Yes
Ephesus was in great prosperity during the times of Alexander the Great Until the arrival of Alexander the Great, Ephesus was consisted of two governing systems, democratic and oligarchic. But the oligarchic system was violated with the coming of a new ruler, and a rebellion existed in Ephesus. Later, Ephesus was dominated by Persians. As Ephesians did not join the Ionian Rebellion against Persians, the city was saved from destruction. The rebellion resulted in the loss of Persian. Alexander the Great won Persians and the Ionian cities got their independence in the year of 334. Artemis was worshiped in most Greek cities but only as a secondary deity. However, to the Greeks in Asia Minor (modern day Turkey) she was a prominent deity. In Ephesus, a principal city of Asia Minor, a great temple was built in her honor, which became one of the Seven Wonders of the Ancient World. But at Ephesus she was worshiped mainly as a fertility goddess, and was identified with Cybele the mother goddess of eastern lands.  Ephesus was one of the seven churches of Asia that are cited in the Book of Revelation. The Gospel of John may have been written here. The city was the site of several 5th century Christian Councils (see Council of Ephesus). It is also the site of a large gladiators ' graveyard. Ephesus revolted after the treacherous death of Agathocles, giving the Hellenistic king of Syria and Mesopotamia Seleucus I Nicator an opportunity for removing and killing Lysimachus, his last rival, at the Battle of Corupedium in 281 BC. After the death of Lysimachus the town again was named Ephesus. According to estimates, Ephesus had a population of 33,600 to 56,000 people in the Roman period, making it the third largest city of Roman Asia Minor after Sardis and Alexandria Troas. The city was famed for the Temple of Artemis (completed around 550 BC), one of the Seven Wonders of the Ancient World. Ephesus revolted after the treacherous death of Agathocles, giving the Hellenistic king of Syria and Mesopotamia Seleucus I Nicator an opportunity for removing and killing Lysimachus, his last rival, at the Battle of Corupedium in 281 BC. After the death of Lysimachus the town again was named Ephesus. Hellenistic Ephesus. Ephesus remained under Persian rule until liberated by Alexander the Great in 334 BCE. Upon entering Ephesus, and seeing the reconstruction of the Temple of Artemis not yet complete, Alexander offered to rebuild it. The name of the city is thought to have been derived from Apasas, the name of a city in the Kingdom of Arzawa meaning the city of the Mother Goddess and some scholars maintain that the sign of the labrys, the double-axe of the mother goddess which adorned the palace at Knossos, Crete, originated in Ephesus. Under the rule of King Croesus of Lydia, construction of the great Temple of Artemis at Ephesus was begun, one of the Seven Wonders of the Ancient World (destroyed, the first time, by fire in 356 BCE, the same night Alexander the Great was born). The name of the city is thought to have been derived from Apasas, the name of a city in the Kingdom of Arzawa meaning the city of the Mother Goddess and some scholars maintain that the sign of the labrys, the double-axe of the mother goddess which adorned the palace at Knossos, Crete, originated in Ephesus. A must-see for any Alexander the Great tour, Pella in Greece was the capital of ancient Macedonia and the birthplace of Alexander. Once you’ve created the list of Alexander the Great sites and selected those you wish to visit you can use our itinerary planner tool to plan your very own Alexander the Great tours and then print off a free pocket guidebook. After the death of Alexander the Great, Ephesus was ruled by the general of him, Lysimakhos, in 287 BC. Later, Ephesus was dominated by Persians. As Ephesians did not join the Ionian Rebellion against Persians, the city was saved from destruction. The rebellion resulted in the loss of Persian. Alexander the Great won Persians and the Ionian cities got their independence in the year of 334. (356-323BC). Great Alexander was one of the most famous conquerors in World History, Alexander was an ingenious military leader but also a subject of controversy. On the one hand he was a brilliant tactician and leader, but he could also be ruthless and cruel, and is by some believed to have been an alcoholic. 
http://www.ephesus.us/ephesus/ephesus_history.htm http://www.ephesus.us/ephesus/mythology_of_artemis.htm https://en.wikipedia.org/wiki/Ephesus https://en.wikipedia.org/wiki/Ephesus http://www.ancient.eu/ephesos/ http://www.ancient.eu/ephesos/ http://www.historvius.com/alexander-the-great-sites/fi88 http://www.ephesus.us/ephesus/ephesus_history.htm http://www.in2greece.com/english/historymyth/history/ancient/alexander.htm
did alexander the great visit ephesus