{"action":"closed","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/11964","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11964/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11964/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/11964/events","html_url":"https://github.com/geneontology/go-ontology/issues/11964","id":97271334,"number":11964,"title":"Changes to GO:0048102 autophagic cell death","user":{"login":"gocentral","id":12972975,"avatar_url":"https://avatars.githubusercontent.com/u/12972975?v=3","gravatar_id":"","url":"https://api.github.com/users/gocentral","html_url":"https://github.com/gocentral","followers_url":"https://api.github.com/users/gocentral/followers","following_url":"https://api.github.com/users/gocentral/following{/other_user}","gists_url":"https://api.github.com/users/gocentral/gists{/gist_id}","starred_url":"https://api.github.com/users/gocentral/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/gocentral/subscriptions","organizations_url":"https://api.github.com/users/gocentral/orgs","repos_url":"https://api.github.com/users/gocentral/repos","events_url":"https://api.github.com/users/gocentral/events{/privacy}","received_events_url":"https://api.github.com/users/gocentral/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/Apoptosis","name":"Apoptosis","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/auto-migrated","name":"auto-migrated","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/autophagy","name":"autophagy","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/Other%20term-related%20request","name":"Other term-related request","color":"bfe5bf"}],"state":"closed","locked":false,"assignee":{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false},"milestone":null,"comments":2,"created_at":"2015-07-09T09:49:11Z","updated_at":"2015-09-14T18:46:54Z","closed_at":"2015-09-14T18:46:54Z","body":"Currently: \r\n\r\n[Term]\r\nid: GO:0048102\r\nname: autophagic cell death\r\nnamespace: biological_process\r\ndef: \"A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagosomes, with little or no uptake by phagocytic cells.\" [GOC:autophagy, GOC:mah, PMID:18846107]\r\nsynonym: \"autophagic death\" BROAD []\r\nsynonym: \"programmed cell death by autophagy\" BROAD [GOC:pr]\r\nsynonym: \"programmed cell death by macroautophagy\" EXACT [GOC:cjm]\r\nsynonym: \"type II programmed cell death\" RELATED [GOC:sl]\r\nis_a: GO:0012501 ! programmed cell death\r\nintersection_of: GO:0012501 ! programmed cell death\r\nintersection_of: has_part GO:0000045 ! autophagosome assembly\r\nrelationship: has_part GO:0000045 ! autophagosome assembly\r\nrelationship: only_in_taxon NCBITaxon:2759 {id=\"GOTAX:0000386\"} ! Eukaryota\r\n\r\nAs agreed at yesterday’s autophagy call (https://docs.google.com/document/d/10vkLY-dV-oiBGVYr8hSF7q4dlowtzKUzeFC0zZbVATE/edit#), please do the following edits:\r\n\r\n- change def to following or similar: “A form of programmed cell death that is accompanied by the formation of autophagosomes [may or may not specify nature of autophagosomes here]. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, [redundant? and accumulation of (double-membraned) autophagosomes], with little or no uptake by phagocytic cells.”\r\n\r\n- add a definition comment along the lines of: “The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others argue that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers on ‘autophagic cell death’, and annotate accordingly”.\r\n\r\nThanks,\r\n\r\nPaola\r\n\n\nReported by: paolaroncaglia\n\nOriginal Ticket: [geneontology/ontology-requests/11803](https://sourceforge.net/p/geneontology/ontology-requests/11803)"}}