Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. 
Macrovascular: Pertaining to the macrovasculature, the portion of the vasculature of the body comprising the larger vessels, those with an internal diameter of more than 100 microns. By contrast to microvascular. The term macrovascular is somewhat less used than microvascular. There is a field of microvascular surgery. Macrovascular disease: Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease. The major long-term complications relate to damage to blood vessels. Diabetes doubles the risk of cardiovascular disease and about 75% of deaths in diabetics are due to coronary artery disease. Other macrovascular diseases are stroke, and peripheral vascular disease. Complications of diabetes. Diabetes complications are divided into microvascular (due to damage to small blood vessels) and macrovascular (due to damage to larger blood vessels). Definition. The microvascular complications of diabetes encompass long-term complications of diabetes affecting small blood vessels. These classically have included retinopathy, nephropathy, and neuropathy. Retinopathy is divided into two main categories: nonproliferative retinopathy and proliferative retinopathy. These complications can occur in blood vessels in any part of the body. Factors that can contribute to macrovascular complications are high blood sugar, insulin resistance, high cholesterol, high blood pressure, smoking, and abnormalities in blood clotting.
http://www.medicinenet.com/script/main/art.asp?articlekey=39260 http://www.medicinenet.com/script/main/art.asp?articlekey=39259 https://en.wikipedia.org/wiki/Diabetes_mellitus http://www.who.int/diabetes/action_online/basics/en/index3.html http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/endocrinology/microvascular-complications-of-diabetes/ http://www.webmd.com/diabetes/tc/macrovascular-diabetes-complications-topic-overview
macrovascular complications definition