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What Drives Your Daily Biological Clock?

WEDNESDAY, Oct. 10 (HealthDay News) -- Researchers working with fruit flies say they have discovered one way that the body's biological clock controls brain-cell activity that influences daily rhythms.


"The findings answer a significant question: how biological clocks drive the activity of clock neurons, which, in turn, regulate behavioral rhythms," study senior author Justin Blau, associate professor in New York University's department of biology, said in a university news release.

Previous research with fruit flies' "clock genes" led to the discovery of similar genes in humans, according to the news release.

It was known that biological clocks control neuronal activity, but it wasn't known how information from biological clocks drives rhythms in the electrical activity of pacemaker neurons that control daily rhythms.



"We were looking for an output of the biological clock that would link the core clock to neuronal activity," Blau said. "Ir seems to do this, but it also, remarkably, feeds back to regulate the core clock itself. Feedback loops seem to be deeply engrained into the biological clock and presumably help these clocks work so well."


-- Robert Preidt

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