osteoblastic metastatic disease symptoms
NCI Dictionary of Cancer Terms When it does occur, signs and symptoms of bone metastasis include: 1  Bone pain. 2  Broken bones. 3  Urinary incontinence.  Bowel 1  incontinence. Weakness in the legs or arms.  High levels of calcium in the blood (hypercalcemia), which can cause nausea, vomiting, constipation and confusion.