{"action":"created","issue":{"url":"https://api.github.com/repos/bulik/ldsc/issues/38","labels_url":"https://api.github.com/repos/bulik/ldsc/issues/38/labels{/name}","comments_url":"https://api.github.com/repos/bulik/ldsc/issues/38/comments","events_url":"https://api.github.com/repos/bulik/ldsc/issues/38/events","html_url":"https://github.com/bulik/ldsc/issues/38","id":112946502,"number":38,"title":"h2 is negative -1.105","user":{"login":"argossy","id":15249818,"avatar_url":"https://avatars.githubusercontent.com/u/15249818?v=3","gravatar_id":"","url":"https://api.github.com/users/argossy","html_url":"https://github.com/argossy","followers_url":"https://api.github.com/users/argossy/followers","following_url":"https://api.github.com/users/argossy/following{/other_user}","gists_url":"https://api.github.com/users/argossy/gists{/gist_id}","starred_url":"https://api.github.com/users/argossy/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/argossy/subscriptions","organizations_url":"https://api.github.com/users/argossy/orgs","repos_url":"https://api.github.com/users/argossy/repos","events_url":"https://api.github.com/users/argossy/events{/privacy}","received_events_url":"https://api.github.com/users/argossy/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":1,"created_at":"2015-10-23T04:04:17Z","updated_at":"2015-10-23T12:32:14Z","closed_at":null,"body":"Hi\r\nmy h2 estimate is negative (shown below). I didn't have any issue during data munging. So I don't know what's wrong. BTW, my sample size is 300+, do you think is it too small for estimating heritability or genetic correlation? Thank you\r\n\r\nTotal Observed scale h2: -1.105 (1.5709)\r\nLambda GC: 1.0436\r\nMean Chi^2: 1.0409\r\nIntercept: 1.0478 (0.0093)\r\nRatio: 1.1669 (0.2275)\r\n"},"comment":{"url":"https://api.github.com/repos/bulik/ldsc/issues/comments/150559164","html_url":"https://github.com/bulik/ldsc/issues/38#issuecomment-150559164","issue_url":"https://api.github.com/repos/bulik/ldsc/issues/38","id":150559164,"user":{"login":"bneale","id":9104153,"avatar_url":"https://avatars.githubusercontent.com/u/9104153?v=3","gravatar_id":"","url":"https://api.github.com/users/bneale","html_url":"https://github.com/bneale","followers_url":"https://api.github.com/users/bneale/followers","following_url":"https://api.github.com/users/bneale/following{/other_user}","gists_url":"https://api.github.com/users/bneale/gists{/gist_id}","starred_url":"https://api.github.com/users/bneale/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/bneale/subscriptions","organizations_url":"https://api.github.com/users/bneale/orgs","repos_url":"https://api.github.com/users/bneale/repos","events_url":"https://api.github.com/users/bneale/events{/privacy}","received_events_url":"https://api.github.com/users/bneale/received_events","type":"User","site_admin":false},"created_at":"2015-10-23T12:32:14Z","updated_at":"2015-10-23T12:32:14Z","body":"Hi\n\nYes - with only 300 samples you're extremely underpowered for this kind of\nanalysis as you need sufficient sample size to start to expose the\npolygenic effects on the trait in question.\n\nBest\nBen\n\nOn Friday, October 23, 2015, argossy <notifications@github.com> wrote:\n\n> Hi\n> my h2 estimate is negative (shown below). I didn't have any issue during\n> data munging. So I don't know what's wrong. BTW, my sample size is 300+, do\n> you think is it too small for estimating heritability or genetic\n> correlation? Thank you\n>\n> Total Observed scale h2: -1.105 (1.5709)\n> Lambda GC: 1.0436\n> Mean Chi^2: 1.0409\n> Intercept: 1.0478 (0.0093)\n> Ratio: 1.1669 (0.2275)\n>\n> —\n> Reply to this email directly or view it on GitHub\n> <https://github.com/bulik/ldsc/issues/38>.\n>\n\n\n-- \nFor scheduling matters, please contact Carla Hammond <\nhammond@atgu.mgh.harvard.edu>\n\nBenjamin Neale, Ph.D.\nAssistant Professor\nAnalytic and Translational Genetics Unit\nMassachusetts General Hospital\nInstitute Member\nStanley Center for Psychiatric Disease and Program in Medical and\nPopulation Genetics\nBroad Institute\n"}}