10.5826/dpc.1303a161
text/xml
2160-9381
3043
en
Jesus Alberto  Cardenas-de la Garza
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
benign connective tissue neoplasms 
Multiple Familiar Eruptive Dermatofibromas: Report of Three Affected Generations
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Research Letter
2023-07-31
2022-12-02
2023-07-31
2023-08-24
e2023161
Dermatol Pract Concept
Jesus Alberto  Cardenas-de la Garza
2023/07/31
10.5826/dpc.1303a161
e2023161
Universidad Autónoma de Nuevo León,  Servicio de Reumatología, Facultad de Medicina y Hospital Universitario “Dr. José E. González’’, Monterrey, Nuevo León, México
2160-9381
benign connective tissue neoplasms 
en
e2023161
Marque M, Pallure V, Huet P, Bessis D, Guillot B. [Multiple familial "eruptive" dermatofibromas]. Ann Dermatol Venereol. 2013;140(6-7):452-454. DOI: 10.1016/j.annder.2013.02.018. PMID: 23773744.
Multiple Familiar Eruptive Dermatofibromas: Report of Three Affected Generations
https://dpcj.org/index.php/dpc/article/download/3043/2221
         Multiple Familiar Eruptive Dermatofibromas:
            Report of Three Affected Generations
       José Alberto García-Lozano1, Gabriel Salerni2, Jesús Alberto Cardenas-de la Garza3


1 Universidad Autónoma de Nuevo León, Departamento de Introducción a la Clínica, Facultad de Medicina y Hospital Universitario
  “Dr. José E. González’’, Monterrey, Nuevo León, Mexico
2 Dermatology Department, Hospital Provincial del Centenario de Rosario, Universidad Nacional de Rosario, Argentina
3 Universidad Autónoma de Nuevo León, Servicio de Reumatología, Facultad de Medicina y Hospital Universitario “Dr. José E. González’’,
  Monterrey, Nuevo León, México



Key words: dermatofibromas, hystiocitomas, benign fiborus hystiocitomas, benign connective tissue neoplasms
Citation: García-Lozano JA, Salerni G, Cardenas-de la Garza JA. Multiple familiar eruptive dermatofibromas: Report of three affected
generations. Dermatol Pract Concept. 2023;13(3):e2023161. DOI: https://doi.org/10.5826/dpc.1303a161
Accepted: December 23, 2022; Published: July 2023
Copyright: ©2023 García-Lozano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-
NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use,
distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing Interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding Author: José Alberto García-Lozano, MD, Universidad Autónoma de Nuevo León, Departamento de Introducción a la
Clínica, Facultad de Medicina y Hospital Universitario “Dr. José E. González’’, Monterrey, NL, México. Tel: 81 8329 4154
E-mail: dr.josealbertogarcia@gmail.com




Introduction                                                             nodules on the trunk and lower limbs, noting the first nodule
                                                                         during adolescence. More lesions appeared during the next de-
Multiple eruptive dermatofibromas (MEDF) is a very rare                  cades, and some increased in size. Clinical examination revealed
entity characterized by the development of 15 or more as-                multiple atrophic purple and firm flesh-colored papules, mea-
ymptomatic lesions all over the body or clustered in one an-             suring between 0.5 and 1 cm in diameter and sinking into the
atomic location within a short period (usually 4 months) [1].            skin with lateral pressure. Dermoscopic examination revealed
The pathogenesis is unknown, although most patients with                 lesions consistent with dermatofibromas. The rest of the clini-
MEDF have underlying causes. Physicians should consider                  cal examination was unremarkable. During the interview, the
a prompt investigation of underlying conditions, including               patient mentioned that her 87-year-old father and his 34-year-
HIV infection, autoimmune disease, immunosuppressant                     old son also presented similar multiple lesions. Both patients
drug use, and hematologic disease [2]. We report three mem-              were invited for clinical examination. The otherwise-healthy
bers of the same family who developed MEDF.                              father had at least 70 lesions on the trunk and lower limbs. The
                                                                         otherwise healthy son had at least 50 lesions in the same areas
Case Presentation                                                        (Figure 1). Upon questioning, the three family members denied
                                                                         infections, autoimmune disease, malignancies, or immunosup-
A 50-year-old woman was referred for consultation due to mel-            pressive drug use. A “familiar” MEDF diagnosis was made, and
anoma. Clinical examination revealed multiple asymptomatic               annual follow-up appointments were scheduled.



Research Letter | Dermatol Pract Concept. 2023;13(3):e2023161                                                                            1
 Figure 1. Polarized clinical images showing multiple lesions consistent with dermatofibromas predominantly located in lower limbs in the
 50-year-old woman (upper row), her father (middle row) and her son (lower row).




Conclusions                                                           same family. A genetic cause for MEDF has been suggested
                                                                      with an autosomal dominant inheritance pattern [3]. To our
The pathogenesis of dermatofibromas remains unknown.                  knowledge, this is the first report in which three genera-
Lesions often develop after a traumatic insult to the skin            tions have MEDF with no associated cause. Dermatologists
(insect bites), but altered immunity may play an import-              should be aware that MEDF may be a sign of altered immu-
ant role in MEDF [3]. The term “multiple familiar eruptive            nity. Nonetheless, it should also be considered an inherited
dermatofibromas” was described by Marque et al in 2013                disorder, especially when multiple family members have the
[4]. This report was the first on healthy individuals of the          same condition.




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Research Letter | Dermatol Pract Concept. 2023;13(3):e2023161                                                                       3
