O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
1-[4-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one
Task: Please answer the multiple choice question.
Question: Rank these molecules from lowest to highest {permeability__names__noun}.
Constraint: You must select all options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Rank these molecules from lowest to highest Caco-2 cell effective permeability.
Constraint: You must select all options from a, b, c, d, or e without using any additional words.
Options:
a C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O
b CC(C)NCC(COc1ccc(CCOCC2CC2)cc1)OC(=O)C1CC1
c O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
d CC(C)(C)NCC(O)COc1ccc(NC(=O)NC2CCCCC2)cc1
e C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C1=O
Answer: c