YERVOY- ipilimumab injection 
E.R. Squibb & Sons, L.L.C.



YERVOY® (yur-voi)

Read this Medication Guide before you start receiving YERVOY and before each infusion. There may be new information. This Medication Guide does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is the most important information I should know about YERVOY?




diarrhea (loose stools) or more bowel movements than usual
blood in your stools or dark, tarry, sticky stools
stomach pain (abdominal pain) or tenderness


yellowing of your skin or the whites of your eyes
dark urine (tea colored)
nausea or vomiting
pain on the right side of your stomach
bleeding or bruise more easily than normal


skin rash with or without itching
sores in your mouth
your skin blisters or peels


unusual weakness of legs, arms, or face
numbness or tingling in hands or feet


persistent or unusual headaches
unusual sluggishness
feeling cold all the time
weight gain
dizziness or fainting

Eye problems. Symptoms may include:

blurry vision, double vision, or other vision problems
eye pain or redness



What is YERVOY?

YERVOY is a prescription medicine used to treat a kind of skin cancer called melanoma. YERVOY may be used:

when your melanoma has spread or cannot be removed by surgery.
to help prevent melanoma from coming back after it and lymph nodes that contain cancer have been removed by surgery.

It is not known if YERVOY is safe and effective in children less than 18 years of age.

What should I tell my healthcare provider before receiving YERVOY?


have immune system problems (autoimmune disease), such as ulcerative colitis, Crohn’s disease, lupus, or sarcoidosis
have had an organ transplant
have liver problems
are breastfeeding or plan to breastfeed.
It is not known if YERVOY passes into your breast milk.


Know the medicines you take. Keep a list to show your healthcare providers and pharmacists each time you get a new medicine.

You should not start a new medicine before you talk with the healthcare provider who prescribes you YERVOY.

How will I receive YERVOY?

YERVOY is given to you into your vein through an intravenous (IV) line over 90 minutes.
Your healthcare provider will decide how many treatments you will need.
Your healthcare provider will do blood tests before starting and during treatment with YERVOY.
It is important for you to keep all appointments with your healthcare provider. Call your healthcare provider if you miss an appointment. There may be special instructions for you.

What are the possible side effects of YERVOY?

YERVOY can cause serious side effects. See What is the most important information I should know about YERVOY?

The most common side effects of YERVOY include:

weight loss
decreased appetite
difficulty falling or staying asleep

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of YERVOY. For more information, ask your healthcare provider.



General information about the safe and effective use of YERVOY.


This Medication Guide summarizes the most important information about YERVOY. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about YERVOY that is written for healthcare professionals. For more information, call 1-800-321-1335.

What are the ingredients of YERVOY?

Active ingredient: ipilimumab

Inactive ingredients: diethylene triamine pentaacetic acid (DTPA), mannitol, polysorbate 80, sodium chloride, tris hydrochloride, and Water for Injection, USP

U.S. License No. 1713

Revised: 10/2015
E.R. Squibb & Sons, L.L.C.