Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States.
Additional resources from MedlinePlus. Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States.  It is less common than CMT1. CMT2A, the most common axonal form of CMT, is caused by mutations in Mitofusin 2, a protein associated with mitochondrial fusion. CMT2A has also been linked to mutations in the gene that codes for the kinesin family member 1B-beta protein, but this has not been replicated in other cases. Some forms of CMT are inherited in an autosomal dominant fashion, which means that only one copy of the abnormal gene is needed to cause the disease. Other forms of CMT are inherited in an autosomal recessive fashion, which means that both copies of the abnormal gene must be present The gene mutations in CMT disease are usually inherited. Each of us normally possesses two copies of every gene, one inherited from each parent. Some forms of CMT are inherited in an autosomal dominant fashion, which means that only one copy of the abnormal gene is needed to cause the disease. Other forms of CMT are inherited in an autosomal recessive fashion, which means that both copies of the abnormal gene must be present to cause the disease. Knowledge center. Charcot-Marie-Tooth Disease (CMT) , also known as Chacot-Marie-Tooth hereditary neuropathy, peroneal muscular atrophy, and hereditary motor and sensory neuropathy, is a genetic disease of nerves, typically with progressive muscle weakness, particularly the arms and legs. As CMT is a hereditary disease, people who have close family members with CMT have a higher risk of developing the condition themselves. Understanding how the periphery nerves function is important if you want to have a better appreciation of what causes CMT. Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. Some forms of CMT are inherited in an autosomal dominant fashion, which means that only one copy of the abnormal gene is needed to cause the disease. Other forms of CMT are inherited in an autosomal recessive fashion, which means that both copies of the abnormal gene must be present For the Canadian channel of the same name, see CMT (Canadian TV channel) . CMT (typically abbreviated as CMT, previously as CMTV) is an American basic cable and satellite television channel that is owned by Viacom Music and Entertainment Group, a unit of the Viacom Media Networks division of Viacom.  1 Charcot-Marie-Tooth disease (CMT) is composed of types of inherited neurological disorders that affect peripheral nerves resulting in weakness in the musculature; the disease may get progressively worse over time. Charcot-Marie-Tooth disease, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. CMT is a genetic disease-it is an inherited disease. It is caused by inherited mutated genes that are involved in producing substances (proteins) which affect either the axon or myelin sheath of the peripheral nerve. In all cases of CMT, several mutated genes are involved in causing the condition (not just one). As CMT is a hereditary disease, people who have close family members with CMT have a higher risk of developing the condition themselves. Understanding how the periphery nerves function is important if you want to have a better appreciation of what causes CMT. Charcot-Marie-Tooth Disease, or CMT, is a group of inherited disorders that affect the peripheral nerves, which are the nerves outside the brain and spinal cord. There are more than 70 kinds of CMT. Each kind is caused by a different kind of mutation, and more causes are being discovered every year. CMT is just one kind of neuropathy (also called peripheral neuropathy), meaning simply that the peripheral nerves are damaged. 1 There are many forms of CMT (for example, CMT 1-4, CMTX); these forms are related to the mutations in the genes that alter the peripheral nerves and/or their myelin sheaths. 2  Charcot-Marie-Tooth disease is diagnosed with the patient's medical history, family history, and neurological examination. Charcot-Marie-Tooth disease, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs.
http://www.ninds.nih.gov/disorders/charcot_marie_tooth/charcot_marie_tooth.htm http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm http://www.medicalnewstoday.com/articles/172056.php http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm https://en.wikipedia.org/wiki/CMT_%28U.S._TV_channel%29 http://www.medicinenet.com/charcot-marie-tooth-disease/article.htm http://www.medicalnewstoday.com/articles/172056.php http://www.cmtausa.org/understanding-cmt/what-is-cmt/ http://www.medicinenet.com/charcot-marie-tooth-disease/article.htm
what is cmt