a   INTERCEPT
                                    0.01607
                                   -0.01521

                                  b     SLOPE
                                    0.0221
                                    0.02535

Table 75.  Sample Analysis for DIPE in blood from male rats exposed to 3600 ppm DIPE.

                                   Peak Area

Animal I.D.
                                  Time point
                                     DIPE
                                     MTBE
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                               Sample weight (g)
Corrected Conc. (ug/ml)
                                     15-01
                                    Predose
                                       0
                                    6650974
                                       0
                                   below LOQ
                                    0.1399
                                      n/a

                                     5 min
                                   19357383
                                    5761758
                                     3.36
                                     57.3
                                    0.2034
                                     28.2

                                    10 min
                                   32067653
                                    5670355
                                     5.66
                                     95.7
                                    0.2459
                                     38.9

                                    15 min
                                    6398213
                                    5243212
                                     1.22
                                     21.5
                                     0.228
                                     9.45

                                    30 min
                                   41085869
                                    4957119
                                     8.29
                                      140
                                    0.2318
                                     60.3

                                     1 hr
                                   37255287
                                    4974313
                                     7.49
                                      126
                                    0.1897
                                     66.6

                                     2 hr
                                   38095594
                                    4822002
                                     7.90
                                      133
                                    0.1835
                                     72.6

                                      4hr
                                   57278086
                                    4889959
                                     11.7
                                      197
                                    0.2473
                                     79.7

                                     6 hr
                                   28629074
                                    4584477
                                     6.24
                                      106
                                    0.1556
                                     67.8
                                     15-02
                                    Predose
                                     3358
                                    6510431
                                   0.000516
                                   below LOQ
                                    0.1537
                                      n/a

                                     5 min
                                   19554405
                                    5927983
                                     3.30
                                     56.3
                                    0.1818
                                     31.0

                                    10 min
                                   25932905
                                    5663788
                                     4.58
                                     77.7
                                    0.1928
                                     40.3

                                    15 min
                                   33358926
                                    5283324
                                     6.31
                                      107
                                    0.1879
                                     56.8

                                    30 min
                                   38388675
                                    5031452
                                     7.63
                                      129
                                    0.2025
                                     63.6

                                     1 hr
                                   31762083
                                    5069904
                                     6.26
                                      106
                                    0.1518
                                     69.8

                                     2 hr
                                   37021772
                                    4764861
                                     7.77
                                      131
                                    0.1871
                                     70.0

                                      4hr
                                   29322786
                                    4533727
                                     6.47
                                      109
                                    0.2055
                                     53.2

                                     6 hr
                                   37929380
                                    4430258
                                     8.56
                                      144
                                    0.2101
                                     68.7
                                     15-03
                                   Predose*
                                       0
                                       0
                                       0
                                      n/a
                                    0.1886
                                      n/a

                                     5 min
                                   16343160
                                    5703199
                                     2.87
                                     49.1
                                    0.1921
                                     25.5

                                    10 min
                                   30274367
                                    5713661
                                     5.30
                                     89.7
                                    0.2225
                                     40.3

                                    15 min
                                   26808824
                                    5229507
                                     5.13
                                     86.9
                                    0.2155
                                     40.3

                                    30 min
                                   33577456
                                    5036211
                                     6.67
                                      113
                                    0.1908
                                     59.0

                                     1 hr
                                   32254129
                                    4831009
                                     6.68
                                      113
                                    0.1819
                                     62.0

                                     2 hr
                                   24685536
                                    4770795
                                     5.17
                                     87.7
                                    0.1519
                                     57.7

                                      4hr
                                   29005108
                                    4582835
                                     6.33
                                      107
                                    0.1703
                                     62.8

                                     6 hr
                                   32316262
                                    4403086
                                     7.34
                                      124
                                    0.1672
                                     74.1
                                     15-05
                                    Predose
                                       0
                                    5940335
                                       0
                                   below LOQ
                                    0.1549
                                      n/a

                                   6.25 min
                                   11363989
                                    4752155
                                     2.39
                                     41.1
                                    0.1917
                                     21.5

                                    6.5 min
                                    4874371
                                    4471155
                                     1.09
                                     19.4
                                    0.1761
                                     11.0

                                     7 min
                                    2202339
                                    4232828
                                     0.520
                                     9.85
                                     0.173
                                     5.69

