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Actin, alpha 2, smooth muscle, aorta
Protein ACTA2 PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACTA2 ; AAT6; ACTSA; MYMY5
External IDs OMIM102620 MGI87909 HomoloGene133938 GeneCards: ACTA2 Gene
RNA expression pattern
PBB GE ACTA2 200974 at tn.png
More reference expression data
Species Human Mouse
Entrez 59 11475
Ensembl ENSG00000107796 ENSMUSG00000035783
UniProt P62736 P62737
RefSeq (mRNA) NM_001141945 NM_007392
RefSeq (protein) NP_001135417 NP_031418
Location (UCSC) Chr 10:
90.69 – 90.75 Mb
Chr 19:
34.24 – 34.26 Mb
PubMed search [1] [2]

Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.[1][2]

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[1]

Alpha-smooth muscle actin (α-SMA) is commonly used as a marker of myofibroblast formation (Nagamoto et al., 2000).


  1. ^ a b "Entrez Gene: ACTA2 actin, alpha 2, smooth muscle, aorta". 
  2. ^ Ueyama H, Bruns G, Kanda N (Oct 1990). "Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10". Jinrui Idengaku Zasshi 35 (2): 145–50. doi:10.1007/BF01876459. PMID 2398629. 

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