Epitope initiates events that activate the lymphocyte receptors are antibodies and B cell receptors.
From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. By contrast, linear epitopes interact with the paratope based on their primary structure. A linear epitope is formed by a continuous sequence of amino acids from the antigen. An antigen is any molecule against which a specific immune response can be generated. This means that lymphocytes are activated: 1  B-cells are activated to produce antibodies and. 2  T-cells are activated to provide helper function and cytotoxic function. IgM 1  -. heavy chain is the mu-chain; 2  it can be a monomer when it is on the surface of the B-cell that made it (it can be a B-cell receptor); 3  It is a pentamer when it is secreted and floating around in the serum -- this is the biggest and heaviest antibody; 4  It is the first antibody made in life by the still immature immune system; 5  It is a good 6  ... It Each B cell and T cell is specific for a particular antigen. What this means is that each is able to bind to a particular molecular structure. The specificity of binding resides in a receptor for antigen: 1  the B cell receptor (BCR) for antigen and. 2  the T cell receptor (TCR) respectively. 3  They are integral membrane proteins. 4  They are present in thousands of identical copies exposed at the cell surface. 5  They are made before the cell ever encounters an antigen. The process works like this: 1  The precursors of T cells — like all blood cells — are formed in the bone marrow. 2  These cells then migrate to the cortex of the thymus. 3  At this time they have neither a complete TCR nor either CD4 or CD8 (thus are called double-negative or DN cells). If an antibody binds to an antigen's epitope, the paratope could become the epitope for another antibody that will then bind to it. If this second antibody is of IgM class, its binding can upregulate the immune response; if the second antibody is of IgG class, its binding can downregulate the immune response. By contrast, linear epitopes interact with the paratope based on their primary structure. A linear epitope is formed by a continuous sequence of amino acids from the antigen. Distinguish between effector cells and memory cells. The binding of an antigen receptor to an epitope initiates events that activate the lymphocyte. Once activated, a B or T cell undergoes multiple cell divisions. For each activated cell, the result of this proliferation is a clone. antibodies and B cell receptors. Antibodies have the same Y-shaped organization as B cell antigen receptors, but they are secreted rather than membrane bound. It is the antibodies, rather than the B cells themselves, that actually help defend against pathogens. Describe the mechanism of clonal selection. The binding of an antigen receptor to an epitope initiates events that activate the lymphocyte. Once activated, a B or T cell undergoes multiple cell divisions. For each activated cell, the result of this proliferation is a clone. antibodies and B cell receptors. Antibodies have the same Y-shaped organization as B cell antigen receptors, but they are secreted rather than membrane bound. It is the antibodies, rather than the B cells themselves, that actually help defend against pathogens. epitope: the small, accessible portion of an antigen that binds to an antigen receptor; a single antigen usually has several different epitopes, each binding a receptor with a different specificity; because all antigen receptors produced by a single B or T cell are identical, they bind to the same epitope. antibodies and B cell receptors. Antibodies have the same Y-shaped organization as B cell antigen receptors, but they are secreted rather than membrane bound. It is the antibodies, rather than the B cells themselves, that actually help defend against pathogens. For example, the epitope is the specific piece of the antigen that an antibody binds to. The part of an antibody that binds to the epitope is called a paratope. By contrast, linear epitopes interact with the paratope based on their primary structure. A linear epitope is formed by a continuous sequence of amino acids from the antigen.
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describe epitope specific receptors