10.5826/dpc.1202a92
text/xml
2160-9381
2025
en
Mohamed Denguezli
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
Solitary nodular lesion on the face in a 9-year-old boy : Nodular lesion on the face
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Image Letter
2022-05-02
2021-09-11
2022-05-02
2022-05-24
e2022092
Dermatol Pract Concept
Mohamed Denguezli
2022/05/02
10.5826/dpc.1202a92
e2022092
Dermatology Department, Anatomopathology Department, Hached University Hospital of Sousse, Sousse, Tunisa
2160-9381
en
e2022092
Solitary nodular lesion on the face in a 9-year-old boy : Nodular lesion on the face
https://dpcj.org/index.php/dpc/article/download/2025/1584
Solitary Nodular Lesion on the Face in a 9-year-old Boy
        Mohamed Ben Rejeb1, Haifa Mkhinini1, Badreddine Sriha1, Mohamed Denguezli1


1 Dermatology Department, Anatomopathology Department, Hached University Hospital of Sousse, Sousse-Tunisa



Citation: Rejeb MB, Mkhinini H, Sriha B, Denguezli M. Solitary nodular lesion on the face in a 9-year-old boy.
Dermatol Pract Concept. 2022;12(2):e2022092. DOI: https://doi.org/10.5826/dpc.1202a92
Accepted: October 3, 2021; Published: April 2022
Copyright: ©2022 Rejeb et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-
NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use,
distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding author: Ben Rejeb Mohamed, Dermatology Department, Hached University Hospital of Sousse-Tunisia.
E-mail: med.benrejeb@gmail.com




Case Presentation                                                        Teaching Point
A 9-year-old boy presented with a 4-month history of                     IFAG is a rare, benignpediatric entity characterized by
chronic nodular lesion on the cheek resistant to antibiot-               chronic, painless erythematous-violaceous nodular lesions
ics. Dermatological examination showed a 15-mm, solitary,                frequently located on cheeks and eyelids with no predispos-
firm erythematous nodule on his right cheek (Figure 1a). A               ing factor [1]. Although pathogenesis remains unclear, the
punch biopsy specimen revealed a dermal chronic inflam-                  disease is thought to be associated with granulomatous ro-
matory, granulomatous perifollicularinfiltrate consisting                sacea in childhood [1]. Histologically, IFAG lesion is char-
of histiocytes, neutrophils, and giant cells without necrosis            acterized by a dermal chronic inflammation of histiocytic
(Figure 1: b, c). Based on these findings,we diagnosed the               granuloma with giant cells, and abscesses without necrosis.
case as idiopathic facial aseptic granuloma (IFAG).                      In general, IFAG tends to resolve spontaneously in less than
                                                                         a year. Antibiotics, such as doxycycline and metronidazole,
                                                                         could be used to accelerate the involution of IFAG [2].




Research Letter | Dermatol Pract Concept. 2022;12(2):e2022092                                                                       1
              Figure 1. (A): Solitary, Firm, nodular, erythematous lesion on the right cheek, chronic granulomatous inflam-
              matory infiltrate in the dermis (B, HE*40) composed of histiocytes, lymphocytes, neutrophils and giant cells
              without necrosis (C, HE*200).



References                                                             2. Hasbún Z C, Ogueta C I, Dossi C T, Wortsman X. Idiopathic
                                                                          Facial Aseptic Granuloma: Updated Review of Diagnostic
1. Satta R, Montesu MA, Biondi G, Lissia A. Idiopathic facial asep-       and Therapeutic Difficulties. ActasDermosifiliogr (Engl Ed).
   tic granuloma: case report and literature review. Int J Derma-         2019;110(8):637-641. DOI: 10.1016/j.ad.2019.01.005. PMID:
   tol.2016;55(12):1381‑1387. DOI: 10.1111/ijd.13161. PMID:               30819406.
   27259697.




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