Heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Our results show that ANA is sensitive in systemic lupus erythematosus (SLE) and progressive systemic sclerosis even in early disease but is not specific. Other specific autoantibodies were seen most frequently in SLE but were relatively insensitive and were seen in low frequency in UCTD.  Noting that many people with lupus had a disease that not only affected the skin but many other organs in the body as well, Osler added the word systemic to the term lupus erythematosus to distinguish this type of disease from discoid lupus erythematosus. Neonatal lupus is the occurrence of SLE symptoms in an infant born from a mother with SLE, most commonly presenting with a rash resembling discoid lupus erythematosus, and sometimes with systemic abnormalities such as heart block or enlargement of the liver and spleen. Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. Neonatal lupus is the occurrence of SLE symptoms in an infant born from a mother with SLE, most commonly presenting with a rash resembling discoid lupus erythematosus, and sometimes with systemic abnormalities such as heart block or enlargement of the liver and spleen. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Neonatal lupus is the occurrence of SLE symptoms in an infant born from a mother with SLE, most commonly presenting with a rash resembling discoid lupus erythematosus, and sometimes with systemic abnormalities such as heart block or enlargement of the liver and spleen. Systemic lupus erythematosus (SLE) is a systemic connective tissue disease. Its prevalence is currently estimated at 40-200 per 100,000 of the general population. SLE is ninefold more common in women than in men. The onset of the disease is usually at 16-55 years of age (in 65% of patients). 1 Pulmonary hypertension is typical for systemic sclerosis and systemic lupus erythematosus. 2  Pulmonary hypertension is an important but still often underestimated component of the clinical picture of systemic connective tissue diseases. The most common connective tissue diseases include systemic lupus erythematosus, antiphospholipid syndrome, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and systemic sclerosis, all of which will be discussed in this chapter. 1 Pulmonary hypertension is typical for systemic sclerosis and systemic lupus erythematosus. 2  Pulmonary hypertension is an important but still often underestimated component of the clinical picture of systemic connective tissue diseases. Systemic connective tissue diseases are associated with the following cardiac abnormalities: 1  Cardiac valvular changes, including nonbacterial vegetations and leaflet fibrosis and thickening, are seen in systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis. 1 Pulmonary hypertension is typical for systemic sclerosis and systemic lupus erythematosus. 2  Pulmonary hypertension is an important but still often underestimated component of the clinical picture of systemic connective tissue diseases. Types of Cardiac Involvement. Pericarditis The most common presentation of cardiac involvement in lupus is pericarditis. The pericardium is a connective tissue that surrounds the heart and cushions it in the chest. When this becomes inflamed by lupus or other inflammatory dise ases it can cause chest pain. Introduction. “Lupus,”or systemic lupus erythematosus (SLE) is a disorder that may affect many different parts of the body including the skin, joints and kidneys. It is generally not known that lupus can involve the heart in several different and important ways. Cutaneous Lupus affects primarily the skin, is common among patients with lupus erythematosus. The most prevalent and severe form of cutaneous lupus is called chronic cutaneous lupus. It is commonly known as discoid lupus, but it has other forms as well. Discoid lupus erythematosus is a chronic skin disorder in which a red, raised rash appears on the face, scalp, or elsewhere. Lupus erythematosus is a chronic, inflammatory, multisystem disorder of the immune system. “Lupus” means wolf and Erythematosus means “redness.” Doctors coined this name for the disease because they thought the facial rash that frequently accompanies lupus looked like the bite of a wolf.
http://www.ncbi.nlm.nih.gov/pubmed/1757935 https://en.wikipedia.org/wiki/Systemic_lupus_erythematosus https://en.wikipedia.org/wiki/Systemic_lupus_erythematosus https://en.wikipedia.org/wiki/Systemic_lupus_erythematosus http://www.wikiecho.org/wiki/Systemic_Lupus_Erythematosus http://www.wikiecho.org/wiki/Systemic_Lupus_Erythematosus http://www.wikiecho.org/wiki/Systemic_Lupus_Erythematosus http://www.lupusinternational.com/About-Lupus-1-1/Lupus-and-the-Heart-.aspx http://lupus.us.com/lupus-overview.html
Lupus erythematosus is a common connective-tissue disease that is most frequently seen in