Health Encyclopedia

Acute Fatty Liver of Pregnancy

What is acute fatty liver of pregnancy (AFLP)?

AFLP is a rare, but serious, condition of pregnancy in which there is an excessive buildup of fat in the liver or liver cells. Fat normally builds up in the liver in the form of triglycerides and fatty acids, but excessive fat can cause liver damage. AFLP is quite rare, however, it is a serious condition that cannot be predicted or prevented.

What causes acute fatty liver of pregnancy?


Why is acute fatty liver of pregnancy a concern?


What are the symptoms of acute fatty liver of pregnancy?


  • Nausea and vomiting

  • Abdominal pain, especially in the right upper side

  • Malaise (general discomfort)

  • Headache

  • Tiredness

  • Confusion


The symptoms of acute fatty liver of pregnancy may look like other medical conditions. Always consult your doctor for a diagnosis.

How is acute fatty liver of pregnancy diagnosed?

In addition to a complete medical history and physical exam, diagnosis of AFLP is most accurate by liver biopsy. This involves taking a sample of liver tissue for examination under a microscope. This may not always possible in pregnancy. Usually, the symptoms of AFLP are often clear enough to diagnose the condition. Blood tests can rule out other conditions or diseases that have similar symptoms. Other tests that may be used include:


  • Computed tomography (CT) scan, a diagnostic imaging procedure that uses a combination of X-rays and computer technology to produce horizontal, or axial, images, often called slices, of the body.

Treatment for acute fatty liver of pregnancy


Medical Reviewers:

  • MMI board-certified, academically affiliated clinician
  • Trevino, Healther, M., BSN, RNC