

MTHFR Maintenance Packages for 1298A & C and C677T Mutations



MTHFR Terminology Basics:



C677T or rs1801133 is a genetic variation—a single nucleotide polymorphism (SNP)—in the MTHFR gene.
You get one copy of this gene from your mother and one from your father, so there are two possible copies that can be either “normal” or “mutant”. (For more information click here..)


  • MTHFR C677C = normal MTHFR gene
  • MTHFR C677T = heterozygous mutation (one mutation)
  • MTHFR T677T = homozygous mutation (two mutations)
  • MTHFR A1298A = normal MTHFR gene
  • MTHFR A1298C = heterozygous mutation (one mutation)
  • MTHFR C1298C = homozygous mutation (two mutations)
  • MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation

Individuals with two copies of 677C (677CC) have the most common genotype. 677TT individuals (homozygous) have lower MTHFR activity than CC or CT (heterozygous) individuals