The "madness" of King George III of England is well-documented, and was later attributed to the genetic disorder porphyria. Porphyria is an inherited or acquired disorder of the heme biosynthetic pathway that leads to the accumulation of the porphyrins (or their chemical precursors). Inherited cases of porphyria are manifested with a combination of seemingly unrelated symptoms including mental disturbances and hallucinations, constipation, vomiting, muscle weakness, pain, and seizures. Which genetic term best describes this type of mutation?

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Variable expressivity


Incomplete penetrance




asked May 5, 2013 in Genetics by GeneX ~Top Expert~ (7,947 points)

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answered May 5, 2013 by GeneX ~Top Expert~ (7,947 points)

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