

Functional Families


Superfamily: nsp15 middle domain

The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle.

nsp15 forms a hexamer which is suggested to be a functional unit. It also has endoribonuclease activity. The nsp15 monomer consists of three domains. This entry represents the middle domain which is made up of a major mixed beta-sheet, three small ones and two short alpha-helices PMID:16873248.

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
154 Unique species

Sequence/Structure Diversity


Superfamily Summary

A general summary of information for this superfamily.
Domains: 27
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 8
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Unique EC: 5
Unique GO: 3
Unique Species: 154