{"action":"closed","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/11480","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11480/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11480/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11480/events","html_url":"https://github.com/geneontology/go-ontology/issues/11480","id":97268731,"number":11480,"title":"New term request: acid sphingomyelinase","user":{"login":"gocentral","id":12972975,"avatar_url":"https://avatars.githubusercontent.com/u/12972975?v=3","gravatar_id":"","url":"https://api.github.com/users/gocentral","html_url":"https://github.com/gocentral","followers_url":"https://api.github.com/users/gocentral/followers","following_url":"https://api.github.com/users/gocentral/following{/other_user}","gists_url":"https://api.github.com/users/gocentral/gists{/gist_id}","starred_url":"https://api.github.com/users/gocentral/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/gocentral/subscriptions","organizations_url":"https://api.github.com/users/gocentral/orgs","repos_url":"https://api.github.com/users/gocentral/repos","events_url":"https://api.github.com/users/gocentral/events{/privacy}","received_events_url":"https://api.github.com/users/gocentral/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/auto-migrated","name":"auto-migrated","color":"ededed"}],"state":"closed","locked":false,"assignee":{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false},"milestone":null,"comments":2,"created_at":"2014-11-13T18:33:56Z","updated_at":"2015-11-11T19:58:52Z","closed_at":"2015-11-11T19:58:52Z","body":"The Wikipedia entry on http://en.wikipedia.org/wiki/Acid_Sphingomyelinase\r\nexplains that the pH with optimal conditions is gives the name. I was just\r\naware of the acidic having a separate inhibitor from the neutral, which to\r\nme indicated the demand for a separate GO term. I suggest\r\nacidic sphingomyelin phosphodiesterase activity\r\nas a specialisation of\r\nGO:0004767: sphingomyelin phosphodiesterase activity\r\nand propose to also add \"neutral\" and possibly also \"alkaline\" as a separate classes. The prior is currently a synonym of 4746. The annotation of UniProt entry\r\nhttp://www.uniprot.org/uniprot/P17405\r\nshould eventually be updated and there is ample of literature to it, just perform a pubmed search as in \r\nhttp://www.ncbi.nlm.nih.gov/pubmed/?term=acidic+sphingomyelinase\r\nA synonym may be aSMase activity.\r\n\r\nCheers,\r\n\r\nSteffen\r\n\r\n\n\nReported by: smoe\n\nOriginal Ticket: [geneontology/ontology-requests/11306](https://sourceforge.net/p/geneontology/ontology-requests/11306)"}}