It is a redox cofactor and a polyphenolic compound usually derived in food plants.
Pyrroloquinoline quinone (PQQ) was discovered by J.G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although he hypothesised that it was naphthoquinone). Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase and named it methoxatin. In 1979, Salisbury and colleagues as well as Duine and colleagues extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues identified that PQQ was also found in Acetobacter. 1 Failure to verify the presence of pyrroloquinoline quinone (PQQ) in bovine plasma amine oxidase by gas chromatography/mass spectrometry. The levels of free pyrroloquinoline quinone (PQQ) in various foods were examined by the use of gas chromatography-mass spectrometry. PQQ was extracted from the samples, after addition of [U-13C]PQQ as internal standard, with n-butanol and Sep-Pak C18 cartridges Pyrroloquinoline quinine, also known as PQQ, is a redox cofactor and a polyphenolic compound usually derived in food plants. It is classified as an essential micronutrient because of its usefulness to the body.  RE: Pyrroloquinoline quinone I recently started taking Life Extension Bio-PQQ, 10 mg, 1-2 per day. I also take Prozac, Risperdal and Immipramine. I noticed after perhaps 30 days of administration of PQQ what seemed like an increase in Norepinephrine and a decline in mood. Pyrroloquinoline quinone is prevalent in many foods associated with a healthy diet, so people that eat well-rounded meals should get enough to sustain their biological need. It is a water-soluble compound making it difficult to achieve PQQ toxicity. Pyrroloquinoline quinone (PQQ) influences energy-related metabolism and neurologic functions in animals. The mechanism of action involves interactions with cell signaling pathways and mitochondrial function. However, little is known about the response to PQQ in humans. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. What is Vitacost PQQ (pyrroloquinoline quinone)? Vitacost PQQ is a convenient way to obtain the micronutrient pyrroloquinoline quinone. PQQ is found in all plant foods, including fruits, vegetables, legumes and fermented beans, as well as in eggs, some meat and dairy products and human milk. http://www.vitacost.com/vitacost-pqq-pyrroloquinoline-quinone-10-mg-30-vegetarian-capsules-2. Vitacost PQQ Pyrroloquinoline Quinone -- 10 mg - 30 Vegetarian Capsules 5 5 4 4. Thank you vitacost for making this more affordable Research this product to find out its benefits. Although I don't really feel a difference, I have decided that it is definitely worth taking These enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. Subsequently, PQQ was found to stimulate growth in bacteria. In addition, antioxidant and neuroprotective effects were also found. In 1979, Salisbury and colleagues as well as Duine and colleagues extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues identified that PQQ was also found in Acetobacter. When I pointed out to the journal Nature that their high reputation was being used to justify investments of millions of dollars in the development of PQQ as a vitamin, they investigated the original paper, agreed with our objections and published our argument against it (Felton & Anthony, Nature Vol. 433, 2005). In 1979, Salisbury and colleagues as well as Duine and colleagues extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues identified that PQQ was also found in Acetobacter.
https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136652/ http://michaelrucker.com/pqq-info/what-is-pqq-pyrroloquinoline-quinine/ http://michaelrucker.com/sandbox/pqq/supplement/ http://www.ncbi.nlm.nih.gov/pubmed/24231099 http://www.vitacost.com/vitacost-pqq-pyrroloquinoline-quinone-10-mg-30-vegetarian-capsules-2 https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone
what is pyrroloquinoline quinone