30 mg once daily for 2 weeks before considering an increase to the target dose of 60 mg.
Elderly. Initiate CYMBALTA at a dose of 30 mg once daily for 2 weeks before considering an increase to the target dose of 60 mg. Thereafter, patients may benefit from doses above 60 mg once daily. If a decision is made to increase the dose beyond 60 mg once daily, increase dose in increments of 30 mg once daily. Administer CYMBALTA at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. Administer CYMBALTA 60 mg once daily. There is no evidence that doses higher than 60 mg confer additional significant benefit and the higher dose is clearly less well tolerated [see Clinical Studies ]. For patients for whom tolerability is a concern, a lower starting dose may be considered. Administer CYMBALTA at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. 1 Major Depressive Disorder: Starting daily dose is 40 mg and should be taken in two separate 20 mg doses. 2  In “maintenance mode” the recommended dose is 60 mg and can be taken all at once or as two separate 30 mg doses. 3  The maximum dose, while not recommended is 120 mg/day. The recommended Cymbalta dosage, based on the published Product Guide, are as follows: 1  Initiate CYMBALTA at a dose of 30 mg once daily for 2 weeks before considering an increase to 60 mg. The recommended dose range is 30 to 60 mg once daily. Some patients may benefit from doses above 60 mg once daily. Administer CYMBALTA at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. The treatment for each of these will be somewhat different, hence the dose is different as well. The recommended Cymbalta dosage, based on the published Product Guide, are as follows: 1  Major Depressive Disorder: Starting daily dose is 40 mg and should be taken in two separate 20 mg doses. 2  In “maintenance mode” the recommended dose is 60 mg and can be taken all at once or as two separate 30 mg doses Depression. The recommended dose for depression is Cymbalta 20 mg twice daily, 30 mg twice daily, or 60 mg once daily. Doses above 60 mg per day are not recommended. Neuropathic Pain. The recommended dosage of Cymbalta for peripheral diabetic neuropathy pain is 60 mg once daily.  1 Fibromyalgia: The typical dose is 60 mg’s / day. 2  However, it is recommended that the patient only take 30 mg’s / day so that there is some time to adjust to the medication. 3  Diabetic Peripheral Neuropathic Pain: The patient should take 60 mg / day in most cases. The recommended Cymbalta dosage, based on the published Product Guide, are as follows: 1  Major Depressive Disorder: Starting daily dose is 40 mg and should be taken in two separate 20 mg doses. A: The starting dose for Cymbalta (generic name is duloxetine) is really dependent on the reason the physician has prescribed it. For the treatment of major depression, the manufacturer's recommended starting dose is 40 to 60 mg orally per day. The initial dose for generalized anxiety disorder is 60 mg orally daily. A: Cymbalta (duloxetine) is a medication that is used to treat depression, anxiety, neuropathy (nerve pain) and fibromyalgia. It is in the class of medications called selective norepinephrine reuptake inhibitors (SNRIs). The recommended dosage of duloxetine for MDD is 40 to 60 mg per day, given either once a day or in divided doses twice daily. Studies have shown that four to eight weeks of therapy at the recommended dosage is optimal at achieving a response, and guidelines reflect this time frame. 
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