{"action":"created","issue":{"url":"https://api.github.com/repos/choderalab/assaytools/issues/16","labels_url":"https://api.github.com/repos/choderalab/assaytools/issues/16/labels{/name}","comments_url":"https://api.github.com/repos/choderalab/assaytools/issues/16/comments","events_url":"https://api.github.com/repos/choderalab/assaytools/issues/16/events","html_url":"https://github.com/choderalab/assaytools/pull/16","id":95251655,"number":16,"title":"Cleanup of example modeling notebooks","user":{"login":"jchodera","id":3656088,"avatar_url":"https://avatars.githubusercontent.com/u/3656088?v=3","gravatar_id":"","url":"https://api.github.com/users/jchodera","html_url":"https://github.com/jchodera","followers_url":"https://api.github.com/users/jchodera/followers","following_url":"https://api.github.com/users/jchodera/following{/other_user}","gists_url":"https://api.github.com/users/jchodera/gists{/gist_id}","starred_url":"https://api.github.com/users/jchodera/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jchodera/subscriptions","organizations_url":"https://api.github.com/users/jchodera/orgs","repos_url":"https://api.github.com/users/jchodera/repos","events_url":"https://api.github.com/users/jchodera/events{/privacy}","received_events_url":"https://api.github.com/users/jchodera/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":9,"created_at":"2015-07-15T17:50:30Z","updated_at":"2015-08-04T23:51:32Z","closed_at":null,"pull_request":{"url":"https://api.github.com/repos/choderalab/assaytools/pulls/16","html_url":"https://github.com/choderalab/assaytools/pull/16","diff_url":"https://github.com/choderalab/assaytools/pull/16.diff","patch_url":"https://github.com/choderalab/assaytools/pull/16.patch"},"body":"I've gone through the \"Two Component Binding\" notebook so far."},"comment":{"url":"https://api.github.com/repos/choderalab/assaytools/issues/comments/127798782","html_url":"https://github.com/choderalab/assaytools/pull/16#issuecomment-127798782","issue_url":"https://api.github.com/repos/choderalab/assaytools/issues/16","id":127798782,"user":{"login":"sonyahanson","id":6333823,"avatar_url":"https://avatars.githubusercontent.com/u/6333823?v=3","gravatar_id":"","url":"https://api.github.com/users/sonyahanson","html_url":"https://github.com/sonyahanson","followers_url":"https://api.github.com/users/sonyahanson/followers","following_url":"https://api.github.com/users/sonyahanson/following{/other_user}","gists_url":"https://api.github.com/users/sonyahanson/gists{/gist_id}","starred_url":"https://api.github.com/users/sonyahanson/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/sonyahanson/subscriptions","organizations_url":"https://api.github.com/users/sonyahanson/orgs","repos_url":"https://api.github.com/users/sonyahanson/repos","events_url":"https://api.github.com/users/sonyahanson/events{/privacy}","received_events_url":"https://api.github.com/users/sonyahanson/received_events","type":"User","site_admin":false},"created_at":"2015-08-04T23:51:32Z","updated_at":"2015-08-04T23:51:32Z","body":"Thanks! Definitely good to talk through this. It certainly does seem like adding noise to the original modeled data fixed the problem. Was just chatting with other members of the lab about this, and am interested in a clarification: Seems like in theory perfect data shouldn't be a problem unless there is a prior that makes it impossible. If this is the case, what is the prior that requires this in our case, and why is it necessary that it is this way?"}}