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Aldosterone Signaling in Epithelial Cells



Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal nephron and colon is the major factor determining total body Na+ levels, and thus, long term blood pressure. Aldosterone, a steroid hormone that is primarily produced in the zona glomerulosa, the outer layer of the adrenal cortex, maintains total organism sodium balance in all higher vertebrates (Ref.1). Principally, in humans, aldosterone is involved in the regulation of electrolyte and water balance through its effects on ion transport in epithelial cells. Electrically tight epithelial monolayers, such as the renal distal tubule and collecting duct system, distal colon, and those in salivary glands, are considered classic aldosterone target tissues (Ref.2). Aldosterone plays a major role in Na+, K+, [...]


Booth RE, Johnson JP, Stockand JD.
Adv Physiol Educ. 2002 Dec;26(1-4):8-20. Review.
2.New ideas about aldosterone signaling in epithelia.
Stockand JD.
Am J Physiol Renal Physiol. 2002 Apr;282(4):F559-76. Review.
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