                                   7.33 min
                                    1350844
                                    4045285
                                     0.334
                                     6.73
                                     0.183
                                     3.68

                                     8  hr
                                    1462936
                                    4041101
                                     0.362
                                     7.20
                                    0.2564
                                     2.81

                                     10 hr
                                    231209
                                    3791022
                                    0.0610
                                     1.22
                                    0.2521
                                     0.483

                                     16 hr
                                     16066
                                    4307916
                                    0.00373
                                   below LOQ
                                    0.1792
                                      n/a

                                     24 hr
                                     3421
                                    4207072
                                   0.000813
                                   below LOQ
                                    0.2012
                                      n/a
                                     15-06
                                    Predose
                                       0
                                    6181256
                                       0
                                   below LOQ
                                    0.1874
                                      n/a

                                   6.25 min
                                   11383529
                                    4699955
                                     2.42
                                     41.6
                                    0.1848
                                     22.5

                                    6.5 min
                                    2895055
                                    4506100
                                     0.642
                                     11.9
                                    0.0962
                                     12.4

                                     7 min
                                    3220375
                                    4180521
                                     0.770
                                     14.0
                                    0.1973
                                     7.11

                                   7.33 min
                                    1580933
                                    3977988
                                     0.397
                                     7.79
                                    0.1957
                                     3.98

                                     8  hr
                                    1817913
                                    3891380
                                     0.467
                                     8.96
                                    0.2484
                                     3.61

                                     10 hr
                                    254372
                                    3848388
                                    0.0661
                                     1.32
                                    0.1891
                                     0.699

                                     16 hr
                                     46793
                                    4351218
                                    0.0108
                                     0.209
                                    0.1589
                                      n/a

                                     24 hr
                                     4053
                                    4000991
                                    0.00101
                                   below LOQ
                                    0.2059
                                      n/a
                                     15-07
                                    Predose
                                       0
                                    5998001
                                       0
                                   below LOQ
                                    0.1597
                                      n/a

                                   6.25 min
                                   11838221
                                    4778418
                                     2.48
                                     42.6
                                    0.1797
                                     23.7

                                    6.5 min
                                    7969624
                                    4421889
                                     1.80
                                     31.3
                                    0.1727
                                     18.1

                                     7 min
                                    4114023
                                    4280926
                                     0.961
                                     17.2
                                    0.1938
                                     8.88

                                   7.33 min
                                    1650829
                                    4085046
                                     0.404
                                     7.90
                                    0.1728
                                     4.57

                                     8  hr
                                    1085588
                                    3770700
                                     0.288
                                     5.96
                                    0.2108
                                     2.83

                                     10 hr
                                    381628
                                    3781985
                                     0.101
                                     2.02
                                    0.2172
                                     0.930

                                     16 hr
                                     9346
                                    4316420
                                    0.00217
                                   below LOQ
                                    0.1559
                                      n/a

                                     24 hr
                                     4331
                                    4127666
                                    0.00105
                                   below LOQ
                                    0.2005
                                      n/a

                                  a   INTERCEPT
                                                                      0.0003471
                                                                       -0.06854

                                  b     SLOPE
                                                                        0.04976
                                                                        0.05981

* ISTD not added into this sample

Table 76.  Low Calibration curve for DIPE in blood for 3600 ppm exposures.

                                   Peak Area

Sample I.D.
Standard/QC I.D
                                 Conc. (ug/ml)
                                     DIPE
                                     MTBE
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                                     Mean
                                      SD
                               RSD% (Precision)
                                 Accuracy (%)
13425-53A
Blood blank
                                       0
                                       0
                                       0
                                      n/a
                                      n/a
                                      n/a
                                      n/a
                                      n/a
                                      n/a
13425-54A
Blood blank
                                       0
                                       0
                                       0
                                      n/a
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-55A
Blood blank
                                       0
                                       0
                                       0
                                      n/a
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-53B
Blood ISTD blank
                                       0
                                       0
                                    5590024
                                       0
                                      n/a
                                      n/a
                                      n/a
                                      n/a
                                      n/a
13425-54B
Blood ISTD blank
                                       0
                                       0
                                    4718950
                                       0
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-55B
Blood ISTD blank
                                       0
                                       0
                                    4347822
                                       0
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-53C
Std A1
                                     0.101
                                     32446
                                    5519553
                                    0.00588
                                     0.111
                                     0.104
                                    0.00663
                                     6.40%
                                     110%
13425-54C
Std A1
                                     0.101
                                     24590
                                    4601476
                                    0.00534
                                     0.100
                                       -
                                       -
                                       -
                                     99.0%
13425-55C
Std A1
                                     0.101
                                     22475
                                    4259263
                                    0.00528
                                    0.0991
                                       -
                                       -
                                       -
                                     97.7%
13425-53D
Std B1
                                     0.258
                                     84482
                                    5500979
                                    0.0154
                                     0.302
                                     0.277
                                    0.0213
                                     7.70%
                                     117%
13425-54D
Std B1
                                     0.258
                                     63535
                                    4663167
                                    0.0136
                                     0.267

