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GPCRG-Protein-Coupled Receptor (proteomics)
GPCRGreat Proletarian Cultural Revolution (China)
GPCRGas-Phase Chemical Reduction
GPCRGuanine Nucleotide-Binding Protein-Coupled Receptor
GPCRGTP-binding Protein-Coupled Receptor
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sativa confers biological activity through its influence on the G-protein-coupled receptor types CB1 and CB (2,10) which pervade human skin epithelium.
Stromal-derived MMP-1 have been shown to cleave and activate G-protein-coupled receptor PAR1, leading to the activation of intracellular signals regulating the invasion process in breast cancer cells [20].
The protein, called the A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.
As an example, the annotation of a transcript as an "opsin" is often based on its sequence similarity to class A/rhodopsin-like members of the G-protein-coupled receptor (GPCR) superfamily and the presence of a lysine residue "invariantly" located in the seventh transmembrane helix (TM7) (i.e., "active-site" lysine).
Their topics include post-translational modifications of tubulin and cilia, the central apparatus of cilia and eukaryotic flagella, transition zone migration: a mechanism for cytoplasmic ciliogenesis and postaxonemal centriole elongation, primary cilia and mammalian hedgehog signaling, G-protein-coupled receptor signaling in cilia, ciliary mechanisms of cyst formation in polycystic kidney disease, sperm sensory signaling, cilia and ciliopathies in congenital heart disease, photoreceptor cilia and retinal ciliopathies, and the evolution of cilia.
Its action in the periphery is mediated by a G-protein-coupled receptor, neurotensin receptor 1 (NTSR1), whilst a second subtype, neurotensin receptor 2 (NTSR2), has mainly been identified in the central nervous system [8].
Lee et al., "Mapping studies of two G-protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor," Biochemical and Biophysical Research Communications, vol.
Griffin et al., "The Epstein-Barr Virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation," PLOS Pathogens, vol.
Molecular Devices has introduced its ClonePix 2 system, proven effective for rapidly assessing endogenous G-protein-coupled receptor (GPCR) target protein expression levels in mammalian cell lines and selecting high expressing clones.