Incredible Health

Service dogs pick up scent of diabetics in danger

About two times a night, Shana Eppler wakes up to an alarm and slips into her daughter Abbie's room to test the 8-year-old's blood sugar.


The alarm Ms. Eppler uses to avoid a health emergency is a furry one named Gracie, a 70-pound, 3-year-old British Labrador retriever trained to sniff out high and low blood-sugar levels. When Abbie's sugar level rises or falls below a certain target at night, Gracie rings a bell and Ms. Eppler gets up.

"The scenting part comes naturally," said Eppler, of Colorado Springs, Colo. "They are hunting blood sugars instead of ducks."



For centuries, doctors diagnosed diabetes by identifying sweetness in the urine of a patient. That scent comes from glucose that isn't absorbed when a person lacks insulin, but the chemicals produced during low-blood-sugar incidents have yet to be identified.

"Whatever is being secreted in that drop in blood sugar…we just don't know what it is," said Dana Hardin, a pediatric endocrinologist who works for Eli Lilly & Co. in Indianapolis. Her goal is to identify what chemical compound the dogs smell, "not only to train dogs but to possibly make a device," she said.


Incidence of Type 1 has been rising in the U.S. by about 2.5 percent to 4 percent a year for reasons scientists can't explain, according to several large-scale studies published in peer-reviewed medical journals. The number of people with Type 1 diabetes in the U.S. is between 1.3 million and 2.6 million, accounting for 5 percent to 10 percent of the total diabetic population.



"They don't get the signs. They just can be having a normal conversation, go from feeling fine to passing out," said Hardin.

Diabetics can use technologies such as continuous glucose monitors to help prevent these episodes, but these don't record blood-sugar drops until after they happen. So hypoglycemic-alert dogs can be lifesavers, said Hardin, who presented the first scientific research on the dogs at this year's annual American Diabetes Association conference in Philadelphia.

Using perspiration samples from patients whose sugars were below 65 milligrams a deciliter—normal is 80 to 120 mg/dL—she trained a two-year-old Labrador/Golden retriever mix to recognize low blood-sugar samples placed in blinded containers on a Lazy Susan-like wheel. Modeled after how police sniffing dogs are trained, trainers around the country use similar techniques. Hardin's dog was then paired with Dustin Hillman, a 36-year-old patient who suffered severe hypoglycemic unawareness.


Since having Tippy—short for Tippecanoe—Hillman has finished his dissertation and will receive his Master's in Chemistry on Sunday from Purdue University. He had been on the verge of dropping out of school and moving back in with his parents, he said.

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