A low platelet count is often assumed to be ITP (immune thrombocytopenia). However, there are many other possible causes of thrombocytopenia, with clinical severity ranging from trivial to life threatening. ITP is a diagnosis of exclusion.It can only be diagnosed after all other causes of low platelets are ruled out.
Many factors can cause thrombocytopenia (a low platelet count). The condition can be inherited or acquired. Inherited means your parents pass the gene for the condition to you. Acquired means you aren't born with the condition, but you develop it. Sometimes the cause of thrombocytopenia isn't known. In general, a low platelet count occurs because: 1  The body's bone marrow doesn't make enough platelets. 2  The bone marrow makes enough platelets, but the body destroys them or uses them up. 3  The spleen holds on to too many platelets A low platelet count is often assumed to be ITP (immune thrombocytopenia). However, there are many other possible causes of thrombocytopenia, with clinical severity ranging from trivial to life threatening. ITP is a diagnosis of exclusion. It can only be diagnosed after all other causes of low platelets are ruled out. When thrombocytopenia is severe (a platelet count less than 20-30,000/microliter), and other obvious causes are ruled out, many doctors administer the first-line treatments for ITP: prednisone, anti-D, IVIG. A rapid response to these therapies supports the diagnosis of ITP. Many people who have large platelets also have a reduced platelet count. The platelet size can be genetic, as seen in people with Bernard-Soulier syndrome, gray platelet syndrome, and May-Hegglin anomaly. In other cases, it may occur in response to problems in the bone marrow, such as cancers that disrupt the production of blood cells. The most common problem experienced by people with large platelets is increased bleeding. Thrombocytopenia is defined as a platelet count of less than 150,000/mm 3. With normal platelet function, thrombocytopenia is rarely the cause of bleeding unless the count is less than 50,000/mm 3. Thrombocytopenia should always be confirmed by examination of a peripheral smear.  4. My report mentions giant platelets.. Giant platelet is a term used to describe platelets that are abnormally large, i.e., as large as a normal red blood cell. These may be seen in certain disorders such as immune thrombocytopenic purpura (ITP) or in rare inherited disorders such as Bernard-Soulier disease.  Large platelet distribution width: A test which provides information about the range of platelet size in a blood sample. See detailed information below for a list of 1 causes of Large platelet distribution width, including diseases and drug side effect causes. Causes of Large platelet distribution width: The following medical conditions are some of the possible causes of Large platelet distribution width. There are likely to be other possible causes, so ask your doctor about your symptoms. 1  Essential thrombocythaemia. Top 10 amazing movie makeup transformations. The dangers of large platelets vary, depending on the underlying cause for the increase in platelet size. In some patients, they may not cause any symptoms or problems, while others may develop bleeding disorders and other medical issues. In other cases, it may occur in response to problems in the bone marrow, such as cancers that disrupt the production of blood cells. The most common problem experienced by people with large platelets is increased bleeding. 1 Thrombotic thrombocytopenic purpura. 2  This is a rare condition that occurs when small blood clots suddenly form throughout your body, using up large numbers of platelets. 3  Hemolytic uremic syndrome. 4  This rare disorder causes a sharp drop in platelets, destruction of red blood cells and impairment of kidney function. Platelets are produced in your bone marrow. If production is low, you may develop thrombocytopenia. Factors that can decrease platelet production include: 1  Leukemia. 2  Some types of anemia. 3  Viral infections, such as hepatitis C or HIV. 4  Chemotherapy drugs A low platelet count can occur even if the bone marrow makes enough platelets. The body may destroy its own platelets due to autoimmune diseases, certain medicines, infections, surgery, pregnancy, and some conditions that cause too much blood clotting. Acquired means you aren't born with the condition, but you develop it. Sometimes the cause of thrombocytopenia isn't known. In general, a low platelet count occurs because: 1  The body's bone marrow doesn't make enough platelets. 2  The bone marrow makes enough platelets, but the body destroys them or uses them up.
http://www.nhlbi.nih.gov/health/health-topics/topics/thcp/causes http://www.pdsa.org/resources/other-platelet-disorders.html http://www.wisegeekhealth.com/what-are-the-dangers-of-large-platelets.htm http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hematology-oncology/disorders-platelet-function/ https://labtestsonline.org/understanding/analytes/platelet/tab/faq http://www.rightdiagnosis.com/sym/large_platelet_distribution_width.htm http://www.wisegeekhealth.com/what-are-the-dangers-of-large-platelets.htm http://www.mayoclinic.org/diseases-conditions/thrombocytopenia/basics/causes/CON-20027170 http://www.nhlbi.nih.gov/health/health-topics/topics/thcp/causes
large platelets causes