{"action":"created","issue":{"url":"https://api.github.com/repos/bhmm/bhmm/issues/39","labels_url":"https://api.github.com/repos/bhmm/bhmm/issues/39/labels{/name}","comments_url":"https://api.github.com/repos/bhmm/bhmm/issues/39/comments","events_url":"https://api.github.com/repos/bhmm/bhmm/issues/39/events","html_url":"https://github.com/bhmm/bhmm/issues/39","id":77447639,"number":39,"title":"Reference to reversible T-matrix estimation preprint?","user":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":1,"created_at":"2015-05-18T01:12:44Z","updated_at":"2015-05-18T03:29:48Z","closed_at":null,"body":"In the Appendix, this note was written:\r\n\r\n> FN: reference to reversible T-matrix estimation preprint when available.\r\n\r\nAny clarification about what work this is referring to, and if the preprint is available?"},"comment":{"url":"https://api.github.com/repos/bhmm/bhmm/issues/comments/102909280","html_url":"https://github.com/bhmm/bhmm/issues/39#issuecomment-102909280","issue_url":"https://api.github.com/repos/bhmm/bhmm/issues/39","id":102909280,"user":{"login":"franknoe","id":6495810,"avatar_url":"https://avatars.githubusercontent.com/u/6495810?v=3","gravatar_id":"","url":"https://api.github.com/users/franknoe","html_url":"https://github.com/franknoe","followers_url":"https://api.github.com/users/franknoe/followers","following_url":"https://api.github.com/users/franknoe/following{/other_user}","gists_url":"https://api.github.com/users/franknoe/gists{/gist_id}","starred_url":"https://api.github.com/users/franknoe/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/franknoe/subscriptions","organizations_url":"https://api.github.com/users/franknoe/orgs","repos_url":"https://api.github.com/users/franknoe/repos","events_url":"https://api.github.com/users/franknoe/events{/privacy}","received_events_url":"https://api.github.com/users/franknoe/received_events","type":"User","site_admin":false},"created_at":"2015-05-18T03:29:48Z","updated_at":"2015-05-18T03:29:48Z","body":"There were some delays in finishing that paper. For our application we \ncan refer to this paper:\n\nNoé, F. (2008) /Probability Distributions of Molecular Observables \ncomputed from Markov Models./ <http://publications.mi.fu-berlin.de/23/> \nJ. Chem. Phys., 128 . p. 244103.\n\nand say that we use a prior of -1, which enforces the mean and the MLE \nto be identical, hence producing uncertainty estimates around the MLE. \nThe new code is much more efficient than the algorithm described above. \nThey algorithms are different if diagonal counts are zero, but this \ndoesn't happen in our applications.\n\nThis is fine for the submission. We can update the reference in the \nrevision of the BHMM paper. Shouldn't take too long before we can submit.\n\nAm 18/05/15 um 03:12 schrieb John Chodera:\n>\n> In the Appendix, this note was written:\n>\n>     FN: reference to reversible T-matrix estimation preprint when\n>     available.\n>\n> Any clarification about what work this is referring to, and if the \n> preprint is available?\n>\n> —\n> Reply to this email directly or view it on GitHub \n> <https://github.com/bhmm/bhmm/issues/39>.\n>\n\n\n-- \n\n----------------------------------------------\nProf. Dr. Frank Noe\nHead of Computational Molecular Biology group\nFreie Universitaet Berlin\n\nPhone: (+49) (0)30 838 75354\nWeb:   research.franknoe.de\nMail:  Arnimallee 6, 14195 Berlin, Germany\n----------------------------------------------\n\n"}}