

The TRB locus is located on chromosome 7 [1-4], on the long arm, at band 7q34 [5], whereas the TRG locus is located on the short arm of chromosome 7 [6,7], at band 7p14 [8].

Vertical red lines indicate the localization of the TRG locus at 7p14 and that of the TRB locus at 7q34.
Blue arrows indicate the orientation 5' → 3' of the loci, and the gene group order in the loci. Note that the TRBV gene localized at the 3' end of the TRB locus is in inverted orientation of transcription (shown by a small black arrow). The blue arrows are proportional to the size of the loci, indicated in kilobases (kb). The total number of genes in the loci are shown between parentheses.

The orientation of the loci has been determined by the analysis of translocations, involving the TRB and the TRG loci, in leukemia and lymphoma and the analysis of chromosome 7 inversions inv(7)(p14-q34), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukemia.

Chromosomal localization human TRB and TRG

IMGT references:
  1. [1] Collins, M.K.L. et al., EMBO J., 3, 2347-2349 (1984).
  2. [2] Barker, P.E. et al., Science, 226, 348-349 (1984).
  3. [3] Caccia, N. et al., Cell, 37, 1091-1099 (1984).
  4. [4] Isobe, M. et al., Science, 228, 580-582 (1985).
  5. [5] Reynolds, T.C. et al., Cell, 50, 107-117 (1987).
  6. [6] Rabbitts, T.H. et al., EMBO J., 4, 1461-1465 (1985).
  7. [7] Murre, C. et al., Nature, 316, 549-5525 (1985).
  8. [8] Bensmana, M., et al., Cytogenet. Cell Genet., 56, 31-32 (1991).
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Chantal Ginestoux and Marie-Paule Lefranc