10.5826/dpc.1203a112
text/xml
2160-9381
2088
en
Daniel Fernandes Melo
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
Perinevoid Alopecia
Perinevoid alopecia: an unusual presentation of alopecia areata
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Image Letter
2022-07-28
2021-10-05
2022-07-28
2022-09-15
e2022112
Dermatol Pract Concept
Daniel Fernandes Melo
2022/07/28
10.5826/dpc.1203a112
e2022112
Dermatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
2160-9381
Perinevoid Alopecia
en
e2022112
Perinevoid alopecia: an unusual presentation of alopecia areata
https://dpcj.org/index.php/dpc/article/download/2088/1674
                    Dermatology Practical & Conceptual


        Perinevoid Alopecia: an Unusual Presentation
                     of Alopecia Areata
               José Leonardo Rodrigues Machado1, Rita Fernanda Cortez de Almeida2,
                         Simone Carolina Frattini3, Daniel Fernandes Melo2


1 Dermatology Department, Faculdade IPEMED de Ciências Médicas (AFYA), Rio de Janeiro, Brazil
2 Dermatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
3 Mental Health Department, Guelph General Hospital, Guelph, Ontario, Canada



Citation: Machado JLR, Cortez de Almeida RF, Frattini SC, Melo DF. Perinevoid alopecia: an unusual presentation of alopecia areata.
Dermatol Pract Concept. 2022;12(3):e2022112. DOI: https://doi.org/10.5826/dpc.1203a112
Accepted: November 12, 2021; Published: July 2022
Copyright: ©2022 Machado et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-
NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use,
distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing interests: None.
Authorship: All authors have contributed significantly to this publication
Corresponding author: Daniel Fernandes Melo, MSc MD, Address: Estrada dos Tres Rios 1200 – office 810 – Zip code 22745-052 Email
address: danielfernandesmelo@yahoo.com.br




Case Presentation
A 19-year-old healthy male complained of sudden onset
of asymptomatic single patch alopecia on the occiput
for three months. The round patch of non-scarring alo-
pecia surrounded a pre-existent pigmented dome-shaped
compound nevus, which did not change over time
(Figure 1). Trichoscopic features were compatible with al-
opecia areata (AA), and the patient decided on conserva-
tive management.


Teaching point
Perinevoid alopecia (PA) is an extremely rare variant of AA
associated with a central generally pigmented nevus [1]. Al-
though the pathogenesis is still unclear, it is thought that PA
is secondary to an inflammatory response against nevus cells
or melanocytic structures [1,2]. Immune cells around the ne-
vus attack the hair follicle, similarly to the destruction of me-       Figure 1. A 1-cm diameter round patch of non-scarring alopecia
lanocytes in a halo nevus, other nevocentric phenomena [2].             surrounding a pre-existent pigmented dome-shaped compound sub-
Surgical removal of the nevus may lead to hair regrowth a               type nevus on the right side of the occiput.



Image Letter | Dermatol Pract Concept. 2022;12(3):e2022112                                                                            1
few weeks after excision [1,2]. Recognizing PA is essential to       2. Ruiz-Arriaga LF, López-García L, Vega-Memije ME. Perinevoid
properly manage this unique variant of AA.                              Alopecia: A Case Report. Skin Appendage Disord. 2019;5(2):
                                                                        94-96. DOI:10.1159/000490469. PMID: 30815441. PMCID:
                                                                        PMC6388562.\
References
1. Kimura H, Nagase K, Narisawa Y. Perinevoid alopecia: a case re-
   port and literature review. Br J Dermatol. 2018;179(4):969-970.
   DOIi:10.1111/bjd.16709. MID: 29704462.




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