Cronkhite-Canada Syndrome

Cronkhite-Canada Syndrome (CSS) is a sporadic disorder characterized by polyposis of the digestive tract, and ectodermal abnormalities. CSS is a very rare, progressive disease. Its etiology may be related to immune dysregulation, particularly autoimmunity.

Treatment includes supportive measures such as correcting fluid, electrolyte, and protein loss and regulating stool frequency, immunosupressive therapy, and/or surgery for complications.

Other possible diagnoses for individuals with similar symptoms:

Juvenile polyposis
Cowden Disease
Bannayan-Riley-Ruvalcaba syndrome
Peutz-Jeghers syndrome.

Case Report

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  1. Article Sources and Footnotes
    1. Werness, Bruce. (February 18, 2020). A GI Odyssey: Cronkhite-Canada Syndrome Case Report.

    2. Cronkhite-Canada Syndrome. Rare Disease Database, NORD.

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