For considering exposure to residues of cypermethrin in drinking water, HED has calculated chronic DWLOCs. These values are the maximum concentration of a chemical that can occur in drinking water after taking into account chronic exposures to residues of cypermethrin from other pathways and sources. Long term exposures from residential uses are not expected for cypermethrin. Therefore, the chronic aggregate risk calculations include contributions only from food and water sources. The chronic DWLOCs are compared against the modeled EECs for chronic exposure provided by EFED ( see Section 4.3). DWLOC values that are greater than the EECs indicate that aggregate exposures are unlikely to exceed HED s level of concern.

As shown in Table 5.3.1, the chronic DWLOCs for the general U. S. population and all of the representative population subgroups modeled by DEEM FCID are greater than both the surface water and ground water EECs. Chronic aggregate risk estimates associated with exposure to cypermethrin residues in food and water do not exceed HED s level of concern.

Table 5.3.1 Chronic DWLOC Calculations.

Population Subgroup cPAD mg/ kg/ day Food Exp mg/ kg/ day Max Water Exp mg/ kg/ daya Ground Water EEC ( µ g/ L) Surface Water EEC ( µ g/ L) DWLOC ( µ g/ L) b General U. S. Population 0.000043 0.059957 2100 All Infants (< 1 year old) 0.000049 0.059951 600 Children 1 2 years old 0.000095 0.059905 600 Children 3 5 years old 0.000083 0.059917 600 Children 6 12 years old 0.000057 0.059943 600 Youth 13 19 years old 0.000038 0.059962 1800 Adults 20 49 years old 0.000037 0.059963 2100 Females 13 49 years old 0.000035 0.059965 1800 Adults 50+ years old 0.06 0.000034 0.059966 0.0036 0.013 2100 a Maximum water exposure ( mg/ kg/ day) = [( chronic PAD ( mg/ kg/ day)  food exposure ( mg/ kg/ day)]

b DWLOC( µ g/ L) = [ maximum water exposure ( mg/ kg/ day) x body weight ( kg)] ÷ [ water consumption ( L) x 10 3      50    71 mg/ µ g]. Consumption = 1 L/ day for populations < 13 years old and 2 L/ day for populations   13 years old.

Default body weights = 70 kg for males > 20 years old and general U. S. population, 60 kg for females   13 years old and youths 13 19 years old, and 10 kg for all others. Values are rounded to 2 significant figures.

5.4 Cancer Aggregate Risk Cypermethrin has been classified as a Category C, possible human carcinogen, based on an increased incidence of lung adenomas and adenomas plus carcinomas combined in female mice ( Cancer Peer Review Committee, 1988). The evidence was not considered strong enough to warrant a quantitative estimation of human risk. The endpoint selected for the chronic population adjusted dose ( cPAD) will be protective of the possible carcinogenic activity of this chemical. Structure activity comparisons with the pyrethroid class of insecticides indicate that lung tumors in mice were induced with 3 other pyrethroids.

6.0 CUMULATIVE RISK Section 408( b)( 2)( D)( v) of the FFDCA requires that, when considering whether to establish, modify, or revoke a tolerance, the Agency consider " available information  concerning the cumulative effects of a particular pesticide's residues and " other substances that have a common mechanism of toxicity.

Cypermethrin is a member of the pyrethroid class of pesticides. Although all pyrethroids alter nerve function by modifying the normal biochemistry and physiology of nerve membrane sodium channels, EPA is not currently following a cumulative risk approach based on a common mechanism of toxicity for the pyrethroids. Although all pyrethroids interact with sodium channels, there are multiple types of sodium channels and it is currently unknown whether the pyrethroids have similar effects on all channels. Nor do we have a clear understanding of effects on key downstream neuronal function e. g., nerve excitability, nor do we understand how these key events interact to produce their compound specific patterns of neurotoxicity. There is ongoing research by the EPA s Office of Research and Development and pyrethroid registrants to evaluate the differential biochemical and physiological actions of pyrethroids in mammals. This research is expected to be completed by 2007. When available, the Agency will consider this research and make a determination of common mechanism as a basis for assessing cumulative risk. For information regarding EPA s procedures for cumulating effects from substances found to have a common mechanism on EPA s website at http:// www. epa. gov/ pesticides/ cumulative/.

7.0 OCCUPATIONAL EXPOSURE AND RISK 7.1 Occupational Handler      51    71 For the agricultural crop scenarios using PHED data, the inhalation risks are not a concern at baseline attire for applying sprays with groundboom and airblast equipment and for flagging to support aerial applications. The risks to handlers mixing and loading to support applications to agricultural crops ( including chemigation applications) are not a concern at baseline attire with one exception, handlers mixing and loading to support aerial applications to cotton ( a high acreage crop) required the addition of a dust mist respirator. EPA has insufficient data to assess exposures to pilots in open cockpits. Risks to pilots in enclosed cockpits ( engineering control scenario) were not a concern for all agricultural crop scenarios. Short and intermediate term dermal exposures and risks were not assessed for cypermethrin, since no short or intermediate term dermal endpoint was identified.

Chronic exposures were only expected for turf ( LCOs) and termiticides ( PCOs) applications in industrial, commercial, and residential settings. The risks are not a concern at baseline attire for mixing/ loading/ applying liquids and water soluble bags to turfgrass using handgun equipment ( ORETF data). Using PHED data, risks are not a concern at baseline attire for mixing/ loading/ applying liquids to turfgrass using a low pressure handwand, mixing/ loading/ applying wettable powders to standing wood ( termites) using a paint brush, and mixing/ loading/ applying wettable powders to wood using a termiticides injector. The risks are not a concern with the addition of chemical resistant gloves to baseline attire for mixing/ loading/ applying wettable powders to turfgrass using handgun equipment ( ORETF data). Using PHED data, risks are not of concern with the addition of chemical resistant gloves to baseline attire for mixing/ loading/ applying with low pressure handwand sprayers ( termiticide applications), backpack sprayers, and paintbrushes ( all other termite applications).

