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Latin tubulus transversus
Gray's subject #
MeSH [1]

A T-tubule (or transverse tubule) is a deep invagination of the sarcolemma, which is the plasma membrane, only found in skeletal and cardiac muscle cells. These invaginations allow depolarization of the membrane to quickly penetrate to the interior of the cell.


Each muscle fiber is surrounded by a sarcolemma (the muscle fiber's plasma membrane) which invaginates perpendicular to the length of the fiber to form what is called a T-tubule. At these invaginations the sarcolemma is studded with a large number of L-type calcium channels.

In skeletal muscle cells specifically, T-tubule invaginations are typically located at the junction overlap between the A and I bands of the sarcomere, and together with a pair of terminal cisternae (bulbous enlarged areas of the sarcoplasmic reticulum) it forms an arrangement called a triad.
Cardiac muscle has a similar structure; instead of a triad there is a diad, which is composed of a T-tubule and a single terminal cisterna, and it occurs at the Z line.

It is physiologically important for excitation-contraction coupling (see section below) that the T-tubules are positioned close to the terminal cisternae of the sarcoplasmic reticulum as the triad or diad arrangement allows physical and functional contact by voltage dependent L-type calcium channels. So, an action potential along the sarcolemma causes calcium channels to open in the terminal cisternae/sarcoplasmic reticulum which enables calcium to move from the sarcoplasmic reticulum into cytoplasm and the intracellular calcium concentration to increase.

Excitation-contraction couplingEdit

See Excitation-contraction coupling

T-tubules are the major sites for the coupling of excitation and contraction, which is the process whereby the spreading depolarization is converted into force production by muscle fibers. The L-type calcium channels in T-tubules activate in response to electrical stimulation; their opening allows calcium to flow down its electrochemical gradient and into the cell. Activation of the L-type channel also causes a mechanical interaction between it and calcium-release channels located on the adjacent sarcoplasmic reticulum membrane.

In skeletal muscle, the influx of calcium through the L-type calcium channel on the T-tubule contributes little to excitation-contraction coupling, whereas it is crucial to the proper function of cardiac muscle (see Cardiac action potential). Conversely, the mechanical interaction between the T-tubule's L-type calcium channel and the calcium-release channel is critical to proper skeletal muscle contraction, whereas it contributes little to the contraction of cardiac muscle.


It is possible to physically and functionally uncouple T-tubules from the surface membrane using a technique known as detubulation. This relies on osmotically active chemicals, such as glycerol (for skeletal muscle) or formamide (mainly for cardiac muscle). Addition of these chemicals to the solution surrounding muscle cells causes the cells to shrink; when the chemical is withdrawn the cells rapidly expand before returning to their normal size. The rapid expansion is thought to cause the t-tubules to detach from the surface membrane, which reseals, and to reseal within the cell. This technique can be used to investigate the function of the t-tubules.

There is some evidence that heart failure precipitates the loss of the T-tubule network, again indicating their importance.[How to reference and link to summary or text]

See alsoEdit

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