10.6092/issn.2038-3460/17210
In this article trends in the design of iconic elite life science buildings is discussed. Four main elite life science buildings of the new century are considered. The buildings reflect things going on in and around elite contemporary life science today, including changing ideas about the relation between the public and science, and about the relation of science to the market. Reading trends in the design of science buildings is a way to follow the evolving epistemology of the life sciences and changing demands of science policy.
application/pdf
2038-3460
17210
2
en
Charis M. Thompson
https://creativecommons.org/licenses/by-nc-sa/2.5/
Tecnoscienza – Italian Journal of Science & Technology Studies
buildings
Designing for the Life Sciences: The Epistemology of Elite Life Science Real Estate
Text.Serial.Journal
https://tecnoscienza.unibo.it/
5
Lectures
2015-01-29
2023-06-14
2015-01-29
2023-07-27
43-58
TS
Charis M. Thompson
2014
10.6092/issn.2038-3460/17210
43
University of California Berkeley
2038-3460
2
buildings
en
58
Designing for the Life Sciences: The Epistemology of Elite Life Science Real Estate
https://tecnoscienza.unibo.it/article/download/17210/16090
5
                                                                                  Lecture

Designing for the Life Sciences: The
Epistemology of Elite Life Science Real
Estate
	
  
Charis M. Thompson
University of California Berkeley
	
  
       Abstract: In this article trends in the design of iconic elite life science build-
       ings is discussed. Four main elite life science buildings of the new century are
       considered. The buildings reflect things going on in and around elite contem-
       porary life science today, including changing ideas about the relation between
       the public and science, and about the relation of science to the market.
       Reading trends in the design of science buildings is a way to follow the evolv-
       ing epistemology of the life sciences and changing demands of science policy.

       Keywords: Design; architecture; STS; Life Sciences; buildings.

       Corresponding author: Charis M. Thompson, UC Berkeley Sociology
       Department – 410 Barrows Hall, Berkeley, CA 94720-1980 – Email:
       charis@berkeley.edu




1. Introduction

    In the current era, it is common for elite life science buildings to be
designed by top architects, and to win prizes and acclaim for their design.
These imposing buildings concretize the valuation and values of the life
sciences. Their layouts are literal interpretations of evolving ideas about
how best to do science: who should have what kind of access to whom
and to what, what activities should happen where, and what relations
there should be between what goes on inside the building and its various
publics. In some ways, this is nothing new. The architecture and design of
elite scientific buildings has always reflected contemporary ideas about
how science is best done and known, who pays for it, and what purposes
it serves. The Ancient Library of Alexandria, built in the 3rd century BC,
was reputedly designed to gather the world’s written knowledge, to dis-
	
  
TECNOSCIENZA
Italian Journal of Science & Technology Studies
5 (2) pp. 43-58 - ISSN 2038-3460
www.tecnoscienza.net                              2014
44                                                                                                                                                                                                                                 Tecnoscienza - 5 (2)

play and aid the exercise of power by rulers, and to attract the greatest
scholars of the day and thereby promote more research and knowledge.
    These same elements of gathering and housing data; service to power
(whether rulers or other paymasters) and publics; and attracting the best
scholars and facilitating the best research continue in various combina-
tions to characterize the design of elite scientific buildings. The specific
forms this takes, however, mirror evolving epistemic and social aspects of
knowledge production. In this paper I consider an iconic elite life science
building from the beginning of the revolution in molecular biology, the
1962 Salk Laboratory in San Diego. I then look at four elite 21st century
life science buildings: Singapore’s 2004 Biopolis Phase One, UC San
Francisco’s 2010 Dolby Regeneration Medicine Building, Cambridge,
UK’s 2011 Sainsbury Laboratory, and London’s 2015 Francis Crick Insti-
tute1. Certain themes of the Salk’s design, such as the emphasis on design
itself, and the provision of basic lab bench needs as part of a flexible but
inbuilt infrastructure have continued to characterize these buildings.
Newer design elements, such as the explicit incorporation of a transla-
tional arc from “bench to bedside”, and the incorporation of data man-
agement into the infrastructure, are evident. So, too, are changing ideas
about innovation in the life sciences and its uses, dangers, and relations to
its publics.


