{"action":"opened","issue":{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/280","labels_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/280/labels{/name}","comments_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/280/comments","events_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/280/events","html_url":"https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/280","id":55748707,"number":280,"title":"Synthesis of 1-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)pyrrolidine (TF16-1)","user":{"login":"tpefoley","id":9027414,"avatar_url":"https://avatars.githubusercontent.com/u/9027414?v=3","gravatar_id":"","url":"https://api.github.com/users/tpefoley","html_url":"https://github.com/tpefoley","followers_url":"https://api.github.com/users/tpefoley/followers","following_url":"https://api.github.com/users/tpefoley/following{/other_user}","gists_url":"https://api.github.com/users/tpefoley/gists{/gist_id}","starred_url":"https://api.github.com/users/tpefoley/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tpefoley/subscriptions","organizations_url":"https://api.github.com/users/tpefoley/orgs","repos_url":"https://api.github.com/users/tpefoley/repos","events_url":"https://api.github.com/users/tpefoley/events{/privacy}","received_events_url":"https://api.github.com/users/tpefoley/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Being%20Synthesised%20Now","name":"Being Synthesised Now","color":"eb6420"},{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Series%203","name":"Series 3","color":"2EFE64"}],"state":"open","locked":false,"assignee":{"login":"tpefoley","id":9027414,"avatar_url":"https://avatars.githubusercontent.com/u/9027414?v=3","gravatar_id":"","url":"https://api.github.com/users/tpefoley","html_url":"https://github.com/tpefoley","followers_url":"https://api.github.com/users/tpefoley/followers","following_url":"https://api.github.com/users/tpefoley/following{/other_user}","gists_url":"https://api.github.com/users/tpefoley/gists{/gist_id}","starred_url":"https://api.github.com/users/tpefoley/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tpefoley/subscriptions","organizations_url":"https://api.github.com/users/tpefoley/orgs","repos_url":"https://api.github.com/users/tpefoley/repos","events_url":"https://api.github.com/users/tpefoley/events{/privacy}","received_events_url":"https://api.github.com/users/tpefoley/received_events","type":"User","site_admin":false},"milestone":null,"comments":0,"created_at":"2015-01-28T12:09:44Z","updated_at":"2015-01-28T12:09:44Z","closed_at":null,"body":"This is the first synthesis in a series of three amino-thienoyprimidine compounds with a modification to the sulfonamide group on the right-hand portion of the molecule. The sulfonamide in this target is substituted with the pyrollidine group.\r\n\r\nThe molecule will be synthesised from 6-bromothieno[3,2-d]pyrimidin-4-amine ([TF15-1](http://malaria.ourexperiment.org/aminotpseries/11450/Amination_of_Bromochlorothienopyrimidine_TF151.html), [AT-6-1](http://malaria.ourexperiment.org/aminotpseries/6857/Amination_of_bromochlorothienopyrimidine_AT61.html)) and 1-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)pyrrolidine ([TF12-1](http://malaria.ourexperiment.org/aminotpseries/11428/Synthesis_of_134455tetramethyl132dioxaborolan2ylphenylsulfonylpyrrolidine_TF121.html)).\r\n\r\n![tf16-1 synthesis](https://cloud.githubusercontent.com/assets/9027414/5937337/3c2ead1a-a6e6-11e4-9bb1-563662a4c6a8.png)\r\n\r\nI'm currently synthesising another batch of the amino-bromothienopyrimidine, then I'll put this reaction and the other two ([TF17-1]() and [TF18-1]()) on simultaneously.\r\n"}}