This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. 1 Studied the association of Tumor Necrosis Factor (TNF-alpha) Locus-308 variant, TNF-alpha and Interleukin (IL-10) Cytokine with the risk of silicosis and its progress in Indonesian cement factory workers. 1 Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. 1 Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. 2  TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia 1 Results suggest that tumor necrosis factor (TNF) is a major cytokine involved in inflammatory reaction and a mortality predictor in patients with coronary artery disease (CAD). 2  TNF-alpha-857 gene polymorphisms influence severity of the disease. 1 Studied the association of Tumor Necrosis Factor (TNF-alpha) Locus-308 variant, TNF-alpha and Interleukin (IL-10) Cytokine with the risk of silicosis and its progress in Indonesian cement factory workers. Tumor necrosis factors (or the TNF family) refer to a group of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were: 1  Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. 2  Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. 1 Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. 2  TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia Anti-tumor necrosis factor (anti-TNF) drugs are a class of drugs that are used worldwide to treat inflammatory conditions such as rheumatoid arthritis (RA) , psoriatic arthritis, juvenile arthritis, inflammatory bowel disease (Crohn’s and ulcerative colitis), ankylosing spondylitis and psoriasis. How it works. TNF is a chemical produced by the immune system that causes inflammation in the body. In healthy individuals, excess TNF in the blood is blocked naturally, but in those who have rheumatic conditions, higher levels of TNF in the blood lead to more inflammation and persistent symptoms. TNF blockers suppress the immune system by blocking the activity of TNF, a substance in the body that can cause inflammation and lead to immune-system diseases, such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and plaque psoriasis.  Author information: (1)IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy. Tumor necrosis factor-alpha (TNF-alpha) is a central regulator of inflammation, and TNF-alpha antagonists may be effective in treating inflammatory disorders in which TNF-alpha plays an important pathogenetic role. Recombinant or modified proteins are an emerging class of therapeutic agents.  From NCBI Gene : This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. 
http://www.ncbi.nlm.nih.gov/gene/7124 https://en.wikipedia.org/wiki/Tumor_necrosis_factors http://www.ncbi.nlm.nih.gov/gene/7124 https://en.wikipedia.org/wiki/Tumor_necrosis_factors https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Anti-TNF http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm109340.htm http://www.ncbi.nlm.nih.gov/pubmed/19689289 http://ghr.nlm.nih.gov/gene/TNF
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