2. Science and Technology Studies and Design

    Since its inception, Science and Technology Studies (STS)2 has em-
phasized the places where science is carried out as part of its commitment
to showing what is social and what is situated about knowledge that func-
tions rhetorically as natural and un-situated (see Thompson 2005, 31-53;
Shapin 2010). STS has also always paid attention to material culture and
to the empirical, technology-mediated and spatialized ways in which epis-
temological judgments are possible (Latour 1999, 24-79; Lynch 1985;
Prentice 2013; Suchman 2007; Thompson 2005, 79-116). Geopolitical
spaces, from citizen science to regions and nations to circuits of
knowledge, facts, materiel, and scientific personnel, have been elucidated
as part of the sine qua non of modern science (Haraway 1984; Jasanoff
2004; Livingstone 2003; Mukerji 2010; Nelson 2011; Thompson 2013, 68-
149). And the actual sites where science is carried out, from the field site
to the lab, and from the Early Modern to the Contemporary era, have
	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
1
  My choice of buildings is idiosyncratic, and reflects paths that my own research
has taken. Although these buildings cannot be said to be representative of new
life science research buildings in general, I suspect that the characteristics to
which I draw attention are not only evident in these particular buildings.
2
   I use STS to refer to cognate work from the history, sociology, anthropology,
and philosophy of science, as well as from STS “proper” (STS as a discipline).
Thompson                                                                                                                                                                                                                           45
long been thematized in STS, as microcosms of the self-contained case-
study method, and as materially relevant to the science produced (Gali-
son 1997; Latour and Woolgar 1986; Rudwick 2014; Thompson 2013).
This paper draws on all these strands of STS.
    Michel de Montaigne’s C16th Tower has come to symbolise the ten-
sion between the ways one’s environment can structure and nurture one’s
work, and the ways in which it stifles or corrupts the imagination and the
intellect. Today, amidst the boom in elite science real estate, this tension
is still evident. The start-up stereotype eschews the real estate of estab-
lished science, and is populated, in the US imaginary, with under-
socialized and vitamin D-deficient young predominantly affluent White
males in basements and garages. The freedom from the trappings of pro-
fessionalized science is equated with creativity and innovation. In fact, the
necessary equipment, regulation, and data are all big science today, and
only a very well connected Silicon Valley garage would be fit for purpose.
Even within establishment science, individual scientists and specific
breakthroughs are still the things that are venerated and credited with ge-
nius in a system of positive feedback by which the leaders pull away from
the rest. This individualism and star system continues to flourish even
though the sciences are in many ways ever more collective and interde-
pendent. To design a building for contemporary life science, it needs to
be seen as allowing for, or actively fostering, individual creativity. The
new elite life science real estate has incorporated elements of these endur-
ing ideas about the nature of innovation and of genius into its novel de-
sign3.


3.The Life Sciences

    The life sciences stand on the brink of being able to re-engineer mo-
lecular life in purposive ways. In this lies the potential to manufacture a
new generation of bioweapons, and a corresponding need to make many
branches of the life sciences secret as part of national and international
security apparatuses. At the same time, never has the scope and depth of
public implication in the life sciences from agricultural biotech to bio-
medicine been so great: our lives, our food, and our governance are part
of a biotech mode of (re)production (Thompson 2005, Ch. 8). Life sci-
ence real estate displays this tension between a heightened need to be ac-
countable to and involve the public, and security needs that re-impose
cordons sanitaires and limits to transparency and public access.
    Life science today also characteristically proceeds according to new
combinations of public and private funding, captured in the bench to

	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
3
  The pedigree of these ideas, and their tension with how science is actually done,
can be traced in the work of Steven Shapin (1991). See also Livingstone (2003).
46                                                           Tecnoscienza - 5 (2)

bedside promise of translational biomedicine. The public is asked to sup-
port open-ended basic science, while private capital is tasked with its
translational uptake, in an aspirational cycle of innovation and trickle
down wealth creation. This rise of what could be called the research-
industrial complex, in a parallel to the military-industrial complex of the
C20th, imposes its own tensions. The extent of public non-military re-
search funding carries with it demands for accountability and participa-
tory science, and for visible, equitably distributed public goods flowing
from research. The private sector money, on the other hand, brings its
own legal and business rationales for keeping knowledge proprietary.
This tension manifests at every level of the life sciences today from crises
of reproducibility, to the open-access publishing movement, and unprec-
edented pressure for academic scientists to publish in high impact jour-
nals and engage in technology transfer and corporate spin-off. The build-
ings I consider below demonstrate their mixed public-private funding,
and in some cases, their interior design attempts to address these tensions
and remedy the problems of the heavily capitalized private versus public
faces of contemporary life science.