For the applications in industrial, commercial, and residential settings, the inhalation risks are not a concern at baseline attire for all mixing/ loading/ applying scenarios. Note that there is no inhalation risk data for applying ready to use ear tags to horses, however the inhalation risk from this exposure pattern is not expected to be a concern because of the low volatility of cypermethrin, the dissipating effects of wind likely in outdoor conditions, and the relatively low amounts of cypermethrin in ear tags.

7.2 Occupational Postapplication Worker EPA did not assess occupational postapplication risks to agricultural workers following treatments to agricultural crops, since no short or intermediate term dermal endpoint of concern was identified and long term dermal exposures are not expected for tasks involving any of the registered crop use patterns. In lieu of a postapplication risk assessment, a restricted entry interval of 12 hours is assumed, unless the active ingredient and formulation meet all of the criteria listed in PR Notice 95 3 for low risk pesticides.      52    71 Table 7.2.1. Cypermethrin Occupational Handler Summary Risks ( Short and Intermediate Term Risks)

Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Mixer/ Loader agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 350 acres 130 660 1,900 cotton 0.1 lb ai/ acre 1200 acres 1,300 6,600 19,000 Mixing/ Loading Liquid Concentrates for Aerial Application ( 1a) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, pecans,

rape greens 0.1 lb ai/ acre 350 acres 4,500 23,000 65,000 Mixing/ Loading Liquid Concentrates for Chemigation Application ( 1b) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, cotton,

head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach,

pecans, rape greens 0.1 lb ai/ acre 350 acres 4,500 23,000 65,000 agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 80 acres 580 2,900 8,400 ornamental plants 3.4 lb ai/ acre 40 acres 1,200 5,800 17,000 cotton 0.1 lb ai/ acre 200 acres 7,900 39,000 110,000 Mixing/ Loading Liquid Concentrates for Groundboom Application ( 1c) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, pecans,

rape greens 0.1 lb ai/ acre 80 acres 20,000 98,000 280,000 pecans 0.1 lb ai/ acre 40 acres 39,000 200,000 570,000 Mixing/ Loading Liquid Concentrates for Airblast Application ( 1d) ornamental plants 3.4 lb ai/ acre 20 acres 2,300 12,000 33,000 agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 350 acres 4 18 660 sodfarms 0.74 lb ai/ acre 350 acres 17 85 3,000 Mixing/ Loading Wettable Powders for Aerial Application ( 2a) cotton 0.1 lb ai/ acre 1200 acres 37 180 6,600      53    71 Table 7.2.1. Cypermethrin Occupational Handler Summary Risks ( Short and Intermediate Term Risks)

Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Mixing/ Loading Wettable Powders for Aerial Application ( 2a) ( cont.) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, pecans,

rape greens, 0.1 lb ai/ acre 350 acres 130 630 23,000 Mixing/ Loading Wettable Powders for Chemigation Application ( 2b) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, cotton,

head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach,

pecans, rape greens, 0.1 lb ai/ acre 350 acres 130 630 23,000 agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 80 acres 16 81 2,900 ornamental plants 3.4 lb ai/ acre 40 acres 32 160 5,800 sodfarms 0.74 lb ai/ acre 80 acres 74 370 13,000 cotton 0.1 lb ai/ acre 200 acres 220 1,100 39,000 Mixing/ Loading Wettable Powders for Groundboom Application ( 2c) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, rape greens 0.1 lb ai/ acre 80 acres 550 2,700 98,000 ornamental plants 3.4 lb ai/ acre 20 acres 65 320 12,000 Mixing/ Loading Wettable Powders for Airblast Application ( 2d) pecans 0.1 lb ai/ acre 40 acres 1,100 5,500 200,000 Applicator agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 350 acres see Eng. Controls see Eng. Controls 2,300 sodfarms 0.74 lb ai/ acre 350 acres see Eng. Controls see Eng. Controls 11,000 Applying Sprays with an Airplane ( 3) cotton 0.1 lb ai/ acre 1200 acres see Eng. Controls see Eng. Controls 23,000 Applying Sprays with an Airplane ( 3) ( cont.) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, pecans,

rape greens 0.1 lb ai/ acre 350 acres see Eng. Controls see Eng. Controls 79,000      54    71 Table 7.2.1. Cypermethrin Occupational Handler Summary Risks ( Short and Intermediate Term Risks)

Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 80 acres 940 4,600 16,000 ornamental plants 3.4 lb ai/ acre 40 acres 1,900 9,300 32,000 sodfarms 0.74 lb ai/ acre 80 acres 4,300 21,000 74,000 cotton 0.1 lb ai/ acre 200 acres 13,000 63,000 220,000 Applying Sprays with Groundboom Application ( 4) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach, rape greens 0.1 lb ai/ acre 80 acres 32,000 160,000 550,000 ornamental plants 3.4 lb ai/ acre 20 acres 620 3,100 6,200 Applying Sprays with an Airblast ( 5) pecans 0.1 lb ai/ acre 40 acres 11,000 53,000 110,000 Flagger agricultural uncultivated areas; fencerows, hedgerows 3.4 lb ai/ acre 350 acres 450 2,300 23,000 sodfarms 0.74 lb ai/ acre 350 acres 2,100 10,000 100,000 Flagging for Aerial Sprays ( 6) broccoli, broccoli raab, brussel sprouts, bok choy, cabbage, cauliflower,

cavalo broccolo, Chinese broccoli, Chinese cabbage, collards, cotton,

head lettuce, kale, kohlrabi mizuna, mustard greens, mustard spinach,

pecans, rape greens 0.1 lb ai/ acre 350 acres 15,000 77,000 770,000 Mixer/ Loader/ Applicator Mixing/ Loading/ Applying Liquid Concentrates with a Low Pressure Handwand ( 7) residential, commercial and industrial lawns 0.44 lb ai/ acre 5 acres 2,900 14,000 Not Feasible Termites applications to soil and sides of buildings near to ground,

building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 40 gallons 3,200 16,000 Not Feasible Termites applications to preconstruction lumber and logs, and to soil under firewood 0.041 lb ai/ gallon 40 gallons 3,800 19,000 Not Feasible Mixing/ Loading/ Applying Liquid Concentrates with a Low Pressure Handwand ( 7) ( cont.) Non termite applications to indoor and outdoor surfaces at residential,

commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 40 gallons 9,300 46,000 Not Feasible      55    71 Table 7.2.1. Cypermethrin Occupational Handler Summary Risks ( Short and Intermediate Term Risks)

Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe applications to horses ornamental plants; termite applications to standing wood in uninhabited areas at residential, commercial and industrial sites 0.008 lb ai/ gallon 40 gallons 20,000 98,000 Not Feasible Termites applications to soil and sides of buildings near to ground,

building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 5 gallons 2,700 14,000 Not Feasible Termites applications to preconstruction lumber and logs, and to soil under firewood 0.041 lb ai/ gallon 5 gallons 3,300 16,000 Not Feasible Mixing/ Loading/ Applying Liquid Concentrates with a Paintbrush ( 8) Non termite applications to indoor and outdoor surfaces at residential,

commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 5 gallons 7,900 40,000 Not Feasible agricultural uncultivated areas; fencerows, hedgerows; ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres 6,200 31,000 Not Feasible Mixing/ Loading/ Applying Liquid Concentrates with a Handheld Handgun ( ORETF) ( 9) residential, commercial and industrial lawns 0.44 lb ai/ acre 5 acres 48,000 240,000 Not Feasible Mixing/ Loading/ Applying Liquid Concentrates with an Termiticide Injector ( 10) Termites: trees, utility poles, fenceposts, building voids 0.05 lb ai/ gallon 500 gallons 3,400 17,000 Not Feasible residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres 57 290 Not Feasible Termites applications to soil and sides of buildings near to ground,

building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 40 gallons 86 430 Not Feasible Mixing/ Loading/ Applying Wettable Powders with a Low Pressure Handwand ( 11) fire ant mounds 0.033 lb ai/ gallon 40 gallons 130 650 Not Feasible Non termite applications to indoor and outdoor surfaces at residential,

commercial and industrial sites, animal premises, and greenhouses;

applications to horses 0.017 lb ai/ gallon 40 gallons 250 1,300 Not Feasible Mixing/ Loading/ Applying Wettable Powders with a Low Pressure Handwand ( 11) ( cont.) ornamental plants; termite applications to standing wood in uninhabited areas at residential, commercial and industrial sites 0.008 lb ai/ gallon 40 gallons 540 2,700 Not Feasible Termites applications to soil and sides of buildings near to ground,

building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 5 gallons 2,700 14,000 Not Feasible Mixing/ Loading/ Applying Wettable Powders with a Paintbrush ( using PHED liquid paintbrush) ( 12)      56    71 Table 7.2.1. Cypermethrin Occupational Handler Summary Risks ( Short and Intermediate Term Risks)

Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Termites applications to preconstruction lumber and logs, and to soil under firewood 0.041 lb ai/ gallon 5 gallons 3,300 16,000 Not Feasible Non termite applications to indoor and outdoor surfaces at residential,

commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 5 gallons 7,900 40,000 Not Feasible agricultural uncultivated areas; fencerows, hedgerows; ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres 170 870 Not Feasible Mixing/ Loading/ Applying Wettable Powders Formulations with a Handheld Handgun ( ORETF) ( 13) residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres 980 4,900 Not Feasible agricultural uncultivated areas; fencerows, hedgerows; ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres 1,500 7,700 Not Feasible Mixing/ Loading/ Applying Wettable Powders in Water Soluble Packaging with a Handheld Handgun ( ORETF) ( 14) residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres 8,800 44,000 Not Feasible Applying Ready to Use Formulations via RTU Tag ( 15) cattle 0.003 lb ai/ 2 ear tags 100 and 1000 cattle No Data No Data Not Feasible Applying Ready to Use Formulations with Pump Trigger Sprayers ( 16) horses 0.017 lb ai/ gallon 1 gallon 90,000 450,000 Not Feasible 500 horses 14,000,000 69,000,000 Not Feasible Applying Ready to Use Formulations with Wipes ( 17) horses 0.00041 lb ai/ wipe 50 horses 140,000,00 0 690,000,000 Not Feasible Applying Ready to Use Formulations with Aerosol Cans ( 18) Non termite applications to indoor and outdoor surfaces at residential,

commercial and industrial sites, animal premises, and greenhouses; 0.005 lb ai/ 16 oz can 2 cans 15,000 73,000 Not Feasible Applying Ready to Use Formulations with Fogger ( 19) Non termite applications to indoor spaces at residential, commercial and industrial sites, animal premises, and greenhouses 0.0014 lb ai/ fogger 4 foggers 26,000 130,000 Not Feasible Footnotes a Application rates are the maximum application rates determined from EPA registered labels for cypermethrin.

b Amount handled per day values are EPA estimates of acreage treated or gallons applied based on Exposure SAC Policy # 9 " Standard Values for Daily Acres Treated in Agriculture".

c Baseline inhalation MOE = short and intermediate term NOAEL ( 2.7 mg/ kg/ day) / baseline inhalation dose ( mg/ kg/ day) and represents no respiratory protection.

d 80% PPE R inhalation MOE = short and intermediate term NOAEL ( 2.7 mg/ kg/ day) / 80 percent PPE R inhalation dose ( mg/ kg/ day) and represents use of a dust mist respirator. Dose is calculated using an 80 percent protection factor applied to baseline inhalation exposure values found in the PHED Surrogate Exposure Guide.      57    71 e Engineering control inhalation MOE = short and intermediate term NOAEL ( 2.7 mg/ kg/ day) / engineering control inhalation dose ( mg/ kg/ day) and represents:

1a, 1b, 1c, 1d: closed mixing 2a, 2b, 2c, 2d: water soluble packet enclosed cockpit and 4, 5, 6: enclosed cab Table 7.2.2. Cypermethrin Long Term Occupational Handler Summary Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Long Term Baseline Dermal +

