what cells don't go through mitosis
- A similar system exists in the marrow for the different kinds of white blood cells (WBCs). While WBCs do retain. their nucleus while in peripheral circulation, most are also what we call terminally differentiated, since they can. no longer undergo mitosis. Skeletal muscle . Skeletal muscle can undergo hypertrophy, as each cell gets bigger. But skeletal muscle cells do undergo hyperplasia, since no new cells are generated. As you can imagine, scientists have searched long and hard for a way to get around this in order to repair muscle damaged by trauma or disease.