Side Effects

Drug information provided by: Micromedex


Along with its needed effects, a medicine may cause some unwanted effects. Although serious side effects occur rarely when this medicine is taken as recommended, they may be more likely to occur if too much medicine is taken, if it is taken in large doses, or if it is taken for a long period of time.


For all combinations

  1. Convulsions (seizures)
  2. dizziness or light-headedness (severe)
  3. fast, slow, or irregular heartbeat
  5. headache (continuing and severe)
  6. increased sweating
  7. mood or mental changes
  8. nausea or vomiting (severe or continuing)
  9. nervousness or restlessness (severe)
  10. shortness of breath or troubled breathing
  11. stomach cramps or pain (severe or continuing)
  12. swelling or tenderness in the upper abdomen or stomach area
  13. trouble in sleeping

For acetaminophen-containing only

  1. Diarrhea
  2. loss of appetite

For aspirin- or salicylamide-containing only

  1. Any loss of hearing
  2. changes in behavior (in children)
  3. confusion
  4. diarrhea (severe or continuing)
  5. drowsiness or tiredness (severe, especially in children)
  6. fast or deep breathing (especially in children)
  7. ringing or buzzing in ears (continuing)
  8. uncontrollable flapping movements of the hands, (especially in elderly patients)
  9. unexplained fever
  10. unusual thirst
  11. vision problems


More common

  1. Nausea, vomiting, or stomach pain (mild—for combinations containing aspirin or ibuprofen)

Less common or rare

  1. Bloody or black, tarry stools
  2. bloody or cloudy urine
  3. blurred vision or any changes in vision or eyes
  4. changes in facial skin color
  5. changes in hearing
  6. changes or problems with urination
  7. difficult or painful urination
  8. fever
  9. headache, severe, with fever and stiff neck
  10. increased blood pressure
  11. muscle cramps or pain
  12. skin rash, hives, or itching
  13. sores, ulcers, or white spots on lips or in mouth
  14. swelling of face, fingers, feet, or lower legs
  15. swollen and/or painful glands
  16. unexplained sore throat and fever
  17. unusual bleeding or bruising
  18. unusual tiredness or weakness
  19. vomiting of blood or material that looks like coffee grounds
  20. weight gain (unusual)
  21. yellow eyes or skin


More common

  1. Heartburn or indigestion (for medicines containing salicylate or ibuprofen)
  2. nervousness or restlessness

Less common

  1. Drowsiness (for medicines containing salicylamide)


