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The presence of methemoglobin in the blood.



the appearance of methemoglobin in the blood as a result of the toxic effect of various chemical substances (nitrates and nitrites, aniline, pyridine) that are capable of converting hemoglobin to methemoglobin (MtHb) upon entering the body through the skin, digestive tract, or lungs. With considerable methemoglobinemia, oxygen starvation, or hypoxia, may result. Methemoglobin may be excreted with the urine (methemoglobinuria); this is sometimes damaging to the kidneys. Methemoglobinemia is treated with antidotes (methylene blue, ascorbic acid) and oxygen therapy.

References in periodicals archive ?
The company also introduced generic versions of the diuretic methazolamide and of Lederle's ocular drug Neptazane (methazolamide) which is used to treat various forms of glaucoma.
CAI research led to the development of first generation CAIs that are still available in the clinic, including acetazolamide (Diamox), methazolamide (Neptazane), ethoxzolamide, and dichlorphenamide (Keveyis).
The first CAIs used to treat glaucoma include acetazolamide, methazolamide, ethoxzolamide, and dichlorphenamide.
Methazolamide, ethoxzolamide, dichlorphenamide, and thiazide have also been used for the treatment of edema [95, 97].
Classic CAIs such as acetazolamide and methazolamide have been clinically used as antiepileptics, but have more recently been replaced by topiramate [98].
Finally, 12 (7.2%) patients were caused by other drugs, including methazolamide (n = 8), dobesilate (n = 1), antifungals (n =1), antidepressant (n =1), and antituberculosis drugs (n = 1).
Zhao, "A case of SJS/TEN overlap induced by oral methazolamide," Chinese Journal of Ophthalmology, vol.
(n) Others including calcium dobesilate (n =1), methazolamide (n = 8), multiple antifungals (itraconazole and voriconazole) (n = 1), multiple antidepressant (amitriptyline and estazolam) (n = 1), and multiple antituberculosis drugs (n = 1).