                                     103%
13425-55D
Std B1
                                     0.258
                                     57111
                                    4253285
                                    0.0134
                                     0.263

                                     102%
13425-53E
Std A2
                                     0.504
                                    141880
                                    5450005
                                    0.0260
                                     0.516
                                     0.475
                                    0.0357
                                     7.51%
                                     102%
13425-54E
Std A2
                                     0.504
                                    107337
                                    4612674
                                    0.0233
                                     0.461
                                       -
                                       -
                                       -
                                     91.4%
13425-55E
Std A2
                                     0.504
                                     92792
                                    4084359
                                    0.0227
                                     0.450
                                       -
                                       -
                                       -
                                     89.2%
13425-53F
Std B2
                                     1.03
                                    307247
                                    5381647
                                    0.0571
                                     1.14
                                     1.03
                                    0.0986
                                     9.60%
                                     111%
13425-54F
Std B2
                                     1.03
                                    224913
                                    4560779
                                    0.0493
                                     0.984

                                     95.9%
13425-55F
Std B2
                                     1.03
                                    198748
                                    4138910
                                    0.0480
                                     0.958

                                     93.4%
13425-53G
Std A3
                                     2.51
                                    658769
                                    5348012
                                     0.123
                                     2.47
                                     2.30
                                     0.144
                                     6.27%
                                     98.3%
13425-54G
Std A3
                                     2.51
                                    512196
                                    4557397
                                     0.112
                                     2.25

                                     89.7%
13425-55G
Std A3
                                     2.51
                                    458379
                                    4183915
                                     0.110
                                     2.19

                                     87.4%
13425-53H
Std B3
                                     5.11
                                    1468059
                                    5270843
                                     0.279
                                     5.59
                                     5.32
                                     0.250
                                     4.70%
                                     109%
13425-54H
Std B3
                                     5.11
                                    1163039
                                    4423667
                                     0.263
                                     5.28
                                       -
                                       -
                                       -
                                     103%
13425-55H
Std B3
                                     5.11
                                    1018971
                                    4012812
                                     0.254
                                     5.10
                                       -
                                       -
                                       -
                                     100%
13425-56-1
LQC
                                     0.504
                                    164032
                                    6467421
                                    0.0254
                                     0.503
                                       -
                                       -
                                       -
                                     99.7%
13425-56-14
LQC
                                     0.504
                                    156593
                                    6057527
                                    0.0259
                                     0.513
                                       -
                                       -
                                       -
                                     102%
13425-57-56
MQC
                                     5.11
                                    1271477
                                    4726986
                                     0.269
                                     5.40
                                       -
                                       -
                                       -
                                     106%
13425-57-57
MQC
                                     5.11
                                    1213134
                                    4663229
                                     0.260
                                     5.22
                                       -
                                       -
                                       -
                                     102%

a   INTERCEPT
                                                                      0.0003471
                                    r=0.999

b     SLOPE
                                                                        0.04976

Table 77.  High Calibration curve for DIPE in blood for 3600 ppm exposures.

