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    Renegat's picture
    Joined: Dec 8 2012
    Perhaps the most fascinating part of the biological organism's the immune system. And the most reliable Manual of the immune system is "Janeway's immunobiology," Kenneth Murphy, Paul Travers, Mark Walport, 7 Edition, Garland Sience, Taylor & Francis Group, LLC, New York and Abingdon. In particular, the instructions that Janeway gives of the immune system of the newborn, should be of interest here. Of course it is not ethically possible to dissect small babies and to look at the lymph vessels. In mice, there are fewer scruples. It was found out that in the first three weeks of life, in the mouse only regulatory cells are produced. Only then the thymus gland is mature enough to send off helper and killer cells to the periphery. Why? The organism is exposed to constant contact with pathogens and toxins. Would he respond to any of these substances with a specific defense response (ie helper and killer cells to respond), so he was in a constant state of inflammation, he would be constantly sick. Therefore, a "thick skin" of regulatory cells is established in the first life, so to speak. These regulatory cells then take care for the rest of life that relatively harmless substances (such as pollen in nose and lung or bacteria in the gut) are not immediately responded with "nuclear weapons", ie a specific immune response. Thus, the immune system learns in the first period of its development tolerance to relatively harmless pollutants. There are two examples that illustrate nicely this mechanism. Crohn's disease, and hay fever. Both developmental disorders of the immune system affecting the mucous membranes. What else, but the mucous membranes are most sensitive barrier of the organism against invading pathogens. Let's start with hay fever. Here is the "hygiene theory" cited to explain the disease. Quite right. If the immune system in early childhood comes not in contact with (here), bee pollen, the "thick skin" of regulatory cells can not develop. Namely the thymus produces only a very small number of cells to grow only in the periphery (in this case in the affected mucous membranes), and only in contact with the intruder to full number. The contact with pollen is essential to ensure that the regulatory cells can be stimulated to divide and populate the mucosa in sufficient number. This settlement does not take place, for example at city children who are not exposed to pollen, then finds himself in a mature immune system morbid majority of helper and killer cells. A pathologic inflammation in the hay fever season is the result. Hygiene theory proved. Crohn's disease (regional enteritis, a cruel chronic inflammation of the intestine, as usual with the reaching adulthood leads to death) has a very similar history. It is the lack of intestinal flora, which leads to the development disorder of the immune system. Professor JA Romijn (University of Amsterdam) has even bothered to write down the incidence of Crohn's disease in some developed countries (found in "Ernährungsmedizin und Diätetik", Kasper, Burghardt, Urban & Fischer, Elsevier, 11th edition, 2009, Munich ). It is noticeable that there were no cases of Crohn's disease before the last world war. Kasper and Burghardt explain this fact with the increasing sugar consumption after the war. Also been shown that children and adolescents (age these are not patients, but casualties) have an increased sugar intake. In order to propose a different idea for ​​the cause of Crohn's disease, the theory must first be exhausted. The increased consumption of sugar is not the cause of MC, but a side effectof it's cause. This side effect has psychological developmental causes. Namely, the infant lacks the intimacy with feeding from the breast, the evolving human being will comfort with an increased consumption of sweets on this gap in the psychological development time. This observed fact is below playing a role. Very well. As we have seen the example of the hygiene theory, pathogens are needed to adapted the developing immune system to the environment. If now the intestine of the infant is sterilized, thus "purified" of bacteria, the regulatory part of the immune system can not develop (see above). Sterilization of the intestine takes place whenever oral antibiotics are given to the infant. And the data given by Romijn fit exactly to the general introduction of antibiotics to public health care. Now would Crohn's desease disaster have a much greater degree if every antibiotic administration in infancy (from what age on this gift is not contraindicated, a note below) would lead to the MC. It must be added a sterile diet. Sterile diet is of course not the case if the child is breastfed! The maternal bacterial flora is retransmitted at each breast-time to the child's intestine. So the question is answered, why CD patients have such a big craving for sugar. They were not breastfed and now compensate with increased consumption of sweets. This is, for someone who is familiar to some extent with the development of the immune system, a completely clear relationship I've also adressed Professor Kenneth Murphy, WUSTL half a year ago, with this subject. Unfortunately, I then heard nothing more from him. There is an another medical issue that is related to the adjustment of the immune system to the environment (I've not finished yet!). Recently I've been listening on the radio (Deutschlandfunk) to a program on the vaccination of children. As has been mentioned, the children are vaccinated at the age of six to eight weeks, my hair stood on end! What happens during a vaccination? The thymus gland is stimulated to produce helper and killer cells. At a time in which it is absolutely forbidden, as well my comments show clearly enough! Well, the development of asthma, hay fever, rheumatism, and possibly multiple sclerosis, just everything there is such niceties in the context of autoimmune diseases, will show. Well vaccination and antibiotic therapy are indeed sometimes very beneficial. I can, for example, remember how a antibiotic therapy has cured me from a year-long bronchitis. But at what point, at what age should you engage in this form into the body without risking severe damage to the immune system? The answer to this questions we find at Professor Charles Janeway's Immunobiology. Much of what we know about the immune system, was obtained from the observation of genetically immunodefiencend children. One of these usually very rapidly leading to death gene defects blockes the MBL system. One speaks of the MBL gap in the preparedness of the child to defend pathogenes. This time window extends from the point at which the maternal antibodies are "consumed" up to the onset of the acquired immune response (so to speak until the child has developed "nuclear weapons"). The limit of this later time window should be the point from which on you can safely vaccinate (my Janeway edition, page 66). An anecdote about how I purchased my Janeway's might be nice here. The book seller recognized at first sight, that I am not a student (to old) and not a Physician, too (to poor). So he told me, this is not about Startrek or Captain Janeway. I countered this offension with a smile and suggested, may be it's just the other way around. The captain of Starship Voyager was named by Charles Janeway! But until today, I don't know exactly, who are the mircoorganisms? The Borg or Starship Voyager? Propably Starship Voyager, because the Borg never try to evade.


