Skip to Content

Neo-Diaral (loperamide) Disease Interactions

There is 1 disease interaction with Neo-Diaral (loperamide):


Antiperistaltic Agents (Includes Neo-Diaral) ↔ Infectious Diarrhea

Severe Potential Hazard, High plausibility

Applies to: Infectious Diarrhea/Enterocolitis/Gastroenteritis

The use of drugs with antiperistaltic activity (primarily antidiarrheal and antimuscarinic agents, but also antispasmodic agents such as dicyclomine or oxybutynin at high dosages) is contraindicated in patients with diarrhea due to pseudomembranous enterocolitis or enterotoxin-producing bacteria. These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary.


View all 6 references

Neo-Diaral (loperamide) drug Interactions

There are 603 drug interactions with Neo-Diaral (loperamide)

Neo-Diaral (loperamide) alcohol/food Interactions

There is 1 alcohol/food interaction with Neo-Diaral (loperamide)

Drug Interaction Classification



Do not stop taking any medications without consulting your healthcare provider.
