When a blood vessel is injured, the coagulation cascade is initiated and each coagulation factor is activated in a specific order to lead to the formation of the blood clot.The body stops this blood loss through a complex clotting process called hemostasis. During hemostasis, the injured blood vessel constricts to reduce blood flow, platelets adhere to the injury site and clump (aggregate) together to form a loose platelet plug, and the coagulation cascade is initiated.
Clotting factors are proteins in the blood that control bleeding. When a blood vessel is injured, the walls of the blood vessel contract to limit the flow of blood to the damaged area. Blood Clots. Blood clotting, or coagulation, is an important process that prevents excessive bleeding when a blood vessel is injured. Platelets (a type of blood cell) and proteins in your plasma (the liquid part of blood) work together to stop the bleeding by forming a clot over the injury. The body stops this blood loss through a complex clotting process called hemostasis. During hemostasis, the injured blood vessel constricts to reduce blood flow, platelets adhere to the injury site and clump (aggregate) together to form a loose platelet plug, and the coagulation cascade is initiated. Blood clotting (technically  blood coagulation ) is the process by which (liquid) blood is transformed into a solid state. This blood clotting is a complex process involving many clotting factors (incl. calcium ions, enzymes, platelets, damaged tissues) activating each other. On the surface of these activated platelets, many different clotting factors work together in a series of complex chemical reactions (known as the coagulation cascade) to form a fibrin clot. The clot acts like a mesh to stop the bleeding. Coagulation factors circulate in the blood in an inactive form. When a blood vessel is injured, the coagulation cascade is initiated and each coagulation factor is activated in a specific order to lead to the formation of the blood clot. Coagulation factors are identified with Roman numerals (e.g. factor I or FI). Watch Dr. Roshni Kulkarni’s interactive animation. When blood vessels are cut or damaged, the loss of blood from the system must be stopped before shock and possible death occur. This is accomplished by solidification of the blood, a process called coagulation or clotting. 1  a plug of platelets enmeshed in a. 2  network of insoluble fibrin molecules.
http://www.wfh.org/en/page.aspx?pid=635 http://www.hematology.org/Patients/Clots/ https://labtestsonline.org/understanding/conditions/hypercoagulable-disorders http://www.ivyroses.com/HumanBody/Blood/Blood_Clotting.php http://www.wfh.org/en/page.aspx?pid=635 http://www.wfh.org/en/page.aspx?pid=635 http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html
process of clotting blood