COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]12
COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]12
methyl(1S,15R,16S,20R)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate
User: I want to {#come up with|create|generate!} a {#molecule |!}{SMILES__description}.
Assistant: {#This sounds very exciting. |This sounds very interesting. !}Should I consider any {#constraints|specific points!} for the {#generation|creation!}?
User: Yes, please. The molecule should have a {permeability__names__noun} value of approximately {permeability#} {permeability__units}.
Assistant: {#Ok|Got it!},{# here you go,|!} this {SMILES__description} has a {permeability__names__noun} value of approximately {permeability#} {permeability__units}: {SMILES#}
User: I want to come up with a molecule SMILES.
Assistant: This sounds very exciting. Should I consider any constraints for the generation?
User: Yes, please. The molecule should have a Caco-2 cell effective permeability value of approximately -4.819 cm/s.
Assistant: Ok, here you go, this SMILES has a Caco-2 cell effective permeability value of approximately -4.819 cm/s: COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]12