Negri bodies
Some electron microscopy studies suggest that the budding step occurs at the level of internal cellular compartments (27, 28). Rabies virus infection induces the formation of cytoplasmic inclusion bodies (IBs) that are called Negri bodies (29). Since these structures are typical of rabies infection of the brain, they have a diagnostic value and have been used as definite histological proof of such infection. The rabies virus is usually transmitted via an animal bite, however, cases have also been reported in which the virus penetrated the body through infected saliva, moist tissues such as the eyes or lips, a scratch on the skin, or the transplantation of infected tissues. The present study characterizes the morphogenesis and functions of the IBs that are found in the cytoplasm of cells infected by rabies virus. We show that these IBs have staining characteristics that are similar to those of the Negri bodies found in certain nerve Rabies is transferred to humans through the bite of an infected animal. In the case of humans, the most common mode of transmission is through dog bites. Rabies is endemic throughout the world except in Australia, Japan, Great Britain, Hawaii, and many smaller islands including most of the islands of the Caribbean. Abstract. Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNA–N complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P). Rabies is an acute viral disease of the central nervous system that affects humans and other mammals but is most common in carnivores (flesh-eaters). It is sometimes referred to as a zoonosis, or disease of animals that can be communicated to humans. Rabies virus infection induces the formation of cytoplasmic inclusion bodies that resemble Negri bodies found in the cytoplasm of some infected nerve cells. ABSTRACT. Rabies virus infection induces the formation of cytoplasmic inclusion bodies that resemble Negri bodies found in the cytoplasm of some infected nerve cells. We have studied the morphogenesis and the role of these Negri body-like structures (NBLs) during viral infection.
http://jvi.asm.org/content/83/16/7948.full http://medical-dictionary.thefreedictionary.com/Rabbies http://jvi.asm.org/content/83/16/7948.full http://webspace.ship.edu/lhelli/rabies/ http://www.sciencedirect.com/science/article/pii/B9780123870407000019 http://medical-dictionary.thefreedictionary.com/Rabbies http://jvi.asm.org/content/83/16/7948.full http://jvi.asm.org/content/83/16/7948.full
characteristic inclusion bodies formed in rabies are called