MCP disease is joint contractures may interfere with activities of daily living and the nodules can be painful.
The key finding in MCP is the chorioretinal lesions scattered in the fundus. Acutely, several to several hundred yellow (sometimes gray) lesions are seen at the level of the RPE and choriocapillaris. Most lesions are 50 to 350 mm in diameter but occasionally may be larger. The cause of MCP is not fully understood. Tiedeman suggested a viral etiology when he found serologic evidence of chronic or persistent Epstein-Barr virus (EBV) infection in 10 patients with MCP which he did not find in 8 control patients(7). A subsequent study by Spaide et al. did not support this hypothesis(8). MCPA, MCP. 2-methyl-4-chlorophenoxyacetic acid; a weedkiller reported to be nontoxic at the levels likely to be encountered on pasture, though it has killed cattle dosed experimentally with large single doses.  Although fibromyalgia is often considered an arthritis-related condition, it is not truly a form of arthritis (a disease of the joints) because it does not cause inflammation or damage to the joints, muscles, or other tissues. A person may have two or more coexisting chronic pain conditions. Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia. Other diseases that should be considered in the differential diagnosis of MCP include sarcoidosis, syphilis, Lyme disease, miliary tuberculosis, intraocular lymphoma, herpes virus infection, inflammatory bowel disease and outer retinal toxoplasmosis. The cause of MCP is not fully understood. Tiedeman suggested a viral etiology when he found serologic evidence of chronic or persistent Epstein-Barr virus (EBV) infection in 10 patients with MCP which he did not find in 8 control patients(7). A subsequent study by Spaide et al. did not support this hypothesis(8). About 25% to 39% of patients with MCP develop macular and peripapillary choroidal neovascular membranes (CNVM's) which may be the presenting cause for decreased vision. Macular CNVM with extensive scarring is the major cause of visual loss in MCP. The cause of MCP is not fully understood. Tiedeman suggested a viral etiology when he found serologic evidence of chronic or persistent Epstein-Barr virus (EBV) infection in 10 patients with MCP which he did not find in 8 control patients(7). A subsequent study by Spaide et al. did not support this hypothesis(8). Like arthritis, however, fibromyalgia can cause significant pain and fatigue, and it can interfere with a person’s ability to carry on daily activities. Also like arthritis, fibromyalgia is considered a rheumatic condition, a medical condition that impairs the joints and/or soft tissues and causes chronic pain. A person may have two or more coexisting chronic pain conditions. Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia. MCP and PIP joint contractures may interfere with activities of daily living and the nodules can be painful. Occasionally, Dupuytren contracture is associated with plantar fascial thickening (Ledderhose disease), involvement of the penis (Peyronie disease), or involvement of the knuckle pads (Garrod nodes). Dupuytren contracture is most commonly observed in persons of Northern European descent and affects 4-6% of Caucasians worldwide. Many individuals have bilateral disease (45%); in unilateral cases, the right side is more often affected. MCP: Membrane cofactor protein. A ubiquitous protein on the surface of cells that regulates complement and is involved in the attachment and ingestion of foreign particles by neutrophils and macrophages. The gene for MCP is on chromosome 1q32. Background. Dupuytren disease is a fibrosing disorder, which results in slowly progressive thickening and shorting of the palmar fascia leading to debilitating digital contractures, particularly of the metacarpophalangeal (MCP) joints or the proximal interphalangeal (PIP) joints. Dupuytren contracture is most commonly observed in persons of Northern European descent and affects 4-6% of Caucasians worldwide. Many individuals have bilateral disease (45%); in unilateral cases, the right side is more often affected. Degenerative arthritis of the finger metacarpophalangeal joints is uncommon and, when seen, a specific etiology should be sought. MP joint arthritis in the absence of a history of trauma may signal an underlying systemic disease. The clinical and radiographic findings may be subtle. Degenerative arthritis of the thumb MP joint is more common following injuries that damage the ligaments on the ulnar or radial side of the MP joint and which result in lateral instability of the joint.
http://www.uveitis.org/multifocal-choroiditis-and-panuveitis http://medical-dictionary.thefreedictionary.com/MCP http://www.niams.nih.gov/health_info/Fibromyalgia/ http://www.uveitis.org/multifocal-choroiditis-and-panuveitis http://www.uveitis.org/multifocal-choroiditis-and-panuveitis http://www.niams.nih.gov/health_info/Fibromyalgia/ http://emedicine.medscape.com/article/329414-overview http://www.medicinenet.com/script/main/art.asp?articlekey=25238 http://emedicine.medscape.com/article/329414-overview http://www.ncbi.nlm.nih.gov/pubmed/3308911
what is a mcp disease