{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/11977","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11977/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11977/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11977/events","html_url":"https://github.com/geneontology/go-ontology/issues/11977","id":97271374,"number":11977,"title":"APC complexed with inhibitor","user":{"login":"gocentral","id":12972975,"avatar_url":"https://avatars.githubusercontent.com/u/12972975?v=3","gravatar_id":"","url":"https://api.github.com/users/gocentral","html_url":"https://github.com/gocentral","followers_url":"https://api.github.com/users/gocentral/followers","following_url":"https://api.github.com/users/gocentral/following{/other_user}","gists_url":"https://api.github.com/users/gocentral/gists{/gist_id}","starred_url":"https://api.github.com/users/gocentral/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/gocentral/subscriptions","organizations_url":"https://api.github.com/users/gocentral/orgs","repos_url":"https://api.github.com/users/gocentral/repos","events_url":"https://api.github.com/users/gocentral/events{/privacy}","received_events_url":"https://api.github.com/users/gocentral/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/auto-migrated","name":"auto-migrated","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/PomBase","name":"PomBase","color":"bfd4f2"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/protein%20complex","name":"protein complex","color":"ededed"}],"state":"open","locked":false,"assignee":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"milestone":null,"comments":27,"created_at":"2015-07-22T10:10:38Z","updated_at":"2015-09-22T11:26:29Z","closed_at":null,"body":"\r\nFollowing on from a discussion with Tanya and Antonia....\r\n\r\nThe APC is inhibited by various CDC20/fizzy family inhibitors at various cell cycle phases (not clear cut, sometimes overlapping).\r\n\r\nOur first question is how to represent these complexes.\r\n\r\n1. Do we request a complex\r\n\r\nAPC-Cdc20\r\nAPC-fizzy related (there is a precedent for this, but there are various fizzy related proteins so it is difficult to establish each complex version without using the gene names\r\nAPC-Srw1 complex, APC-Mfr1 etc)\r\n\r\n2. Alternatively as this is a complex inhibitor, we could annotate this as \r\nAPC -complex binding.\r\n\r\n(IN which case we would obsolete the existing APC-inhibitor complex terms)\r\n\r\n\r\nOne advantage of 2 is that we would not need to ensure that all 15 APC subunits were annotated to all complexes, and we would not have the difficulties defining the complexes which do not seem to be exactly conserved in their role between species.\r\n\r\nHowever, if people would expect to see these annotated as a complex in their own right we should do 1.\r\nIf we decide to do 1. we will need a better way to describe the various permutations (I can't think of anything easily without including gene product names we would not easily be able to  distinguish the specific variations.\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\n\nReported by: ValWood\n\nOriginal Ticket: [geneontology/ontology-requests/11816](https://sourceforge.net/p/geneontology/ontology-requests/11816)"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/142258998","html_url":"https://github.com/geneontology/go-ontology/issues/11977#issuecomment-142258998","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11977","id":142258998,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2015-09-22T11:26:29Z","updated_at":"2015-09-22T11:26:29Z","body":"The processes should be curated , because AFAIK, CC-BP links are not genrating annotations at present (please correct me if I'm wrong). Also, yes in this case it would not be possible to establish CC-BP links specific enough for PomBase."}}