Chromosome 4
Huntington's Disease (HD) is a progressive brain disorder caused by a defective gene. This disease causes changes in the central area of the brain, which affect movement, mood and thinking skills. About Huntington's Disease. George Huntington, M.D., who first described the disease that bears his name. Huntington's disease is a progressive brain disorder caused by a single defective gene on chromosome 4 — one of the 23 human chromosomes that carry a person’s entire genetic code. This defect is dominant, meaning that anyone who inherits it from a parent with Huntington's will eventually develop the disease Causes: Huntington’s Disease is caused by a single defect on a single chromosome. This gene is found in every human being and contains a triplet repeat sequence. In a case of Huntington’s Disease, the gene contains an abnormally large number of triplet repeats. The disease does not skip generations.  Huntington’s disease is caused by changes (mutations) of a gene that is located on the short arm (p) of chromosome 4 (4p16.3). Chromosomes are found in the nucleus of all body cells. They carry the genetic characteristics of each individual.  Huntington's disease (or Huntington's chorea) is a neurological disorder that is caused by a faulty gene on chromosome number 4. As such, it can not be caught, but can only be … passed from parents to children. A person who has a parent with HD has a 50%-50% chance of inheriting the gene.  Humans have 46 chromosomes (23 pairs). The faulty gene that causes Huntington's disease is found on chromosome number four. The normal copy of the gene produces a protein called huntingtin, but the faulty gene contains an abnormal region of what are called CAG repeats. This area is larger than normal and produces a mutant form of huntingtin. Inheriting Huntington's disease. A parent with the Huntington's disease gene has one good copy of the gene and one faulty copy. Their child will inherit one of these genes. Therefore, there's a 50:50 chance that the child will get the faulty gene and develop Huntington's disease. Huntington’s Disease After the Cheering. In 1983, optimism swept the world of brain science: a marker had been found for the gene for Huntington’s disease—an invariably fatal affliction that had dogged certain families in America for 12 generations. A long, difficult decade later, scientists made another thrilling announcement: The gene had been found.  Such is the current state of Huntington's disease (HD), an adult-onset autosomal dominant disorder. Today, researchers can literally measure the HD-associated gene, called huntingtin (HTT), by determining the number of repeats of a set of three specific bases within this gene. After determining that the HD gene is located on chromosome 4, the members of the Huntington's Disease Collaborative Research Group (HDCRG) joined forces and spent the next 10 years working diligently to identify the HD gene and to determine the nature of the HD-associated mutation (MacDonald et al. Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition). Adult-onset Huntington disease, the most common form of this disorder, usually appears in a person's thirties or forties. The HTT gene provides instructions for making a protein called huntingtin. Although the function of this protein is unknown, it appears to play an important role in nerve cells (neurons) in the brain. The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat.
http://www.alz.org/dementia/huntingtons-disease-symptoms.asp http://www.alzfdn.org/RelatedIllnesses/huntingtondisease.html http://rarediseases.org/rare-diseases/huntingtons-disease/ http://www.answers.com/Q/What_allele_and_chromosome_is_huntington%27s_disease_found_on http://www.nhs.uk/Conditions/Huntingtons-disease/Pages/Causes.aspx http://www.dana.org/Cerebrum/Default.aspx?id=39308 http://www.nature.com/scitable/topicpage/Huntington-s-Disease-The-Discovery-of-the-851 http://ghr.nlm.nih.gov/condition/huntington-disease
what chromosome is huntington's disease found on