{"action":"opened","issue":{"url":"https://api.github.com/repos/lomereiter/sambamba/issues/131","labels_url":"https://api.github.com/repos/lomereiter/sambamba/issues/131/labels{/name}","comments_url":"https://api.github.com/repos/lomereiter/sambamba/issues/131/comments","events_url":"https://api.github.com/repos/lomereiter/sambamba/issues/131/events","html_url":"https://github.com/lomereiter/sambamba/issues/131","id":63065522,"number":131,"title":"best options for a markdups on a huge RAM machine?","user":{"login":"lonestar21","id":9285915,"avatar_url":"https://avatars.githubusercontent.com/u/9285915?v=3","gravatar_id":"","url":"https://api.github.com/users/lonestar21","html_url":"https://github.com/lonestar21","followers_url":"https://api.github.com/users/lonestar21/followers","following_url":"https://api.github.com/users/lonestar21/following{/other_user}","gists_url":"https://api.github.com/users/lonestar21/gists{/gist_id}","starred_url":"https://api.github.com/users/lonestar21/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/lonestar21/subscriptions","organizations_url":"https://api.github.com/users/lonestar21/orgs","repos_url":"https://api.github.com/users/lonestar21/repos","events_url":"https://api.github.com/users/lonestar21/events{/privacy}","received_events_url":"https://api.github.com/users/lonestar21/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":0,"created_at":"2015-03-19T18:56:36Z","updated_at":"2015-03-19T18:56:36Z","closed_at":null,"body":"Hi.\r\nI have a machine with almost 800Gigs of RAM.  I also have a 200X super-deep genome bam needing duplicate marking.   What set of parameters would you recommend to get the best (fastest) markdups results?\r\n\r\nIf there are other tools better suited, I'd be happy to hear about those too.\r\n\r\nthanks,\r\nRichard\r\n"}}