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Secretin stimulation test


The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. Secretin is produced by the small intestine when partially digested food has moved into the area from the stomach.

Alternative Names

Pancreatic function test

How the Test is Performed

A tube is inserted through the nose and into the stomach, then into the first part of the small intestine (duodenum). Secretin is given through a vein (intravenously). Then, over the next 1 - 2 hours, the contents of the material released from the pancreas into the duodenum are removed through the tube.

How to Prepare for the Test


How the Test Will Feel

You may experience a gagging sensation as the tube is inserted.

Why the Test is Performed

Secretin normally causes the pancreas to release a fluid containing digestive enzymes. These enzymes break down food and help the body absorb nutrients.

The secretin stimulation test is done to check the digestive function of the pancreas. People with diseases involving the pancreas may have abnormal pancreatic function. Such diseases include:


Normal Results


What Abnormal Results Mean

Abnormal values may mean there is pancreatic insufficiency.


There is a slight risk of the tube being placed through the windpipe and into the lungs, instead of through the esophagus and into the stomach. The health care provider will be sure the tube is correctly placed before continuing with the test.




Review Date: 11/23/2010

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