{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143/events","html_url":"https://github.com/geneontology/go-ontology/issues/12143","id":114777057,"number":12143,"title":"NTR - neuronal action potential intiation / back propagation","user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"milestone":null,"comments":2,"created_at":"2015-11-03T09:40:41Z","updated_at":"2015-11-03T09:50:42Z","closed_at":null,"body":"(Pasted from mail from @vhinard )\r\n\r\nI'd like to annotate voltage-gated sodium channels to the following terms, that do not \"exist\" in GO (see definition at the end):\r\nneuronal action potential initiation\r\nneuronal action potential backpropagation\r\nReferences: PMID 9061867\r\n\r\nI suggest that these 2 terms would be in parallel with the GO:0019227 \"neuronal action potential propagation\", because there are, all of 3, processes that describe the \"life\" in space and time of the neuronal action potential and because there are the consequence of different types of ionic channels.\r\n\r\nSo, before to go further, I would like to know what you would suggest because you described \"membrane depolarization during action potential\" with the exact synonym \"generation of action potential\".\r\nThis is for me 2 separate concepts. The first being a part of the action potential (like repolarization is a part of it); and the second being the first step of the \"life\" of the action potential (followed by propagation or backpropagation).\r\nWhat do you think about the idea to make a distinction between \"membrane depolarization\" and \"initiation\"? And to detail the steps of action potential \"life\"?\r\nIs it within the scope of GO?\r\n\r\nneuronal action potential initiation\r\nDefinition: The process in which a neuronal action potential is generated in the axon following depolarization of the membrane potential to a threshold level.\r\nSynonym: neuronal action potential generation\r\n\r\nneuronal action potential backpropagation\r\nDefinition: The process in which a neuronal action potential is propagated in a retrograde direction from the axon back to the dendritic tree, in a passive or active manner, following depolarization of the membrane potential to a threshold level. "},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/153301505","html_url":"https://github.com/geneontology/go-ontology/issues/12143#issuecomment-153301505","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12143","id":153301505,"user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"created_at":"2015-11-03T09:50:42Z","updated_at":"2015-11-03T09:50:42Z","body":"label \"neuronal action potential\"^^string\r\ndefinition \"An action potential that occurs in a neuron.\"^^string\r\nEquivalentTO: 'action potential'\r\n and ('occurs in' some neuron)\r\nSuClassOf: 'action potential'\r\n'part of' some 'transmission of nerve impulse'\r\n\r\nlabel \"transmission of nerve impulse\"^^string\r\ndefinition \"The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.\"^^string\r\n\r\n\r\nlabel \"action potential initiation\"@en\r\ndefinition \"The begining of an action potential, due to depolarization of the membrane across a firing threshold by some stimulus other than an action potential.\" \r\n'part of' some 'action potential'\r\nSubClassOf: 'regulation of membrane potential'\r\n\r\nNOTES: As Ruth says - we need a clearer statement of where this begins and ends.  Is this a full cycle through all the phases of an action potential, just happening at the site of initiation (in which case, should probably be subClassOf 'action potential')?  Or is it just the initial, depolarization phase?"}}