10.5826/dpc.1202a86
&nbsp;

text/xml
2160-9381
1969
en
Tao Chen
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
Milium of the Nipple
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Image Letter
2022-05-02
2021-08-17
2022-05-02
2022-05-24
e2022086
Dermatol Pract Concept
&nbsp;

Tao Chen
2022/05/02
10.5826/dpc.1202a86
e2022086
Department of Dermatovenereology, Chengdu Second People’s Hospital, Chengdu, Sichuan, China
2160-9381
en
e2022086
Jain S, Sarkar R, Garg VK, Khurana N. Epidermal inclusion cyst or giant milium of the nipple. Indian J Dermatol Venereol Leprol. 2012;78(1):103-105. 2011/12/27. DOI: 10.4103/0378-6323.90960. PMID: 22199072.
Milium of the Nipple
https://dpcj.org/index.php/dpc/article/download/1969/1581
                                          Milium of the Nipple
                              Li-wen Zhang1, Juan Wu2, Ling-yi Zhao1, Tao Chen1


1 Department of Dermatovenereology, Chengdu Second People’s Hospital, Chengdu, Sichuan, China
2 Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China



Citation: Zhang L, Wu J, Zhao L, Chen T. Milium of the Nipple. Dermatol Pract Concept. 2022;12(2):e2022086. DOI: https://doi
.org/10.5826/dpc.1202a86
Accepted: October 7, 2021; Published: April 2022
Copyright: ©2022 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-
NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use,
distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding author: Tao Chen, Department of Dermatovenereology, Chengdu Second People’s Hospital, 165 Caoshi Street,
Chengdu 610017, Sichuan, China. E-mail: 13980427003@163.com




Case Presentation                                                        found by searching PubMed databases [1,2]. Among them,
                                                                         the male-to-female ratio was 1:3; the age range was from 6
A 4-year-old boy presented with a 1-year history of a s­ ingle           to 16 months. They presented a unilateral single pearly white
pearly white papule on the right nipple (Figure 1A). No                  dome-shaped papule with a diameter of 3 mm to 8 mm. Three
previous skin inflammation or trauma was observed at the                 cases underwent surgical excision, and 1 spontaneously dis-
same location. The left nipple was normal. His growth and                appeared. The dermoscopic manifestation shows a white or
psychomotor development were normal. The dermoscopy                      yellowish-white rounded structure with linear or branching
showed a pearly white rounded structure with branching                   vessels. The differential diagnosis includes molluscum con-
vessels (Figure 1B). Histopathology showed an epidermoid                 tagiosum, calcinosis cutis, juvenile xanthogranuloma, and
cyst containing keratinous material (Figure 1C). The diagno-             syringoma.
sis of milium was made.

                                                                         References
Teaching Point                                                            1. Ferreira MG, Salgado MB. Congenital Milium of the Nipple. Pe-
                                                                             diatr Dermatol. 2017;34(1):E28–E29. DOI: 10.1111/pde.13010.
Milium is a common benign keratinous cyst characterized
                                                                             PMID: 27778385.
by pearly white dome-shaped lesion of 1 mm to 4 mm in
                                                                          2. Jain S, Sarkar R, Garg VK, Khurana N. Epidermal inclusion
diameter, but the involvement of the nipple seems to be rare                 cyst or giant milium of the nipple. Indian J Dermatol Venereol
and bigger. Milium may occur as either primary or second-                    Leprol. 2012;78(1):103–105. 2011/12/27. DOI: 10.4103/0378-
ary lesions. Four cases of milium involving the nipple were                  6323.90960. PMID: 22199072.




Image Letter | Dermatol Pract Concept. 2022;12(2):e2022086                                                                               1
Figure 1. (A) A single pearly white papule on the right nipple. (B) The dermoscopy showed a pearly white rounded structure with branching
vessels. (C) Histopathology showed an epidermoid cyst containing keratinous material (H&E; ×100 magnification)




2                                                                            Image Letter | Dermatol Pract Concept. 2022;12(2):e2022086