                                   Peak Area

Sample I.D.
Standard/QC I.D
                                 Conc. (ug/ml)
                                     DIPE
                                     MTBE
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                                     Mean
                                      SD
                               RSD% (Precision)
                                 Accuracy (%)
13425-53H
Std B3
                                     5.11
                                    1468059
                                    5270843
                                     0.279
                                     5.80
                                     5.58
                                     0.208
                                     3.73%
                                     114%
13425-54H
Std B3
                                     5.11
                                    1163039
                                    4423667
                                     0.263
                                     5.54
                                       -
                                       -
                                       -
                                     108%
13425-55H
Std B3
                                     5.11
                                    1018971
                                    4012812
                                     0.254
                                     5.39
                                       -
                                       -
                                       -
                                     106%
13425-53I
Std A4
                                     9.90
                                    2682950
                                    5146673
                                     0.521
                                     9.86
                                     9.71
                                     0.160
                                     1.65%
                                     99.6%
13425-54I
Std A4
                                     9.90
                                    2351612
                                    4587193
                                     0.513
                                     9.72
                                       -
                                       -
                                       -
                                     98.2%
13425-55I
Std A4
                                     9.90
                                    2074316
                                    4130294
                                     0.502
                                     9.54
                                       -
                                       -
                                       -
                                     96.4%
13425-53J
Std B4
                                     25.5
                                    7680672
                                    5238991
                                     1.47
                                     25.7
                                     24.8
                                     0.741
                                     2.99%
                                     101%
13425-54J
Std B4
                                     25.5
                                    6386931
                                    4562156
                                     1.40
                                     24.6
                                       -
                                       -
                                       -
                                     96.3%
13425-55J
Std B4
                                     25.5
                                    5678380
                                    4109284
                                     1.38
                                     24.2
                                       -
                                       -
                                       -
                                     95.1%
13425-53K
Std A5
                                     49.1
                                   15027472
                                    5221518
                                     2.88
                                     49.3
                                     47.2
                                     1.94
                                     4.11%
                                     100%
13425-54K
Std A5
                                     49.1
                                   12903502
                                    4703148
                                     2.74
                                     47.0
                                       -
                                       -
                                       -
                                     95.8%
13425-55K
Std A5
                                     49.1
                                   11450319
                                    4326032
                                     2.65
                                     45.4
                                       -
                                       -
                                       -
                                     92.5%
13425-53L
Std B5
                                      102
                                   31044916
                                    5225846
                                     5.94
                                      100
                                     98.9
                                     2.40
                                     2.43%
                                     98.5%
13425-54L
Std B5
                                      102
                                   27242382
                                    4607191
                                     5.91
                                      100
                                       -
                                       -
                                       -
                                     98.0%
13425-55L
Std B5
                                      102
                                   24176221
                                    4256983
                                     5.68
                                     96.1
                                       -
                                       -
                                       -
                                     94.2%
13425-53M
Std A6
                                      246
                                   76224567
                                    4876695
                                     15.6
                                      262
                                      252
                                     11.9
                                     4.72%
                                     107%
13425-54M
Std A6
                                      246
                                   67815885
                                    4477249
                                     15.1
                                      254
                                       -
                                       -
                                       -
                                     103%
13425-55M
Std A6
                                      246
                                   56038219
                                    3938070
                                     14.2
                                      239
                                       -
                                       -
                                       -
                                     97.1%
13425-56-9
HQC
                                      102
                                   32485831
                                    5301970
                                     6.13
                                      104
                                       -
                                       -
                                       -
                                     102%
13425-57-38
HQC
                                      102
                                   26587841
                                    4463255
                                     5.96
                                      101
                                       -
                                       -
                                       -
                                     98.8%

                                 a   INTERCEPT
                                                                       -0.06854
                                    r=0.999

                                  b     SLOPE
                                                                        0.05981

Table 78.  Low Calibration curve for Isopropanol in blood for 3600 ppm exposures.

