Death-inducing signaling complex

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Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.


  1. ^ Kischkel, FC; Hellbardt, S; Behrmann, I; Germer, M; Pawlita, M; Krammer, PH; Peter, ME (Nov 15, 1995). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO Journal 14 (22): 5579–88. PMC 394672. PMID 8521815. Retrieved 8 May 2011. 

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