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Erceflora (Bacillus clausii)

Know the basics|Know the precautions & warnings|Know the side effects|Understand the dosage

Know the basics

What is Erceflora?

Erceflora is a product that contains the spores of Bacillus clausii, a type of bacteria that is resistant to antibiotics. It helps replenish and support the normal flora of the gut. Additionally, it is considered a probiotic. Indications for probiotics include post-antibiotic use, chronic diarrhea or constipation, and certain vitamin malabsorption disorders.

How should I take Erceflora?

Oral suspension

  • Some aggregates or particles may be seen, however, this is normal. Shake well before use.
  • To open the bottle, twist and pull off the top.
  • Dilute the contents of the ampule into a glass of water or other beverage (e.g. juice, milk, formula).
  • Lastly, consume the entire content of the bottle immediately to prevent contamination.

How do I store Erceflora?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of Bacillus clausii that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.


Know the precautions & warnings

What should I know before using Erceflora?

You should not use it if you are hypersensitivity to the active ingredient or any of the excipients.

During treatment with antibiotics, Erceflora can be administered during the interval between antibiotic administrations.

Is it safe during pregnancy or breastfeeding?

Erceflora is pregnancy risk category A, according to the US Food and Drug Administration (FDA). Therefore, it is considered safe to use during pregnancy and lactation.

However, still consult your doctor before taking this medication.

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown

Know the side effects

What side effects can occur from Erceflora?

No adverse effects have been reported when taken as directed. However, if you experience any side effects or worsening of your condition, inform your doctor or pharmacist.

Know the interactions

What drugs may interact with Erceflora?

No drugs or food are known to modify the effect of Erceflora. However, if you are taking other medications, consult your doctor or pharmacist.

Does food or alcohol interact with Erceflora?

No drugs or food are known to modify the effect of Erceflora. If you are taking other medicines, inform your doctor or pharmacist.

What health conditions may interact with Erceflora?

Erceflora may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Understand the dosage


What is the dose of Erceflora for an adult?

Take 2 to 3 bottles per day at regular intervals, or as directed by a doctor.

What is the dose of Erceflora for a child?

Administer 1 to 2 bottles per day at regular intervals, or as directed by a doctor.

How is Erceflora available?

Erceflora is available in the following dosage forms and strengths:

  • Oral suspension, each 5 mL bottle contains 2 billion Bacillus clausii spores

What should I do in case of an emergency or overdose?

Fortunately, there are no reports of overdose or toxicity with Erceflora. However, if you feel ill or experience serious side effects contact your doctor or emergency medical services.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it is almost time for the next dose, just take one. Do not take a double dose.



Erceflora https://www.mims.com/philippines/drug/info/erceflora?type=full Accessed March 8, 2021

Preventing Antibiotic-Associated DiarRhea Using Erceflora (PADRE) https://www.clinicaltrials.gov/ct2/show/NCT00447161 Accessed March 8, 2021

Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116021/ Accessed March 8, 2021

Are probiotics safe for use during pregnancy and lactation?, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056676/, Accessed Sept. 8, 2021

Bacillus clausii as adjunctive treatment for acute community-acquired diarrhea among Filipino children: a large-scale, multicenter, open-label study (CODDLE), https://tdtmvjournal.biomedcentral.com/articles/10.1186/s40794-019-0089-5, Accessed Sept. 8, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated 2 weeks ago