effects
  38. Drugs used to treat HTN and Benign prostatic hyperplasia?
    • Prozasin
    • Terazosin
    • Doxazosin
Card Set:
pharm T2, L20 Adrenergic antagonists.txt
2011-10-04 23:11:55
pharm T2 L20 Adrenergic antagonists

pharm T2, L20 Adrenergic antagonists
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