HIV Vaccine

Tue Oct 27 10:40:31 EST 1998

An HIV vaccine poses a unique problem:  We don't know what a 
protective immune response against HIV is.  If you don't know what are 
the most important immune parameters, it is difficult to rationally 
devise a vaccine.  With that said, a vaccine against HIV would 
probably need to induce neutralizing antibodies against the spike 
proteins gp120, and perhaps gp41.  In addition, it would probably be 
desireable to induce an effective cell mediated immune response.  This 
usually requires an attenuated vaccine, rather than a killed or a 
subunit vaccine.

Jay Mone'

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