{"action":"created","issue":{"url":"https://api.github.com/repos/monarch-initiative/mckb/issues/9","labels_url":"https://api.github.com/repos/monarch-initiative/mckb/issues/9/labels{/name}","comments_url":"https://api.github.com/repos/monarch-initiative/mckb/issues/9/comments","events_url":"https://api.github.com/repos/monarch-initiative/mckb/issues/9/events","html_url":"https://github.com/monarch-initiative/mckb/issues/9","id":68489136,"number":9,"title":"Improve modelling of drug, disease, variant relationship","user":{"login":"kshefchek","id":1467299,"avatar_url":"https://avatars.githubusercontent.com/u/1467299?v=3","gravatar_id":"","url":"https://api.github.com/users/kshefchek","html_url":"https://github.com/kshefchek","followers_url":"https://api.github.com/users/kshefchek/followers","following_url":"https://api.github.com/users/kshefchek/following{/other_user}","gists_url":"https://api.github.com/users/kshefchek/gists{/gist_id}","starred_url":"https://api.github.com/users/kshefchek/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/kshefchek/subscriptions","organizations_url":"https://api.github.com/users/kshefchek/orgs","repos_url":"https://api.github.com/users/kshefchek/repos","events_url":"https://api.github.com/users/kshefchek/events{/privacy}","received_events_url":"https://api.github.com/users/kshefchek/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":7,"created_at":"2015-04-14T20:31:05Z","updated_at":"2015-04-22T23:59:15Z","closed_at":null,"body":"The modelling discussed in #1 could be improved.  As suggested by @nlwashington, here is another way to model these relationships:\r\n\r\n        Monarch:DiseaseID is an OWL Class\r\n        Monarch:Disease rdfs:label \"Adenocarcinoma\"\r\n        Monarch:DiseaseInstance is an individual of Monarch:DiseaseID\r\n        Monarch:DiseaseInstance rdfs:label \"Adenocarcinoma caused by variant MLH1 any mutation\"\r\n\r\n        Monarch:DiseaseInstance RO:caused_by Monarch:GenotypeID\r\n\r\n        Monarch:DrugID Monarch:detrimental_effect Monarch:AssociationID\r\n\r\n        Monarch:AssociationID dc:evidence Traceable Author Statement (ECO:0000033)\r\n        Monarch:AssociationID dc:source PMID:20498393\r\n        Monarch:AssociationID :hasSubject A Monarch:DiseaseInstance\r\n        Monarch:AssociationID :hasPredicate RO:caused_by\r\n        Monarch:AssociationID :hasObject Monarch:GenotypeID\r\n\r\nWill update the code to generate the above given a row of data from CGD."},"comment":{"url":"https://api.github.com/repos/monarch-initiative/mckb/issues/comments/95371148","html_url":"https://github.com/monarch-initiative/mckb/issues/9#issuecomment-95371148","issue_url":"https://api.github.com/repos/monarch-initiative/mckb/issues/9","id":95371148,"user":{"login":"kshefchek","id":1467299,"avatar_url":"https://avatars.githubusercontent.com/u/1467299?v=3","gravatar_id":"","url":"https://api.github.com/users/kshefchek","html_url":"https://github.com/kshefchek","followers_url":"https://api.github.com/users/kshefchek/followers","following_url":"https://api.github.com/users/kshefchek/following{/other_user}","gists_url":"https://api.github.com/users/kshefchek/gists{/gist_id}","starred_url":"https://api.github.com/users/kshefchek/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/kshefchek/subscriptions","organizations_url":"https://api.github.com/users/kshefchek/orgs","repos_url":"https://api.github.com/users/kshefchek/repos","events_url":"https://api.github.com/users/kshefchek/events{/privacy}","received_events_url":"https://api.github.com/users/kshefchek/received_events","type":"User","site_admin":false},"created_at":"2015-04-22T23:59:15Z","updated_at":"2015-04-22T23:59:15Z","body":"I could be lost but is this what we're proposing?\r\n        \r\n        CGD:VariantID has_phenotype(RO:0002200) CGD:DiseaseInstance\r\n\r\n        A CGD:AssociationID dc:evidence Traceable Author Statement (ECO:0000033)\r\n        A CGD:AssociationID dc:source PMID:20498393\r\n        A CGD:AssociationID has_response CGD:DrugID\r\n        A CGD:AssociationID :hasSubject A CGD:VariantID\r\n        A CGD:AssociationID :hasPredicate has_phenotype\r\n        A CGD:AssociationID :hasObject CGD:DiseaseInstance"}}