{"action":"closed","issue":{"url":"https://api.github.com/repos/sys-bio/roadrunner/issues/214","labels_url":"https://api.github.com/repos/sys-bio/roadrunner/issues/214/labels{/name}","comments_url":"https://api.github.com/repos/sys-bio/roadrunner/issues/214/comments","events_url":"https://api.github.com/repos/sys-bio/roadrunner/issues/214/events","html_url":"https://github.com/sys-bio/roadrunner/issues/214","id":110806424,"number":214,"title":"Odd effect on conserve cycles","user":{"login":"hsauro","id":1054990,"avatar_url":"https://avatars.githubusercontent.com/u/1054990?v=3","gravatar_id":"","url":"https://api.github.com/users/hsauro","html_url":"https://github.com/hsauro","followers_url":"https://api.github.com/users/hsauro/followers","following_url":"https://api.github.com/users/hsauro/following{/other_user}","gists_url":"https://api.github.com/users/hsauro/gists{/gist_id}","starred_url":"https://api.github.com/users/hsauro/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hsauro/subscriptions","organizations_url":"https://api.github.com/users/hsauro/orgs","repos_url":"https://api.github.com/users/hsauro/repos","events_url":"https://api.github.com/users/hsauro/events{/privacy}","received_events_url":"https://api.github.com/users/hsauro/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/sys-bio/roadrunner/labels/bug","name":"bug","color":"fc2929"}],"state":"closed","locked":false,"assignee":{"login":"0u812","id":7402146,"avatar_url":"https://avatars.githubusercontent.com/u/7402146?v=3","gravatar_id":"","url":"https://api.github.com/users/0u812","html_url":"https://github.com/0u812","followers_url":"https://api.github.com/users/0u812/followers","following_url":"https://api.github.com/users/0u812/following{/other_user}","gists_url":"https://api.github.com/users/0u812/gists{/gist_id}","starred_url":"https://api.github.com/users/0u812/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/0u812/subscriptions","organizations_url":"https://api.github.com/users/0u812/orgs","repos_url":"https://api.github.com/users/0u812/repos","events_url":"https://api.github.com/users/0u812/events{/privacy}","received_events_url":"https://api.github.com/users/0u812/received_events","type":"User","site_admin":false},"milestone":null,"comments":1,"created_at":"2015-10-10T17:12:52Z","updated_at":"2015-10-30T22:09:15Z","closed_at":"2015-10-30T22:09:15Z","body":"This script runs ok, however if I comment out the second r.conservedMoietyAnalysis = True I get jacobian singular error. Why?\r\n\r\n\r\nimport tellurium as te\r\nimport roadrunner\r\n\r\nr = te.loada ('''\r\nmodel feedback()\r\n   // Reactions:\r\n   J0: $X0 -> S1; (Vm1 * (X0 - S1/Keq1))/(1 + X0 +  S3^h);\r\n   J1: S1 -> S2; Vm2*(10 * S1) / (1 + S1);\r\n   J2: S2 -> S3; (10 * S2) / (1 + S2);\r\n   J4: S3 -> $X1; (V4 * S3) / (KS4 + S3);\r\n \r\n  // Species initializations:\r\n  X0 = 10; X1 = 0;\r\n\r\n  // Variable initialization:\r\n  Vm1 = 30; Keq1 = 40; h = 4; V4 = 1; KS4 = 1;\r\n  Vm2 = 1;\r\nend''')\r\n\r\nr.conservedMoietyAnalysis = True\r\nr.steadyState()\r\nprint \"With Negative Feedback\"\r\nprint'CC = ' + str (r.getCC ('J0', 'Vm1'));\r\n\r\n\r\nprint \"Without Negative Feedback\"\r\nr.h = 0;\r\nr.conservedMoietyAnalysis = True\r\nr.steadyState()\r\nprint 'CC = ' +  str (r.getCC ('J0', 'Vm1'));"}}