Baseline Inhalation ARIc Long Term PPE Gloves Dermal +

Baseline Inhalation ARId Long Term PPEGloves Dermal +

Dust/ Mist Respirator Inhalation ARIe Mixer/ Loader/ Applicator residential, commercial and industrial lawns 0.44 lb ai/ acre 5 acre 0.71 9.1 38 Termites applications to soil and sides of buildings near to ground, building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 40 gallons 0.78 10 41 Termites applications to preconstruction lumber and logs,

and to soil under firewood 0.041 lb ai/ gallon 40 gallons 0.95 12 50 Non termite applications to indoor and outdoor surfaces at residential, commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 40 gallons 2.3 29 120 Mixing/ Loading/ Applying Liquid Concentrates with a Low Pressure Handwand ( 1) ornamental plants; termite applications to standing wood in uninhabited areas at residential, commercial and industrial sites 0.008 lb ai/ gallon 40 gallons 4.9 62 260 Termites applications to soil and sides of buildings near to ground, building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 5 gallons 2.6 6.8 17 Termites: preconstruction lumber and logs, soil under firewood 0.041 lb ai/ gallon 5 gallons 3.2 8.3 21 Mixing/ Loading/ Applying Liquid Concentrates with a Paintbrush ( 2) Non termite applications to indoor and outdoor surfaces at residential, commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 5 gallons 7.8 20 51      58    71 Table 7.2.2. Cypermethrin Long Term Occupational Handler Summary Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Long Term Baseline Dermal +

Baseline Inhalation ARIc Long Term PPE Gloves Dermal +

Baseline Inhalation ARId Long Term PPEGloves Dermal +

Dust/ Mist Respirator Inhalation ARIe agricultural uncultivated areas; fencerows, hedgerows;

ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres no baseline dermal data 11 18 Mixing/ Loading/ Applying Liquid Concentrates with a Handheld Handgun ( ORETF)

( 3) residential, commercial and industrial lawns 0.44 lb ai/ acre 5 acres no baseline dermal data 82 140 Mixing/ Loading/ Applying Liquid Concentrates with a Termiticide Injector ( 4) Termites: trees, utility poles, fenceposts, building voids 0.05 lb ai/ gallon 500 gallons no baseline dermal data 7.1 18 residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres no baseline dermal data 0.19 0.83 Termites applications to soil and sides of buildings near to ground, building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 40 gallons no baseline dermal data 0.28 1.2 fire ant mounds 0.033 lb ai/ gallon 40 gallons no baseline dermal data 0.42 1.9 Non termite applications to indoor and outdoor surfaces at residential, commercial and industrial sites, animal premises, and greenhouses; applications to horses 0.017 lb ai/ gallon 40 gallons no baseline dermal data 0.82 3.7 Mixing/ Loading/ Applying Wettable Powders with a Low Pressure Handwand ( 5) ornamental plants; termite applications to standing wood in uninhabited areas at residential, commercial and industrial sites 0.008 lb ai/ gallon 40 gallons no baseline dermal data 1.7 7.8 Termites applications to soil and sides of buildings near to ground, building perimeters, masonry voids, and standing wood in uninhabited areas at residential, commercial and industrial sites 0.05 lb ai/ gallon 5 gallons 2.6 6.8 17 Termites: preconstruction lumber and logs, soil under firewood 0.041 lb ai/ gallon 5 gallons 3.2 8.3 21 Mixing/ Loading/ Applying Wettable Powders with a Paintbrush ( using PHED liquid paintbrush data) ( 6) Non termite applications to indoor and outdoor surfaces at residential, commercial and industrial sites, animal premises, and greenhouses; 0.017 lb ai/ gallon 5 gallons 7.8 20 51      59    71 Table 7.2.2. Cypermethrin Long Term Occupational Handler Summary Exposure Scenario Crop or Target Application Ratea ( lb ai/ unit) Amount Handled Dailyb Long Term Baseline Dermal +

Baseline Inhalation ARIc Long Term PPE Gloves Dermal +

Baseline Inhalation ARId Long Term PPEGloves Dermal +

Dust/ Mist Respirator Inhalation ARIe agricultural uncultivated areas; fencerows, hedgerows;

ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres no baseline dermal data 0.55 2.3 Mixing/ Loading/ Applying Wettable Powders with a Handheld Handgun ( ORETF) ( 7) residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres no baseline dermal data 3.1 13 agricultural uncultivated areas; fencerows, hedgerows;

ornamental plants; potting soil, topsoil 3.4 lb ai/ acre 5 acres no baseline dermal data 3.9 9.7 Mixing/ Loading/ Applying WSB Formulations with a Handheld Handgun ( ORETF) ( 8) residential, commercial and industrial lawns 0.6 lb ai/ acre 5 acres no baseline dermal data 22 55 Footnotes a Application rates are the maximum application rates determined from EPA registered labels for Cypermethrin.

b Amount handled per day values are EPA estimates of acreage treated or gallons applied based on Exposure SAC Policy # 9 " Standard Values for Daily Acres Treated in Agriculture".

c Aggregate Risk Index = 1/{[ 1/( Baseline Dermal MOE/ Dermal UF 100)] + [ 1/( Baseline Inhalation MOE/ Inhalation UF 300)]} where an ARI greater than 1 is considered acceptable d Aggregate Risk Index = 1/{[ 1/( PPE gloves Dermal MOE/ Dermal UF 100)] + [ 1/( Baseline Inhalation MOE/ Inhalation UF 300)]} where an ARI greater than 1 is considered acceptable.

e Aggregate Risk Index = 1/{[ 1/( PPE gloves Dermal MOE/ Dermal UF 100)] + [ 1/( Dust/ Mist Respirator Inhalation MOE/ Inhalation UF  300)]} where an ARI greater than 1 is considered acceptable. Table 7.2.3: Zeta Cypermethrin Occupational Handler Short and Intermediate Term Risks Exposure Scenario Crop or Target Application Ratea Area Treated Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Mixer/ Loader Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, and Triticale 0.05 lb ai/ acre 1200 acres 2,600 13,000 38,000 Mixing/ Loading Liquid Concentrates for Aerial Applications ( 1a) Leafy Brassica Greens, Head and Stem Brassica Vegetables,

Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica), Succulent Edible Podded Peas, 0.05 lb ai/ acre 350 acres 9,000 45,000 130,000      60    71 Table 7.2.3: Zeta Cypermethrin Occupational Handler Short and Intermediate Term Risks Exposure Scenario Crop or Target Application Ratea Area Treated Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Succulent Edible Podded Beans, Head Lettuce, Pecans, Grain Sorghum and Millet, Sugarbeets, Sugarcane Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, and Triticale 0.05 lb ai/ acre 350 acres 9,000 45,000 130,000 Mixing/ Loading Liquid Concentrates for Chemigation Applications ( 1b) Leafy Brassica Greens, Head and Stem Brassica Vegetables,

Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica), Succulent Edible Podded Peas,

Succulent Edible Podded Beans, Head Lettuce, Pecans, Grain Sorghum and Millet, Sugarbeets, Sugarcane 0.05 lb ai/ acre 350 acres 9,000 45,000 130,000 Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, and Triticale 0.05 lb ai/ acre 200 acres 16,000 79,000 230,000 Mixing/ Loading Liquid Concentrates for Groundboom Applications ( 1c) Leafy Brassica Greens, Head and Stem Brassica Vegetables,

Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica), Succulent Edible Podded Peas,

Succulent Edible Podded Beans, Head Lettuce, Grain Sorghum and Millet, Sugarbeet, Sugarcane 0.05 lb ai/ acre 80 acres 39,000 200,000 570,000 Mixing/ Loading Liquid Concentrates for Airblast Applications ( 1d) Pecans 0.05 lb ai/ acre 40 acres 79,000 390,000 1,100,000 Loading Dusts into Mechanical Duster or Dust Bags ( using PHED mixing/ loading wettable powders data)

( 2) Livestock ( beef & dairy cattle, sheep, goats, horses) 0.000094 lb ai/ animal 1000 animals 47,000 230,000 Not Feasible Applicator      61    71 Table 7.2.3: Zeta Cypermethrin Occupational Handler Short and Intermediate Term Risks Exposure Scenario Crop or Target Application Ratea Area Treated Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, and Triticale 0.05 lb ai/ acre 1200 acres No Data No Data 46,000 Applying Sprays via Aerial Equipment ( 3) Leafy Brassica Greens, Head and Stem Brassica Vegetables,

Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica), Succulent Edible Podded Peas,

Succulent Edible Podded Beans, Head Lettuce, Pecans, Grain Sorghum and Millet, Sugarbeet, Sugarcane 0.05 lb ai/ acre 350 acres No Data No Data 160,000 Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, and Triticale 0.05 lb ai/ acre 200 acres 26,000 130,000 440,000 Applying Sprays via Groundboom Equipment ( 4) Leafy Brassica Greens, Head and Stem Brassica Vegetables,

Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica), Succulent Edible Podded Peas,

Succulent Edible Podded Beans, Head Lettuce, Grain Sorghum and Millet, Sugarbeet, Sugarcane 0.05 lb ai/ acre 80 acres 64,000 320,000 1,100,000 Applying Sprays via Airblast Equipment ( 5) Pecans 0.05 lb ai/ acre 40 acres 21,000 110,000 210,000 Applying Dusts via Mechanical Duster ( 6) Livestock ( beef & dairy cattle, sheep, goats, horses) 0.000094 lb ai/ animal 1000 animals No Data No Data No Data Flagger Flagging for Aerial Spray Applications ( 7) Alfalfa, Alfalfa grown for seed, Corn, sweet, field, pop, and field grown for seed; Cotton ( foliar use), Rice, Soybeans,

Wheat, Triticale, Leafy Brassica Greens, Head and Stem Brassica Vegetables, Bulb Vegetables, Fruiting Vegetables ( except cucurbits), Leafy Vegetables ( except Brassica),

Succulent Edible Podded Peas, Succulent Edible Podded Beans, Head Lettuce, Pecans, Grain Sorghum and Millet,

Sugarbeet, Sugarcane 0.05 lb ai/ acre 350 acres 31,000 150,000 1,500,000      62    71 Table 7.2.3: Zeta Cypermethrin Occupational Handler Short and Intermediate Term Risks Exposure Scenario Crop or Target Application Ratea Area Treated Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe Mixer/ Loader/ Applicator Indoor surfaces 0.0044 lb ai/ gallon 40 gallons 36,000 180,000 Not Feasible Residential Lawns and Turfgrass at Commercial Sites 0.3 lb ai/ acre 5 acres 4,200 21,000 Not Feasible Mixing/ Loading/

Applying Liquid Concentrates with Low Pressure Handwand ( PHED) ( 8) Outdoor surfaces 0.001 lb ai/ gallon 40 gallons 160,000 790,000 Not Feasible residential lawns 0.3 lb ai/ acre 5 acres 70,000 350,000 Not Feasible Mixing/ Loading/

Applying Liquid Concentrates with a Handgun Sprayer ( LCO ORETF data)

( 9) outdoor surfaces, surfaces of buildings, porches, screens,

window frames, eaves, patios, lawn area adjacent to or around private homes, duplexes, townhouses, condominiums, house trailers apartment complexes, carports, garages, fence lines,

storage sheds, barns, and other residential structures plus commercial, industrial, institutional buildings, vegetation,

refuse dumps, garages, and other outdoor surfaces 0.4356 lb ai/ acre 5 acres 48,000 240,000 Not Feasible Applying Dusts via Shaker Can ( MRID 444598 01) ( 10) Livestock ( beef & dairy cattle, sheep, goats, horses) 0.000094 lb ai/ animal 100 animals 32,000 1,600,000 Not Feasible Mixing/ Loading/

Applying Liquid Concentrates with a Watering Can ( using ORETF residential hose end data) ( 12) outdoor surfaces ( ant mounds) 0.006 lb ai/ mound 40 mounds 46,000 230,000 Not Feasible Mixing/ Loading/

