A multiplex lab on a chip.
Professor Daniel Geschwind describes microarrays, small slides onto which DNA can be pasted, as an efficient way to study genes that cause disorders. Transcript: A microarray is essentially, an ordered array of DNA or any nucleic acids. It’s typically gridded out onto some kind of solid support, so that, basically in a very small area, let’s say a microscope slide, you can put down every single gene in the genome, forty, fifty-thousand genes in that small area.  microarray. An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. A microarray is a sequence of dots of DNA, protein, or tissue arranged on an array for easy simultaneous analysis. The most famous is the DNA microarray, which plays an integral role in gene expression profiling. A DNA microarray is sometimes referred to as a gene chip or DNA chip. Scientists can use DNA microarrays to study the activity of several thousand genes at the same time. A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10 −12 moles) of a specific DNA sequence, known as probes (or reporters or oligos). The two Cy-labeled cDNA samples are mixed and hybridized to a single microarray that is then scanned in a microarray scanner to visualize fluorescence of the two fluorophores after excitation with a laser beam of a defined wavelength. A microarray is a multiplex lab-on-a-chip. It is a 2D array on a solid substrate (usually a glass slide or silicon thin-film cell) that assays large amounts of biological material using high-throughput screening miniaturized, multiplexed and parallel processing and detection methods.  Microarray technology is a developing technology used to study the expression of many genes at once. It involves placing thousands of gene sequences in known locations on a glass slide called a gene chip.  Introduction. Microarray is a hybridization of a nucleic acid sample (target) to a very large set of oligonucleotide probes, which are attached to a solid support, to determine sequence or to detect variations in a gene sequence or expression or for gene mapping (MeSH). DNA microarray analysis is a technique that scientists use to determine whether genes are on or off. Scientists know a gene is on in a cell if its mRNA is present. DNA microarray analysis is one of the fastest-growing new technologies in the field of genetic research. Scientists are using DNA microarrays to investigate everything from cancer to pest control. Now you can do your own DNA microarray experiment! Search... The study of genes is crucial to our understanding of the cell and its diseases. Combining robotics, chemistry, computer science, and biology, DNA microarrays allow us to study many points within a genome – which is composed of thousands of genes – at one time. The microarray itself is a small support on which thousands of DNA sequences from different genes are attached at specific locations. One such support is a silicon wafer (just the size of a fingernail) embedded in a plastic case.  The core principle behind microarrays is hybridization between two DNA strands, the property of complementary nucleic acid sequences to specifically pair with each other by forming hydrogen bonds between complementary nucleotide base pairs. The two Cy-labeled cDNA samples are mixed and hybridized to a single microarray that is then scanned in a microarray scanner to visualize fluorescence of the two fluorophores after excitation with a laser beam of a defined wavelength.
https://www.dnalc.org/view/1178-What-is-a-Microarray-.html http://medical-dictionary.thefreedictionary.com/Microarray+technology http://www.wisegeek.com/what-is-a-microarray.htm https://en.wikipedia.org/wiki/DNA_microarray https://en.wikipedia.org/wiki/Microarray http://www.ghr.nlm.nih.gov/glossary=microarraytechnology http://www.ncbi.nlm.nih.gov/genome/probe/doc/TechMicroarray.shtml http://learn.genetics.utah.edu/content/labs/microarray/ https://www.coriell.org/research-services/genotyping-microarray/what-is-a-microarray/ https://en.wikipedia.org/wiki/DNA_microarray
what is a microarray