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Finding objective and effective thresholds for voxelwise statistics derived from neuroimaging data has been a long-standing problem. With at least one test performed for every voxel in an image, some correction of the thresholds is needed to control the error rates, but standard procedures for multiple hypothesis testing (e.g., Bonferroni) tend to not be(More)
More than one subject is scanned in a typical functional brain imaging experiment. How can the scientist make best use of the acquired data to map the specific areas of the brain that become active during the performance of different tasks? It is clear that we can gain both scientific and statistical power by pooling the images from multiple subjects;(More)
To characterize cognitive maturation through adolescence, processing speed, voluntary response suppression, and spatial working memory were measured in 8- to 30-year-old (N = 245) healthy participants using oculomotor tasks. Development progressed with a steep initial improvement in performance followed by stabilization in adolescence. Adult-level mature(More)
Functional magnetic resonance imaging is a technique developed in the last decade and used in the elds of cognitive psychology and neuroscience, among others, to study the processes underlying the working of the human brain. In this paper we examine some of the statistical issues in functional magnetic resonance imaging for brain research. We start by(More)
In this article, we propose an efficient approach to find optimal experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). We consider multiple objectives, including estimating the hemodynamic response function (HRF), detecting activation, circumventing psychological confounds and fulfilling customized requirements. Taking(More)
OBJECTIVE To test the hypothesis that deficits in spatial working memory in autism are due to abnormalities in prefrontal circuitry. METHODS Functional MRI (fMRI) at 3 T was performed in 11 rigorously diagnosed non-mentally retarded autistic and six healthy volunteers while they performed an oculomotor spatial working memory task and a visually guided(More)
OBJECTIVE The relationship between athlete reports of symptoms, neurophysiological activation, and neuropsychological functioning is investigated in a sample of high school athletes. METHODS All athletes were evaluated using functional magnetic resonance imaging (fMRI), a computer-based battery of neurocognitive tests, and a subjective symptom scale.(More)