Applying Liquid Concentrates with a Paint Brush ( 13) outdoor surfaces ( general) 0.001 lb ai/ gallon 5 gallons 140,000 680,000 Not Feasible      63    71 Table 7.2.3: Zeta Cypermethrin Occupational Handler Short and Intermediate Term Risks Exposure Scenario Crop or Target Application Ratea Area Treated Dailyb Baseline Inhalation MOEc Dust/ Mist Respirator Inhalation MOEd Engineering Control Inhalation MOEe livestock ( cattle) 0.004 lb ai/ 2 ear tags/ cattle 100 &

1000 cattle No Data No Data Not Feasible Applying Ready to Use Ear Tags ( 14) livestock ( cattle) 0.003 lb ai/ 1 ear tag/ cattle 100 &

1000 cattle No Data No Data Not Feasible Loading Dusts into Self Applying Dust Bags ( using PHED mixing/ loading wettable powders data)

( 15) Livestock ( beef & dairy cattle, sheep, goats, horses) 0.000094 lb ai/ animal 1000 animals 47,000 230,000 Not Feasible Footnotes a Application rates are the maximum application rates determined from EPA registered labels for Zeta Cypermethrin.

b Amount handled per day values are HED estimates of acres, square feet, or cubic feet treated or gallons applied based on Exposure SAC SOP # 9   Standard Values for Daily Acres Treated in Agriculture,  industry sources, and HED estimates.

c Baseline inhalation: no respirator.

d PPE inhalation: assumes a dust/ mist removing quarter face style respirator providing an 80% protection factor ( PF5)

e Eng Controls Inhalation: Closed mixing/ loading system, enclosed cab, or enclosed cockpit.

Table 7.2.4: Zeta cypermethrin Long Term Occupational Handler Summary Exposure Scenario Crop or Target Applicati on Ratea Area Treated Dailyb Long term Baseline Dermal +

Baseline Inhalation ARIc Long term PPE Gloves Dermal +

Baseline Inhalation ARId Long term PPEGloves Dermal +

Dust/ Mist Respirator Inhalation ARIe Mixer/ Loader/ Applicator      64    71 Table 7.2.4: Zeta cypermethrin Long Term Occupational Handler Summary Exposure Scenario Crop or Target Applicati on Ratea Area Treated Dailyb Long term Baseline Dermal +

Baseline Inhalation ARIc Long term PPE Gloves Dermal +

Baseline Inhalation ARId Long term PPEGloves Dermal +

Dust/ Mist Respirator Inhalation ARIe Indoor surfaces and Outdoor surfaces ( outdoor rate supplied by Registrant) 0.0044 lb ai/ gallon 40 gallons 0.095 110 470 Residential Lawns and Turfgrass at Commercial Sites ( Rate supplied by Registrant) 0.3 lb ai/ acre 5 acres 0.011 13 55 Mixing/ Loadin g/ Applying Liquid Concentrates with Low Pressure Handwand ( PHED) Outdoor surfaces ( rate from label) 0.001 lb ai/ gallon 40 gallons 0.42 500 2100 residential lawns 0.3 lb ai/ acre 5 acres No Baseline Dermal Data 120 210 Mixing/ Loadin g/ Applying Liquid Concentrates with a Handgun Sprayer ( LCO ORETF data) outdoor surfaces, surfaces of buildings, porches,

screens, window frames, eaves, patios, lawn area adjacent to or around private homes, duplexes,

townhouses, condominiums, house trailers apartment complexes, carports, garages, fence lines, storage sheds, barns, and other residential structures plus commercial, industrial,

institutional buildings, vegetation, refuse dumps,

garages, and other outdoor surfaces 0.4356 lb ai/ acre 5 acres No Baseline Dermal Data 83 140 Mixing/ Loadin g/ Applying Liquid Concentrates outdoor surfaces ( ant mounds) 0.006 lb ai/ mound 40 mounds 1.2 No PPE Dermal Data No PPE Dermal Data      65    71 with a Watering Can ( using ORETF residential hose end data)

Mixing/ Loadin g/ Applying Liquid Concentrates with a Paint Brush outdoor surfaces ( general) ( rate from label) 0.001 lb ai/ gallon 5 gallons 1.9 340 860 Footnotes a Application rates are the maximum application rates determined from EPA registered labels for zeta cypermethrin.

b Amount handled per day values are HED estimates of acres, square feet, or cubic feet treated or gallons applied based on Exposure SAC SOP # 9   Standard Values for Daily Acres Treated in Agriculture,  industry sources, and HED estimates.

c Baseline inhalation: no respirator.

d PPE inhalation: assumes a dust/ mist removing quarter face style respirator providing an 80% protection factor e Eng Controls Inhalation: Closed mixing/ loading system, enclosed cab, or enclosed cockpit.      66    71 8.0 DATA NEEDS AND LABEL REQUIREMENTS Toxicology · None.

Product and Residue Chemistry Data Requirements · The registrant has addressed the product chemistry deficiencies identified in the phase 2 risk assessment document. Upon completion of review of the submitted data, HED will comment on any remaining outstanding data requirements for product chemistry.

· Needed label changes pertain to the following: 1) minimum retreatment intervals, 2) minimum aerial application volumes, and 3) impractical cotton forage grazing/ feeding restrictions. The registrant has agreed to make these changes. Upon receipt of the updated label, this data requirement will be satisfied.

