chromic phosphate

Posted on April 28th, 2009 by

Class: Radiopharmaceutical

Generic Name: Chromic phosphate (KROE-mik FOSS-fate) 32
Trade Name: Phosphocol P32®

For which conditions is this drug approved? Chromic phosphate is FDA-approved to treat the leaking of fluid (effusion) into the peritoneum (sac surrounding the abdominal organs) or pleura (sac surrounding the lungs) as a result of advanced cancer. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.

What is the mechanism of action? Chromic phosphate belongs to a group of agents classified as radiopharmaceuticals. Chromic phosphate produces its anti-cancer effects by emitting radiation to tissues surrounding it.

How is chromic phosphate typically given (administered)? Chromic phosphate is administered by catheter into a body cavity (intracavitary) and the dose depends on several factors, including the condition being treated, the size of the patient, the particular regimen being used and the overall health of the patient.

How are patients typically monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with chromic phosphate.  Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver.  Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.

What are the common (occurs in 10-29% of patients) side effects of treatment with chromic phosphate?

• Nausea and vomiting
• Low levels of white blood cells
• Low levels of red blood cells (anemia)
• Low levels of platelets (thrombocytopenia)
• Abdominal cramping
• Feeling of discomfort
• Inflammation of the peritoneum
• Inflammation of the pleura
• Diarrhea
• Loss of appetite
• Weakness




• Maintain adequate rest and nutrition.
• Eat small meals frequently to help alleviate nausea.
• Wash hands often to reduce the risk of infection.
• Avoid activities that may cause injury or bruising.


• Chromium phosphate is a radioactive substance. Patients should speak with their physician about taking radiation precautions.

When should patients notify their physician?

• Difficulty breathing
• Extreme abdominal cramping
• Fever, chills, cough, sore throat, flu or cold-like symptoms
• Signs of infection – redness, swelling, pus, tenderness
• Persistent or severe fatigue
• Chest pain
• Dry cough
• Severe nausea or vomiting

What is a package insert?

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Tags: C, Radiopharmaceutical
