Thursday, March 2, 2017

No increased risks to newborns linked to taking influenza drugs during pregnancy

BMJ: A study published by The BMJ today finds no increased risks to newborn babies if their mothers have taken drugs to prevent or treat influenza during pregnancy. This is the largest study to date to assess potential risks of taking antiviral drugs (known as neuraminidase inhibitors) during pregnancy and the results support previous findings. Seasonal influenza occurs every year and millions of pregnant women risk severe illness during seasons with a more aggressive strain.

Regulatory agencies in Europe and the USA therefore recommend neuraminidase inhibitors for pregnant women with confirmed or suspected influenza, or those exposed to close contacts with the illness, despite limited knowledge on their safety and effectiveness during pregnancy.
After several health-related factors were taken into account, such as age, smoking and use of other medications, the team found no increased risks of adverse outcomes including low birth weight, low Apgar score (a test of a baby’s condition at birth), preterm birth, stillbirth, or birth defects.
The researchers point out that their study included some limitations that could have influenced the findings. For example, the study did not assess risks of adverse outcomes before 22 weeks of pregnancy, and some women could have filled a prescription without taking the drug
However, they say their results “support previously reported findings that the use of neuraminidase inhibitors is not associated with increased risks of adverse fetal or neonatal outcomes.”