Tests and procedures used to diagnose Merkel cell carcinoma include:

  • Physical exam. Your doctor will examine your skin for unusual moles, freckles, pigmented spots and other growths.
  • Removing a sample of suspicious skin. During a procedure called a skin biopsy, your doctor removes the tumor or a sample of the tumor from your skin. The sample is analyzed in a laboratory to look for signs of cancer.

Determining the extent

Your doctor may use the following tests to help determine whether the cancer has spread beyond your skin:

  • Sentinel node biopsy. A sentinel node biopsy is a procedure to determine whether cancer has spread to your lymph nodes. This procedure involves injecting a dye near the cancer. The dye then flows through the lymphatic system to your lymph nodes.





Treatments for Merkel cell carcinoma can include:

  • Surgery. During surgery, your doctor removes the tumor along with a border of normal skin surrounding the tumor. If there's evidence that the cancer has spread to lymph nodes in the area of the skin tumor, those lymph nodes are removed (lymph node dissection).

    The surgeon most often uses a scalpel to cut away the cancer. In some cases, your doctor may use a procedure called Mohs surgery.

    During Mohs surgery, thin layers of tissue are methodically removed and analyzed under the microscope to see whether they contain cancer cells. If cancer is found, the surgical process is repeated until cancer cells are no longer visible in the tissue. This type of surgery takes out less normal tissue — thereby reducing scarring — but ensures a tumor-free border of skin.

  • Radiation therapy. Radiation therapy involves directing high-energy beams, such as X-rays, at cancer cells. During radiation treatment, you're positioned on a table and a large machine moves around you, directing the beams to precise points on your body.

    Radiation therapy is sometimes used after surgery to destroy any cancer cells that remain after the tumor is removed.

    Radiation also may be used as the sole treatment in people who choose not to undergo surgery. Radiation can also be used to treat areas where the cancer has spread.

  • Chemotherapy. Chemotherapy uses drugs to kill the cancer cells. Chemotherapy drugs can be administered through a vein in your arm or taken as a pill or both.

    Your doctor may recommend chemotherapy if your Merkel cell carcinoma has spread to your lymph nodes or other organs in your body, or if it has returned despite treatment.

Preparing for your appointment

If you have a mole, freckle or bump on your skin that concerns you, start by making an appointment with your doctor. If your doctor suspects you may have skin cancer, you'll likely be referred to a skin specialist (dermatologist).


What can you do

  • Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For Merkel cell carcinoma, some basic questions to ask your doctor include:

  • What is likely causing my symptoms or condition?
  • Are there other possible causes for my symptoms or condition?
  • What are my treatment options?
  • How will you check my response to treatment?
  • How likely is my condition to recur? What treatment options would be available in that case?
  • What follow-up tests will I need to monitor for recurrence?
  • Are there any restrictions that I need to follow?


What to expect from your doctor


  • When did you first notice your symptoms?
  • How have your symptoms changed over time?
  • Does anything seem to improve your symptoms?
  • Have you spent a lot of time in the sun, or have you used tanning beds?
  • Do you have a history of other skin conditions, such as skin cancer or psoriasis? What treatments have you received for those conditions?
  • Have you been diagnosed with any immune system disorders? If so, what treatments have you received?
  • Have you been diagnosed or treated for any other health conditions?