Occupational & Residential · The residential postapplication residential assessment for cypermethrin is based on limited chemical specific studies. Additional data could potentially be used to refine risk estimates for the other settings such as TTR data which are more appropriate for hand tomouth and object to mouth exposures.      67    71 9.0 TOLERANCE REASSESSMENT The tolerances listed in 40 CFR § 180.418( a)( 1) are expressed in terms of residues of cypermethrin per se [( ± )  alpha cyano( 3 phenoxyphenyl) methyl [( ± )  cis, trans 3( 2,2 dichloroethenyl) 2,2 dimethylcyclopropanecarboxylate]], while those listed in 40 CFR § 180.418( a)( 2) are expressed in terms of residues of zeta cypermethrin [( S cyano( 3 phenoxyphenyl) methyl [( ± )  cis, trans 3( 2,2 dichloroethenyl) 2,2 dimethylcyclopropanecarboxylate]] and its inactive R isomers. The HED MARC has determined that the current tolerance expression for plant and livestock commodities is appropriate. Because the analytical enforcement method does not distinguish between cypermethrin and zeta cypermethrin, all tolerance levels for livestock commodities should be the same for the racemic and enriched isomers. In light of label restrictions and the different total application rates between formulations containing cypermethrin and zetacypermethrin different tolerance levels may be appropriate for some plants, such as green onions.

Tolerances Listed Under 40 CFR § 180.418( a)( 1):

Plant commodity tolerances: Sufficient field trial data are available to ascertain the adequacy of the established tolerances listed in 40 CFR § 180.418 for the following plant commodities: head and stem Brassica subgroup; leafy greens Brassica subgroup; undelinted cottonseed; head lettuce; bulb onion; green onion; and pecans. For the purposes of tolerance reassessment, the existing field trial data for these RACs have been re evaluated. With the exception of head lettuce, the data suggest that the existing tolerance levels for all plant commodities are appropriate, and no increase or decrease in levels are warranted. Based on acceptable field trial data for head lettuce, the established tolerance for this commodity should be lowered from 10 ppm to 4.0 ppm. The available data indicate that the maximum residue of cypermethrin found in head lettuce following applications of a representative cypermethrin formulation, according to the maximum registered patterns, was 3.4 ppm.

Although a tolerance for garlic has not been established, the existing tolerance for bulb onions will cover the registered uses of cypermethrin on garlic, as permitted according to 40 CFR § 180.1( h).

Livestock commodity tolerances: An acceptable ruminant feeding study is available to ascertain the adequacy of the established tolerances listed in 40 CFR § 180.418( a)( 1) for the following livestock commodities: meat, fat, and meat byproducts of cattle, goats, hogs, horses and sheep. Also, an acceptable poultry feeding study is available to determine the need for tolerances in/ on poultry commodities.      68    71 Tolerances That Need To Be Proposed Under 40 CFR § 180.418( a)( 1):

Based on the recently submitted magnitude of the residue data for cotton gin byproducts, a tolerance level of 11 ppm is appropriate for this commodity. This level was determined through use of the tolerance spreadsheet calculator. Based on the poultry feeding study and dietary burden and Codex considerations, HED recommends that a tolerance level of 0.05 ppm be established for cypermethrin residues in/ on egg; poultry, fat; and poultry, meat.

Tolerances That Need To Be Changed Under 40 CFR § 180.418( a)( 2):

As discussed previously, tolerance levels for livestock commodities should be the same for cypermethrin and zeta cypermethrin. Comparison of the dietary burden calculated for swine shows that it is approximately 10X lower than that for cattle. Accordingly, lower tolerance levels are appropriate for hog commodities. Thus, the present data supports the following changes to hog tolerances: 1) reduce the current tolerance level of 1.0 ppm for hog, fat to 0.10 ppm, 2) reduce the current tolerance level of 0.2 ppm for hog, meat to 0.05 ppm, and 3) remove the current tolerance level of 0.05 ppm for hog, meat byproducts. In addition, the current tolerance level of 10.00 ppm for lettuce, head may be removed since this RAC is already included in the crop group 4 listing. Finally, the poultry, meat byproducts tolerance level of 0.05 ppm should be removed as the present analysis shows expected residues to be so low that a tolerance is not necessary [ 40 CFR § 180.6( a)( 3)].

A summary of cypermethrin tolerance reassessments is presented in Table 9.1.

Table 9.1. Tolerance Reassessment Summary for Cypermethrin.

Commodity Current Tolerance ( ppm) Tolerance Reassessment ( ppm) Comment/ Correct Commodity Definition Tolerances listed under 40 CFR 180.418( a)( 1):

Brassica, head and stem 2.0 2.0 [ Brassica, head and stem, subgroup]

Brassica, leafy 14.0 14.0 [ Brassica, leafy greens, subgroup]

Cattle, fat 0.05 1.0 Based on a MTDB of 18 ppm Cattle, meat 0.05 0.20 Based on a MTDB of 18 ppm Harmonizes with Codex MRL Cattle, mbyp 0.05 0.05 Based on a MTDB of 18 ppm [ Cattle, meat byproducts]

Cottonseed 0.5 0.50 [ Cotton, undelinted seed]

Goats, fat 0.05 1.0 Based on a MTDB of 18 ppm [ Goat, fat]

Goats, meat 0.05 0.20 Based on a MTDB of 18 ppm. [ Goat, meat]

Goats, mbyp 0.05 0.05 Based on a MTDB of 18 ppm. [ Goat, meat byproducts]

Hogs, fat 0.05 0.10 Based on a MTDB of 1.8 ppm      69    71 Commodity Current Tolerance ( ppm) Tolerance Reassessment ( ppm) Comment/ Correct Commodity Definition [ Hog, fat]

Hogs, meat 0.05 0.05 Based on a MTDB of 1.8 ppm [ Hog, meat]

Hogs, mbyp 0.05   Based on a MTDB of 1.8 ppm Residue data support removal of tolerance.

Horses, fat 0.05 1.0 Based on a MTDB of 18 ppm [ Horse, fat]

Horses, meat 0.05 0.20 Based on a MTDB of 18 ppm [ Horse, meat]

Horses, mbyp 0.05 0.05 Based on a MTDB of 18 ppm [ Horse, meat byproducts]

Lettuce, head 10.0 4.0 Residue data support reduction of tolerance.

