{"action":"created","issue":{"url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/27","labels_url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/27/labels{/name}","comments_url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/27/comments","events_url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/27/events","html_url":"https://github.com/choderalab/bayesian-itc/issues/27","id":56297616,"number":27,"title":"Allow reference calibration files to be included, attached to either an Instrument or ExperimentSet?","user":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":2,"created_at":"2015-02-02T21:43:21Z","updated_at":"2015-03-11T21:06:44Z","closed_at":null,"body":"It would be useful to be able to add calibration datasets (like water titrations) to use in inference, since these help constrain parameters like `sigma`"},"comment":{"url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/comments/78371761","html_url":"https://github.com/choderalab/bayesian-itc/issues/27#issuecomment-78371761","issue_url":"https://api.github.com/repos/choderalab/bayesian-itc/issues/27","id":78371761,"user":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"created_at":"2015-03-11T21:06:44Z","updated_at":"2015-03-11T21:06:44Z","body":"Filter time (the time between writing samples) will be constant over the whole .itc file for MicroCal data, but I suppose it is possible that someone will try to load files with different filter times to use together.\r\n\r\nI think it might make sense to use a fundamental baseline noise \\sigma where we model the measurement error in an integrated injection heat as (\\sigma_0^2 * T_inject), where T_inject is the time between injections N_samples * \\tau, where N_samples are collected per injection and \\tau is the time between samples.  The error in each single measurement (for modeling uncertainty in baselines) would be \\sigma_0^2 * \\tau."}}