                                   Peak Area

Sample I.D.
                               Standard/QC I.D
                                 Conc. (ug/ml)
                                  Isopropanol
                                  1-Prepanol
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                                     Mean
                                      SD
                               RSD% (Precision)
                                 Accuracy (%)
13425-53A
                                  Blood blank
                                      n/a
                                     4017
                                     21912
                                      n/a
                                      n/a
                                      n/a
                                      n/a
                                      n/a
                                      n/a
13425-54A
                                  Blood blank
                                      n/a
                                       0
                                     11676
                                      n/a
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-55A
                                  Blood blank
                                      n/a
                                       0
                                     9865
                                      n/a
                                      n/a
                                       -
                                       -
                                       -
                                      n/a
13425-53B
                               Blood ISTD blank
                                      n/a
                                     6466
                                    4606930
                                    0.00140
                                   below LOQ
                                      n/a
                                      n/a
                                      n/a
                                      n/a
13425-54B
                               Blood ISTD blank
                                      n/a
                                     3639
                                    2693947
                                    0.00135
                                   below LOQ
                                       -
                                       -
                                       -
                                      n/a
13425-55B
                               Blood ISTD blank
                                      n/a
                                     3815
                                    2618763
                                    0.00146
                                   below LOQ
                                       -
                                       -
                                       -
                                      n/a
13425-53C
                                    Std A1
                                    0.0978
                                     21575
                                    4387254
                                    0.00492
                                    0.0880
                                    0.0999
                                    0.0110
                                     11.0%
                                     90.0%
13425-54C
                                    Std A1
                                    0.0978
                                     15609
                                    2831899
                                    0.00551
                                     0.102
                                       -
                                       -
                                       -
                                     104%
13425-55C
                                    Std A1
                                    0.0978
                                     14999
                                    2571339
                                    0.00583
                                     0.110
                                       -
                                       -
                                       -
                                     112%
13425-53D
                                    Std B1
                                     0.250
                                     46886
                                    4398065
                                    0.01066
                                     0.224
                                     0.251
                                    0.0242
                                     9.62%
                                     89.6%
13425-54D
                                    Std B1
                                     0.250
                                     34114
                                    2790910
                                    0.01222
                                     0.261
                                       -
                                       -
                                       -
                                     104%
13425-55D
                                    Std B1
                                     0.250
                                     32847
                                    2610276
                                    0.01258
                                     0.270
                                       -
                                       -
                                       -
                                     108%
13425-53E
                                    Std A2
                                     0.486
                                     87398
                                    4605013
                                    0.0190
                                     0.421
                                     0.472
                                    0.0452
                                     9.58%
                                     86.6%
13425-54E
                                    Std A2
                                     0.486
                                     62534
                                    2768174
                                    0.0226
                                     0.506
                                       -
                                       -
                                       -
                                     104%
13425-55E
                                    Std A2
                                     0.486
                                     64978
                                    2971274
                                    0.0219
                                     0.489
                                       -
                                       -
                                       -
                                     101%
13425-53F
                                    Std B2
                                     0.992
                                    165843
                                    4402041
                                    0.0377
                                     0.864
                                     0.983
                                     0.104
                                     10.6%
                                     87.0%
13425-54F
                                    Std B2
                                     0.992
                                    125732
                                    2820543
                                    0.0446
                                     1.03
                                       -
                                       -
                                       -
                                     104%
13425-55F
                                    Std B2
                                     0.992
                                    117974
                                    2570951
                                    0.0459
                                     1.06
                                       -
                                       -
                                       -
                                     107%
13425-53G
                                    Std A3
                                     2.42
                                    393508
                                    4388038
                                    0.0897
                                     2.09
                                     2.44
                                     0.305
                                     12.5%
                                     86.6%
13425-54G
                                    Std A3
                                     2.42
                                    305825
                                    2784045
                                    0.1098
                                     2.57
                                       -
                                       -
                                       -
                                     106%
13425-55G
                                    Std A3
                                     2.42
                                    291188
                                    2562615
                                    0.1136
                                     2.66
                                       -
                                       -
                                       -
                                     110%
13425-53H
                                    Std B3
                                     4.94
                                    803626
                                    4413628
                                     0.182
                                     4.28
                                     4.94
                                     0.566
                                     11.5%
                                     86.7%
13425-54H
                                    Std B3
                                     4.94
                                    637896
                                    2849453
                                     0.224
                                     5.27
                                       -
                                       -
                                       -
                                     107%
13425-55H
                                    Std B3
                                     4.94
                                    677919
                                    3038317
                                     0.223
                                     5.25
                                       -
                                       -
                                       -
                                     106%
13425-56-1
                                      LQC
                                     0.486
                                    102665
                                    4533497
                                    0.0226
                                     0.508
                                       -
                                       -
                                       -
                                     104%
13425-56-14
                                      LQC
                                     0.486
                                     91040
                                    3814599
                                    0.0239
                                     0.537
                                       -
                                       -
                                       -
                                     110%
13425-57-56
                                      MQC
                                     4.94
                                    626134
                                    2655507
                                     0.236
                                     5.55
                                       -
                                       -
                                       -
                                     112%
13425-57-57
                                      MQC
                                     4.94
                                    690877
                                    2828588
                                     0.244
                                     5.75
                                       -
                                       -
                                       -
                                     116%

a   INTERCEPT
                                                                      0.0011996
r=0.994

                                  b     SLOPE
                                                                        0.04224

Table 79.  High Calibration curve for Isopropanol in blood for 3600 ppm exposures.