    Renegat's picture
    Joined: Dec 8 2012

    This morning I woke up with a fright. For I have missed yesterday a significant point in my brief sketch of the immune system. It is probably not the manipulation of the thymus gland, which results in the generation of helper and killer cells in the vaccine, but a completely different mechanism. Namely the reprogramming of a vaccine is suitable for the reprogramming of a regulator cell. Namely, this is also a way to produce specific immune response.

    All day I've chewed on this problem around, with alternating hot and cold feelings (I do have three-quarters of humanity made mad with my "latest findings" and I would like for there, when everything was just hot air?). But the difference in the genesis makes no difference in the effect. The effect is that the areas of the immune system that are actually intended for regulatory cells are populated with helper and killer cells.

    Maybe even a first look at the thymus before I report what I have (again) remembered. Einstein once said, with reference to the quantum mechanics, God does not play dice. For the thymus and the development of the T-cell receptor that statement is not true. The contrary, the randomness of T-cell origin is probably the most perfect random number generator that was ever invented. Better than any calculator (what is sold to us by the computer science as random is, on closer inspection, namely, none at all!). Let's look at the date on which vaccination is not so risky, the later end of the "MBL window". Previously, all randomly generated T-cell receptors were dismissed as regulatory cells in the periphery. As of now this is no longer the case. While the dicing goes merrily on, but the now helper and killer cells that are generated, while trying to leave the thymus, are killed (out of apoptosis).

    Only when the peripheral requests a specific immune response, the situation changes. This is done as follows: A phagocyte on the extreme defensive front takes, say, a bacterium on. It shreds his constituents and presentes them on their surface, while making his way to the thymus gland. First stop is the layer that is populated by regulatory cells. Drifts this now called antigen presenting cell defense cell to an appropriate regulatory cell, it is destroyed. The problem with the Bacteria that would infect the body is done.

    Now what if no suitable regulator cell is found? The layer of regulator cells is broken and the APC (antigen presenting cell) reaches the layer with killer and helper cells. Here she meets on their matching T-cell, their journey is also terminated. And the acquired immune response is triggered. The T-cell divides (if I remember correctly, resulting from a triggered T-cell about 1000 daughter cells), selects appropriate B cells, the inflammation reaction starts. Anyway, roughly. The details are of course much more complicated.

    Only if no suitable helper or killer cell is found, the APC can leave the lymph system and travels through on blood way to the thymus. There they will be happy in case their partner and finally – has to die. However, it has previously it's partner cell, "a license to kill" granted. Now it's the other way around ie. Not the resident cells in the thymus kill the newly diced cell, but the new cell kills the cell colony! The result is a breach in the wall that normally prevents the escape of the T cell from the thymus. And also for all subsequent T-cells with the same specificity.

