A B cell chronic lymphoproliferative disorder.
Splenic lymphoma with villous lymphocytes (SLVL). 1  The most common abnormalities are those involving structural abnormalities of chromosome 7q22-q32 [20-40% of cases] in the form of translocation, mainly unbalanced, and 7q deletion (see Fig 2). 2  Some cases have been reported to show t(11;14)(q13;q32) [10-15%]. Clinics. splenomegaly without hepatomegaly nor enlarged lymph nodes; monoclonal Ig in a third of cases, autoimmune phenomena in 10% of patients, transformation to high grade lymphoma in 10% of cases. Peripheral blood lymphocytosis in 75% of patients and villous lymphocytes on peripheral blood smears (Fig 1). 5 The presence of circulating villous lymphocytes defines splenic lymphoma with villous lymphocytes. 6 Symptomatic splenomegaly is the presenting feature in almost all patients; anemia-related symptoms and B symptoms are rare. Splenic diffuse red pulp small B-cell lymphoma. Splenic diffuse red pulp small B-cell lymphoma is an uncommon subtype of lymphoma in which the splenic red pulp is diffusely involved by a neoplastic population of monomorphous small B-lymphocytes. 21, 22 Traverse-Glehen et al. Copyright notice. This report describes the occurrence of splenic lymphoma with villous lymphocytes (SLVL) in a 56 year old white female with a family history of chronic lymphocytic leukaemia. The spleen had nodular infiltrates of B lymphocytes in the region of the white pulp with minimal red pulp involvement. Electron microscopy of peripheral blood lymphocytes revealed cells with polar cytoplasmic processes. Splenic lymphoma with villous lymphocytes (SLVL) is a chronic B-cell lymphoproliferative disorder characterized by a clonal expansion of atypical B lymphocytes with villous projections in peripheral blood. SLVL involves mainly the spleen and the bone marrow. Villous lymphocytes have immunologic and Immunophenotypical characters of marginal zone lymphocytes. SLVL is usually treated by splenectomy or chemotherapy or both, with an overall 5-year survival rate of 80%. Abstract. Hepatitis C virus (HCV) has been associated with the development of B-cell non-Hodgkin lymphomas. We recently reported the regression of splenic lymphoma with villous lymphocytes (SLVL) in patients with HCV after antiviral treatment, demonstrating a direct role of HCV in lymphomagenesis. This study expands our previous results in 18 patients with chronic HCV and SLVL Splenic lymphoma with villous lymphocytes: clinical presentation, biology and prognostic factors in a series of 100 patients. Groupe Francais d'H©matologie Cellulaire (GFHC). Troussard X, Valensi F, Duchayne E, Garand R, Felman P, Tulliez M, Henry-Amar M, Bryon PA, Flandrin G. Clinics. splenomegaly without hepatomegaly nor enlarged lymph nodes; monoclonal Ig in a third of cases, autoimmune phenomena in 10% of patients, transformation to high grade lymphoma in 10% of cases. Peripheral blood lymphocytosis in 75% of patients and villous lymphocytes on peripheral blood smears (Fig 1). Splenic marginal zone lymphoma (SMZL) is a lymphoma made up of B-cells that replace the normal architecture of the white pulp of the spleen. With splenic involvement a requirement for a diagnosis of SMZL, splenomegaly is seen in almost all patients, commonly without lymphadenopathy. Aside from the uniform involvement of the spleen, the bone marrow is frequently positive in patients with SMZL. Abstract. This report describes the occurrence of splenic lymphoma with villous lymphocytes (SLVL) in a 56 year old white female with a family history of chronic lymphocytic leukaemia. The spleen had nodular infiltrates of B lymphocytes in the region of the white pulp with minimal red pulp involvement. Electron microscopy of peripheral blood lymphocytes revealed cells with polar cytoplasmic processes. Molecular cytogenetic analysis in splenic lymphoma with villous lymphocytes: frequent allelic imbalance of the RB1 gene but not the D13S25 locus on chromosome 13q14. Garca-Marco JA, Nouel A, Navarro B, Matutes E, Oscier D, Price CM, Catovsky D. Cancer research. Clinics. splenomegaly without hepatomegaly nor enlarged lymph nodes; monoclonal Ig in a third of cases, autoimmune phenomena in 10% of patients, transformation to high grade lymphoma in 10% of cases. Peripheral blood lymphocytosis in 75% of patients and villous lymphocytes on peripheral blood smears (Fig 1). Splenic lymphoma with villous lymphocytes (SLVL) is a B cell chronic lymphoproliferative disorder. Splenectomy and/or chlorambucil are usually regarded as the most effective treatment in SLVL patients. However, a few patients relapse and the second-line treatment remains questionable. Fludarabine: an effective treatment in patients with splenic lymphoma with villous lymphocytes. F Lefrere, Lefrère O, Hermine C, Belanger S, Francois François, H-Tilly J c Lebas De, La Cour, F Valensi b Varet And. x troussard
http://atlasgeneticsoncology.org/Anomalies/splenvillousID2063.html http://www.haematologica.org/content/95/4/534 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC502697/ http://www.bloodjournal.org/content/105/1/74?sso-checked=true http://atlasgeneticsoncology.org/Anomalies/splenvillousID2063.html https://en.wikipedia.org/wiki/Splenic_marginal_zone_lymphoma http://www.ncbi.nlm.nih.gov/pmc/articles/PMC502697/ http://atlasgeneticsoncology.org/Anomalies/splenvillousID2063.html http://www.nature.com/leu/journal/v14/n4/full/2401710a.html
what are villous lymphocytes