It is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.
Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Coagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host. an antigenic substance of bacterial origin, produced chiefly by staphylococci, which may be causally related to thrombus formation. coagulase test. enzymatic conversion of fibrinogen in rabbit plasma to fibrin is used as a means of identifying pathogenic species of staphylococci. The test may be carried out rapidly on a slide or in several hours or overnight in a tube. Most coagulase-positive staphyloccoci are pathogenic; coagulase-negative ones commonly are not. The coagulase tube test has been set up as a demo for you to observe in class. This version of the coagulase test is used to identify the presence of either bound coagulase or free coagulase, which is an extracellular enzyme. Free coagulase reacts with a component of plasma called coagulase-reacting factor. The result is to cause the plasma to coagulate. In the demo, the coagulase plasma has been inoculated with Staphylococcus aureus and Staphylococcus epidermidis and allowed to incubate at 37˚C for 24 hours. Staphylococcus aureus produces free coagulase; Staphylococcus epidermidis does not. in the coagulase test, normally a virulent staphylococcus is put into plasma. plasma contains the plasma protein fibrinogen. when fibrinogen is acted upon by a fibrinogenase, … it is then converted to fibrin. fibrin has te ability to form clots. so in the case of staphylococcus aureus which has the enzyme coagulase also called fibrinogenase, the enzyme acts on the fibrinogen in plasma which is converted to fibrin hence the clots that are seen suspending in the solution after 4 hours. An enzyme that induces coagulation. Classified under: Nouns denoting substances. Hypernyms (coagulase is a kind of...): enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions). Hyponyms (each of the following is a kind of coagulase): thrombin (an enzyme that acts on fibrinogen in blood causing it to clot) However it is now known that not all S. aureus are coagulase-positive. It is also produced by Yersinia pestis. Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme protease to convert fibrinogen, a plasma protein produced by the liver, to fibrin. Coagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host. coagulase. a bacterial enzyme that reacts with a cofactor found in blood plasma to catalyze the formation of fibrin from fibrinogen. It is produced by most of the virulent strains of staphylococci, and by Yersinia pestis. enzymatic conversion of fibrinogen in rabbit plasma to fibrin is used as a means of identifying pathogenic species of staphylococci. The test may be carried out rapidly on a slide or in several hours or overnight in a tube. Most coagulase-positive staphyloccoci are pathogenic; coagulase-negative ones commonly are not. an antigenic substance of bacterial origin, produced chiefly by staphylococci, which may be causally related to thrombus formation. coagulase test. enzymatic conversion of fibrinogen in rabbit plasma to fibrin is used as a means of identifying pathogenic species of staphylococci. The test may be carried out rapidly on a slide or in several hours or overnight in a tube. coagulase. a bacterial enzyme that reacts with a cofactor found in blood plasma to catalyze the formation of fibrin from fibrinogen. It is produced by most of the virulent strains of staphylococci, and by Yersinia pestis.
https://en.wikipedia.org/wiki/Coagulase http://medical-dictionary.thefreedictionary.com/Coagulase-negative http://www.austincc.edu/microbugz/coagulase_test.php http://www.answers.com/Q/What_does_the_enzyme_coagulase_do http://www.audioenglish.org/dictionary/coagulase.htm https://en.wikipedia.org/wiki/Coagulase http://medical-dictionary.thefreedictionary.com/Coagulase-negative http://medical-dictionary.thefreedictionary.com/coagulase
what does coagulase do