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Synchronized brain waves enable rapid learning

June 12, 2014
Massachusetts Institute of Technology

Credit: Jose-Luis Olivares/MIT


The researchers found that as monkeys learn to categorize different patterns of dots, two brain areas involved in learning -- the prefrontal cortex and the striatum -- synchronize their brain waves to form new communication circuits.

"We're seeing direct evidence for the interactions between these two systems during learning, which hasn't been seen before. Category-learning results in new functional circuits between these two areas, and these functional circuits are rhythm-based, which is key because that's a relatively new concept in systems neuroscience," says Earl Miller, the Picower Professor of Neuroscience at MIT and senior author of the study, which appears in the June 12 issue of Neuron.

There are millions of neurons in the brain, each producing its own electrical signals. These combined signals generate oscillations known as brain waves, which can be measured by electroencephalography (EEG). The research team focused on EEG patterns from the prefrontal cortex -- the seat of the brain's executive control system -- and the striatum, which controls habit formation.


"If you can change your thoughts from moment to moment, you can't be doing it by constantly making new connections and breaking them apart in your brain. Plasticity doesn't happen on that kind of time scale," says Miller, who is a member of MIT's Picower Institute for Learning and Memory. "There's got to be some way of dynamically establishing circuits to correspond to the thoughts we're having in this moment, and then if we change our minds a moment later, those circuits break apart somehow. We think synchronized brain waves may be the way the brain does it."


Humming together

Miller's lab has previously shown that during category-learning, neurons in the striatum become active early, followed by slower activation of neurons in the prefrontal cortex. "The striatum learns very simple things really quickly, and then its output trains the prefrontal cortex to gradually pick up on the bigger picture," Miller says. "The striatum learns the pieces of the puzzle, and then the prefrontal cortex puts the pieces of the puzzle together."


At first, the animals were shown just two different examples, or "exemplars," from each category. After each round, the number of exemplars was doubled. In the early stages, the animals could simply memorize which exemplars belonged to each category. However, the number of exemplars eventually became too large for the animals to memorize all of them, and they began to learn the general traits that characterized each category.


As the monkeys shifted from rote memorization to learning the categories, the researchers saw a corresponding shift in EEG patterns. Brain waves known as "beta bands," produced independently by the prefrontal cortex and the striatum, began to synchronize with each other. This suggests that a communication circuit is forming between the two regions, Miller says.

"There is some unknown mechanism that allows these resonance patterns to form, and these circuits start humming together," he says. "That humming may then foster subsequent long-term plasticity changes in the brain, so real anatomical circuits can form. But the first thing that happens is they start humming together."



"Expanding your knowledge"

Previous studies have shown that during cognitively demanding tasks, there is increased synchrony between the frontal cortex and visual cortex, but Miller's lab is the first to show specific patterns of synchrony linked to specific thoughts.


"That's how you get the open-ended nature of human thought. You keep expanding your knowledge," Miller says. "The prefrontal cortex learning the categories isn't the end of the game. The cortex is learning these new categories and then forming circuits that can send the categories down to the striatum as if it's just brand-new material for the brain to elaborate on."


The research was funded by the National Institute of Mental Health.

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Journal Reference:

  1. Evan G. Antzoulatosemail , Earl K. Milleremail. Increases in Functional Connectivity between Prefrontal Cortex and Striatum during Category Learning. Neuron, 2014 DOI: 10.1016/j.neuron.2014.05.005

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Massachusetts Institute of Technology. "Synchronized brain waves enable rapid learning." ScienceDaily. ScienceDaily, 12 June 2014. <>.
Massachusetts Institute of Technology. (2014, June 12). Synchronized brain waves enable rapid learning. ScienceDaily. Retrieved September 1, 2015 from
Massachusetts Institute of Technology. "Synchronized brain waves enable rapid learning." ScienceDaily. (accessed September 1, 2015).

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