Presence of high levels of cholesterol in the blood
Mutations in the APOB, LDLR, LDLRAP1, and PCSK9 genes cause hypercholesterolemia. High blood cholesterol levels typically result from a combination of genetic and environmental risk factors. Lifestyle choices including diet, exercise, and tobacco smoking strongly influence the amount of cholesterol in the blood. Introduction. Hypercholesterolemia, or high cholesterol, occurs when there is too much cholesterol in the body. Cholesterol is a soft, waxy, fat-like substance that is a natural component of all the cells in the body. Your body makes all the cholesterol it needs. People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). Familial hypercholesterolemia (FH), also known as pure hypercholesterolemia, refers to a condition in which people have a genetic tendency for high cholesterol or high lipid levels. High cholesterol can boost a person’s chances for developing heart disease and other conditions. Causes of hypercholesterolemia. There are many factors that can raise the risk of hypercholesterolemia causing stroke or heart disease. These include a diet rich in saturated fats, smoking, diabetes, high blood pressure, and having a family history of Hypercholesterolemia (also spelled hypercholesterolaemia also called dyslipidemia) is the presence of high levels of cholesterol in the blood. It is a form of  hyperlipidemia  (elevated levels of lipids in the blood) and hyperlipoproteinemia (elevated levels of lipoproteins in the blood).
http://ghr.nlm.nih.gov/condition/hypercholesterolemia http://umm.edu/health/medical/altmed/condition/hypercholesterolemia http://ghr.nlm.nih.gov/condition/hypercholesterolemia http://www.healthline.com/health/high-cholesterol/pure-hypercholesterolemia http://www.news-medical.net/health/What-is-Hypercholesterolemia.aspx https://en.wikipedia.org/wiki/Hypercholesterolemia
what is hypercholesterolemia