                                   Peak Area

Sample I.D.
                               Standard/QC I.D
                                 Conc. (ug/ml)
                                  Isopropanol
                                  1-Prepanol
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                                     Mean
                                      SD
                               RSD% (Precision)
                                 Accuracy (%)
13425-53H
                                    Std B3
                                     4.94
                                    803626
                                    4413628
                                     0.182
                                     4.74
                                     5.22
                                     0.419
                                     8.02%
                                     95.9%
13425-54H
                                    Std B3
                                     4.94
                                    637896
                                    2849453
                                     0.224
                                     5.47
                                       -
                                       -
                                       -
                                     111%
13425-55H
                                    Std B3
                                     4.94
                                    677919
                                    3038317
                                     0.223
                                     5.45
                                       -
                                       -
                                       -
                                     110%
13425-53I
                                    Std A4
                                     9.54
                                    1598901
                                    4368269
                                     0.366
                                     7.96
                                     9.06
                                     0.966
                                     10.7%
                                     83.4%
13425-54I
                                    Std A4
                                     9.54
                                    1286864
                                    2843467
                                     0.453
                                     9.47
                                       -
                                       -
                                       -
                                     99.3%
13425-55I
                                    Std A4
                                     9.54
                                    1172848
                                    2503076
                                     0.469
                                     9.75
                                       -
                                       -
                                       -
                                     102%
13425-53J*
                                    Std B4
                                     24.6
                                    4481663
                                    4513107
                                     0.993
                                     18.9
                                       -
                                       -
                                       -
                                     77.0%
13425-54J
                                    Std B4
                                     24.6
                                    3599317
                                    2965869
                                     1.21
                                     22.8
                                     23.4
                                     0.863
                                     3.68%
                                     92.7%
13425-55J
                                    Std B4
                                     24.6
                                    3234827
                                    2520829
                                     1.28
                                     24.0

                                     97.6%
13425-53K*
                                    Std A5
                                     47.4
                                    8829285
                                    4650229
                                     1.90
                                     34.8
                                       -
                                       -
                                       -
                                     73.4%
13425-54K
                                    Std A5
                                     47.4
                                    7534612
                                    3031994
                                     2.49
                                     45.1
                                     45.6
                                     0.819
                                     1.80%
                                     95.1%
13425-55K
                                    Std A5
                                     47.4
                                    6603166
                                    2588250
                                     2.55
                                     46.2
                                       -
                                       -
                                       -
                                     97.5%
13425-53L*
                                    Std B5
                                     98.6
                                   19239954
                                    4762741
                                     4.04
                                     72.3
                                       -
                                       -
                                       -
                                     73.3%
13425-54L
                                    Std B5
                                     98.6
                                   16025635
                                    3030320
                                     5.29
                                     94.2
                                     95.9
                                     2.43
                                     2.54%
                                     95.5%
13425-55L
                                    Std B5
                                     98.6
                                   14675068
                                    2675625
                                     5.48
                                     97.6
                                       -
                                       -
                                       -
                                     99.0%
13425-53M*
                                    Std A6
                                      238
                                   50339410
                                    4989667
                                     10.1
                                      178
                                       -
                                       -
                                       -
                                     75.0%
13425-54M
                                    Std A6
                                      238
                                   39678959
                                    2865652
                                     13.8
                                      244
                                      244
                                     0.653
                                    0.268%
                                     103%
13425-55M
                                    Std A6
                                      238
                                   35090659
                                    2543970
                                     13.8
                                      243
                                       -
                                       -
                                       -
                                     102%
13425-56-9
                                      HQC
                                     98.6
                                   18264020
                                    3445056
                                     5.30
                                     94.4
                                       -
                                       -
                                       -
                                     95.7%
13425-57-38
                                      HQC
                                     98.6
                                   16032429
                                    2964297
                                     5.41
                                     96.3
                                       -
                                       -
                                       -
                                     97.6%

                                  a  INTERCEPT
                                                                       -0.08833
r=0.999

                                  b     SLOPE
                                                                         0.0571

* Excluded from standard curve

Table 80.  High Calibration curve for Acetone in blood for 3600 ppm exposures.

