{"action":"opened","issue":{"url":"https://api.github.com/repos/veg/hyphy/issues/341","labels_url":"https://api.github.com/repos/veg/hyphy/issues/341/labels{/name}","comments_url":"https://api.github.com/repos/veg/hyphy/issues/341/comments","events_url":"https://api.github.com/repos/veg/hyphy/issues/341/events","html_url":"https://github.com/veg/hyphy/issues/341","id":108964626,"number":341,"title":"MEME results interpretation  ","user":{"login":"jwconnolly","id":14192241,"avatar_url":"https://avatars.githubusercontent.com/u/14192241?v=3","gravatar_id":"","url":"https://api.github.com/users/jwconnolly","html_url":"https://github.com/jwconnolly","followers_url":"https://api.github.com/users/jwconnolly/followers","following_url":"https://api.github.com/users/jwconnolly/following{/other_user}","gists_url":"https://api.github.com/users/jwconnolly/gists{/gist_id}","starred_url":"https://api.github.com/users/jwconnolly/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/jwconnolly/subscriptions","organizations_url":"https://api.github.com/users/jwconnolly/orgs","repos_url":"https://api.github.com/users/jwconnolly/repos","events_url":"https://api.github.com/users/jwconnolly/events{/privacy}","received_events_url":"https://api.github.com/users/jwconnolly/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":0,"created_at":"2015-09-29T21:33:40Z","updated_at":"2015-09-29T21:33:40Z","closed_at":null,"body":"Hi all, \r\nI ran MEME on 70 hsp70 sequences and want to make sure I understand the results. The test found 17 sites with evidence of diversifying selection at p=.05. What I do not understand are the β+ and β- values, I looked at the MEME paper but can't seem to figure this out. \r\nAlso is there a way to infer what type of selection the site is usually undergoing versus what MEME identified? For example can one say \"86% of the time site x is constrained but 14% it is undergoing positive selection.\" If someone could take a look it would be much appreciated.\r\n\r\nhttp://www.datamonkey.org/cgi-bin/datamonkey/slacpvalue.pl?file=upload.37483454943897.1&pvalue=0.05&task=12\r\n\r\nthanks, Joe"}}