{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12054","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12054/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12054/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12054/events","html_url":"https://github.com/geneontology/go-ontology/issues/12054","id":105398483,"number":12054,"title":"Regulation of somatic stem cell maintenance","user":{"login":"rachhuntley","id":7962316,"avatar_url":"https://avatars.githubusercontent.com/u/7962316?v=3","gravatar_id":"","url":"https://api.github.com/users/rachhuntley","html_url":"https://github.com/rachhuntley","followers_url":"https://api.github.com/users/rachhuntley/followers","following_url":"https://api.github.com/users/rachhuntley/following{/other_user}","gists_url":"https://api.github.com/users/rachhuntley/gists{/gist_id}","starred_url":"https://api.github.com/users/rachhuntley/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/rachhuntley/subscriptions","organizations_url":"https://api.github.com/users/rachhuntley/orgs","repos_url":"https://api.github.com/users/rachhuntley/repos","events_url":"https://api.github.com/users/rachhuntley/events{/privacy}","received_events_url":"https://api.github.com/users/rachhuntley/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"milestone":null,"comments":11,"created_at":"2015-09-08T14:49:33Z","updated_at":"2015-09-12T00:50:39Z","closed_at":"2015-09-12T00:50:39Z","body":"Hi,\r\n\r\nI'm wondering whether it would be possible to have regulation terms for somatic stem cell maintenance (GO:0035019). This term is a child of negative regulation of cell differentiation, so would it cause problems to have regulation of regulation? (there are already terms for regulation of stem cell maintenance, so maybe not).\r\n\r\nAlso, I notice there is no link between GO:0017145 stem cell division and GO:0019827 stem cell maintenance. Wouldn't you expect division to be part of maintenance?\r\n\r\nThanks,\r\nRachael."},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/139693495","html_url":"https://github.com/geneontology/go-ontology/issues/12054#issuecomment-139693495","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12054","id":139693495,"user":{"login":"tberardini","id":4998871,"avatar_url":"https://avatars.githubusercontent.com/u/4998871?v=3","gravatar_id":"","url":"https://api.github.com/users/tberardini","html_url":"https://github.com/tberardini","followers_url":"https://api.github.com/users/tberardini/followers","following_url":"https://api.github.com/users/tberardini/following{/other_user}","gists_url":"https://api.github.com/users/tberardini/gists{/gist_id}","starred_url":"https://api.github.com/users/tberardini/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tberardini/subscriptions","organizations_url":"https://api.github.com/users/tberardini/orgs","repos_url":"https://api.github.com/users/tberardini/repos","events_url":"https://api.github.com/users/tberardini/events{/privacy}","received_events_url":"https://api.github.com/users/tberardini/received_events","type":"User","site_admin":false},"created_at":"2015-09-12T00:50:39Z","updated_at":"2015-09-12T00:50:39Z","body":"Thanks for your input, David.  Very helpful.\r\n\r\nAdded 'population' to the terms when appropriate.\r\nRemoved 'stem cell development ' and 'neg reg of cell diff' parents of SCPM. Agreed, these were not appropriate.\r\n\r\nRachael -  I went ahead and made this term for you:\r\n\r\n[Term]\r\nid: GO:1904671\r\nname: negative regulation of cell differentiation involved in stem cell population maintenance\r\nnamespace: biological_process\r\ndef: \"Any negative regulation of cell differentiation that is involved in stem cell population maintenance.\" [GO_REF:0000060, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]\r\nsynonym: \"down regulation of cell differentiation involved in maintenance of pluripotency\" RELATED [GOC:TermGenie]\r\nsynonym: \"down regulation of cell differentiation involved in stem cell population maintenance\" EXACT [GOC:TermGenie]\r\nsynonym: \"down-regulation of cell differentiation involved in maintenance of pluripotency\" RELATED [GOC:TermGenie]\r\nsynonym: \"down-regulation of cell differentiation involved in stem cell population maintenance\" EXACT [GOC:TermGenie]\r\nsynonym: \"downregulation of cell differentiation involved in maintenance of pluripotency\" RELATED [GOC:TermGenie]\r\nsynonym: \"downregulation of cell differentiation involved in stem cell population maintenance\" EXACT [GOC:TermGenie]\r\nsynonym: \"inhibition of cell differentiation involved in maintenance of pluripotency\" RELATED [GOC:TermGenie]\r\nsynonym: \"inhibition of cell differentiation involved in stem cell population maintenance\" NARROW [GOC:TermGenie]\r\nsynonym: \"negative regulation of cell differentiation involved in maintenance of pluripotency\" RELATED [GOC:TermGenie]\r\nis_a: GO:0045596 {is_inferred=\"true\"} ! negative regulation of cell differentiation\r\nintersection_of: GO:0045596 ! negative regulation of cell differentiation\r\nintersection_of: part_of GO:0019827 ! stem cell population maintenance\r\nrelationship: part_of GO:0019827 {is_inferred=\"true\"} ! stem cell population maintenance\r\ncreated_by: tb\r\ncreation_date: 2015-09-12T00:46:08Z\r\n\r\n\r\nIf you need the term specifically for somatic stem cell population maintenance, please request that through TG."}}