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Related to tranylcypromine: Tranylcypromine sulfate


A monoamine oxidase inhibitor, C9H11N, used in its sulfate form as an antidepressant.

[trans- + (phe)nylcy(clo)pro(pana)mine.]
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Noun1.tranylcypromine - an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
MAOI, monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
References in periodicals archive ?
2) Monamine Oxidase Inhibitors (MAOIs): They were also the first medications used to treat "Reactive Depression" and include Phenelzine (Nardil), Selegiline (Emsam) and Tranylcypromine (Parnate).
Phenelzine and tranylcypromine are irreversible inhibitors of the monoamine oxidase enzyme (MAO).
5 75-225 Serotonin modulators Trazodone 50 75-400 Norepinephrine-serotonin modulator (NaSSA) Mirtazapine 15 15-45 Monoamine oxidase inhibitors (MAOIs) Irreversible, nonselective Phenelzine 15 15-90 Tranylcypromine 10 30-60 Isocarboxazid 20 30-60 Reversible MAOI-A Moclobemide 300 300-600 Melatonergic agonist Agomelatine 25 25-50 * Reprinted with permission from APA Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed, [c] 2010).
For patients with refractory bipolar depression, he said his favorite combination has been lamotrigine and MAO inhibitors, particularly tranylcypromine.
There's also selegiline, which has been used for a long time to treat Parkinson's disease, but it's controversial as to whether dietary and pharmacologic restrictions should be as vigorous as with phenelzine and tranylcypromine.
In the new study Arthur Zelent and his colleagues at the ICR have shown that the key could be an antidepressant called tranylcypromine (TCP).
Tranylcypromine Versus Venlafaxine Plus Mirtazapine Following Three Failed Antidepressant Medication Trials for Depression: A STAR*D Report.
Patient Age [greater than Antidepressant or equal to]65 <65 Sertraline 25 50 Paroxetine 10 20 Citalopram * 20 20 Fluoxetine 10 20 Fluvoxamine * 100 100 Amitriptyline NR 50 Desipramine 25 100 Doxepin 30 75 Imipramine 30 75 Nortriptyline 30 75 Protriptyline 15 15 Trimipramine 50 75 Clomipramine 75 75 Trazodone 25 150 Buproprion 50 200 Phenelzine 45 45 Tranylcypromine 20 20 Maprotiline 25 75 Nefazodone 100 200 Venlafaxine 50 75 Mirtazapine 15 15 Amoxapine 50 100 * These antidepressants were not addressed in 1997 Department of Veterans Affairs depression guidelines; minimum daily dosage for these medications derived from expert consensus.
57) Of these agents, tranylcypromine is the most likely to raise blood pressure, as opposed to moclobemide and brofaromine, which are the least likely to elevate pressures.
They include phenelzine (Nardil), isocarboxazid (Marplan) and tranylcypromine (Parnate).