{"action":"created","issue":{"url":"https://api.github.com/repos/OpenMS/OpenMS/issues/1221","labels_url":"https://api.github.com/repos/OpenMS/OpenMS/issues/1221/labels{/name}","comments_url":"https://api.github.com/repos/OpenMS/OpenMS/issues/1221/comments","events_url":"https://api.github.com/repos/OpenMS/OpenMS/issues/1221/events","html_url":"https://github.com/OpenMS/OpenMS/issues/1221","id":56123177,"number":1221,"title":"Moving average for MS1 spectra in SpectraMerger","user":{"login":"lars20070","id":6149805,"avatar_url":"https://avatars.githubusercontent.com/u/6149805?v=3","gravatar_id":"","url":"https://api.github.com/users/lars20070","html_url":"https://github.com/lars20070","followers_url":"https://api.github.com/users/lars20070/followers","following_url":"https://api.github.com/users/lars20070/following{/other_user}","gists_url":"https://api.github.com/users/lars20070/gists{/gist_id}","starred_url":"https://api.github.com/users/lars20070/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/lars20070/subscriptions","organizations_url":"https://api.github.com/users/lars20070/orgs","repos_url":"https://api.github.com/users/lars20070/repos","events_url":"https://api.github.com/users/lars20070/events{/privacy}","received_events_url":"https://api.github.com/users/lars20070/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":4,"created_at":"2015-01-31T12:19:00Z","updated_at":"2015-02-04T13:21:34Z","closed_at":null,"body":"The SpectraMerger tool can already sum subsequent MS1 spectra of an LC-MS experiment. But that reduces the number of spectra. SpectraMerger should also allow for a moving average of 3, 5 or 7 etc. MS1 spectra leaving the number of spectra constant.\r\n\r\nSuch a signal processing step should improve the performance of all OpenMS feature finder tools. RT profiles will be smoothed, isotope patterns in m/z will be clearer."},"comment":{"url":"https://api.github.com/repos/OpenMS/OpenMS/issues/comments/72852846","html_url":"https://github.com/OpenMS/OpenMS/issues/1221#issuecomment-72852846","issue_url":"https://api.github.com/repos/OpenMS/OpenMS/issues/1221","id":72852846,"user":{"login":"lars20070","id":6149805,"avatar_url":"https://avatars.githubusercontent.com/u/6149805?v=3","gravatar_id":"","url":"https://api.github.com/users/lars20070","html_url":"https://github.com/lars20070","followers_url":"https://api.github.com/users/lars20070/followers","following_url":"https://api.github.com/users/lars20070/following{/other_user}","gists_url":"https://api.github.com/users/lars20070/gists{/gist_id}","starred_url":"https://api.github.com/users/lars20070/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/lars20070/subscriptions","organizations_url":"https://api.github.com/users/lars20070/orgs","repos_url":"https://api.github.com/users/lars20070/repos","events_url":"https://api.github.com/users/lars20070/events{/privacy}","received_events_url":"https://api.github.com/users/lars20070/received_events","type":"User","site_admin":false},"created_at":"2015-02-04T13:21:34Z","updated_at":"2015-02-04T13:21:34Z","body":"Yes. It is of possible. Which of these two options is best we could only find out after comparing both implementations.\r\n\r\nI still would go for moving average preprocessing. Not on every dataset, but only where this problem occurs.\r\n\r\n"}}