3 gram/day
Safe Dosage of Acetaminophen. Acetaminophen is a very safe drug only if it is used within therapeutic doses. The safe dose is 3 grams per day and the maximum daily dose is 4g per day for adults. However, the elderly who tend to have a lower body weight than younger adults should not exceed the safe dose. Most acetaminophen tablets are available in 500 milligram (mg) doses so it is a safe provided that one does not take more than 6 tablets (500mg tablets) per day. Late last week, the FDA announced that it has asked manufacturers of prescription products that contain an acetaminophen combination to limit the amount of acetaminophen in these products to no more than 325mg per dose. Currently, some of these medications contain 500 mg or 750  The toxic dose of acetaminophen for adults is between 7 to 10 grams per day with doses above 10g/day being potentially lethal. Toxicity is at lower doses for a person with any of the risk factors discussed above. Acetaminophen overdose and poisoning is more liklely in the elderly for several possible reasons : 1. Reduce the maximum recommended daily intake of acetaminophen from 4,000 mg per day to around 2,600-3,200 mg per day. 2. Reduce the maximum recommended single dose from 1,000 mg per day (two extra strength Tylenol) to 650 mg per day (two regular strength Tylenol). 3. Require that only one concentration of liquid acetaminophen be marketed to avoid confusion and accidental overdose, especially in children. For adults and children 12 years of age and older, the recommended dose of acetaminophen is 650 to 1000 mg every 4 to 6 hours as needed, not to exceed 4000 mg in 24 hours (Table 2). For extended-release acetaminophen, the dose is 1300 mg every 8 hours as needed, not to exceed 3900 mg in 24 hours.
http://www.seniorhealth365.com/2011/11/24/acetaminophen-overdose-and-poisoning-in-the-elderly/ http://www.geriatricpain.org/Pages/acetaminophen.aspx http://www.seniorhealth365.com/2011/11/24/acetaminophen-overdose-and-poisoning-in-the-elderly/ http://www.goldenlivingcenters.com/expert-thinking/blogs/post.aspx?assetId=7d500000-04a0-4f86-bd02-a81ced759bfc http://www.rxlist.com/tylenol-drug/indications-dosage.htm
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