How do bacteria escape gut to get into lungs?

Scientists aren’t sure how they got there, but bacteria that normally live in the gut have turned up in the lungs of critically ill people and animals. The environment is one where bacteria are not normally found and can’t usually survive.

“.. we need to start thinking of the microbiome as an organ that can fail in critically ill patients.”

In addition, the more severe the patients’ critical illness, the more their usual lung bacteria were outnumbered by the misplaced gut bugs. The findings could mean a lot for intensive care patients.

The findings suggest that critical illness involving the lungs has more to do with disruptions to the body’s natural population of microbes, or microbiome, than previously thought, scientists say.


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“Our results suggest that in our past attempts to find treatments for sepsis and ARDS, we may have been overlooking a major part of the story,” says lead author Robert P. Dickson, a critical care physician and laboratory scientist at the University of Michigan. “Virtually all of our attempts to treat these critical illnesses have been aimed at fixing the disordered inflammation and tissue injury we can see in our patients. But our study raises the possibility that this inflammation and injury may actually be downstream consequences of an upstream source: disordered bacterial communities in the gut and lung.”

Researchers believe that patients with these conditions may actually be stuck in a vicious cycle caused by dysbiosis—an out-of-whack microbiome. Based on their findings, they suggest that the insult that caused the patient’s or animal’s illness in the first place triggers a “chicken and the egg” feedback loop.

Changes in the microbiome lead to inflammation, as the body’s immune system tries to fend off what it sees as invaders. And that inflammation in turn injures the delicate lung tissue. But then that injury and inflammation change the environment within the lung, allowing microbes that don’t normally grow there to invade—or to “bloom” if they were already present in low levels.

Lungs as an ecosystem

Improving survival of critically ill patients, then, would require breaking that cycle—which means figuring out how to keep the microbiome relatively normal.

To do that, the researchers know they’ll have to show where the gut bacteria in the lung originally came from. In animals with sepsis, they’ve ruled out the usual route by which microbes get into the lung every day—through the upper respiratory tract of the mouth, nose and throat.

One possible explanation—one that researchers have speculated about since the 1950s—is that in patients with critical illness, the walls of the intestines get “leaky,” and bacteria escape and travel upward into the lungs. Another potential explanation is that small numbers of these gut bacteria were present in the lungs all along, but couldn’t grow for lack of the proper environmental conditions.


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The new findings, published in the journal Nature Microbiology,  help explain something that critical care teams have known for decades: that the gut microbiome is somehow linked to a person’s chances of surviving a critical illness.


In other countries, doctors even treat uninfected ICU patients with antibiotics to suppress their microbiomes, and decrease their rates of organ failure and death. They call the practice selective decontamination of the digestive tract. But such prophylactic tactics aren’t commonly used in the US because of concerns that antibiotic use could accelerate the rise of “superbugs” resistant to modern antibiotics.

“In the long run, we need to start thinking of the microbiome as an organ that can fail in critically ill patients,” says Dickson. “We’re studying how it gets disordered, how it impacts other organs, and how we can fix it. The importance of the microbiome in the ICU has been clear for decades, but with these new tools we’re finally able to ask and answer the right questions. It’s a really exciting time.”

The National Institutes of Health, the Michigan Institute for Clinical & Health Research, and the Medical School’s Host Microbiome Initiative funded the work.

Source: University of Michigan

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Source: Futurity