The first step in the process of receiving the PRRT is to give the patient a dose of 1,500 ml of an amino acid solution designed to protect the kidneys from the effects of the radiation. The amino acid infusion (Lysin HCL 5% plus 250 ml L-Argiin HCL 10% plus 250 ml NaCl) is administered through the IV tube that is placed in the patient's arm or hand (most common location). This solution is started about 45 minutes to an hour before the radioisotope is put into the circulation system via the same IV tube. Once the radioisotope is administered then more amino acid solution is given to the patient. In total the administration of the amino acid solution is done over a period of about 4 hours.

In addition, an anti-nausea medication is often administered during the infusion.