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Secretin receptor family

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Template:Pfam box

Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.[1]

This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors.They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated by peptide hormoness from the glucagon hormone family.

The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors, all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.

Subfamily B1 Edit

Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

Subfamily B2 Edit

Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin (such as UniProt O94910, and brain-specific angiogenesis inhibitor receptors (such as UniProt O14514) amongst others.

Subfamily B3 Edit

Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

Unclassified subfamiliesEdit

Unclassified membersEdit

DREG; HCTR-5; HCTR-6; KPG_003; KPG_006; KPG_008; KPG_009; RESDA1


  1. Harmar AJ (2001). Family-B G-protein-coupled receptors. Genome Biol. 2 (12): REVIEWS3013.

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