4. The Salk Institute

    The Salk institute was built in 1962 and designed by architect Louis
Kahn, in collaboration with Jonas Salk, famous for developing the polio
vaccine. It is one of the world’s most iconic science buildings: starkly
masculinist and framed by the frontier landscape of Southern California’s
Pacific Coast. The basic design has two rows of rectangular parallel la-
boratories running parallel to the coastline over which it is perched, on ei-
ther side of a travertine marble courtyard. The courtyard is dissected by a
straight line of water running, infinity-pool style, toward the cliff edge,
and continuous to the eye with the Pacific Ocean. At sunset, the court-
yard frames the setting sun. On the inside courtyard side of the laborato-
ries are hemi-chevron shaped offices, blending wood with the warm ce-
ment mix of the labs. There are separate towers at the East end of utili-
ties, and three of the six floors of the laboratory portion is given over to
heating, ventilating, gas, electricity, and other support systems by then es-
sential to bench science. See image 1 for the vista, and image 2 for the of-
fices, seen from the ocean side. In 1992, the Salk received a 25-year award
from the American Institute for Architects.
    The labs themselves have no internal walls and have lighting units that
can be moved, as well as the easily accessible, flexible support systems
made possible by the service floors. These features were designed to sup-
port maximum collaborative potential, as well as to be easy to maintain
and to leave open for the future exactly what configuration of working
would best serve the science being conducted in the building. The Salk
Thompson                                                                        47
remains one of the most productive and perhaps the single most illustri-
ous life science facility in the world, in terms of its current researchers
and many Nobel and other prize winning alumni. This speaks to the con-
tinuing attractiveness to researchers and funders, and scientific efficacy
and longevity of the design.




Image 1 – The iconic view of the Salk Institute (reproduced from: http://
pic.pimg.tw/leecocoa/1327583338-3916316003.jpg).




Image 2 – The hemi-chevron offices of the Salk Institute, seen from the ocean
side (photo by Jim Harper/Wikimedia Commons).
48                                                            Tecnoscienza - 5 (2)

    The principle of building collaboration into the laboratory design so
as to promote scientific discovery and innovation has continued in newer
elite life science buildings. Nonetheless, the version of collaboration the
Salk embodies is not the same as that more commonly seen today. The
Salk is an austerely beautiful building, a scientific retreat of the most aes-
theticized modernist kind, frequently described as monastic. It is charac-
terized by its symmetry and precision, and its interior spaces remains the
sole preserve of scientists and researchers themselves. The collaboration
is among scientists. The public is not part of its design, although the Salk
was from the start a monument to science in the service of the human
race, having been designed at the dawn of the molecular biology revolu-
tion, in the duel context of eradicating the greatest diseases of mankind
and the Cold War. It has played a highly significant role in the life scienc-
es from plant biology to neuroscience ever since. More recent life science
buildings design the pros and cons of collaboration differently, incorpo-
rating a participatory relation to the public, rather than serving in a salva-
tional relation to a greater humanity from which it is separate.


