{"action":"created","issue":{"url":"https://api.github.com/repos/choderalab/yank/issues/107","labels_url":"https://api.github.com/repos/choderalab/yank/issues/107/labels{/name}","comments_url":"https://api.github.com/repos/choderalab/yank/issues/107/comments","events_url":"https://api.github.com/repos/choderalab/yank/issues/107/events","html_url":"https://github.com/choderalab/yank/issues/107","id":48109524,"number":107,"title":"Cache minimization and energies of identical configurations to speed up 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1.0","description":null,"creator":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"open_issues":52,"closed_issues":24,"state":"open","created_at":"2013-11-07T21:09:29Z","updated_at":"2015-06-04T08:29:38Z","due_on":null,"closed_at":null},"comments":6,"created_at":"2014-11-07T17:36:11Z","updated_at":"2015-06-04T08:29:38Z","closed_at":"2015-06-04T08:29:38Z","body":"If we are minimizing or computing energies for the same configurations, we should cache these values to speed up setup."},"comment":{"url":"https://api.github.com/repos/choderalab/yank/issues/comments/108784085","html_url":"https://github.com/choderalab/yank/issues/107#issuecomment-108784085","issue_url":"https://api.github.com/repos/choderalab/yank/issues/107","id":108784085,"user":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"created_at":"2015-06-04T08:29:38Z","updated_at":"2015-06-04T08:29:38Z","body":"Actually, memoization will not work here, since each alchemical state will have a different potential function, and would lead to a different minimized conformation and energy."}}