Pediatric acute-onset neuropsychiatric syndrome (PANS) is a neuropsychiatric syndrome still under research, leading to rapid onset Obsessive-compulsive disorder (OCD) and/or tics in children and adolescents.
Like PANS, children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) have an acute onset – within 2 to 3 days – of neuropsychiatric symptoms, specifically OCD or tics (involuntary, purposeless movements). Although PANDAS was identified as a medical syndrome more than a decade before PANS, it has been classified as a subset of PANS. To date, PANDAS is the only known subset of PANS, but we may discover more causes in the future. From Wikipedia, the free encyclopedia. Pediatric acute-onset neuropsychiatric syndrome (PANS) is a neuropsychiatric syndrome still under research, leading to rapid onset Obsessive-compulsive disorder (OCD) and/or tics in children and adolescents. The proposed criteria claims that children can be distinguished from traditional childhood onset OCD by the severity, abruptness and dramatic onset of symptoms. According to Swedo, Leckman and Rose (2012), pediatric patients suffering from PANS would be identified by the following criteria: Like PANS, children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) have an acute onset – within 2 to 3 days – of neuropsychiatric symptoms, specifically OCD or tics (involuntary, purposeless movements). They are often diagnosed with obsessive-compulsive disorder (OCD) or an eating disorder, but the sudden onset of symptoms separates PANS from these other disorders. In addition, they may have symptoms of depression, irritability, anxiety, and have difficulty with schoolwork. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinical diagnosis given to children who have a dramatic – sometimes overnight – onset of neuropsychiatric symptoms including obsessions/compulsions or food restriction. Although PANDAS was identified as a medical syndrome more than a decade before PANS, it has been classified as a subset of PANS. To date, PANDAS is the only known subset of PANS, but we may discover more causes in the future. In the rest of the cases, the cause(s) is presently unknown, and the disease is said to be “idiopathic” in nature. PAN is a multisystem disease that may present with fever, sweats, weight loss, and severe muscle and joint aches/pains. PAN may develop in a subacute fashion, over several weeks or months. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinical diagnosis given to children who have a dramatic – sometimes overnight – onset of neuropsychiatric symptoms including obsessions/compulsions or food restriction. They are often diagnosed with obsessive-compulsive disorder (OCD) or an eating disorder, but the sudden onset of symptoms separates PANS from these other disorders. In addition, they may have symptoms of depression, irritability, anxiety, and have difficulty with schoolwork. PANDAS is hypothesized to be an autoimmune disorder that results in a variable combination of tics, obsessions, compulsions, and other symptoms that may be severe enough to qualify for diagnoses such as chronic tic disorder, OCD, and Tourette syndrome (TS or TD). The proposed link between infection and these disorders is that an initial autoimmune reaction to a GABHS infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations. It has been proposed that this autoimmune response can result in a broad range of neuropsychiatric symptoms. Polyarteritis nodosa (PAN) is a rare disease that results from blood vessel inflammation (vasculitis) causing injury to organ systems. The areas most commonly affected by PAN include the nerves, intestinal tract, heart, and joints. High blood pressure is common in PAN and usually due to vasculitis decreasing blood flow to the kidneys. PAN may affect nerves and cause abnormal sensations, numbness or loss of strength. Any combination of these symptoms may be present. PANDAS has not been validated as a disease entity; it is not listed as a diagnosis by the International Statistical Classification of Diseases and Related Health Problems (ICD) or the Diagnostic and Statistical Manual of Mental Disorders (DSM). The proposed link between infection and these disorders is that an initial autoimmune reaction to a GABHS infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations. It has been proposed that this autoimmune response can result in a broad range of neuropsychiatric symptoms. Treatment of OCD or Tourette possibly caused by PANS is generally the same as the standard therapies for OCD and Tourettes (symptomatic treatment). It has, however, been observed that children with PANS appear to be unusually sensitive to the side-effects of SSRIs. The proposed criteria claims that children can be distinguished from traditional childhood onset OCD by the severity, abruptness and dramatic onset of symptoms. According to Swedo, Leckman and Rose (2012), pediatric patients suffering from PANS would be identified by the following criteria:
http://www.stanfordchildrens.org/en/service/pans-pandas/what-are-pans-pandas https://en.wikipedia.org/wiki/Pediatric_acute-onset_neuropsychiatric_syndrome_(PANS) http://med.stanford.edu/pans.html http://www.stanfordchildrens.org/en/service/pans-pandas/what-are-pans-pandas http://www.hopkinsvasculitis.org/types-vasculitis/polyarteritis-nodosa/ http://med.stanford.edu/pans.html https://en.wikipedia.org/wiki/PANDAS http://my.clevelandclinic.org/health/diseases_conditions/hic_Polyarteritis_Nodosa https://en.wikipedia.org/wiki/PANDAS https://en.wikipedia.org/wiki/Pediatric_acute-onset_neuropsychiatric_syndrome_(PANS)
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