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Von Willebrand disease is a bleeding disorder that slows the blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience easy bruising, long-lasting nosebleeds, and excessive bleeding or oozing following an injury, surgery, or dental work. No single test can diagnose VWD. Your doctor may recommend one or more blood tests to diagnose the disorder. These tests may include: 1  Von Willebrand factor antigen. 2  This test measures the amount of von Willebrand factor in your blood. 3  Von Willebrand factor ristocetin (ris-to-SEE-tin) cofactor activity. Clinical Significance. von Willebrand Disease is the most common hereditary bleeding disorder; it may also be acquired. von Willebrand Factor is necessary for platelet adhesion to injured endothelium. von Willebrand Factor Antigen is useful in assessing the quantity of von Willebrand Factor. von Willebrand disease (VWD) is the most common bleeding disorder, with a prevalence of up to 1%. VWD is caused by either a quantitative or qualitative defect of von Willebrand factor (VWF), which mediates platelet adhesion by binding to the GP1b platelet glycoprotein and to collagen on injured blood vessels. The cause of von Willebrand disease is a deficiency in or impairment of a protein called von Willebrand factor, an important component in your blood-clotting process. In general, it takes longer for people with von Willebrand disease to form clots and stop bleeding when they're cut. Because many people with von Willebrand disease have very mild signs, the condition can be difficult to diagnose. If you have any indication of a bleeding disorder, your doctor may refer you to a blood disorders specialist (hematologist). Quest Diagnostics offers 2 panels (von Willebrand Comprehensive Panel and von Willebrand Comprehensive Panel 2) that include key tests for VWD diagnosis and typing, along with an interpretation of results and additional comments (Figure 2) . Early diagnosis of von Willebrand disease (VWD) is important to make sure that you're treated and can live a normal, active life. Sometimes VWD is hard to diagnose. People who have type 1 or type 2 VWD may not have major bleeding problems. von Willebrand Disease Type 2N (VWF:Factor VIII Binding Activity; VWF:FVIIIB). von Willebrand Factor Antigen (VWF:Ag). This test measures the total amount of VWF protein. Levels are decreased in types 1 and 3 VWD. VWF antigen levels may be normal or decreased in types 2A, 2B, and 2M.
http://ghr.nlm.nih.gov/condition/von-willebrand-disease http://www.nhlbi.nih.gov/health/health-topics/topics/vwd/diagnosis http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=4919 http://www.questdiagnostics.com/testcenter/testguide.action?dc=CF_vWD http://www.mayoclinic.org/diseases-conditions/von-willebrand-disease/basics/definition/CON-20030195 http://www.mayoclinic.org/diseases-conditions/von-willebrand-disease/basics/tests-diagnosis/CON-20030195 http://www.questdiagnostics.com/testcenter/testguide.action?dc=CF_vWD http://www.nhlbi.nih.gov/health/health-topics/topics/vwd/diagnosis http://www.questdiagnostics.com/testcenter/testguide.action?dc=CF_vWD
do quest test for von willebrand disease