Disease
These two types of neurons--one of which is dopamine neurons in a brain region called the substantia nigra--degenerate during Parkinson's disease. To see if living neurons use MHC-1 to display antigens (and not for some other purpose), Drs. We need to show that there are certain T cells in Parkinson's patients that can attack their neurons.. If the immune system does kill neurons in Parkinson's disease, Dr. Sulzer cautions that it is not the only thing going awry in the disease. This idea may explain the final step, he says. The researchers then confirmed that T cells recognized and attacked neurons displaying specific antigens. The results raise the possibility that Parkinson's is partly an autoimmune disease, Dr. Sulzer says, but more research is needed to confirm the idea.  Parkinson's commonly occurs in patients who have other autoimmune diseases. Chemicals like pesticides trigger Parkinson's. Just walking the garden aisle of a superstore packed with pesticide will give you enough exposure to cause this diseases.  The cause of neuronal death in Parkinson's disease is still unknown, but a new study proposes that neurons may be mistaken for foreign invaders and killed by the person's own immune system, similar to the way autoimmune diseases like type I diabetes, celiac disease, and multiple sclerosis attack the body's cells. These two types of neurons—one of which is dopamine neurons in a brain region called the substantia nigra—degenerate during Parkinson's disease. To see if living neurons use MHC-1 to display antigens (and not for some other purpose), Drs. The results raise the possibility that Parkinson’s is partly an autoimmune disease, Dr. Sulzer says, but more research is needed to confirm the idea. “This is a new, and likely controversial, idea in Parkinson’s disease.”. The new hypothesis about Parkinson’s emerges from other findings in the study that overturn a deep-seated assumption about neurons and the immune system. Parkinson's disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome (HRS), or paralysis agitans) is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. The causes of this cell death are poorly understood. Parkinson’s disease is a neurological condition resulting from an imbalance of dopamine and acetylcholine, two chemical messengers (“neurotransmitters”) in the brain that help control movement. Too little dopamine leads to problems with gross and fine motor coordination.  Symptoms. Symptoms of Parkinson's disease differ from person to person. They also change as the disease progresses. Symptoms that one person gets in the early stages of the disease, another person may not get until later-or not at all. Symptoms typically begin appearing between the ages of 50 and 60. Tremor is often the first symptom that people with Parkinson's disease or their family members notice. At first the tremor may appear in just one arm or leg or only on one side of the body. The tremor also may affect the chin, lips, and tongue. As the disease progresses, the tremor may spread to both sides of the body
http://www.eurekalert.org/pub_releases/2014-04/cumc-ipa041714.php http://forum.parkinson.org/index.php?/topic/16182-is-parkinsons-an-autoimmune-disease/ http://www.cidpusa.org/parkinson.html http://medicalxpress.com/news/2014-04-parkinson-autoimmune-disease.html http://newsroom.cumc.columbia.edu/blog/2014/04/17/parkinsons-autoimmune-disease/ https://en.wikipedia.org/wiki/Parkinson%27s_disease http://www.autoimmunemom.com/autoimmune-neuromuscular/is-parkinsons-autoimmune.html http://www.webmd.com/parkinsons-disease/default.htm
is parkinson's disease autoimmune