4. Fast forward to the 21st Century

    By the twenty-first century, the Cold War, if not nuclear
(dis)armament, was behind us, and the life and biomedical sciences had
grown and capitalized dramatically. We worried about global warming,
not nuclear winter. Our concerns with empirical science were more likely
to stem from big data’s lack of intelligence or justice, than from the gap
between non-falsifiability and truth. Epistemological crises of science as
an institution, such as failures of reproducibility, and their apparent caus-
es in excesses of market and competitiveness, all threatened the life sci-
ences’ special relation with democracy. Could it be that the life sciences
were contributing to a world caught up in increasing inequality rather
than serving as the place from which to “speak truth to power”? The new
iconic life science buildings displayed the concerns of the era, from spac-
es designed to mitigate excessive competitiveness to those designed to
acknowledge a public who talks back. Like the Salk in its time, these con-
cerns were literally part of the design of these labs, showing in another in-
stantiation the claim made by Science and Technology Studies that sci-
ence is co-produced with the social order of its time and place.
    The new building design, then, reflected how people were thinking
about science in the early twenty-first century, from innovation to ethics
to participation to sustainability to interdisciplinarity to markets and se-
curity. Although all these elements are evident in all of the buildings I
discuss below, for the sake of clarity and brevity, I am focusing on only
certain particularly striking aspects of each building. I take the buildings
in the order in which they were opened. For Singapore’s 2004 Biopolis, I
emphasize flow between the public and private sectors and between dis-
Thompson                                                                 49
ciplines and nations; for UC San Francisco’s 2010 Dolby Regeneration
Medicine Building, I emphasize innovation and sustainability as rationales
for public funding and private profit; for Cambridge, UK’s 2011 Sains-
bury Laboratory, I emphasize good science and the new monasticism
against threats to reproducibility and excellence in science; and for Lon-
don’s 2015 Francis Crick Institute, I emphasize the invitation in and con-
tainment and management of publics.


5. Singapore’s 2004 Biopolis Phase One

    Singapore’s Biopolis Phase One is a seven-building biomedical re-
search compound that was built in 2003-4. Like the Salk, it was designed
by a world famous architect, but one very much of the turn of the new
century rather than the mid -20th century, the Iraqi-British architect, Zara
Hadid. Hadid was the first Muslim and first woman to win the Pritzker
Architecture Prize, in 2004, and she has also won the Stirling Prize. Her
buildings are known for their flamboyant curves, and their futurism, con-
juring up artificial natures rather than being at one with, or sustainable
within, a threatened nature. Hadid’s dual heritage betokening her global
citizenship, and her familiarity with designing for new wealth-attracting
global cities, made her a good choice for Biopolis. The names of the seven
buildings of Biopolis, Chromos, Helios, Genome, Proteos, Centros, Ma-
trix, and Nanos, made no secret of their life-science ambition to re-
purpose nature and re-master life itself, and Hadid’s buildings reflected
that. The buildings are the landscape, rather than built into the landscape.
    Biopolis has something in common with such places as Silicon Valley’s
Googleplex in that it is governed by a view of innovation that is near to-
talizing. Many aspects of life are encompassed within the complex itself;
you can eat, drink, get your hair cut, attend arts programs and drop off
your kids and your dry cleaning. There are also nearby residential facili-
ties for scientists and their families to live. The ethos – at least when I
toured it – was not at all the Peter Pan-like one that I experienced at
Googleplex, but rather, professional and urbane, and translational. Biop-
olis emerged as a microcosm for the city-state of Singapore trying to posi-
tion itself in the knowledge economy as a global and regional hub for in-
ternational life science.
    The seven Biopolis Phase One buildings themselves are connected via
sky bridges, again emphasizing the literal links between areas of speciali-
zation. Some of the buildings contain privately funded laboratories, and
others are publicly funded; some of the research is basic, but it is imaged
in connection to translational research. The built environment links them
as a single manufactured landscape of research. Some of the labs are set
up so as to facilitate collaboration among scientists coming from different
national science traditions, having different kinds of experimental condi-
50                                                                                                                                                                                                                                 Tecnoscienza - 5 (2)

tions built into the infrastructure, and thereby facilitating attracting the
best and the brightest ex-patriate scientists as well as Singapore’s next
generation of knowledge workers4. All in all, Biopolis Phase One de-
signed into being a world of life science research that was flexible, inter-
nationally co-operative, and intrinsically translational, or “bench to bed-
side”. The brain drain to Biopolis, and subsequent disillusioned exit of,
several internationally recognized life scientists spoke to the tensions in-
herent in this model between basic, creative university science and sci-
ence too explicitly in the service of the economy.




Image 3 – The landscape of Biopolis Phase One and its Sky Bridges (reproduced
from: http://upload.wikimedia.org/wikipedia/commons/4/43/Biopolis-Singapore
-20080712.jpg).


