Cytoplasmic.
Aldolase A. From Wikipedia, the free encyclopedia. Aldolase A is an enzyme that catalyses a reversible aldol reaction: The substrate, fructose 1,6-bisphosphate (F-1,6-BP) is broken down into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis. Reference Range. Aldolase is an enzyme responsible for breaking down glucose products into energy, specifically converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate. (redirected from Liver-type aldolase). A gene on chromosome 9q21.3-q22.2 that encodes aldolase B (fructose-bisphosphate aldolase), a glycolytic enzyme that catalyses the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Aldolase is present in all animal and plant tissue, and in most microorganisms. Class I aldolase, found in animal and higher plant tissue, is characterized by the lack of requirement for a bivalent metal cofactor, and by the formation of ketimine Schiff base intermediate with the substrate dihyroxyacetone phosphate. Alteration of the shape of the enzyme makes it difficult for the aldolase B enzymes to bind together and form tetramers. If it is not in a tetramer, aldolase B cannot metabolize fructose. A lack of functional aldolase B results in an accumulation of fructose-1-phosphate in liver cells. Description. Aldolase is a cytoplasmic enzyme responsible for converting sugar into energy, specifically splitting aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate (a reversible reaction). The ALDOB gene provides instructions for making the aldolase B enzyme. This enzyme is one of a group of three aldolase enzymes that are responsible for breaking down certain molecules in cells throughout the body. Four identical aldolase B enzymes need to be attached (bound) to each other in a four-enzyme unit called a tetramer to work. SUMMARY 1. Both the yeast and muscle aldolase reactions are shown to proceed almost exclusively by an ordered sequence Enzyme + fructose diphosphate + glyceraldehyde 3-phosphate + enzyme-dihydroxyacetone phosphate (lacking a proton on the a-carbon) = enzyme + dihydroxyacetone phosphate 2.
https://en.wikipedia.org/wiki/Aldolase_A http://emedicine.medscape.com/article/2087158-overview http://medical-dictionary.thefreedictionary.com/Liver-type+aldolase http://www.worthington-biochem.com/ALD/default.html http://ghr.nlm.nih.gov/gene/ALDOB http://emedicine.medscape.com/article/2087158-overview http://ghr.nlm.nih.gov/gene/ALDOB http://www.jbc.org/content/240/4/1758.full.pdf
what type of enzyme is aldolase