O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
1-[4-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one
Task: Please answer the multiple choice question.
Question: Which molecule has the highest {permeability__names__noun}?
Constraint: Even if you are {#uncertain|not sure!}, you must pick either {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Which molecule has the highest Caco-2 cell permeability?
Constraint: Even if you are not sure, you must pick either a, b, or c without using any other words.
Options:
[a] COc1cc2nc(N3CCN(C(=O)c4occc4Cl)CC3)nc(N)c2cc1OC
[b] O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
[c] COC(=O)c1cc(OC)c2c(c1-c1c(C(=O)OC)cc(OC)c3c1OCO3)OCO2
Answer: b