The final enzyme in the biosynthetic pathway of ascorbic acid (vitamin C), is a subject that comes up often in discussions of common ancestry.
Jonathan M. L-gulonolactone oxidase (GULO), the final enzyme in the biosynthetic pathway of ascorbic acid (vitamin C), is a subject that comes up often in discussions of common ancestry. The functioning GULO gene allows most plants and many animals to produce vitamin C from glucose or galactose. Loss of vitamin C pathway function and GULO gene degradation has also been detected in guinea pigs, great apes, and humans (Lachapelle and Drouin 2011; Nishikimi, Kawai, and Yagi 1992; Nishikimi et al. 1994; Ohta and Nishikimi 1999). L-gulonolactone oxidase (GULO) is the final enzyme of the biosynthetic pathway leading to the production of vitamin C (ascorbic acid) from glucose and galactose. Many animals (and most plants) possess a GULO gene that produces a functional protein. Another important aspect of consideration for the GULO gene degradation found in humans is the fact that it occurs frequently in mammals and birds, and the events typically are associated with complete or partial loss of exons. This indicates that the gene may be predisposed to the effects of genetic entropy. Posted. The GULO gene is responsible for processing ascorbic acid (vitamin C), but is broken in humans, many old world monkeys (Africa), hamsters, and fruitbats. This doesn't cause a problem since we, monkeys, hamsters and fruitbats can get vitamin C from our diets. L-gulonolactone oxidase (GULO), the final enzyme in the biosynthetic pathway of ascorbic acid (vitamin C), is a subject that comes up often in discussions of common ancestry. In some taxa, however, the GULO gene does not function in this capacity and is given the pseudogene label. The GULO gene is thought to be broken in humans (Nishikimi and Yagi, 1991), primates and guinea pigs (Nishikimi et al., 1994; Nishikimi et al., 1988), as well as in bats of the genus Pteropus (Cui et al., 2011). In humans, the GULO gene locus appears to be a broken gene suffering major deletions of key exons associated with a functional mammalian GULO gene (fig. 2A). Over the past 25+ years of messenger RNA sequencing from a large diversity of human tissues and cell lines, no GULO transcripts have been detected (Yang 2013). L-gulono-γ-lactone oxidase (GULO) is the forth and final enzyme of the metabolic pathway that converts glucose to 2-keto-gulono-γ-lactone, witch spontaneously converts into L-ascorbic acid (vitamin C); a critical vitamin in biosynthesis; acting as a cofactor, substrate, or electron donor for numerous enzymes.
http://www.evolutionnews.org/2012/02/gulo_shared_mut056281.html https://answersingenesis.org/genetics/human-gulo-pseudogene-evidence-evolutionary-discontinuity-and-genetic-entropy/ http://www.evolutionnews.org/2013/08/a_simple_propos075721.html https://answersingenesis.org/genetics/human-gulo-pseudogene-evidence-evolutionary-discontinuity-and-genetic-entropy/ http://evolutionfairytale.com/forum/index.php?/topic/2209-gulo-gene/ http://www.evolutionnews.org/2012/02/gulo_shared_mut056281.html http://www.evolutionnews.org/2012/02/gulo_shared_mut056281.html https://answersingenesis.org/genetics/human-gulo-pseudogene-evidence-evolutionary-discontinuity-and-genetic-entropy/ http://www.evolutionarymodel.com/pseudogenes.htm
what is the gulo gene