{"action":"opened","issue":{"url":"https://api.github.com/repos/cmungall/go-test/issues/256","labels_url":"https://api.github.com/repos/cmungall/go-test/issues/256/labels{/name}","comments_url":"https://api.github.com/repos/cmungall/go-test/issues/256/comments","events_url":"https://api.github.com/repos/cmungall/go-test/issues/256/events","html_url":"https://github.com/cmungall/go-test/issues/256","id":84304398,"number":256,"title":"parentage of 'CREB binding' term (GO:0008140)","user":{"login":"cmungall","id":50745,"avatar_url":"https://avatars.githubusercontent.com/u/50745?v=3","gravatar_id":"","url":"https://api.github.com/users/cmungall","html_url":"https://github.com/cmungall","followers_url":"https://api.github.com/users/cmungall/followers","following_url":"https://api.github.com/users/cmungall/following{/other_user}","gists_url":"https://api.github.com/users/cmungall/gists{/gist_id}","starred_url":"https://api.github.com/users/cmungall/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/cmungall/subscriptions","organizations_url":"https://api.github.com/users/cmungall/orgs","repos_url":"https://api.github.com/users/cmungall/repos","events_url":"https://api.github.com/users/cmungall/events{/privacy}","received_events_url":"https://api.github.com/users/cmungall/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":0,"created_at":"2015-06-03T01:47:17Z","updated_at":"2015-06-03T01:47:17Z","closed_at":null,"body":"**Reported by rfoulger on 2014-12-02 12:58 UTC**\ncAMP response element binding protein binding ; GO:0008140 is missing an is_a parent in the protein binding node (which is causing issues for creating reciprocal protein binding annotations in Protein2GO).\r\n\r\nIt currently has:\r\ntranscription coactivator activity ; GO:0003713\r\n--[isa]cAMP response element binding protein binding ; GO:0008140\r\n\r\nI don't think everything that binds CREB is necessarily a transcriptional coactivator, so I think it would be best to remove the above relationship, and instead add in:\r\n\r\ntranscription factor binding ; GO:0008134\r\n--[isa]cAMP response element binding protein binding ; GO:0008140\r\nComment: Consider also annotating to 'transcription coactivator activity ; GO:0003713'.\r\nNew synonym: CREB binding protein\r\nNew synonym: CBP\r\n\r\n\r\nAlso, since there's multiple CREB proteins, perhaps the definition should be broadened\r\nfrom:\r\nInteracting selectively and non-covalently with the cAMP response element binding protein.\r\nto:\r\nInteracting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).\r\n\r\nHappy to edit.\r\nThanks,\r\nRebecca\r\n\r\n\r\n\r\n"}}