Generic Name: Moexipril

  • What is this medication and its most common uses?

    Uniretic is a medicine used to treat high blood pressure. Uniretic contains two medicines that work in two different ways to reduce your blood pressure: moexipril and hydrochlorothiazide.


    How does this medication work?

    Moexipril works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, moexipril relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide is a water pill and works by eliminating extra fluid and sodium (salt) from your body. Together, they help lower your blood pressure.


    What: By lowering your blood pressure, Uniretic may lower your risk of a stroke or a heart attack.


    How do I know it is working?


  • What are the possible side effects of this medication?



    More common side effects may include: cough.

    Less common side effects may include:


    Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking Uniretic. Dehydration, excessive sweating, diarrhea, or vomiting can lead to an excessive fall in your blood pressure, which can cause lightheadedness and possible fainting.





  • Who should not take this medication?


    Do not take Uniretic if you are unable to produce urine.

    If you are diabetic, do not take Uniretic in combination with aliskiren.



  • What is the usual dosage?


    Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication, and may increase your dose as needed, until the desired effect is achieved.

  • How should I take this medication?

    Take Uniretic exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Uniretic without first talking to your healthcare provider.

    Take Uniretic 1 hour before a meal.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not become dehydrated. Drink plenty of fluids while you are taking Uniretic.



    If Uniretic is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Uniretic with the following: alcohol, aliskiren, barbiturates (such as phenobarbital), blood pressure/heart medications called angiotensin receptor blockers (ARBs) (such as losartan or valsartan), cholestyramine, colestipol, diabetes medicines (such as insulin), guanabenz, injectable gold (sodium aurothiomalate), lithium, muscle relaxants (such as tubocurarine), narcotic painkillers (such as hydrocodone or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, potassium supplements, propantheline, salt substitutes that contain potassium, steroids (such as prednisone), or water pills (such as amiloride, spironolactone, or triamterene).


    Do not take Uniretic if you are pregnant or breastfeeding. Uniretic can harm your unborn baby. Uniretic can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.



  • How should I store this medication?

    Store at room temperature. Protect from excessive moisture.

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