{"action":"published","release":{"url":"https://api.github.com/repos/jeremymcrae/clinical-filter/releases/1668321","assets_url":"https://api.github.com/repos/jeremymcrae/clinical-filter/releases/1668321/assets","upload_url":"https://uploads.github.com/repos/jeremymcrae/clinical-filter/releases/1668321/assets{?name}","html_url":"https://github.com/jeremymcrae/clinical-filter/releases/tag/0.3.6","id":1668321,"tag_name":"0.3.6","target_commitish":"master","name":"","draft":false,"author":{"login":"jeremymcrae","id":1767732,"avatar_url":"https://avatars.githubusercontent.com/u/1767732?v=3","gravatar_id":"","url":"https://api.github.com/users/jeremymcrae","html_url":"https://github.com/jeremymcrae","followers_url":"https://api.github.com/users/jeremymcrae/followers","following_url":"https://api.github.com/users/jeremymcrae/following{/other_user}","gists_url":"https://api.github.com/users/jeremymcrae/gists{/gist_id}","starred_url":"https://api.github.com/users/jeremymcrae/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jeremymcrae/subscriptions","organizations_url":"https://api.github.com/users/jeremymcrae/orgs","repos_url":"https://api.github.com/users/jeremymcrae/repos","events_url":"https://api.github.com/users/jeremymcrae/events{/privacy}","received_events_url":"https://api.github.com/users/jeremymcrae/received_events","type":"User","site_admin":false},"prerelease":false,"created_at":"2015-08-13T15:35:32Z","published_at":"2015-08-13T16:03:01Z","assets":[],"tarball_url":"https://api.github.com/repos/jeremymcrae/clinical-filter/tarball/0.3.6","zipball_url":"https://api.github.com/repos/jeremymcrae/clinical-filter/zipball/0.3.6","body":" - shifted start_lost to loss-of-function consequences\r\n - fixed bug where we missed long CNVs not in known genes\r\n - CNVs now use the per-gene symbols when available\r\n - turned on filtering using ExAC frequencies\r\n - reworked removing variants based on polyphen predictions\r\n   - now use per gene polyphen predictions\r\n   - all variants with polyphen benign get removed, not just the \r\n     ones in trios\r\n - re-include compound hets in proband-only analyses\r\n - fixed bugs that lead to missing CNVs\r\n - updated rules for CNVs overlapping syndrome regions\r\n - exclude monoallelic and X-linked dominant variants with high\r\n   ExAC allele frequencies\r\n - exclude compound hets when proband-only where both hets are \r\n   missense\r\n - only include compound hets in trios when in trans\r\n - fixed bug when checking if CNVs intersect known gene boundaries"}}