10.5826/dpc.1302a84
text/xml
2160-9381
2647
en
Daniel Morgado-Carrasco
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
Dermoscopic Features of Granular Cell Tumor
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Image Letter
2023-04-29
2022-06-12
2023-04-29
2023-06-05
e2023084
Dermatol Pract Concept
Daniel Morgado-Carrasco
2023/04/29
10.5826/dpc.1302a84
e2023084
Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain
2160-9381
en
e2023084
Alaoui A, Douhi Z, Elloudi S, Baybay H, Mernissi F. Abrikossoff’s tumor: Clinical and dermoscopic features. Journal of Dermatology & Cosmetology. 2019;3(5):130. DOI: 10.15406/jdc.2019.03.00129
Dermoscopic Features of Granular Cell Tumor
https://dpcj.org/index.php/dpc/article/download/2647/2095
         Dermoscopic Features of Granular Cell Tumor
               Lluís Corbella-Bagot1, Jaime Piquero-Casals2, Daniel Morgado-Carrasco1


1 Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain
2 Dermik, Clínica Dermatológica Multidisciplinar, Barcelona, Spain



Citation: Corbella-Bagot L, Piquero-Casals J, Morgado-Carrasco D. Dermoscopic Features of Granular Cell Tumor.
Dermatol Pract Concept. 2023;13(2):e2023084. DOI: https://doi.org/10.5826/dpc.1302a84
Accepted: August 22, 2022; Published: April 2023
Copyright: ©2023 Corbella-Bagot et al. This is an open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted
noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing Interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding Author: Daniel Morgado-Carrasco, Dermatology Department, Hospital Clínic de Barcelona, C/ Villarroel, 170, 08036,
Barcelona, Spain. Tel: (+34) 93 227 54 00; Fax: (+34) 932275438 E-mail: morgadodaniel8@gmail.com




Case Presentation
An otherwise healthy 35-year-old male presented with a ten-
der and fast-growing nodule on the flank, of one year of evo-
lution. Clinical examination showed a 2 cm firm and shiny
pigmented nodule. Dermoscopy revealed brown radial lines
and perifollicular scaling, together with coiled and twisted
hairs. Structureless pale areas were also observed (Figure 1).
Histologic evaluation confirmed the diagnosis of a benign
form of a granular cell tumor (GCT).


Teaching Point
GCT is an infrequent tumor usually presenting as a firm,
sometimes pigmented nodule on mucosae or on the skin of
the head or neck. GCT seems to originate from Schwann                    Figure 1. Dermoscopic image showing a pigmented tumor with
cells, which is supported by the expression of S-100 and my-             large, radial brown lines. Perifollicular scaling, together with coiled
elin proteins upon immunohistochemical staining. Dermal                  and twisted hairs is also observed, as well as structureless pale areas.




Image Letter | Dermatol Pract Concept. 2023;13(2):e2023084                                                                                    1
collagen, small nerves and adnexal structures are commonly          Differential diagnosis of pigmented lesions can be chal-
infiltrated by tumoral cells, even though only 1%-2% of          lenging. Dermoscopy may help to confirm suspected GCT.
GCT are malignant. Surgical excision is the recommended             A written consent form signed by the patient has been
treatment. Very few dermoscopic reports are found in the         obtained.
literature. Dermoscopy of GCT can show a yellowish cen-
ter (with or without hypopigmented lines), surrounded by
                                                                 References
thin brown reticular lines. Small pale circles have also been
described [1,2]. Differential diagnosis of tumors presenting     1. Popadić M. Dermoscopy of cutaneous Abrikossoff tumor (gran-
with brown reticular lines is broad and includes melanocytic        ular cell tumor) in a pediatric patient. J Am Acad Dermatol.
                                                                    2015;73(4):e137-e138.     DOI:     10.1016/j.jaad.2015.06.056.
and non-melanocytic lesions such as dermatofibroma, sebor-
                                                                    PMID: 26369852.
rheic keratosis, solar lentigo, cutaneous mastocytosis, super-
                                                                 2. Alaoui A, Douhi Z, Elloudi S, Baybay H, Mernissi F. Abrikos-
numerary accessory nipple and syringoma [1]. We present             soff’s tumor: Clinical and dermoscopic features. J Dermatol
new dermoscopic features of GCT: large, radial brown lines,         ­Cosmetol. 2019;3(5):130 DOI: 10.15406/jdc.2019.03.00129
and the presence of follicular involvement.




2                                                                      Image Letter | Dermatol Pract Concept. 2023;13(2):e2023084