6. UC San Francisco’s 2010 Dolby Regeneration Medicine
Building

   I turn next to the Ray and Dagmar Dolby Regeneration Medicine
Building at UCSF, which houses the Eli and Edythe Broad Center of Re-
	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
4
  In Good Science (Thompson 2013), I described Biopolis as “internationalist” in
its layout, labs, and epistemology, while being very much a product of Singapore,
with its city-state merging of private capital and government agencies, literally
connected by sky bridges.
Thompson                                                                                                                                                                                                                           51
generation Medicine and Stem Cell Research. This building was designed
by the New York firm, Rafael Vinoly Architects, and was paid for by a
combination of private funds and taxpayer money awarded for stem cell
facilities by the California Institute for Regenerative Medicine. It won an
American Institute of Architects Design Award in 2011, among other
recognition, and is widely regarded as a beautiful building.
    The Dolby Regeneration Medicine Building is credited with four
striking properties. First, it was built very quickly. Second, it is seen as an
engineering feat, having been built on a 60% slope, curving horizontally
along the Parnassus Heights hillside. Adding to the engineering prowess,
the Nabih Youssef Association of engineers gave it remarkable seismic
properties. The building was constructed on a steel framework with isola-
tion bearings that reputedly would be able to move over two feet side-
ways and even vertically by an inch or two in the event of an earthquake.
Everything about the building is innovative.
    Third, the building was designed to receive Energy and Environmen-
tal Design for New Construction (LEED-NC) Gold level certification.
Unusually for laboratories, it maximizes natural light, and it was built us-
ing many kinds of energy conservation methods. The building itself is also
blended in with the environment, and aims to minimize its contribution
to greenhouse emissions not just through energy conservation, but also
through using the roofs of its various levels to grow native grasses. The
Salk was designed in such a way that it aggrandizes its natural setting and
vice versa. The Dolby is also an impressive building that fits its natural
setting and affords splendid views, but it is more about energy and envi-
ronmental sustainability and not disrupting its habitat than it is about
grandeur and monumentality of nature inside and outside the lab.
    Finally, the Dolby Regeneration Medicine Building, like Biopolis, was
explicitly designed to foster connections between the public and the pri-
vate sector. Its collaborative design was different than that of Biopolis (or
the Salk), however. Biopolis was designed to connect different sub-
disciplines to serve the growth of an international economy. The Dolby
Regeneration Medicine Building, on the other hand, was built to connect
sub-disciplines so as to facilitate and stage an interplay of ideas, the shar-
ing of new techniques, and the growth of knowledge. This in turn was to
speed the translational trajectory from basic research funded by the pub-
lic all the way to clinical therapies, via commercialization and clinical tri-
als. The economic benefit was implied in the translational design but it
was secondary. Cures from stem cell research and regenerative medicine
were the primary goal of the building’s design5.
    At the Salk, the offices were off to one side. In the Dolby Regenera-
tion Medicine Building, the offices and meeting and lounge spaces were
	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
5
 In Good Science (Thompson 2013) I characterized this as “pro-curial” science,
concerned with cures, and with the procurement and curation of life tissues and
data.
52                                                           Tecnoscienza - 5 (2)

placed in the areas that were directly between different labs. Getting to
and from one’s lab required interaction with personnel from other labs.
In this way, walking, talking and thinking, were designed to be spontane-
ous and interactional. Research funded by public and by private sources
would come into serendipitous contact in this interactive flow of minds
and bodies through the building’s layout. The building bears a literal sig-
nature of this collaboration in the 140-foot long, 90 foot above-ground,
glass enclosed steel bridge which serves as the building’s main entrance.
In this entryway, the eponymous private donors are named and matched
by a commemoration of the tax-payer and the innovative voter initiative,
California’s Proposition 71, that also provided funding.




Image 4 – The Dolby Regeneration Medicine Building’s curving hilltop design.
(reproduced from: http://buildipedia.com/aec-pros/featured-architecture/ucsf-
institute-regenerative-medicine).


