CGRP Monoclonal Antibody is directed against rat CGRP protein. The antibody was purified from concentrated tissue culture supernate by Protein G chromatography.
Calcitonin gene-related peptide (CGRP) is a well-studied neuropeptide of relevance for migraine pathophysiology. Jugular levels of CGRP are increased during migraine attacks, and intravenous CGRP administration induces migraine-like headache in most individuals with migraine. CGRP antibody recognizes Calcitonin Gene Related Peptide or CGRP which is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known. CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. It is a strong endogenous vasodilator. CGRP concentration increases in migraine attacks and hence, it is involved in the pathogenesis of migraine headaches 2. Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunoneutralization and radioimmunoassay. Monoclonal antibody (mAb) treatment has revolutionized the approach to many diseases. They comprise immunoglobulin G (IgG) isotypes. Calcitonin gene-related peptide (CGRP) is important in migraine pathogenesis. Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for immunohistochemistry at a working antibody dilution of 1:200 to 1:1000 using formalin-fixed, paraffin-embedded sections or cryostat tissue sections. The antibody may be used for immunofluorescence at a working dilution of 1:500. Application. Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunocytochemistry and immunohistochemistry 1. It can also be used in ELISA. Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for ELISA at a working concentration of 0.25- 0.5 μg/ml. The antibody may be used for immunofluorescence at a working dilution of 1:100 in rat nerve fibres and human dorsal root ganglia. Anti-CGRP Monoclonal Antibody is directed against rat CGRP protein. The antibody was purified from concentrated tissue culture supernate by Protein G chromatography. This antibody is specific for human and CGRP monoclonal antibodies show promise in treating migraine. Migraine researchers and clinicians are growing excited about a new class of drugs called Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies, which are showing promise in treating high-frequency episodic migraine and chronic migraine.
http://www.ncbi.nlm.nih.gov/pubmed/24638916 http://www.rockland-inc.com/Product.aspx?id=40809 http://www.sigmaaldrich.com/catalog/product/sigma/c7113?lang=en&region=US http://www.touchneurology.com/articles/therapeutic-monoclonal-antibodies-migraine http://www.sigmaaldrich.com/catalog/product/sigma/c9487?lang=en&region=US http://www.sigmaaldrich.com/catalog/product/sigma/c7113?lang=en&region=US http://www.rockland-inc.com/Product.aspx?id=40809 http://www.news-medical.net/news/20150617/CGRP-monoclonal-antibodies-show-promise-in-treating-migraine.aspx
what is cgrp monoclonal antibodies