{"action":"closed","issue":{"url":"https://api.github.com/repos/clingen-data-model/clingen-data-model/issues/143","labels_url":"https://api.github.com/repos/clingen-data-model/clingen-data-model/issues/143/labels{/name}","comments_url":"https://api.github.com/repos/clingen-data-model/clingen-data-model/issues/143/comments","events_url":"https://api.github.com/repos/clingen-data-model/clingen-data-model/issues/143/events","html_url":"https://github.com/clingen-data-model/clingen-data-model/issues/143","id":98846579,"number":143,"title":"IntronOffsetStart and IntronOffsetEnd with different directions","user":{"login":"ppawliczek","id":13280685,"avatar_url":"https://avatars.githubusercontent.com/u/13280685?v=3","gravatar_id":"","url":"https://api.github.com/users/ppawliczek","html_url":"https://github.com/ppawliczek","followers_url":"https://api.github.com/users/ppawliczek/followers","following_url":"https://api.github.com/users/ppawliczek/following{/other_user}","gists_url":"https://api.github.com/users/ppawliczek/gists{/gist_id}","starred_url":"https://api.github.com/users/ppawliczek/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ppawliczek/subscriptions","organizations_url":"https://api.github.com/users/ppawliczek/orgs","repos_url":"https://api.github.com/users/ppawliczek/repos","events_url":"https://api.github.com/users/ppawliczek/events{/privacy}","received_events_url":"https://api.github.com/users/ppawliczek/received_events","type":"User","site_admin":false},"labels":[],"state":"closed","locked":false,"assignee":{"login":"larrybabb","id":959003,"avatar_url":"https://avatars.githubusercontent.com/u/959003?v=3","gravatar_id":"","url":"https://api.github.com/users/larrybabb","html_url":"https://github.com/larrybabb","followers_url":"https://api.github.com/users/larrybabb/followers","following_url":"https://api.github.com/users/larrybabb/following{/other_user}","gists_url":"https://api.github.com/users/larrybabb/gists{/gist_id}","starred_url":"https://api.github.com/users/larrybabb/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/larrybabb/subscriptions","organizations_url":"https://api.github.com/users/larrybabb/orgs","repos_url":"https://api.github.com/users/larrybabb/repos","events_url":"https://api.github.com/users/larrybabb/events{/privacy}","received_events_url":"https://api.github.com/users/larrybabb/received_events","type":"User","site_admin":false},"milestone":null,"comments":5,"created_at":"2015-08-03T21:59:31Z","updated_at":"2015-09-03T18:35:38Z","closed_at":"2015-09-03T18:35:38Z","body":"It seems to me that HGVS allows for definition of ranges with begin and end in different introns (for coding DNA), e.g.:\r\nc.100-5_200+4\r\nThe problem arise when two intron offsets have different signs. How can we save something like that? In the SimpleAllele object there is one common intronOffsetDirection field for both intronOffsetStart and intronOffsetEnd fields. "}}