7. Cambridge, UK’s 2011 Sainsbury Laboratory

    Cambridge University’s 2011 Sainsbury laboratory was funded by Da-
vid Sainsbury’s Gatsby foundation, and designed by the architects Stan-
ton Williams. In 2012, the building won the Royal Institute of British Ar-
chitects Stirling prize, a prestigious architecture prize awarded for the
building that contributed the most to British architecture in the last year.
Thompson                                                                  53
The Sainsbury laboratory is a plant biology facility, and was designed
with containment facilities for known pathogens. In other ways, though,
it was designed with a high degree of openness and flow from the outside
to the inside and among its inside spaces. Those working in the biomedi-
cal branches of the life sciences work in buildings designed for the unique
challenges of animal research and human subjects (and in the case of stem
cell research, embryos). As I discuss below, openness in biomedicine
building design is constrained by the containment of animal rights activ-
ism and by privacy and property and propriety claims of human subjects.
Openness means something different when human and animal subjects
are not at stake. Those working in plant genetics encounter a not always
supportive public, especially around the GMO question, but in general
they can afford to be less concerned with dealing with the public actually
or metaphorically inside their research premises than those working in
biomedicine. Openness as a design feature functions differently. It still
fosters research creativity and productivity by encouraging researchers to
interact and share information and findings through working in shared
spaces with few walls. Instead of a means of collating and containing the
public, however, openness provides visibility and accountability. This is
turn can encourage a research culture designed to avoid the pitfalls and
temptations of hyper-competitive closed science.
    The Sainsbury laboratory is situated in Cambridge University’s Botan-
ic Gardens, and is strongly connected to the botanic gardens, not just
through its core mission of working to discover the mechanisms of
growth regulation of plants, but also in its design. Although the laborato-
ry is concerned with plant genetics and development at least in part so as
to address the grand social challenges of food security and climate change
mitigation, the building was built to emphasize the ethos of fundamental
science, including the herbarium and covered growing area and the flexi-
ble lab benches and non-hierarchical layout of the lab. The pressures that
might be associated with highly commercialized fields were counted in el-
ements of the design. Only the laboratory’s director has a proper office,
and all other researchers of all ranks must do their meeting and working
in shared spaces that overlook the garden and are contiguous with the lab
space itself. Like the Dolby building, this building’s design made interac-
tion inevitable. The arrangement of space highlighted intellectual contri-
bution rather than rank.
    The Sainsbury laboratory building was built with a serene and calming
combination of stone, cement, and wood, and was explicitly conceived of
as monastic by the architects. This is a new monasticism since the Salk,
however. The space is not public, but the public is able to enter the audi-
torium and the café and herbarium and the botanic gardens in which the
building is set. The monasticism comes not so much from being a sepa-
rate citadel from the world in which humanity is at risk, as in the Salk,
but from the designed rigor required to pursue scientific excellence and
truth in the face of politicized and capitalized applications for the science
54                                                            Tecnoscienza - 5 (2)

at hand. The space both ensures that the work is relevant to the pressing
global challenges of the day (food and climate), while steering a path that
avoids the excesses of competitiveness, temptation to fame, and proprie-
tory or secret behavior that might be expected to attend elite science at
Cambridge, as well as science of value to the agricultural biotech private
sector and the politically contested areas of climate change and GM
crops. The pressures that threaten to corrupt science and scientists, hier-
archy and competitiveness and secrecy, are designed to be as minimal as
possible in the building. The new monasticism stands for good science in
both the ethical and intellectually significant senses of the expression.
Where Salk was aesthetic, the Sainsbury laboratory, for all its beauty, em-
bodies a certain intellectual and organizational asceticism.




Image 5 – The Sainsbury Laboratory, Cambridge, UK, in its new monastic sereni-
ty (reproduced from: http://www.stantonwilliams.com/data/projects/372/img2.
jpg).



