10.5826/dpc.1401a94
text/xml
2160-9381
3786
en
Aimilios  Lallas
https://creativecommons.org/licenses/by-nc/4.0
Dermatology Practical & Conceptual
Dermal nevus
Differentiation of Dermal Nevus and Basal Cell Carcinoma Based on Optical Super-High Magnification Dermoscopy
Text.Serial.Journal
https://dpcj.org/index.php/dpc
Research Letter
2024-01-31
2023-09-02
2024-01-31
2024-02-21
e2024094
Dermatol Pract Concept
Aimilios  Lallas
2024/01/31
10.5826/dpc.1401a94
e2024094
First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece
2160-9381
Dermal nevus
en
e2024094
Segura S, Puig S, Carrera C, Palou J, Malvehy J. Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. Arch Dermatol. 2007;143(7):883-886. doi:10.1001/archderm.143.7.883
Differentiation of Dermal Nevus and Basal Cell Carcinoma Based on Optical Super-High Magnification Dermoscopy
https://dpcj.org/index.php/dpc/article/download/3786/2458
           Differentiation of Dermal Nevus and Basal
          Cell Carcinoma Based on Optical-Super High
                   Magnification Dermoscopy
                         Joanna Pogorzelska-Dyrbuś1, Elisa Cinotti2, Aimilios Lallas3


1 “Estevita” Specialist Medical Practice, Tychy, Poland
2 Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
3 First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece



Key words: Optical super-high magnification dermoscopy, Basal cell carcinoma, Dermal nevus
Citation: Pogorzelska-Dyrbuś J, Cinotti E, Lallas A. Differentiation of Dermal Nevus and Basal Cell Carcinoma Based on Optical-Super
High Magnification Dermoscopy. Dermatol Pract Concept. 2024;14(1):e2024094. DOI: https://doi.org/10.5826/dpc.1401a94
Accepted: November 20, 2023; Published: January 2024
Copyright: ©2024 Pogorzelska-Dyrbuś et al. This is an open-access article distributed under the terms of the Creative Commons
Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted
noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None.
Competing Interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding Author: Joanna Pogorzelska-Dyrbuś, MD PhD, “Estevita” Specialist Medical Practice, 43-100 Tychy,Silesia, Poland.
phone: +48 32 227 96 30 e-mail: jpogorzelskadyrbus@gmail.com




Introduction                                                             The first DN in standard dermoscopy displayed a blue-grey
                                                                         globule with branched linear vessel in the center and short
Although dermoscopy usually allows for discriminating                    linear vessels at the periphery (Fig 1A). These findings could
­between dermal nevi (DN) and basal cell carcinoma (BCC),                mislead to the diagnosis of BCC. OSHMD ­revealed prom-
the dermoscopic features might occasionally be indistin-                 inent stem and looped vessels, but also m
                                                                                                                 ­ ultiple small pale
guishable [1].                                                           brown circular structures of the same size (Fig 1B), possibly
    Optical Super-High magnification dermoscopy (OSHMD)                  corresponding to melanocytes in the upper part of dermal
with magnification up to 400x may provide new differentiat-              nests. In the second patient, conventional dermoscopy re-
ing structures invisible in conventional dermoscopy [2].                 vealed a central light brown pigmentation and linear curved
                                                                         vessels distributed throughout the whole lesion (Fig 1D).

Case Presentation                                                        OSHMD showed vessels and brown circular s­tructures
                                                                         similar to the previous case (Fig 1E). In both patients,
We present the dermoscopic features of two DN and two                    ­histopathology confirmed the diagnosis of DN (Fig 1C, F).
BCC examined with the Medicam 1000 (Fotofinder System,                        The BCCs developed in a 55-year-old woman who pre-
Bad Birnbach, Germany), at standard 20x and at 400x mag-                 sented with a 5 mm firm papule on the upper lip reported
nification (OSHMD).                                                      to have appeared several years earlier (Fig 2A-C), and a
    The DN were located on the abdomen of a 36-year-old man              45-year-old woman with a pink flat papule on the lower
(Fig 1A-C) and the face of a 45-year-old woman (Fig 1D-F).               eyelid (Fig 2D-F). In the first patient, standard dermoscopy



Research Letter | Dermatol Pract Concept. 2024;14(1):e2024094                                                                          1
    Figure 1: Standard dermoscopy (A, D) OSHMD (B, E) and histopathology of Dermal Nevi (C, F). Roundish
    ­melanocytes indicated by asterisks
    Abbreviations: OSHMD – Optical Super-High Magnification Dermoscopy,




    Figure 2: Standard dermoscopy (A, D) OSHMD (B, E) and histopathology of BCC (C, F). Fine pigmented structures
    are indicated by arrows.
    Abbreviations: BCC – Basal cell carcinoma; OSHMD – Optical Super-High Magnification Dermoscopy




2                                                               Research Letter | Dermatol Pract Concept. 2024;14(1):e2024094
revealed branched vessels and brown globules located fo-         between DN and BCC by revealing circular cells probably
cally at the periphery (Fig 2A). OSHMD revealed aggre-           corresponding to typical melanocytes in the DN and the fine
gated fine pigmented structures, and looped vessels (Fig 2B).    pigmented structures in BCC. Our findings require confor-
In the standard dermoscopy of the second patient, a grey         mation by studies with a larger sample.
globule and branched vessels were noticed (Fig 2D), while
OSHMD revealed distinctive tree-like vessels with branches
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technique might significantly enhance the discrimination            2007;143(7):883-886. doi:10.1001/archderm.143.7.883




Research Letter | Dermatol Pract Concept. 2024;14(1):e2024094                                                                      3
