The rare forms of congenital thrombophilia are typically caused by a deficiency of natural anticoagulants.They are classified as type I and are more severe in their propensity to cause thrombosis. The main ones are antithrombin III deficiency, protein C deficiency and protein S deficiency.
Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). The most common ones are factor V Leiden (a mutation in the F5 gene at position 1691) and prothrombin G20210A, a mutation in prothrombin (at position 20210 in the 3' untranslated region of the gene). The rare forms of congenital thrombophilia are typically caused by a deficiency of natural anticoagulants. They are classified as type I and are more severe in their propensity to cause thrombosis. The main ones are antithrombin III deficiency, protein C deficiency and protein S deficiency Idiopathic (unprovoked) venous thrombotic events are defined as the occurrence of venous thrombosis in the absence of any of the risk factors mentioned above. About 50% of patients presenting with a first idiopathic venous thrombosis have an underlying thrombophilia. Thrombophilias are hereditary conditions that are risk factors for venous thrombosis (see Table 1). Lupus anticoagulants are acquired risk factors for venous as well as arterial thrombosis The best clue for the presence of hypercoagulability is a positive family history. Clinical suspicions occur when patients are seen with unexpected venous thromboembolic disease, recurrent thrombosis, or thrombosis at unusual sites, such as the brain, portal vein, or hepatic vein. In addition, this entity should be considered in cases of unanticipated arterial occlusive disease of the central nervous system, extremities, mesenteric vessels, or cardiac tree. The defects that are responsible for hypercoagulability can be divided into inherited defects and acquired forms. Table 1 also includes noncoagulant factors. Before 1993, the chance of discovering a coagulation abnormality in patients with traditional hypercoagulability was as low as 5% to 15% Blood coagulation protein and platelet defects are now known to account for up to ninety percent of unexplained venous thrombosis and up to seventy percent of unexplained arterial thrombotic or ischemic events.  Venous thrombosis may also occur in more unusual places: in the veins of the brain, liver (portal vein thrombosis and hepatic vein thrombosis), mesenteric vein, kidney (renal vein thrombosis) and the veins of the arms. The most common ones are factor V Leiden (a mutation in the F5 gene at position 1691) and prothrombin G20210A, a mutation in prothrombin (at position 20210 in the 3' untranslated region of the gene). The rare forms of congenital thrombophilia are typically caused by a deficiency of natural anticoagulants. They are classified as type I and are more severe in their propensity to cause thrombosis. The main ones are antithrombin III deficiency, protein C deficiency and protein S deficiency However, the risk of venous thrombosis in protein C, protein S, and antithrombin III (ATIII) deficiencies is greater than in factor V Leiden and prothrombin 20210A, as shown in Table 1, above. The risk for thrombosis can be markedly increased in patients with 2 or more risk factors for thrombosis. About 50% of patients presenting with a first idiopathic venous thrombosis have an underlying thrombophilia. Thrombophilias are hereditary conditions that are risk factors for venous thrombosis (see Table 1). Thrombophilia. Thrombophilia, which may be congenital or acquired, is a clotting disorder associated with hypercoagulability that causes the appearance of deep venous thrombosis (DVT).  The difference between that sort of clotting and the clotting present in hypercoagulation is that these clots develop in circulating blood. This disorder can cause clots throughout the body's blood vessels, sometimes creating a condition known as thrombosis. Thrombosis can lead to infarction, or death of tissue, as a result of blocked blood supply to the tissue. However, hypercoagulability does not always lead to thrombosis. In pregnancy, and other hypercoagulable states, the incidence of thrombosis is higher than that of the general population, but is still under 10%
https://en.wikipedia.org/wiki/Thrombophilia http://emedicine.medscape.com/article/211039-overview http://www.medscape.com/viewarticle/415086_2 http://www.ncbi.nlm.nih.gov/pubmed/9646773 https://en.wikipedia.org/wiki/Thrombophilia http://emedicine.medscape.com/article/211039-overview http://www.stago.com/haemostasis/tests-clinical-applications/thrombophilia/ http://medical-dictionary.thefreedictionary.com/Hypercoagulation+Disorders
what is congenital hypercoagulability