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A. A. Arthritis means inflammation in a joint. That inflammation causes redness, warmth, swelling, and pain within the joint. Rheumatoid arthritis affects joints on both sides of the body, such as both hands, both wrists, or both knees. This symmetry helps to set it apart from other types of arthritis. RA can also affect the skin, eyes, lungs, heart, blood, or nerves. Rheumatoid arthritis is a disease where the immune system attacks the lining of some joints. This cause pain and swelling in those joints. The cause of rheumatoid arthritis is not completely understood. We know that it effects women more than men and that it is more common in people that smoke.  A genetic variation has been identified that increases the risk of two chronic, autoimmune inflammatory diseases: rheumatoid arthritis (RA) and systemic lupus erythematosus (lupus). The research also suggests a shared disease pathway for RA and lupus. For this complex disease, rheumatoid arthritis, this is the first instance of a genetic linkage study leading to a chromosomal location, which then, in a genetic association study, identified a disease susceptibility gene, says Dr. Gregersen. Long-term smoking is a well-established risk factor for developing rheumatoid arthritis; it is also associated with more severe signs and symptoms in people who have the disease. The inheritance pattern of rheumatoid arthritis is unclear because many genetic and environmental factors appear to be involved. However, having a close relative with rheumatoid arthritis likely increases a person's risk of developing the condition. Abstract. Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5–1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease.  In rheumatoid arthritis, they mainly attack the cells of the lining of certain joints, which gives rise to pain, swelling, redness and inflammation of joints. It is also observed that the disease is more common in women than in men, and also, smokers are more likely to get affected by it than non-smokers. The studies have shown that a genetic factor does play a role in the occurrence of rheumatoid arthritis. While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule.  Well, so far, from the studies, the cause of rheumatoid arthritis is not definitely known. It is an autoimmune disease, and autoimmune diseases are caused when the white blood cells in our body, which normally fight the outside infectious bodies, wrongly take our own cells as foreign substances and start killing them. It is also observed that the disease is more common in women than in men, and also, smokers are more likely to get affected by it than non-smokers. The studies have shown that a genetic factor does play a role in the occurrence of rheumatoid arthritis. Rheumatoid arthritis probably results from a combination of genetic and environmental factors, many of which are unknown. Rheumatoid arthritis is classified as an autoimmune disorder, one of a large group of conditions that occur when the immune system attacks the body's own tissues and organs. In people with rheumatoid arthritis, the immune system triggers abnormal inflammation in the membrane that lines the joints (the synovium). The inheritance pattern of rheumatoid arthritis is unclear because many genetic and environmental factors appear to be involved. However, having a close relative with rheumatoid arthritis likely increases a person's risk of developing the condition. Rheumatoid arthritis (RA) is an autoimmune disease in which the body’s immune system mistakenly attacks the membranes that line the body’s joints. The result is inflammation and pain in the joints. RA is a chronic disease that can cause periods of intense activity called flare-ups. Researchers have established that certain genetic markers may increase your risk of developing RA. The genes in question are related to the immune system in general, to chronic inflammation, or with RA in particular. It is important to note that not everyone with these markers develops RA.
http://www.webmd.com/rheumatoid-arthritis/guide/rheumatoid-arthritis-basics https://www.zocdoc.com/answers/8312/is-rheumatoid-arthritis-hereditary http://niams.nih.gov/News_and_Events/Press_Releases/2007/09_06.asp http://ghr.nlm.nih.gov/condition/rheumatoid-arthritis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132380/ http://www.rheumatoid-arthritisdiet.com/isrheumatoid-arthritis-hereditary.html https://en.wikipedia.org/wiki/Rheumatoid_arthritis http://www.rheumatoid-arthritisdiet.com/isrheumatoid-arthritis-hereditary.html http://ghr.nlm.nih.gov/condition/rheumatoid-arthritis http://www.healthline.com/health-slideshow/rheumatoid-arthritis-hereditary
rheumatoid arthritis is it hereditary