Spironolactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.It can also be used in combination with other drugs to treat elevated blood pressure and for treating diuretic-induced low potassium (hypokalemia). NHYA Class III–IV
Therefore, spironolactone is classified as a potassium-sparing diuretic, a drug that promotes the output of urine (diuretic) while allowing the kidneys to retain potassium. The FDA approved spironolactone in October 1985. PRESCRIBED FOR: Spironolactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat elevated blood pressure and for treating diuretic-induced low potassium (hypokalemia). (At the same time, it also causes the kidneys to eliminate potassium.) The body then becomes overloaded with salt and water, and this worsens the heart failure. Spironolactone inhibits the action of aldosterone thereby causing the kidneys to excrete salt and fluid in the urine while retaining Spironolactone (INN, BAN, USAN) (pronounced /spɪˌrɒnɵˈlaektoʊn/), spɪˌrɒnɵˈlæktoʊn marketed mainly under the brand Name aldactone in most, countries is a, synthetic steroidal, antimineralocorticoid as well, as to a lesser, extent an, antiandrogen, progestin and. antigonadotropin In a randomized evaluation which studied people with severe congestive heart failure, patients treated with spironolactone were found to have a relative risk of death of 0.70 or an overall 30% relative risk reduction compared to the placebo group, indicating a significant Death and morbidity benefit of the drug. Indications for ALDACTONE: To increase survival and to reduce hospitalization for heart failure (NYHA class III–IV) when used in addition to standard of therapy. Name & class of drug – generic and trade name. GENERIC NAME: Aldactone, Novospiroton BRAND NAME: Spironolactone CLASSIFICATION: Electrolyte and water balance agent; potassium sparing diuretic 2. Dose range and routes for adult & geriatric client.  As a secondary use, spironolactone is also frequently employed off-label for the purpose of reducing androgen levels and activity in the body, such as in the treatment of hyperandrogenism in women and as a component of hormone replacement therapy for trans women. In a randomized evaluation which studied people with severe congestive heart failure, patients treated with spironolactone were found to have a relative risk of death of 0.70 or an overall 30% relative risk reduction compared to the placebo group, indicating a significant Death and morbidity benefit of the drug. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. The effect of food on spironolactone absorption (two 100 mg ALDACTONE tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized spironolactone by almost 100%. Featured: spironolactone, Aldactone Main Article. Spironolactone (Aldactone) is classified as a potassium-sparing diuretic. Spironolactone (Aldactone) is prescribed for the treatment of congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat diuretic induced low potassium and high blood pressure.  The familiar diuretic spironolactone has taken on new life as a treatment for left-sided congestive heart failure. Spironolactone has been shown to decrease mortality in such patients who are New York Heart Association class IV. One study 3 has shown that spironolactone improves morbidity and mortality in patients with severe heart failure. The particular advantages of spironolactone for prevention are that it is inexpensive, is taken once daily and has relatively few side effects. spironolactone. [spī′rənəlak′tōn]. a potassium-sparing aldosterone antagonist diuretic. indications It is prescribed in the treatment of primary hyperaldosteronism, edema of congestive heart failure, cirrhosis of the liver accompanied by edema, nephrotic syndrome, essential hypertension, and hypokalemia. Aldactone (spironolactone) is an aldosterone receptor antagonist that causes the kidneys to remove water and sodium from the body, with reduced losses of potassium. Aldactone is used to reduce edema caused by heart, liver or kidney problems, hypertension, and certain patients with hyperaldosteronism. Aldactone is available in a generic form named spironolactone. Common side effects of Aldactone include skin rash, headache, dizziness, nausea, vomiting, gas, and stomach pain.
http://www.medicinenet.com/spironolactone/article.htm https://en.wikipedia.org/wiki/Spironolactone http://www.empr.com/aldactone/drug/52/ https://www.scribd.com/doc/104050/Spironolactone https://en.wikipedia.org/wiki/Spironolactone http://www.rxlist.com/aldactone-drug/clinical-pharmacology.htm http://www.medicinenet.com/spironolactone/index.htm http://www.aafp.org/afp/2001/1015/p1393.html http://medical-dictionary.thefreedictionary.com/spironolactone http://www.rxlist.com/aldactone-side-effects-drug-center.htm
what class is aldactone