8. London’s 2015 Francis Crick Institute

    The Francis Crick Institute for Medical Research and Innovation, in
London, UK, is slated for completion in 2015. I toured it while it was still
a building site, and was able to see the extraordinary engineering and de-
sign that went into the basic services housed in its basement. From gas
and air, ventilation and cooling, clean and contained human and animal
and pathogen handling facilities, and on-site data storage and back up,
the Crick was the largest scale building and the most comprehensively
serviced of the buildings. The Salk’s innovation of having service systems
built into the design and infrastructure of science buildings so as to pro-
mote sustainable unpredictable research and collaborations is alive and
Thompson                                                                        55
                    st
well in all these 21 century buildings. A growing need for quality control,
biosafety, and big data storage and management have all intensified the
needs these needs for built in service infrastructure. The fact that the bio-
logical is beginning to yield new kinds of fundamental knowledge that
can bridge the data-human-animal divides is mirrored in the facilities that
need to be designed to permit this fungibility.
    The Crick is a massive edifice, not remotely monastic, but instead po-
sitioned in the heart of the King’s Cross development area of London,
and explicitly engaged with its more and less local publics. The once-
religious motives are not gone, for the basic design of the building is a gi-
ant cross. But it is an active and secular congregation that is beckoned.
There is a team involved in public participation, and the public relations
surrounding the building emphasize the public good to which the science
inside is to be directed. Unlike the other buildings discussed in this pa-
per, the public is to be invited into the belly of the beast, having access to
much of an enormous ground floor atrium. In the emphasis on public en-
gagement and the way the atrium has been designed, the Crick evokes a
21st century hands-on science museum more than a conventional labora-
tory space. There is a café, and a cinema pod in which demonstrations
and films will be shown. Exhibits will be geared toward topics that are of
interest and good to the public living in the areas that surround the build-
ing.




Image 6 – The public part of the soaring central atrium of the Francis Crick Insti-
tute (reproduced from: http://www.hok.com/uploads/2012/03/23/francis-crick-
st05.jpg).
56                                                          Tecnoscienza - 5 (2)

    It has become a commonplace of science today to pay some heed to
public engagement and participation in science, rather than simply seek-
ing to educate the public. The Crick manifests this. It also manifests
starkly the limits to public engagement in science, corralling the public in
the central atrium, rather than in areas where the core science of the
building is happening. The active research part of the building – the
sides, top, and back of the building – are secured from public entry, so as
to protect scientists from potentially dangerous animal rights activists (so
I was told), and from others who might unwittingly or not disrupt the
business of doing cutting edge science. Public participation, then, is more
hands on than the earlier idiom of the public understanding of science,
and no doubt, having the public in the building will serve to remind sci-
entists of the centrality of the public good to their mission as scientists.
Nonetheless, it is a far cry from the citizen science or crowd-sourced ex-
perimental space many of us have imagined might be the next design
phase of 21st century life science.


9. Concluding Thoughts on the New Design

    The iconic new buildings for the life sciences are like the Salk in that
they continue to be award-winning not just as architecture, but as archi-
tecture in the service of research. They continue to design “the basics” in-
to the infrastructure, but their design shows that the basics have expand-
ed to include animal and data storage, and cooling and freezing capacity,
and clean and efficient interfaces between human, animal, and data.
Changing or blurring boundaries between human, non-human animal,
and data are emblematic of the biomedical contemporary life sciences
and are embodied in the design of these buildings. In layout the new
buildings are: a) bench to bedside, including public and private funding
in a single research trajectory, and affirming the link between basic and
translational research; b) in touch with their environments, and even
award-winningly green; c) participatory, but with strict limits; and d) de-
signed for “good science” that would promote translation and spurs to
innovation without falling prey to the excesses of “publish or perish,” or
the corrupting influences of the market. Reading elite science buildings is
a way to follow the evolving epistemology of the life sciences and chang-
ing demands of science policy.
    Applied to these elite science buildings, the STS claim of the co-
production of science and society requires some further discussion. I have
argued that the buildings reflect several rather different kinds of things
going on in and around elite contemporary life science. For example, the
buildings reflect changing ideas about the relation between the public
and science, or about the relation of science to the market, which seem on
the face of it to be science policy issues. The buildings also display a new
Thompson                                                                                                                                                                                                                           57
relation to the cityscape or to the environment in the age of global warm-
ing that seems to be taken from wider culture. In addition, the buildings
display current interpretations of certain ideals of science, such as open-
ness, good science, and the fostering of creativity through interaction,
which might or might not reflect much about how science actually pro-
ceeds. The question arises, then, as to whether these phenomena have an-
ything to do with scientific knowledge itself, or whether they just concern
the cultural context of science6. As I tried to indicate above, the cultural
context and the science itself cannot in fact be that cleanly separated,
even though the entanglements between these things are different for
each issue. So, although the buildings reflect changing (and in some cases,
persistent) ideas about science to be found in the wider culture, they also
reflect, and in turn help produce, changing scientific knowledge. For ex-
ample, translational biomedical science aimed at finding cures needs to
produce knowledge that survives translation from an animal model to
humans, from proof of concept to scaleability, and this requires develop-
ing instrumentation, regulation, characterization, and different and
tougher standards of reproducibility, among other things directly part of
the science itself.
    Contemporary science buildings’ relations to the environment reflect
the rhetorical role of science as evidence-based reason in naming and in
mitigating global warming. The buildings, by mitigating climate change,
impart that reason to what goes on within them. But elements of climate
friendly design such as open plan and natural light are part of encourag-
ing an interactive and transparent approach to science that guards it from
becoming corrupted by excessive money and competition, and that en-
sures that creativity is constantly catalysed. This is true whether the open-
ness literally renders everything visible and whether spontaneous open
plan interactions actually cause more creativity, or whether those ideas
function rhetorically as an ideal; in either case, the knowledge is pro-
duced and judged according to those standards. Likewise, the role of the
public in the buildings’ designs, whether as an absent guarantor of good
science, or as present and participating in parts of the building, makes the
scientific knowledge itself something that must be accountable to the
public in certain ways. The public can talk back to science, appropriate it
for its own ends, demand regulation, refuse a standard of proof, and
many other things that affect what constitutes scientific knowledge and
who is qualified to make that determination. In conclusion, then, the de-
sign of new elite life science real estate tells us about changing ideals of
science, about contemporary issues in science and society, and even about
some changing aspects of scientific knowledge itself.



