COCCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2ccc3c(c2)OCO3)c2ccc(F)cc21
COCCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2ccc3c(c2)OCO3)c2ccc(F)cc21
2-(1,3-benzodioxol-5-yl)-2-[6-fluoro-1-(2-methoxyethyl)indol-3-yl]-N-(2-methoxy-4-methylphenyl)sulfonylacetamide
Task: Please answer the multiple choice question.
Question: Which molecule has the highest {permeability__names__noun}?
Constraint: Even if you are {#uncertain|not sure!}, you must pick either {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Which molecule has the highest Caco-2 permeability?
Constraint: Even if you are uncertain, you must pick either a, b, c, d, or e without using any additional words.
Options:
(a) O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1
(b) COCCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2ccc3c(c2)OCO3)c2ccc(F)cc21
(c) OC[C@@H]1O[C@@](O)(CO)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
(d) Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1
(e) COc1ccc2cc3[n+](cc2c1O)CCc1cc2c(cc1-3)OCO2
Answer: b