

Polymyxin B sulfate - bacitracin zinc contains a combination of antibiotics used to treat certain types of infections caused by bacteria. The topical ointment can be used to treat certain skin infections such as infected wounds, burns, skin grafts, boils, and acne. The eye ointment is used to treat some types of eye infections such as conjunctivitis. All preparations work by killing the bacteria that cause these infections.



What form(s) does this medication come in?

Polysporin Antibiotic Ointment
Each gram contains polymyxin B (as sulfate) 10,000 units and bacitracin zinc 500 units. Nonmedicinal ingredients: butylated hydroxytoluene, cocoa butter, cotton seed oil, olive oil, petrolatum, sodium pyruvate, and vitamin E (dl-alpha tocopheryl acetate).

Polysporin Sterile Ophthalmic Ointment
Each gram contains polymyxin B (as sulfate) 10,000 units and bacitracin zinc 500 units. Nonmedicinal ingredients: butylated hydroxytoluene and petrolatum.

How should I use this medication?

Topical ointment: Apply 1 to 3 times a day to the affected area. Cover with a dressing or leave exposed as directed by your doctor. Do not use the ointment in the eyes.

Eye ointment: Apply 4 times a day or more frequently, as directed by your doctor. It may be applied to the outside of the eyelid or a ribbon of ointment may be placed inside the lower conjunctival sac (inside of the eyelid).



Store this medication at room temperature, and keep it out of the reach of children.



Who should NOT take this medication?

Do not use this medication if you are allergic to polymyxin B sulfate, bacitracin zinc, or any ingredients of the medication.

What side effects are possible with this medication?





  • blurred vision (usually occurs after the ophthalmic ointment is applied and lasts for a few minutes)
  • irritation of the area where the ointment is applied



  • signs of a severe allergic reaction such as severe rash or hives; difficulty breathing; or swelling of the mouth, lips, tongue, or throat


Are there any other precautions or warnings for this medication?




Pregnancy: It is not clear what effects polymyxin B sulfate - bacitracin zinc may have in pregnant women. Talk to your doctor about the risks and benefits of taking this medication. If you become pregnant while taking this medication, contact your doctor.

Breast-feeding: It is not known if polymyxin B sulfate - bacitracin zinc passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.


What other drugs could interact with this medication?


  • stop taking one of the medications,
  • change one of the medications to another,
  • leave everything as is.

