O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
1-[4-[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one
Task: Please answer the multiple choice question.
Question: Which molecule has the highest {permeability__names__noun}?
Constraint: Even if you are {#uncertain|not sure!}, you must pick either {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
Task: Please answer the multiple choice question.
Question: Which molecule has the highest Caco-2 permeability?
Constraint: Even if you are not sure, you must pick either a, b, c, d, or e without using any other words.
Options:
[a] O=C1CCCN1CCCCN1CCN(c2cc(C(F)(F)F)ccn2)CC1
[b] CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(N)=O
[c] CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O
[d] O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccnn1CCc1ccncc1
[e] CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1
Answer: a