Faulty gene.it known as the CFTR gene.
Understanding What Causes Cystic Fibrosis. The cause of cystic fibrosis (CF) is a defect in a gene called the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This gene makes a protein that controls the movement of salt and water in and out of the cells in your body Causes. In cystic fibrosis, a defect (mutation) in a gene changes a protein that regulates the movement of salt in and out of cells. The result is thick, sticky mucus in the respiratory, digestive and reproductive systems, as well as increased salt in sweat. Many different defects can occur in the gene.  1. Cystic fibrosis is an autosomal recessive genetic disorder. Cystic fibrosis (CF) is an autosomal recessive disease that affects many body systems. It is caused by mutations to the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Located on human chromosome 7, the CFTR gene is made up of 250,000 DNA nucleotides. Cystic fibrosis is a hereditary disease that causes the body to produce thick and sticky mucus that can clog the lungs and obstruct the pancreas. This genetic disease can be life threatening, and affects an estimated 30,000 children and adults in the US, with around 1,000 new cases diagnosed each year. 1 Cystic fibrosis is most commonly diagnosed via a sweat test. 2  There are over 1,900 known mutations of the cystic fibrosis gene. 3  Even people with the same gene variation can have vastly different phenotypes, causing significant differences in symptoms and prognosis. 4  There is currently no absolute cure for cystic fibrosis. The CFTR gene provides instructions for making a protein called the cystic fibrosis transmembrane conductance regulator. This protein functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes.  In people with cystic fibrosis, the body produces mucus that is abnormally thick and sticky. This abnormal mucus can clog the airways, leading to severe problems with breathing and bacterial infections in the lungs. These infections cause chronic coughing, wheezing, and inflammation. Mutations in the CFTR gene cause cystic fibrosis. The CFTR gene provides instructions for making a channel that transports negatively charged particles called chloride ions into and out of cells. A defect in the CFTR gene causes cystic fibrosis (CF). This gene makes a protein that controls the movement of salt and water in and out of your body's cells. In people who have CF, the gene makes a protein that doesn't work well. This causes thick, sticky mucus and very salty sweat. Research suggests that the CFTR protein also affects the body in other ways. This may help explain other symptoms and complications of CF. More than a thousand known defects can affect the CFTR gene. Cystic fibrosis is a genetic condition caused by a faulty gene (known as the CFTR gene). The CFTR gene normally creates a protein that moves salt and water out of a cell. If the CFTR gene is defective, it results in a build-up of thick, sticky mucus in the body's tubes and passageways.  Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs. The disorder's most common signs and symptoms include progressive damage to the respiratory system and chronic digestive system problems. Mutations in the CFTR gene cause cystic fibrosis. The CFTR gene provides instructions for making a channel that transports negatively charged particles called chloride ions into and out of cells.
http://cystic-fibrosis.emedtv.com/cystic-fibrosis/causes-of-cystic-fibrosis.html http://www.mayoclinic.org/diseases-conditions/cystic-fibrosis/basics/causes/CON-20013731 http://www.nchpeg.org/nutrition/index.php?option=com_content&view=article&id=468&tmpl=component http://www.medicalnewstoday.com/articles/147960.php http://ghr.nlm.nih.gov/gene/CFTR http://ghr.nlm.nih.gov/condition/cystic-fibrosis http://www.nhlbi.nih.gov/health/health-topics/topics/cf/causes http://www.nhs.uk/Conditions/Cystic-fibrosis/Pages/Causes.aspx http://ghr.nlm.nih.gov/condition/cystic-fibrosis
cystic fibrosis location of genetic cause