Poor sleep can cause memory decline in elderly

Last Updated: Monday, January 28, 2013 - 13:34

Washington: Scientists at the University of California, Berkeley have for the first time found a link between poor sleep, memory loss and brain deterioration in older adults.

They have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus - which provides short-term storage for memories - to the prefrontal cortex`s longer term "hard drive."

However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep `slow wave` sleep, and are then overwritten by new memories, the findings suggested.


"What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older - and with that, a potentially new treatment avenue," said UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley and senior author of the study.

The findings shed new light on some of the forgetfulness common to the elderly that includes difficulty remembering people`s names.

"When we are young, we have deep sleep that helps the brain store and retain new facts and information. But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night," Walker said.

Healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain`s middle frontal lobe. Deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep, the study found.


UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. "Can you jumpstart slow wave sleep and help people remember their lives and memories better? It`s an exciting possibility," said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.

For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night`s sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.




The study will be published in the journal Nature Neuroscience.



First Published: Monday, January 28, 2013 - 13:34

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