

Kurup A. Ravikumar, Parameswara Achutha Kurup


Neanderthal genes have been related to human disease. The human genome has been found to have up to 10 percent Neanderthal genes. The pyruvate dehydrogenase gene as well as those coding for MHC alleles are of Neanderthal origin. Neanderthal genes have been related to autism and autoimmune disease. There is high incidence of autism and Neanderthal anthropometry in the matrilineal and Dravidian language speaking nair community of Kerala. The autistic brain is comparable to the large-sized Neanderthal brain. Metabolic patterns were compared among the following groups: matrilineal nairs, non nairs, autism, schizophrenia and systemic diseases to find out a pattern of Neanderthal metabolism. The aim of the study aimed to detect fossilized Neanderthal matrilineal societies and new Neanderthal hybrids in relation to civilisational diseases. Four groups, 25 numbers in each group were chosen for the study—the autistic population diagnosed according to DSM criteria, the normal nair population, the normal non-nair population and civilisational disease group including metabolic syndrome x, alzheimer’s disease, cancer, schizophrenia and multiple sclerosis. Archaeal cholesterol catabolism as well as PDH activity, glycolytic pathway, the GABA shunt, porphyrins, homocysteine and ammonia metabolism were studied to find out a pattern of Neanderthal metabolism. Autistic metabolonomic patterns include low pyruvate dehydrogenase activity, mitochondrial dysfunction, GABA shunt, Warburg glycolytic phenotype, hyperammonemia, hyperhomocysteinemia, porphyria, low cholesterol/bile acid levels and a similar pattern is seen in the normal nair population of Kerala. Neanderthal metabolonomic patterns include a low efficiency PDH activity. Autistic and matrilineal societies like nair can be considered as remnants of the Neanderthals. The autistic and nair population have increased cytochrome F420 activity suggestive of endosymbiotic archaeal growth resulting in PDH and mitochondrial suppression. The increased archaeal digoxin synthesis later on shuts down the metabolic machinery the neuronal and other tissue cells and the human cells and tissues including the brain are taken over by an atavistic actinidic colony network. This leads onto a Neanderthal hybrid zombie syndrome. The increased archaeal growth in ice age conditions contributed to the neanderthal evolution and similar endosymbiotic archaeal growth related to global warming leads to neanderthalisation of homo sapiens. The autistic and neanderthalic metabolonomic patterns are also seen in civilisational diseases like syndrome X, schizophrenia, cancer, multiple sclerosis and alzheimer’s disease. The results suggest neanderthalisation of the humans due to global warming and archaeal growth. The Neanderthalisation of the human species is the basis of the global autistic, schizophrenic and civilisational disease epidemic—epidemic Neanderthal hybrid zombie syndrome. The matrilineal societies are fossilized Neanderthal remnants and neoneanderthal hybrids contribute to civilisational diseases.


Autism; Nair; Matrilineal; Neanderthal; Archaea; Pyruvate dehydrogenase; Cholesterol oxidase; Global warming; Systemic diseases

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Bastir, M., O’Higgins, P., & Rosas, A. (2007). Facial ontogeny in Neanderthals and modern humans. Proc. Biol. Sci., 274, 1125-1132.

Bruner, E, Manzi, G, & Arsuaga, J. L. (2003). Encephalization and allometric trajectories in the genus homo: Evidence from the Neandertal and modern lineages. Proc. Natl. Acad. Sci. USA, 100, 15335-15340.

Courchesne, E., & Pierce, K. (2005). Brain overgrowth in autism during a critical time in development: Implications for frontal pyramidal neuron and interneuron development and connectivity. Int. J. Dev. Neurosci, 23, 153-170.

Eswaran, V., Harpending, H., & Rogers, A. R. (2005). Genomics refutes an exclusively African origin of humans. Journal of Human Evolution, 49(1), 1-18.

Gooch, S. (2006). The dream culture of the Neanderthals: Guardians of the ancient wisdom. Inner Traditions. London: Wildwood House.

Gooch, S. (2008). The Neanderthal legacy: Reawakening our genetic and cultural origins. Inner Traditions. London: Wildwood House.

Graves, P. (1991). New models and metaphors for the Neanderthal debate. Current Anthropology, 32(5), 513-541.

Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., & Zhai, W. (2010). A draft sequence of the Neanderthal genome. Science, 328, 710-722.

Kurtén, B. (1978). Den svarta tigern. Stockholm, Sweden: ALBA Publishing.

Kurup, R. A., & Kurup, P. A. (2012). Endosymbiotic actinidic archaeal mediated warburg phenotype mediates human disease state. Advances in Natural Science, 5(1), 81-84.

Mithen, S. J. (2005). The singing Neanderthals: The origins of music, language, mind and body.

Morgan, E. (2007). The Neanderthal theory of autism, asperger and ADHD. Retrieved from

Neubauer, S., Gunz, P., & Hublin, J. J. (2010). Endocranial shape changes during growth in chimpanzees and humans: A morphometric analysis of unique and shared aspects. J. Hum. Evol., 59, 555-566.

Sawyer, G. J., & Maley, B. (2005). Neanderthal reconstructed. The Anatomical Record Part B: The New Anatomist, 283B(1), 23-31.

Spikins P. (2009). Autism, the integrations of “difference”and the origins of modern human behaviour. Cambridge Archaeological Journal, 19(2), 179-201.

Weaver, T. D., & Hublin, J. J. (2009). Neandertal birth canal shape and the evolution of human childbirth. Proc. Natl. Acad. Sci. USA, 106, 8151-8156.



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