	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
6
       I am grateful to Paolo Volonté for correspondence on this matter.
58                                                                 Tecnoscienza - 5 (2)

References

Galison, P. (1997) Image and Logic: A Material Culture of Mycrophysics, Chicago,
   University of Chicago Press.
Haraway, D. (1984) Teddy Bear Patriarchy: Taxidermy in the Garden of Eden, New
   York City, 1908-1936, in “Social Text”, 11, pp. 20-64.
Jasanoff, S. (2004) Science and Citizenship: A New Synergy, in “Science and Public
    Policy”, 31 (2), pp. 90-94.
Latour, B. (1999) Pandora’s Hope: Essays on the Reality of Science Studies, Cam-
   bridge, MA, Harvard University Press.
Latour, B. and Woolgar, S. (1986 [1979]) Laboratory Life: The Construction of
   Scientific Facts, Princeton, NJ, Princeton University Press.
Livingstone, D. (2003) Putting Science in Its Place: Geographies of Scientific
    Knowledge, Chicago, University of Chicago Press.
Lynch, M. (1985) Discipline and the Material Form of Images, in “Social Studies of
   Science”, 15 (1), pp. 37-66.
Mukerji, C. (2010) The Territorial State as a Figured World of Power: Strategics,
  Logistics and Impersonal Rule, in “Sociological Theory”, 28 (4), pp. 402-425.
Nelson, A. (2011) Body and Soul: The Black Panther Party and the Fight Against
   Medical Discrimination, Minneapolis, University of Minnesota Press.
Prentice, R. (2013) Bodies in Formation: An Ethnography of Anatomy and Surgery
   Education, Durham Duke University Press.
Rudwick, M. (2014) Earth’s Deep History: How It Was Discovered and Why It
   Matters, Chicago, University of Chicago Press.
Shapin, S. (1991) “The Mind Is Its Own Place”: Science and Solitude in Seventeenth
   Century England, in “Science in Context”, 4 (1), pp. 191-218.
Shapin, S. (2010) Never Pure: Historical Studies of Science as if It Was Produced by
   People with Bodies, Situated in Time, Space, Culture, and Society, and Strug-
   gling for Credibility and Authority, Baltimore, Johns Hopkins University Press.
Suchman, L. (2007) Human-Machine Reconfigurations: Plans and Situated Actions,
   Cambridge, UK, Cambridge University Press.
Thompson, C. (2005) Making Parents: The Ontological Choreography of Reproduc-
   tive Technologies, Cambridge, MA and London, The MIT Press.
Thompson, C. (2013) Good Science: The Ethical Choreography of Stem Cell Re-
   search, Cambridge, MA and London, The MIT Press.
