We also specialize in diagnosing and treating primary immunodeficiency syndromes which are a group of more than 200 rare, chronic hereditary or genetic disorders in which part of the body’s immune system is missing or functions improperly.Some affect a single part of the immune system; others may affect one or more components of the system. Because one of the most important functions of the normal immune system is to protect us against infection, patients commonly have recurrent infections, but can also have autoimmune disease, malignancies, and other complications.