Drug Targets

Identification of drug targets in human (for disorder related disease, like cancer) and targets in pathogen (for pathogen associated disease) is crucial for designing medicine. In past, large number of in silico tools have been developed for identification of drug targets, following are major types; i) prediction of receptors (e.g., GPCR), ii) cytokines, iii) enzymes and iv) binders.

Prediction of Drug Targets (Raghava's Group)

  3. BTXpred: A server for predicting bacterial toxins.
  4. CancerCSP: Gene expression-based biomarkers for discriminating early and late stage of clear cell renal cancer.
  5. ChemoPred: A server to predict chemokines and their receptor
  9. GPCRsclass: This webserver predicts amine type of G-protein coupled receptors
  10. GPSR: A resource for genomocs, proteomics and system biology
  11. GSTpred: SVM-based method for predicting Glutathione S-transferase protein.
  12. HIVint: Prediction of protein-protein interaction between HIV and Human proteins.
  13. HMRbase: A manually curated database of hormones and their Receptors.
  14. HSLpred: Prediction of subcellular localization of human proteins with high accuracy
  15. LPIcom: Analysis and prediction of ligand protein interaction.
  16. MARSpred: Prediction of mitochondrial aminoacyl tRNA synthetases.
  17. MitPred: Prediction of mitochondrial proteins using SVM and hidden Markov model.
  18. MtbVeb: A webportal for designing vaccine against drug resistant and emerging strains of M. tuberculosis.
  19. NPpred:  A webserver for the prediction of nuclear proteins.
  20. NRpred:  A SVM based method for the classification of nuclear receptors .
  21. NTXpred: Identification of neurotoxins their source and function from primary amino acid sequence.
  22. OXYpred: Classification and prediction of oxygen binding proteins.
  23. PFMpred: Predicting mitochondrial proteins of malaria parasite Plasmodium falciparum.
  24. PSEApred: Prediction of Plasmodium Secretory and Infected Erythrocyte Associated Proteins.
  25. PSLpred: Predict subcellular localization of prokaryotic proteins.
  26. RNApred: A webserver for the prediction of RNA binding proteins.
  27. RSLpred: A method for the subcellular localization prediction of rice proteins.
  29. THPdb: A database of FDA approved therapeutic peptides and proteins.
  31. VGIchan: Voltage gated ion channel prediction server.


External Links to web servers developed/mainatined by Indian groups


  1. CSIdesigner: An siRNA designing tool with a unique functional off:target filtering approach.
  2. FiloBase: Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase--a comprehensive drug target database for Lymphatic filariasis.
  3. TiD: Standalone software for mining putative drug targets from bacterial proteome.
  4. VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets.