{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/events","html_url":"https://github.com/geneontology/go-ontology/issues/12143","id":114777057,"number":12143,"title":"NTR - neuronal action potential intiation / back propagation","user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"milestone":null,"comments":2,"created_at":"2015-11-03T09:40:41Z","updated_at":"2015-11-03T11:03:13Z","closed_at":null,"body":"(Pasted from mail from @vhinard )\r\n\r\nI'd like to annotate voltage-gated sodium channels to the following terms, that do not \"exist\" in GO (see definition at the end):\r\nneuronal action potential initiation\r\nneuronal action potential backpropagation\r\nReferences: PMID 9061867\r\n\r\nI suggest that these 2 terms would be in parallel with the GO:0019227 \"neuronal action potential propagation\", because there are, all of 3, processes that describe the \"life\" in space and time of the neuronal action potential and because there are the consequence of different types of ionic channels.\r\n\r\nSo, before to go further, I would like to know what you would suggest because you described \"membrane depolarization during action potential\" with the exact synonym \"generation of action potential\".\r\nThis is for me 2 separate concepts. The first being a part of the action potential (like repolarization is a part of it); and the second being the first step of the \"life\" of the action potential (followed by propagation or backpropagation).\r\nWhat do you think about the idea to make a distinction between \"membrane depolarization\" and \"initiation\"? And to detail the steps of action potential \"life\"?\r\nIs it within the scope of GO?\r\n\r\nneuronal action potential initiation\r\nDefinition: The process in which a neuronal action potential is generated in the axon following depolarization of the membrane potential to a threshold level.\r\nSynonym: neuronal action potential generation\r\n\r\nneuronal action potential backpropagation\r\nDefinition: The process in which a neuronal action potential is propagated in a retrograde direction from the axon back to the dendritic tree, in a passive or active manner, following depolarization of the membrane potential to a threshold level. "},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/153315428","html_url":"https://github.com/geneontology/go-ontology/issues/12143#issuecomment-153315428","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143","id":153315428,"user":{"login":"vhinard","id":13695856,"avatar_url":"https://avatars.githubusercontent.com/u/13695856?v=3","gravatar_id":"","url":"https://api.github.com/users/vhinard","html_url":"https://github.com/vhinard","followers_url":"https://api.github.com/users/vhinard/followers","following_url":"https://api.github.com/users/vhinard/following{/other_user}","gists_url":"https://api.github.com/users/vhinard/gists{/gist_id}","starred_url":"https://api.github.com/users/vhinard/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/vhinard/subscriptions","organizations_url":"https://api.github.com/users/vhinard/orgs","repos_url":"https://api.github.com/users/vhinard/repos","events_url":"https://api.github.com/users/vhinard/events{/privacy}","received_events_url":"https://api.github.com/users/vhinard/received_events","type":"User","site_admin":false},"created_at":"2015-11-03T11:03:13Z","updated_at":"2015-11-03T11:03:13Z","body":"Hi David, \r\n\r\nThank you for all these definitions.\r\n\r\nTo answer your questions: \r\n(NOTES: As Ruth says - we need a clearer statement of where this begins and ends. Is this a full cycle through all the phases of an action potential, just happening at the site of initiation (in which case, should probably be subClassOf 'action potential')? Or is it just the initial, depolarization phase?)\r\n\r\nMy idea is that the \"neuronal action potential initiation\" from the literature does not represent the depolarization phase of the AP but, like you said, the full cycle through all the phases of an AP, and \r\nlike in the definition, at a precise neuronal localization, the axon hillock or axon initial segment in vertebrate, where information captured at the dendrites and soma converge and is integrated.\r\nAnother reason is that the depolarization phase of the AP (GO:0086010 membrane depolarization during AP) occurs similarly during \"neuronal action potential initiation\", \"neuronal action potential propagation\" and \"neuronal action potential back-propagation\". So \"neuronal action potential initiation\" cannot be represented by \"membrane depolarization during AP\". It is another concept.\r\n\r\nTo be clearer in the statement of where this begins and ends, I suggested (in the mail sent to @RLovering) to make the starts and ends of the processes depending on their localization in the neuron and not depending on the time. So we can easily define in \"space\" these events: initiation starts at the axon initial segment (AIS) and stops when propagation or back-propagation start. The back-propagation starts after the AIS in direction to the soma and dendrites. The propagation starts after the AIS in direction to the axon. \r\n\r\nSo from my side, the definitions you gave correspond perfectly to what I wanted to annotate. \r\nI only have doubt concerning the \"action potential initiation\".\r\ndefinition \"The beginning of an action potential, due to depolarization of the membrane across a firing threshold by some stimulus other than an action potential.\"\r\n\r\nIs this corresponding to the first action potential at the postsynaptic membrane? or in other types of cell than neurons?   I am not sure to get the idea.\r\n\r\nThank you again for all this work.\r\n-val\r\n\r\n"}}