The colon, breast, stomach, and pancreas.
1 Bones – breast cancer can spread to many parts of the skeleton, but the ribs, spine, pelvis and long bones of the arms and legs are the most common metastatic sites. 2  Persistent pain, achiness, or tenderness on pressure are usually the first symptom of bone metastases. Thirteen percent of patients present in stage IV. Among these, liver and lungs are the most common metastatic sites. During the course of the disease, one-third of all ovarian cancer patients have pleural effusions, and three-quarters of these contain malignant cells. Metastases occur in the spleen on occasion and may necessitate splenectomy. Median age at ovarian cancer diagnosis was 54.8 years, median age at brain metastasis diagnosis was 58.3 years, and 88% had stage III/IV disease at initial diagnosis. Fifty-six percent of patients had metastases in the cerebral hemisphere alone, 15% in the cerebellum alone, and 28% had metastases at both sites. Ovarian cancer patients with multiple metastases to the brain are also more likely to have leptomeningeal disease, in which cancer cells spread throughout the spinal fluid. “This is the largest series to investigate outcomes and predictors of survival in ovarian cancer and brain metastasis. Common sites of metastasis. The most common sites for cancers to metastasize include the brain, bones, lungs and liver. Other places can include the adrenal gland, lymph nodes, skin and other organs. Sometimes, a metastasis will be found without a known primary cancer. 1 Metastatic tumors: Only 5% of ovarian cancers have spread from other sites to the ovary. 2  The most common sites from which they spread are the colon, breast, stomach, and pancreas. 3  Within these main classes are many different subtypes of tumors. Among 78 women with ovarian cancer who presented with one or more brain metastasis, 50% had only a single metastasis. Another 19% had 2 or 3 metastases at initial diagnosis, 23% had 4 or more, and 8% had developed leptomeningeal disease.
http://advancedbc.org/node/9 http://ovariancancer.jhmi.edu/prognosis.cfm http://www.onclive.com/publications/obtn/2011/december-2011/brain-metastasis-common-in-ovarian-cancer http://www.onclive.com/publications/obtn/2011/december-2011/brain-metastasis-common-in-ovarian-cancer http://my.clevelandclinic.org/health/diseases_conditions/metastatic-cancer-can-overview http://www.emedicinehealth.com/ovarian_cancer/article_em.htm http://www.onclive.com/publications/obtn/2011/december-2011/brain-metastasis-common-in-ovarian-cancer
common sites of metastasis of ovarian cancer