A substance that interferes with the neural transmission between motor neurons and skeletal muscles.
Unlike acetylcholine, however, most neuromuscular blocking agents (non-depolarizing NMBs) do not cause the receptor to open when they bind, so the receptor stays closed, and acetylcholine can't bind to it to open it since the NMB molecule is there instead. Click here for an index of neuromuscular blocking agents. This article is under construction. I do love NMBs though. I'm trying to make this into a category so I can put like SCh and dTC and stuff in it. Everything in blue text has been copied from my new site The Art of Paralytics. Some of the most fascinating chemicals known are neuromuscular blocking agents (also called NMBs, neuromuscular blockers and neuromuscular blocking drugs). Only a few milligrams of a NMB can completely paralyze a human like you. Click here for an index of neuromuscular blocking agents. This article is under construction. I do love NMBs though. I'm trying to make this into a category so I can put like SCh and dTC and stuff in it. Everything in blue text has been copied from my new site The Art of Paralytics. Depolarizing blocking agents such as succinylcholine chloride also compete with acetylcholine for cholinergic receptors of the motor end plate but work by first activating the receptor and then blocking its ability to be reset for subsequent stimulation. Neuromuscular blocking agents: mechanism of action, hazards, and USE ... by Gardenhire, Doug / FOCUS: Journal for Respiratory Care & Sleep Medicine. For a number of types of surgery, an anaesthetist will also induce muscle relaxation using a. • NEUROMUSCULAR BLOCKING AGENT (noun). The noun NEUROMUSCULAR BLOCKING AGENT has 1 sense: 1. a substance that interferes with the neural transmission between motor neurons and skeletal muscles. Familiarity information: NEUROMUSCULAR BLOCKING AGENT used as a noun is very rare. Flaxedil; gallamine (neuromuscular blocking agent (trade name Flaxedil) used as a muscle relaxant in the administration of anesthesia). curare; tubocurarine (a toxic alkaloid found in certain tropical South American trees that is a powerful relaxant for striated muscles). Key points. Neuromuscular blocking drugs (NMBDs) act at several sites at the neuromuscular junction, but their main effects are as agonists and antagonists at postjunctional nicotinic receptors. Succinylcholine is the only available depolarizing NMBD; it has several undesirable side-effects.  These drugs fall into two groups: 1  Non-depolarizing blocking agents: These agents constitute the majority of the clinically relevant neuromuscular blockers. 2  Depolarizing blocking agents: These agents act by depolarizing the sarcolemma of the skeletal muscle fiber. The main difference is in the reversal of these two types of neuromuscular-blocking drugs. 1  Non-depolarizing blockers are reversed by acetylcholinesterase inhibitor drugs since they are competitive antagonists at the ACh receptor so can be reversed by increases in ACh. 1 Depolarizing blocking agents: These agents act by depolarizing the sarcolemma of the skeletal muscle fiber. 2  This persistent depolarization makes the muscle fiber resistant to further stimulation by ACh. The main difference is in the reversal of these two types of neuromuscular-blocking drugs. 1  Non-depolarizing blockers are reversed by acetylcholinesterase inhibitor drugs since they are competitive antagonists at the ACh receptor so can be reversed by increases in ACh. a chemical substance that interferes locally with the transmission or reception of impulses from motor nerves to skeletal muscles. Nondepolarizing agents such as metocurine, pancuronium, and tubocurarine competitively block the transmitter action of acetylcholine at the motor end plate. Neuromuscular blocking agents: mechanism of action, hazards, and USE ... by Gardenhire, Doug / FOCUS: Journal for Respiratory Care & Sleep Medicine. For a number of types of surgery, an anaesthetist will also induce muscle relaxation using a.
http://paralytics.wikia.com/wiki/Neuromuscular_Blocking_Agents http://paralytics.wikia.com/wiki/Neuromuscular_Blocking_Agents http://medical-dictionary.thefreedictionary.com/neuromuscular+blocking+agent http://www.audioenglish.org/dictionary/neuromuscular_blocking_agent.htm http://ceaccp.oxfordjournals.org/content/4/1/2.full https://en.wikipedia.org/wiki/Neuromuscular-blocking_drug https://en.wikipedia.org/wiki/Neuromuscular-blocking_drug http://medical-dictionary.thefreedictionary.com/neuromuscular+blocking+agent
what do neuromuscular blocking agents do