Researchers Discover How Virulent Bacteria Sabotage Immune Response Against Them




When patrolling immune-system cells encounter non-pathogenic microbes, they normally engulf and destroy them. However, certain pathogens such as Listeria can grow within immune cells, which then release alarm signals to other nearby cells. One of these alarms is IFN-aß. IFN-aß protects host cells from viral infection. However, IFN-aß also increases growth of Listeria and certain other bacteria.

Dr. Lenz and his colleagues showed that IFN-aß does this by down-regulating expression of receptors for interferon-? (IFN-?). With its receptors down-regulated, IFN-? cannot drive resting macrophages into an activated state that is especially effective against bacterial pathogens inside the cell.
"IFN-aß acts as a sort of anesthetic to numb the response of immune cells to IFN-?," said Dr. Lenz.

The research highlights the crosstalk that exists between the antibacterial and anti-viral arms of the immune response. Dr. Lenz's findings demonstrate that IFN-aß, well known to stimulate antiviral defenses, dampens anti-bacterial activity as well.

He speculates that this may be a way for the immune system to more efficiently defend against viral pathogens, while avoiding collateral damage caused by an overactive immune cells. In fact, interferon-ß, a medication widely used for multiple sclerosis, may do just that. Dr. Lenz speculates that this medication may act in part by down-regulating expression of IFN-? receptors on myeloid cells, thus reducing the stimulation of autoimmune T cells.

The next step will be to define more precisely how IFN-aß mediates down-regulation of the IFN-? receptors, and to determine whether prevention of these effects improves resistance to infection by Listeria and other bacterial pathogens.


Last Updated: 5/2014

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