Murine typhus

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Murine typhus
Classification and external resources
Specialty Infectious disease
ICD-10 A75.2
ICD-9-CM 081.0
DiseasesDB 32211
MeSH D014437

Murine typhus (also called endemic typhus) is a form of typhus transmitted by fleas (Xenopsylla cheopis), usually on rats. (This is in contrast to epidemic typhus, which is usually transmitted by lice.) Murine typhus is an under-recognized entity, as it is often confused with viral illnesses. Most people who are infected do not realize that they have been bitten by fleas.


It is caused by the bacteria Rickettsia typhi, and is transmitted by the fleas that infest rats. While rat fleas are the most common vectors, cat fleas and mouse fleas are less common modes of transmission. These fleas are not affected by the infection. Human infection occurs because of flea-fecal contamination of the bites on human skin. Rats, cats, opossums maintain the rickettsia colonization by providing it with a host for its entire life cycle. Rats can develop the infection, and help spread the infection to other fleas that infect them, and help multiply the number of infected fleas that can then infect humans.

Less often, endemic typhus is caused by Rickettsia felis and transmitted by fleas carried by cats or opossums.

In the United States of America, Murine typhus is found most commonly in southern California,[1] Texas and Hawaii. In some studies, up to 13% of children were found to have serological evidence of infection.[2]


Chest Xray of a 40 yr old male in acute respiratory distress syndrome as a complication of murine typhus

Symptoms of endemic typhus include headache, fever, muscle pain, joint pain, nausea and vomiting. 40–50% of patients will develop a discrete rash six days after the onset of signs. Up to 45% will develop neurological signs such as confusion, stupor, seizures or imbalance.

Symptoms may resemble those of measles, rubella, or possibly Rocky Mountain spotted fever. These symptoms are likely caused by a vasculitis caused by the rickettsia.

Treatment and prognosis[edit]

Endemic typhus is highly treatable with antibiotics. Most people recover fully, but death may occur in the elderly, severely disabled or patients with a depressed immune system. The most effective antibiotics include tetracycline and chloramphenicol.

See also[edit]


  1. ^ "Murine (endemic) Typhus" (PDF). California Department of Public Health. Retrieved 30 May 2012. 
  2. ^ The Pediatric Infectious Disease Journal (Impact Factor: 3.57). 07/2000; 19(6):535-8.