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Acute myelogenous leukemia







Signs and symptoms of acute myelogenous leukemia include:

  • Fever
  • Bone pain
  • Lethargy and fatigue
  • Shortness of breath
  • Pale skin
  • Frequent infections
  • Easy bruising

When to see a doctor



Acute myelogenous leukemia occurs when a bone marrow cell develops changes (mutations) in its genetic material or DNA. A cell's DNA contains the instructions that tell a cell what to do. Normally, the DNA tells the cell to grow at a set rate and to die at a set time. In acute myelogenous leukemia, the mutations tell the bone marrow cell to continue growing and dividing.

When this happens, blood cell production becomes out of control. The bone marrow produces immature cells that develop into leukemic white blood cells called myeloblasts. These abnormal cells are unable to function properly, and they can build up and crowd out healthy cells.

It's not clear what causes the DNA mutations that lead to leukemia, but doctors have identified factors that increase the risk.

Risk factors

Factors that may increase your risk of acute myelogenous leukemia (AML) include:

  • Dangerous chemical exposure. Exposure to certain chemicals, such as benzene, is linked to a greater risk of AML.
  • Other blood disorders. People who've had another blood disorder, such as myelodysplasia, myelofibrosis, polycythemia vera or thrombocythemia, are at greater risk of developing AML.



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