    This creates a gradually range of T-cells, according to the environmental conditions. However, this is not the old saying "what does not kill us only makes us harder." In fact, the more immunizations learns the immune system, the longer time the acquired immune response requieres, because the probability decreases for an APC to meet "their" T cell. That is one reason why I'm skeptical of vaccinations that are not absolutely necessary. And also the whole traveling around the world, that confrontes the people with new pathogens, does not serve the health.

    Well you know, the thymus atrophies with the adult becoming. Nevertheless, the adult organism is still capable of immunization. Here is probably the reprogramming of regulatory cells to helper and killer cells in the periphery responsible. How this works I do not know. Probably this is to read the last chapter of the immunobiology, "Manipulation of the immune system" (I have not yet read, but on the other hand, those tricks are a secret of economical interest).

    But now the idea I had this morning as well. Rubella vaccination and multiple sclerosis. First, of course, notice that at least during the time when I had this suspicion (about twenty years ago, I was at that time a young colleague with MS was diagnosed), almost only women and girls have been vaccinated against rubella. And multiple sclerosis affected almost exclusively women. Unfortunately, the epidemiological data in general are a great mystery, which are traded only in medical circles. I would not get it as a mortal stonemason.

    Why it would be interesting to look here again after? The rubella virus is indeed one of the villains that affects the central nervous system when blood-brain barrier is broken. Therefore it has to have a certain affinity for the surface of the nerve cell to invade it. Now the swan cells that are attacked autoimmune in MS, ontogenetically are closely related to the nerve cells. Maybe if one applies the key-lock principle, multiple, there is a way in which the killer cells T-cell receptor generated by a rubella vaccination, that fits the virus protein, albeit a low affinity for the surface of the swan sheaths may have.

    Following the same line of thought is corroborated also occasionally expressed suspicion that the triple vaccination in infancy (mumps, measles, rubella, MMR) for the novel disease Attention deficite and Hyperactivity - Disorder (ADHD) can be held responsible. How so? In short, the children itches their skin! Suspect is a clinically undetectable, low affinity of T cells generated by the vaccine, in this case probably the helper cells that attack the nerves with chemical agents. But the children do not complain of itching! Right, because they do not notice it at all! The biological development of the central nervous system has to be taken in to calculus. A constant distracting stimulus that reaches the brain in early childhood age is blinded from the consciousness of. This is quite clear when one observes how infants react in the very beginning very sensitive to almost all environmental stimuli (except the mother) and then gradually learn to hide the stimuli.

    What remains are the spinal reflexes on the chronic stimulation of the peripheral nerves - fidget Syndrome!

    Renegat's picture
    Joined: Dec 8 2012

    I needed the final chapter of Janeway's Immunobiology not to read to give a sketch of reprogramming the regulator cell to helper or killer T-cell.

    On the relevant websites the vaccination accelerators are described which are included in the vaccination serum. They are strong organic (eg formaldehyde) or organo (eg mercury compounds) poisons.

    These toxins put the infantile immune system so to speak "in turmoil", that is, preparing the regulatory cells prior to reprogramming. The immune system is indeed responsible for the elimination of toxins (Toxiden). At the same time the specific antigen is present in the organism. In this "state of rebellion" any regulator cell is switched to helper or killer cells, that their right antigen (in this case the vaccine, such as may be envelope protein of polio pathogen) is presented to. Successful immunization.

    Regrettable as the vaccination serum is not the only antigen presented to regulator cells in the time window of the "levée en masse". The immune system is indeed responsible for the "garbage" of the organism. Very nice this feature is visible in some thyroid disorders. The fact that the phagocytes can not migrate into the tissue, there are remains of the cell debris. This results in clumps of protein forming a colloid. Very nice to see the typical edema. Alzheimer's disease is just one example of the failing cell debris removal.

    So now, the macrophages also take up the body's own substances and present them to T cells. If in the acute phase of the vaccination now by chance Schwann cell (the sheath of the nerves) is presented to an appropriate regulator cell, we have multiple sclerosis. If this happens with a cartilage cell, followed by rheumatism. And all the rest of it. As luck would have it the stupid (beta-cells of the pancreas, diabetes Typ I, who knows more?).

    During my research I came across the case of a young, severely disabled man whose parents have been fighting for decades for recognition of the obvious handicap as vaccine damage.