Milk 0.05 2.5 Based on a MTDB of 18 ppm [ Milk, fat ( reflecting 0.10 in whole milk)]

Onions, bulb 0.1 0.10 [ Onion, bulb]

Onions, green 6.0 6.0 Residue data support a tolerance level of 3.0 ppm for zeta cypermethrin / [ Onion, green]

Pecans 0.05 0.05 Sheep, fat 0.05 1.0 Based on a MTDB of 18 ppm Sheep, meat 0.05 0.20 Based on a MTDB of 18 ppm Harmonizes with Codex MRL Sheep, mbyp 0.05 0.05 Based on a MTDB of 18 ppm [ Sheep, meat byproducts]

Tolerances That Need To Be Proposed under 40 CFR 180.418( a)( 1):

Cotton gin byproducts  11 Based on new data submitted.

Egg   0.05 Based on a MTDB of 1.4 ppm Poultry, fat   0.05 Based on a MTDB of 1.4 ppm Poultry, meat   0.05 Harmonizes with Codex MRL Tolerances That Need To Be Changed under 40 CFR 180.418( a)( 2):

Hog, fat 1.0 0.10 Based on a MTDB of 1.8 ppm Hog, meat 0.2 0.05 Based on a MTDB of 1.8 ppm Hog, meat byproducts 0.05 None Based on a MTDB of 1.8 ppm Lettuce, head 10.00 None Covered by Vegetable, leafy, except Brassica, group 04 Poultry, meat byproducts 0.05 None Based on a MTDB of 1.4 ppm      70    71


[Federal Register Volume 77, Number 213 (Friday, November 2, 2012)]
[Notices]
[Page 66194]
[FR Doc No: 2012-26863]

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SECURITIES AND EXCHANGE COMMISSION

[Release No. IC-30253]

Notice of Applications for Deregistration Under Section 8(f) of
the Investment Company Act of 1940

October 26, 2012.
    The following is a notice of applications for deregistration under
section 8(f) of the Investment Company Act of 1940 for the month of
October 2012. A copy of each application may be obtained via the
Commission's Web site by searching for the file number, or for an
applicant using the Company name box, at http://www.sec.gov/search/search.htm or by calling<PHONE_NUMBER>. An order granting each
application will be issued unless the SEC orders a hearing. Interested
persons may request a hearing on any application by writing to the
SEC's Secretary at the address below and serving the relevant applicant
with a copy of the request, personally or by mail. Hearing requests
should be received by the SEC by 5:30 p.m. on November 19, 2012, and
should be accompanied by proof of service on the applicant, in the form
of an affidavit or, for lawyers, a certificate of service. Hearing
requests should state the nature of the writer's interest, the reason
for the request, and the issues contested. Persons who wish to be
notified of a hearing may request notification by writing to the
Secretary, U.S. Securities and Exchange Commission, 100 F Street NE.,
Washington, DC 20549-1090.

FOR FURTHER INFORMATION CONTACT: Diane L. Titus at<PHONE_NUMBER>, SEC,
Division of Investment Management, Office of Investment Company
Regulation, 100 F Street NE., Washington, DC 20549-8010.

Acadia Mutual Funds [File No. 811-22341]

    Summary: Applicant seeks an order declaring that it has ceased to
be an investment company. On June 29, 2012, applicant made a final
liquidating distribution to its shareholders, based on net asset value.
Expenses of $6,500 incurred in connection with the liquidation were
paid by Acadia Mutual Fund Management, LLC, applicant's investment
adviser.
    Filing Dates: The application was filed on August 23, 2012, and
amended on October 3, 2012.
    Applicant's Address: One Penn Plaza, 36th Floor, New York, NY
10119.

BlackRock Investment Quality Municipal Income Trust [File No. 811-7666]

    Summary: Applicant, a closed-end investment company, seeks an order
declaring that it has ceased to be an investment company. On June 29,
2012, applicant made a liquidating distribution to its shareholders,
based on net asset value. Expenses of $67,715 incurred in connection
with the liquidation were paid by BlackRock Advisors, LLC, applicant's
investment adviser. Applicant has retained approximately $72,806 in
cash to pay for contingent liabilities.
    Filing Dates: The application was filed on July 5, 2012, and
amended on October 10, 2012.
    Applicant's Address: 100 Bellevue Parkway, Wilmington, DE 19809.

Dreyfus Cash Management Plus Inc. [File No. 811-5295]

    Summary: Applicant seeks an order declaring that it has ceased to
be an investment company. The applicant has transferred its assets to
Dreyfus Cash Management and, on August 25, 2011, made a final
distribution to shareholders based on net asset value. Expenses of
approximately $78,100 incurred in connection with the reorganization
were paid by The Dreyfus Corporation, applicant's investment adviser.
    Filing Dates: The application was filed on August 14, 2012, and
amended on October 10, 2012.
    Applicant's Address: c/o The Dreyfus Corporation, 200 Park Ave.,
New York, NY 10166.

Pearl Mutual Funds [File No. 811-10261]

    Summary: Applicant seeks an order declaring that it has ceased to
be an investment company. On October 1, 2012, applicant made a
liquidating distribution to its shareholders, based on net asset value.
Expenses of $65,291 incurred in connection with the liquidation were
paid by applicant and Pearl Management Company, applicant's investment
adviser.
    Filing Date: The application was filed on October 5, 2012.
    Applicant's Address: 2610 Park Ave., Muscatine, IA 52761.

BlackRock Floating Rate Income Strategies Fund II, Inc. [File No. 811-
21464]

BlackRock Diversified Income Strategies Fund, Inc. [811-21637]

    Summary: Each applicant, a closed-end investment company, seeks an
order declaring that it has ceased to be an investment company. The
applicants transferred their assets to BlackRock Floating Rate Income
Strategies Fund, Inc. and, on October 8, 2012, made final liquidating
distributions to their shareholders based on net asset value. Expenses
of approximately $297,156 and $300,345, respectively, incurred in
connection with the reorganizations were paid by each applicant.
    Filing Date: The applications were filed on October 22, 2012.
    Applicants' Address: 100 Bellevue Parkway, Wilmington, DE 19809.

    For the Commission, by the Division of Investment Management,
pursuant to delegated authority.
Kevin M. O'Neill,
Deputy Secretary.
[FR Doc. 2012-26863 Filed 11-1-12; 8:45 am]
BILLING CODE 8011-01-P