Seamless integration of cell biology and molecular analysis at the single-cell level


The Future is Functional Genomics

Imagine if you could explore the genomes of every cell to find the gene networks that regulate them. You could correlate a cell’s phenotype, physiological condition and molecular signature to discover the genetic circuits regulating cell function or compare a population’s sensitivity to environmental changes. It’s the future of single-cell biology, and it’s available now on Polaris™, the first system to seamlessly integrate cell and molecular biology at the single-cell level. Select individual cells, challenge them with factors you choose under strict environmental conditions for up to 24 hours and measure each cell’s acute response transcriptionally via next-generation sequencing. And because it all happens on one precisely designed IFC, controlled by an intuitive touchscreen interface, all that’s left to the imagination is what question you’ll answer next. 


Select your target cell by phenotype, viability or transgenic reporter.


Select, dose and prepare cells for analysis in one integrated workflow.


Observe and manipulate cells in their biological environment.


Challenge cells with a variety of parameters with the tap of a touchscreen.


An innovative integrated fluidic circuit (IFC) enables Polaris to actively select single cells from heterogeneous cell samples and hold them in individual, environmentally controlled reaction chambers. Once isolated, cells can be challenged with a variety of factors, including transcription factors, RNAs and small molecules, at the dosage or intervals you define. Then the cells are automatically lysed and RNA template is prepared for mRNA sequencing analysis. Polaris does it all in a single IFC and with minimal hands-on time, controlled by an elegant, intuitive touchscreen interface.


  1. Prime
  2. Transfer
  3. Load
  4. Dose
  5. Lyse
  6. Harvest




Pipet live cells in suspension and reagents into the IFC.




Challenge selected cells with a variety of parameters and stain, if desired.


Lyse each cell to reverse transcribe and amplify within the IFC.




Polaris Support



IFCs, Assays and Reagents

Polaris IFC

Select, perturb and observe transcriptional changes in individual cells with the Polaris™ IFC. Our most sophisticated microfluidic IFC integrates cell biology and genomic analysis into one workflow so you can find the gene networks that regulate each cell. Designed for use with the Polaris system.

  1. Polaris IFC

Related Systems

Biomark HD

Biomark HD Analyze gene expression with real-time PCR, industry-leading flexibility and consistently high-quality results on the Biomark™ HD system.



Isolate, stain, lyse and amplify single cells in one precise yet flexible workflow—all in as little as four hours with the innovative C1 system.

  1. Biomark HD
  2. C1


Singular Analysis Toolset Software v3.6.2


  1. Singular Analysis Toolset Software v3.6.2


Dimensions as Shipped

Height 42.0 in (106.8 cm)
Width 28.6 in (72.7 cm)
Depth 37.3 in (94.8 cm)
Weight 300 lb (136 kg)


Height 27.8 in (70.6 cm)
Width 20.6 in (52.2 cm)
Depth 34.1 in (86.6 cm)
Weight 242 lb (110 kg)

Site Requirements

Clearance 6 in (15 cm) from the rear
Temperature 15–28 ºC (59–82 ºF) stable
Humidity 30–80%, noncondensing
Altitude site preparation <8,202 ft (2,500 m)


Current 10 A (max)
Voltage 90 V (min) to 240 V (max)
Frequency 50/60 Hz
Main supply fluctuation not to exceed ±10% of the nominal supply voltage
Connection 4x USB 2.0
Humidity 30–80%, noncondensing

Gas Requirements

Grade Clean, dry premixed gas (standard grade)
Blood gas 5% CO2, 5% oxygen and 90% nitrogen
Mixed gas 5% CO2, 20% oxygen and 75% nitrogen
Regulatory 22–25 psi