Non-Small Cell Lung Cancer - Non-Small Cell Lung Cancer Molecular Markers

Lung cancer is the leading cause of cancer-related mortality in the United States. Diagnosis typically involves a combination of imaging studies, cytologic or histopathologic specimen evaluation, and subsequent immunohistochemistry (IHC) and genetic analysis.  More than 80% of lung cancer cases are classified as non-small cell lung cancers (NSCLCs), and adenocarcinoma is the most common NSCLC subtype in nonsmokers.  Adenocarcinoma is characterized by a prevalence of oncogenic driver (EGFR, ALK, ROS1, and BRAF) genetic alterations, which if present may influence prognosis and predict response to targeted therapies. Guidelines recommend IHC and/or molecular analysis to identify actionable targets and guide subsequent therapy selection.

Tabs Content
Content Review: 
July 2019

Last Update: August 2019