    What had happened? A short time before the vaccine the child had been playing (the mother portrays this very heartbreaking) and knocked out a tooth. The tooth was reimplanted to him again, but a severe local inflammation developed. After all the rules of medical science, vaccination was therefore absolutely contraindicated, it was a serious malpractice, lead by the vaccination.

    Why? As outlined briefly in my last mail, it may not happen in the acute phase of vaccination, that to the regulatory immune system an autoantigen (ie, an endogenous protein) is presented. Autoimmunity would be the inevitable consequence. Now it is in an inflammation as described above, that cells perish in mass, including nerve cells. These dead cells are taken up by the macrophages (phagocytosis) and the specitic to thiese antigens regulator cells that are in the excited state, such as during a vaccination, are reprogrammed to helper and killer cells. In the case of this young man severely handicapped the inflammation was so severe that the number of reprogrammed cells has led to a fulminant autoimmune destruction of the nervous system.

    And now sit two old men of the Stiko as an expert in court and lead the Justice behind the spruce. Ask the two gentlemen yet again why it is forbidden to vaccinate during acute inflammation. I'll bet one of my three white shirts (the one with the broken collar) that tell you something from experience know, you really do not know the mechanism, the research is still trying to understand. Well, you give them asking for trouble a helping hand!

    Moreover, I have my doubts whether it is really true that the severe neurological damage that may occur in rare cases in measles infection, is to lead directly to virus influence back. It is possible that this is a "natural" autoimmunization according to the scheme described above. Maybe I should look in my "Microbiology" again.

    For rheumatism (another autoimmune disease) I believe this is already accepted. Rheumatism often occurs after a severe infection. Well, it is so, the age, the bones are tired, in the joints increasingly cells perish to bustle the corresponding autoantigens. Then comes e.g. a serious, "real" flu be added, connected the ready to be reprogrammed regulator cells and you know the rest already.

    Now the whole band of monkeys screaming out loud: Yes exactly, so just elder people have to be vaccinated against the flu! You do not. Whether it is the virus or the vaccination accellerator that cause the risk of a autoimmunization, does not matter. Not true, if occurring after the flu the rheumatism, it was the flu. Does the rheumatism occures after a flu vaccination, it may have been only progressing age.

    And then there is still the "Spanish flu" H1N1 1918 / 19. It is estimated the number of deaths as significantly more than the number of war victims of the immediately preceding World War I. What led to this fatal pandemic? Returning soldiers had become infected and carried the virus in the whole world (at least in the colonies of the British Empire and the United States). This experience also teaches us how we have to deal with this threat. With timely quarantine. A prerequisite is a timely diagnosis, you can not isolate any cold indeed. This is now but a solvable problem at a reasonable cost. It would also save the cost of vaccinations and the cost of treatment of vaccine damage (how high the latter are only the RKI can estimate by his complete statistics, I mean when was begun which vaccination and how has the public health developed after ).

    And when it comes but once an "Outbreak", an epidemic, an appropriate vaccination serum should be present of course. This cannot of course afford private companys, who are forced to mass vaccinate so that the development of the vaccine also is economically converted.

    Maybe even a little anecdote from the cold war at the end. Around the mid-1970s succeeded in biology, from dead specimens that were preserved during the Spanish flu, to produce a live H1N1 virus. He occured in 1977 (where else, the inventors were Americans) in Moscow. An epidemic could then be prevented (quarantined). Also in 1977 came also H3N2 from 1968 (I still remember how my father fell ill at the time) back. Not true, H1N1 was after 1919 no longer detectable because humanity was immunized (under high casualties that would nowadays no longer necessary because of death in influenza infection by a bacterial superinfection is triggered, so may be controled well with antibiotics), as H3N1 after 1968. Since 1977, both types of virus circulating again in humanity until today (see "Medical Microbiology" Jawetz, Melnick, Adelberg, McGraw Hill Lange Medical Books, 24th edition, New York, Chicago, San Francisco, Lisbon, London, Madrid, Mexico City, Milan , New Delhi, San Juan, Seoul, Singapore, Sydney, Toronto, 2007, reads like a partial list of the friends of my friends on facebook). But now I really am coming to the chat. What actually drive the colleagues at the Ernst-Loeffler Institute for Animal Disease Research on the Island of Riems with theire fancy stage-4 lab?

    Sincerely yours

    John Buhlmann

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