LRP5 gene and EN1 gene.
Genes are not solely to blame for the cause of osteoporosis; there are other factors as well which can lead to osteoporosis. Osteoporosis is the loss of bone mass. For example, being deficient or not consuming enough calcium can contribute to loss of bone mass, which then contributes to osteoporosis. New genetic cause of osteoporosis found, rare gene identified. By: Bel Marra Health | Osteoporosis | Tuesday, September 15, 2015 - 17:30 PM. A rare gene – the EN1 gene – has been identified as a potential osteoporosis cause by researchers at McGill University. With the use of extensive genetic data from the UK10K project, the research team uncovered that a variant of the EN1 gene has a large effect on bone mineral density (BMD) Role of genes in osteoporosis. The study of genes and how they relate to osteoporosis has been an area of study for a long time. Osteoporosis may be affected by many gene variants and how they interact with environmental factors. New genetic cause of osteoporosis found, rare gene identified. By: Bel Marra Health | Osteoporosis | Tuesday, September 15, 2015 - 17:30 PM. A rare gene – the EN1 gene – has been identified as a potential osteoporosis cause by researchers at McGill University. With the use of extensive genetic data from the UK10K project, the research team uncovered that a variant of the EN1 gene has a large effect on bone mineral density (BMD) The risk of osteoporosis is influenced by many factors such as age, sex, diet, physical activity, medication use and menopausal status, but one of the most important clinical risk factors is a positive family history, underscoring the role of genetic factors in determining disease susceptibility.  As a common bone disease, osteoporosis increases the risk of bone fractures as bone mineral density decreases over time, making them frail. As the population continues to age, osteoporosis is becoming more prevalent. The UK10K measured genetic variants from 10,000 individuals in great detail. New genetic cause of osteoporosis found, rare gene identified. By: Bel Marra Health | Osteoporosis | Tuesday, September 15, 2015 - 17:30 PM. A rare gene – the EN1 gene – has been identified as a potential osteoporosis cause by researchers at McGill University. With the use of extensive genetic data from the UK10K project, the research team uncovered that a variant of the EN1 gene has a large effect on bone mineral density (BMD) Juvenile primary osteoporosis is a skeletal disorder characterized by thinning of the bones (osteoporosis) that begins in childhood. Osteoporosis is caused by a shortage of calcium and other minerals in bones (decreased bone mineral density), which makes the bones brittle and prone to fracture. Many people with childhood-onset osteoporosis do not have a mutation in the LRP5 gene. (When its cause is unknown, the condition is often called idiopathic juvenile osteoporosis). It is likely that mutations in other genes that have not been identified are involved in this condition. Read more about Mutations in the LRP5 gene can cause juvenile primary osteoporosis. This gene provides instructions for making a protein that participates in a chemical signaling pathway that affects the way cells and tissues develop. In particular, the LRP5 protein is involved in the regulation of bone mineral density. Many people with childhood-onset osteoporosis do not have a mutation in the LRP5 gene. (When its cause is unknown, the condition is often called idiopathic juvenile osteoporosis). It is likely that mutations in other genes that have not been identified are involved in this condition. Read more about Osteoporosis is a common disease with a strong genetic component. In recent years, some progress has been made in understanding the genetic basis of osteoporosis. Genetic factors contribute to osteoporosis by influencing not only bone mineral density but also bone size, bone quality, and bone turnover. Meta-analysis has been used to define the role of several candidate genes in osteoporosis Genes that cause monogenic bone diseases also contribute to regulation of bone mass in the normal population. Genome-wide association studies and functional genomics approaches have recently begun to apply to genetic studies of osteoporosis. In recent years, some progress has been made in understanding the genetic basis of osteoporosis. Genetic factors contribute to osteoporosis by influencing not only bone mineral density but also bone size, bone quality, and bone turnover. Defining Osteoporosis. Osteoporosis is a disease marked by reduced bone strength leading to an increased risk of fractures, or broken bones. Bone strength has two main features: bone mass (amount of bone) and bone quality. Osteoporosis is the major underlying cause of fractures in postmenopausal women and the elderly. Although low bone mass (or low bone density) plays an important role in determining a person's risk of osteoporosis, it is only one of many risk factors for fractures. Fracture risk results from a combination of bone-dependent and bone-independent factors.
http://www.belmarrahealth.com/new-genetic-cause-of-osteoporosis-found-rare-gene-identified/ http://www.belmarrahealth.com/new-genetic-cause-of-osteoporosis-found-rare-gene-identified/ http://www.medscape.com/viewarticle/738867 http://www.belmarrahealth.com/new-genetic-cause-of-osteoporosis-found-rare-gene-identified/ http://ghr.nlm.nih.gov/condition/juvenile-primary-osteoporosis http://ghr.nlm.nih.gov/condition/juvenile-primary-osteoporosis http://www.ncbi.nlm.nih.gov/pubmed/16762578 http://www.ncbi.nlm.nih.gov/pubmed/16762578 http://www.niams.nih.gov/health_info/Bone/Osteoporosis/osteoporosis_hoh.asp
what genes cause osteoporosis