O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
1-[4-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one
Task: Please answer the multiple choice question.
Question: Rank these molecules from lowest to highest {permeability__names__noun}.
Constraint: You must select all options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Rank these molecules from lowest to highest Caco-2 cell effective permeability.
Constraint: You must select all options from a, b, c, d, or e without using any other words.
Options:
a. CCS(=O)(=O)CCn1c(N(O)O)cnc1C
b. Nc1c(CC(=O)O)cccc1C(=O)c1ccccc1
c. O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
d. O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1
e. COc1ccc(-c2oc3c(CC=C(C)C)c(O)cc(O)c3c(=O)c2O[C@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@@H]2O)cc1
Answer: c