FC(F)(F)c1cccc(C2=CCN(CCc3ccc4ccccc4c3)CC2)c1
FC(F)(F)c1cccc(C2=CCN(CCc3ccc4ccccc4c3)CC2)c1
1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine
Task: Please answer the multiple choice question.
Question: Which molecule has the highest {permeability__names__noun}?
Constraint: Even if you are {#uncertain|not sure!}, you must pick either {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Which molecule has the highest Caco-2 cell permeability?
Constraint: Even if you are uncertain, you must pick either a, b, c, d, or e without using any additional words.
Options:
a.) FC(F)(F)c1cccc(C2=CCN(CCc3ccc4ccccc4c3)CC2)c1
b.) CO[C@H](CCC(C)C)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@@]4(C)C3CC[C@]12C
c.) COCCc1ccc(OCC(O)CNC(C)C)cc1
d.) Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O
e.) Oc1ccc(-c2cnc(-c3cccc(O)c3)o2)cc1
Answer: a