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Axoplasmic transport

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Revision as of 18:44, March 27, 2007 by Dr Joe Kiff (Talk | contribs)




Cytoplasmic dynein




Microtubules, or neurotubules, lie along the axis of the axon. The motor proteins kinesin and dynein, which change their shape in the presence of adenosine triphosphate, inch up and down microtubules. The motor proteins bind and can carry anything from large molecules like RNA and cytoskeletal building blocks, to organelles such as ribosomes, to vesicles with products like neurotransmitters packaged into them.[1][4]

Mitochondria that are transported along microtubules continue making ATP, which can be used by motor proteins carrying them.[3]

Some evidence suggests that products such as neurofilament subunits can be transported along actin with myosin as a motor.[5]

Anterograde transport



Retrograde transport


Consequences of interruption




  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Oztas E. 2003. Neuronal Tracing. Neuroanatomy. 2: 2-5. Retrieved on January 25, 2007.
  5. Jung C., Chylinski T. M., Pimenta A., Ortiz D., and Shea T. B. 2004. Neurofilament transport is dependent on actin and myosin. Journal of Neuroscience 24(43): 9486-9496. PMID 15509735. Retrieved on January 25, 2007.

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