Paroxysmal attack

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"Paroxysms" redirects here. For the waltz by Johann Strauss, see Paroxysmen.
Not to be confused with proximal.
Paroxysmal attack
Classification and external resources
ICD-10 G40-G47

Paroxysmal attacks or paroxysms (from Greek παροξυσμός) are a sudden recurrence or intensification of symptoms, such as a spasm or seizure.[1] These short, frequent and stereotyped symptoms can be observed in various clinical conditions. They are usually associated with multiple sclerosis or pertussis, but they may also be observed in other disorders such as encephalitis, head trauma, stroke, asthma, trigeminal neuralgia, breath-holding spells, epilepsy, malaria, tabes dorsalis, and Behçet's disease, paroxysmal nocturnal hemoglobinuria (PNH). It has also been noted as a symptom of gratification disorder in children.

Paroxysmal attacks in various disorders have been reported extensively and ephaptic coupling of demyelinated nerves has been presumed as one of the underlying mechanisms of this phenomenon. This is supported by the presence of these attacks in multiple sclerosis and tabes dorsalis, which both involve demyelination of spinal cord neurons. Exercise, tactile stimuli, hot water, anxiety and neck flexion may provoke paroxysmal attacks. Most reported paroxysmal attacks are painful tonic spasms, dysarthria and ataxia, numbness and hemiparesis. They are typically different from other transient symptoms by their brevity (lasting no more than 2 minutes), frequency (from 1-2 times/day up to a few hundred times/day), stereotyped fashion and excellent response to drugs (usually carbamazepine). Withdrawal of symptoms without any residual neurological finding is another key feature in their recognition.

The word paroxysm means "sudden attack, outburst",[2] and comes from the Greek παροξυσμός (paroxusmos), "irritation, exasperation".[3]

See also[edit]


  1. ^ Saunders Elsevier, "Dorland's Illustrated Medical Dictionary 31e", Philadelphia (2007), p1405, ISBN 978-1-4160-2364-7
  2. ^ paroxysm, on Oxford Dictionaries
  3. ^ παροξυσμός, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus