What are Polyphenols?



Polyphenol is a generic term for the several thousand plant-based molecules that have antioxidant properties. The health benefits of antioxidants are well known and polyphenols are also helpful for regulating enzyme function and stimulating cell receptors. [1] Polyphenols are divided into four primary groups: phenolic acids, lignans, stilbenes, and flavonoids. [2] Plants with polyphenol activity have played a major role in traditional Chinese and Ayurvedic medicine for centuries. With an anti-inflammatory action, support for the liver, and promoting normal circulatory health, their benefits are plentiful.

6 Benefits of Polyphenol Consumption

Polyphenols are available in a wide variety of unprocessed raw vegetables and fruits. With the explosion of polyphenol research and the extensive discussion in scientific journals, potential therapeutic applications for these compounds have been discovered. Here are just a few of the benefits related to polyphenols.

1. Skin Protection

The consumption of fruits, vegetables, legumes, nuts and seeds, and antioxidant-rich beverages may protect the skin from UV radiation. Resveratrol, a compound in red wine, has active polyphenic qualities that aid in protecting the skin. Other compounds, like silymarin, genistein, delphinidin, pomegranate fruit extract, grape seed, proanthocyanidins, and green tea polyphenols, may also ward off UV damage. [3]

2. Brain Health

The antioxidant effect of polyphenols offers holistic support for the aging neurological system, possibly combating the early onset of dementia-like symptoms. Polyphenols have been linked with lower risk for Alzheimer’s disease, stroke, multiple sclerosis, Parkinson’s disease, and Huntington’s disease. Researchers also note that polyphenols offer a holistic approach to neurological health by addressing the complex physiology involved with certain brain disorders. [4]

3. Supports Normal Blood Sugar

Glucose management is an issue for many people in the United States, with about 1 out of every 10 people having type II diabetes or prediabetes. Flavonoids, a group of polyphenols, has displayed beneficial effects for supporting normal blood sugar levels. These flavonoids, typically found in foods like tea and cocoa, appear to enhance insulin secretion, reduce cell death, regulate glucose metabolism, improve insulin sensitivity, reduce oxidative stress, and increase glucose uptake by cells. [5]

4. Nutritional Support for Cancer?

While polyphenols won’t cure cancer, research has explored their potential therapeutic role. Some polyphenols appear to offer protection against carcinogens — cancer-causing substances present in food and the environment. [6] [7] Although coffee raises an eyebrow among some health-conscious consumers, research suggests that the polyphenols in coffee may help to reduce the risk of colorectal cancer. [8]

5. Blood Pressure

Studies indicate flavonoids, like catechins, anthocyanins, and phenolic acids, are important dietary compounds that support normal blood pressure by inhibiting the physiological mechanisms which trigger hypertension. [9]

6. Cardiovascular Health

Polyphenols found in cocoa have been shown to reduce cardiovascular stress through the inhibition of LDL cholesterol, or “bad” cholesterol, oxidation. These compounds also increase the vasodilation of blood vessels to promote circulation. [10] Keep in mind that organic dark chocolate, 72% cacao and above, is where the benefits have been found. In other words, cheap candy is not good for your health.

The Best Sources of Polyphenols

Natural foods like vegetables, fruits, tea, coffee, and red wine are some of the primary sources of polyphenols. Citrus fruits contain specific types of polyphenols, like flavanones, while other fruits contain a wider range of polyphenols. It’s believed that growing conditions play a substantial role in polyphenol content. To ensure the best and most potent sources of polyphenols from foods, choose produce that is organic and non-GMO. Local foods may also be fresher and more abundant in their natural antioxidant compounds compared with imported varieties.


  1. Elliott Middleton Jr., Chithan Kandaswami, and Theoharis C. Theoharides. The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer. Pharmacological Reviews December 1, 2000 vol. 52 no. 4 673-751.
  2. Claudine Manach, Augustin Scalbert, Christine Morand, Christian Rémésy, and Liliana Jiménez. Polyphenols: food sources and bioavailability. Am J Clin Nutr May 2004 vol. 79 no. 5 727-747.
  3. Afaq F, Katiyar SK. Polyphenols: skin photoprotection and inhibition of photocarcinogenesis. Mini Rev Med Chem. 2011 Dec;11(14):1200-15.
  4. Bhullar KS, Rupasinghe HP. Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev. 2013;2013:891748. doi: 10.1155/2013/891748.
  5. Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem. 2013 Sep 9. pii: S0955-2863(13)00127-7. doi: 10.1016/j.jnutbio.2013.06.003.
  6. Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicology in Vitro. 2006 March;20(2):187-201.
  7. Lautraite S, Musonda AC, Doehmer J, Edwards GO, Chipman JK. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis. 2002 January;17(1):45-53.
  8. Wang ZJ, Ohnaka K, Morita M, Toyomura K, Kono S, Ueki T, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Maekawa T, Yasunami Y, Takenaka K, Ichimiya H, Terasaka R. Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study. World J Gastroenterol. 2013 May 7;19(17):2683-90. doi: 10.3748/wjg.v19.i17.2683.
  9. Huang WY, Davidge ST, Wu J. Bioactive natural constituents from food sources-potential use in hypertension prevention and treatment. Crit Rev Food Sci Nutr. 2013;53(6):615-30. doi: 10.1080/10408398.2010.550071.
  10. Arranz S, Valderas-Martinez P, Chiva-Blanch G, Casas R, Urpi-Sarda M, Lamuela-Raventos RM, Estruch R. Cardioprotective effects of cocoa: clinical evidence from randomized clinical intervention trials in humans. Mol Nutr Food Res. 2013 Jun;57(6):936-47. doi: 10.1002/mnfr.201200595.


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