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(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.


1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.


A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.


A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: Hope this helps.

More discussions about clock
References in periodicals archive ?
The visit will focus on solving the customs issues between the parties, increasing the number of customs exemptions, organization of the round-the-clock work of customs checkpoints in Astara and Bilasuvar by providing them with the necessary equipment and personnel," said Pak Ayeen.
More details about Fraport's free round-the-clock Wi-Fi service can be found on our airport Web site: http://www.
QIB's round-the-clock e-services will also be available through ATMs in more than 170 locations in Qatar, as well as its Internet banking, mobile application, and phone banking.
See your progress in your private Weight Tracker ROUND-THE-CLOCK SUPPORT ?
CATASTROPHIC Elaine Kennedy-Lee with son James who needs round-the-clock care after being hit by a car
When we are supplying power round-the-clock, the opposition is saying the bill is too high.
In a statement, the bank said, 'A local presence will allow the SNB to extend its coverage of markets in Asia, and will facilitate its round-the-clock operations on the foreign exchange market - for example, to enforce the minimum exchange rate.
LAHORE -- Police contingents equipped with sophisticated weapons deployed in various cities throughout the province have been put on high alert to cope with any untoward incident during the Eid holidays besides ensuring round-the-clock patrolling.
Sami bin Mohamed Ba&'Dawood said the number of medical teams offering round-the-clock services to the needy in Jeddah affected districts amounted to 20 teams including 120 medical cadres.
Summary: Ahlan Dubai, the DSF Office call centre, is now receiving calls round-the-clock to ensure residents and visitors have up-to-date information on almost every aspect of Dubai.
The new number is already operational and is manned round-the-clock, which means people can speak to a waste management specialist any time and get advice on all aspects concerning the efficient management of waste.
In the midst of the bombings, rocket attacks and the fighting, nurses in Israel and Gaza are working round-the-clock shifts to treat the wounded and tend the dying.