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Citrulline, which is scientifically known as L-citrulline, is a non essential amino acid  that is found in foods high in protein. However, it is being highly promoted as an amino acid that is found in watermelons.

The reason for this is that new studies show that watermelons can, in fact, increase the libido. What this means is that citrulline products are often sold for erectile dysfunction.

Is citrulline able to correct erectile dysfunction? The answer to that is unclear. If you read through supplement websites, the answer is yes. However, while there have been numerous studies on citrulline, none have shown any positive results in terms of erectile dysfunction. However, anecdotal evidence seems to indicate that it is effective.

A deficiency of citrulline can cause extreme tiredness, even after you get enough sleep, and muscle weakness. The thing is, this could also be an indication of many other conditions so it is important to see your doctor and get checked out for other medical reason for the way that you feel before assuming that you have a citrulline deficiency.



Citrulline Benefits Citrulline actually has a number of great functions in the human body. What’s more, it has been tested in human trials under conditions approved by the FDA, although citrulline supplements aren’t monitored or approved by the FDA. Citrulline, once ingested into the b... more

Citrulline Benefits


Citrulline, once ingested into the body, converts into nitric oxide (NO)  and arginine. Both of these elements are very important in human development, a healthy heart, and a healthy body.

Citrulline and Nitric Oxide Benefits

Nitric oxide is so important to the body, that the scientists that discovered its uses won a Nobel Peace Prize in 1988.

Nitric oxide regulates the blood flow in the body. It is also responsible for oxygen delivery to the brain, lungs, kidney, liver, muscles, and vital organs. Nitric oxide helps to maintain a healthy blood pressure, which is important to a healthy heart. In addition, nitric oxide aids in the function of blood clotting at the site of injuries.

Nitric oxide aids the body’s immune system because it kills bacteria. Bone health is increased by nitric oxide because it increases the production of bone marrow and helps prevent the development of cancer cells in bone marrow.

Truthfully, nitric oxide provides so many benefits to the human body, it would be safe to say that nearly every function of the body benefits from the participation of nitric oxide!

Citrulline and Arginine Benefits

Arginine is another important part of your body’s function. Arginine aids in the health function of the kidneys. It helps the urea process and ensures that toxic ammonia is removed from the body when you urinate.

In addition, like nitric oxide, arginine helps the blood flow through the body. That is because it opens up the blood vessels for easier transport of blood flow. Arginine also helps to create creatine. Creatine provides energy to the muscles and also aids in muscle development. This can help with fat loss and muscle gain.

Studies have shown that you can get more arginine by taking citrulline than by taking an arginine supplement. This may be odd, but sometimes the human body is picky about what it absorbs and somehow it likes citrulline better than arginine.

So, what does this mean for you? Well, newer studies show that citrulline has a moderate affect on blood pressure as well as cholesterol. What this means is that if you have serious heart disease, then citrulline probably won’t be effective for you. However, if you are in the warning or beginning stages, citrulline is an excellent supplement to help your heart health.

In addition, citrulline has shown in studies to prevent fatigue and muscle weakness. This is not to say that it will aid in building muscle, only that it prevents shakes and spasms in the muscles.  

Citrulline is also used for the treatment of Alzheimer’s disease and dementia. While studies are still being studied on their uses in these areas, the benign nature of a citrulline supplement makes it safe to use even though it is not fully tested.

Citrulline and Weight Training

In addition, citrulline is used by body builders as a method of improving athletic performance. The interesting thing about this is that the studies that use citrulline in an athletic setting either had no results or had negative results.

In fact, in once study, the participants who took citrulline for the duration of the study became tired faster than the control group that was taking placebo. What this means is that in athletics, citrulline doesn’t really show a benefit.

That doesn’t mean that you shouldn’t take citrulline if you are an athlete. There are some very clear benefits for the body. However, if you are a weight lifter , don’t expect citrulline to help you get better pumps or achieve faster result. What it will do, however, is keep you healthy!

Citrulline and Erectile Cysfunction

Citrulline is also advertised as a erectile dysfunction product. As mentioned above, there are no studies to back up this claim. Because citrulline has so many benefits for the human body, trying it for this purpose is not likely to hurt you.

Citrulline Side Effects

Citrulline is one of the few supplements that have no reported side effects, even when taken in large doses. Because it has been clinically studied in humans, it is easier to accept the claims that there have been no side effects. In addition, there are no known drug interactions for citrulline. You should still talk to your doctor if you plan to take citrulline while taking other medications, but you don’t need to worry about any deaths or serious problems occurring.

Studies have shown that there are no adverse reactions to long term use of citrulline. However, it is important that you always follow the dosing and time frame listed on the product that you use. This is especially true if the citrulline supplements you purchase is combined with other supplements. Any dosing recommendations or time frames may be present to prevent problems from some of the other ingredients contained in your supplement. Because there have not been any studies conducted on pregnant women or children, you should not use citrulline if you fall under either of these categories.

Citrulline and Who Benefits

Citrulline is easily obtained in the food that you eat. You will find it in meat, eggs, milk, melons, apples, and legumes. Most people get all that they need from the food that they eat unless they are vegetarians. Most vegetarians will not eat quite enough melon and apples to get their daily allowance of citrulline.

With that being said, pretty much anyone with the exception of those mentioned in the side effects section, should consider taking citrulline supplements. The reason for this is that it is super beneficial to the human body. What’s more, with no known side effects, there is no concern that you are going to take too much and cause toxicity.

If you are an athlete taking citrulline, just be aware that there really aren’t any studies backing up its use as an athletic performance enhancer. You may, however, perform better simply because your heart is healthier and you have better oxygen flow in the body.

Whether you are looking for a way to boost your immune system, lower your blood pressure, increase blood flow in your body, or simply have more energy, citrulline is one of those amino acids that seem to do it all. Use the free supplement finder now!


  • Side Effects
  • Other Names
  • Uses
None Known
L-Citrulline, 2-amino-5-(carbamoylamino)pentanoic acid, Citrulline Malate, L-Citrulina
Blood Pressure
Cancer Prevention
Fat Loss
Heart Health
Kidney Function
Muscle Development
Oxygen Delivery To Vital Organs
Regulate Blood Flow
Bone Health