Chorionic Villus Sampling (CVS)

What is chorionic villus sampling?

Chorionic villus sampling (CVS) is a prenatal test that involves taking a sample of some of the placental tissue. This tissue contains the same genetic material as the fetus and can be tested for chromosomal abnormalities and some other genetic problems. Testing is available for other genetic defects and disorders depending on the family history and other factors. In comparison to amniocentesis, another type of prenatal invasive test, CVS does not provide information on neural tube defects such as spina bifida. For this reason, women who undergo CVS will also need a follow-up blood test between 16 to 18 weeks of their pregnancy, to screen for neural tube defects.

How is chorionic villus sampling performed?


  • The tissue samples are sent to a genetic laboratory where they are grown and analyzed.
  • Women with twins or other multiples usually need sampling from each placenta, however, because of the complexity of the procedure, and positioning of the placentas, CVS is not always feasible or successful with multiples.

Some women may not be candidates for CVS or may not obtain results that are 100 percent accurate, and may, therefore, require a follow-up amniocentesis. If women are experiencing an active vaginal infection such as herpes or gonorrhea, which will prohibit the procedure. Other times, the physician obtains a sample that does not have enough tissue to grow in the laboratory, and results are incomplete or inconclusive.

How long does it take for the results?


What are the risks and benefits of chorionic villus sampling?

The risks of CVS include:

  • Infection CVS is an invasive procedure and may cause infection.
  • Limb defects Some reports show that babies born after CVS may have an increased rate of limb (arm, leg, or finger) defects. Other studies have not shown an increase, except when CVS is performed before 10 weeks of pregnancy.

The benefits of CVS include:

  • early diagnosis of a chromosomal abnormality
  • early diagnosis of certain genetic defects


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