                                   Peak Area

Sample I.D.
                               Standard/QC I.D
                                 Conc. (ug/ml)
                                    Acetone
                                  1-Propanol
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                                     Mean
                                      SD
                               RSD% (Precision)
                                 Accuracy (%)
13425-53H
                                    Std B3
                                     4.96
                                    662598
                                    4413628
                                     0.150
                                     4.36
                                     5.02
                                    0.6081
                                     12.1%
                                     87.8%
13425-54H
                                    Std B3
                                     4.96
                                    537017
                                    2849453
                                     0.188
                                     5.55
                                       -
                                       -
                                       -
                                     112%
13425-55H
                                    Std B3
                                     4.96
                                    535511
                                    3038317
                                     0.176
                                     5.17
                                       -
                                       -
                                       -
                                     104%
13425-53I
                                    Std A4
                                     9.68
                                    1118262
                                    4368269
                                     0.256
                                     7.64
                                       -
                                       -
                                       -
                                     78.9%
13425-54I
                                    Std A4
                                     9.68
                                    937914
                                    2843467
                                     0.330
                                     9.94
                                     10.2
                                     0.352
                                     3.46%
                                     103%
13425-55I
                                    Std A4
                                     9.68
                                    865774
                                    2503076
                                     0.346
                                     10.43
                                       -
                                       -
                                       -
                                     108%
13425-53J
                                    Std B4
                                     24.7
                                    2717760
                                    4513107
                                     0.602
                                     18.4
                                       -
                                       -
                                       -
                                     74.5%
13425-54J
                                    Std B4
                                     24.7
                                    2239890
                                    2965869
                                     0.755
                                     23.1
                                     24.0
                                     1.275
                                     5.30%
                                     93.7%
13425-55J
                                    Std B4
                                     24.7
                                    2050186
                                    2520829
                                     0.813
                                     24.9
                                       -
                                       -
                                       -
                                     101%
13425-53K
                                    Std A5
                                     48.0
                                    5159481
                                    4650229
                                     1.11
                                     34.1
                                       -
                                       -
                                       -
                                     71.1%
13425-54K
                                    Std A5
                                     48.0
                                    4478070
                                    3031994
                                     1.48
                                     45.5
                                     46.7
                                     1.673
                                     3.58%
                                     94.9%
13425-55K
                                    Std A5
                                     48.0
                                    4019910
                                    2588250
                                     1.55
                                     47.9
                                       -
                                       -
                                       -
                                     99.8%
13425-53L
                                    Std B5
                                     98.9
                                   10820018
                                    4762741
                                     2.27
                                     70.2
                                       -
                                       -
                                       -
                                     71.0%
13425-54L
                                    Std B5
                                     98.9
                                    9097305
                                    3030320
                                     3.00
                                     92.9
                                     95.3
                                     3.405
                                     3.57%
                                     93.9%
13425-55L
                                    Std B5
                                     98.9
                                    8447514
                                    2675625
                                     3.16
                                     97.7
                                       -
                                       -
                                       -
                                     98.8%
13425-53M
                                    Std A6
                                      241
                                   27339815
                                    4989667
                                     5.48
                                      170
                                       -
                                       -
                                       -
                                      70%
13425-54M
                                    Std A6
                                      241
                                   22942634
                                    2865652
                                     8.01
                                      248
                                     245.8
                                     3.495
                                     1.42%
                                     103%
13425-55M
                                    Std A6
                                      241
                                   19962222
                                    2543970
                                     7.85
                                      243
                                       -
                                       -
                                       -
                                     101%
13425-57-56
                                      MQC
                                     4.96
                                    552876
                                    2655507
                                     0.208
                                     6.16
                                       -
                                       -
                                       -
                                     124%
13425-57-57
                                      MQC
                                     4.96
                                    567767
                                    2828588
                                     0.201
                                     5.93
                                       -
                                       -
                                       -
                                     119%
13425-56-9
                                      HQC
                                     98.9
                                   10596786
                                    3445056
                                     3.08
                                     95.2
                                       -
                                       -
                                       -
                                     96.2%
13425-57-38
                                      HQC
                                     98.9
                                    9360064
                                    2964297
                                     3.16
                                     97.7
                                       -
                                       -
                                       -
                                     98.8%

                                   a INTERCEPT
                                                                        0.00984

                                  b     SLOPE
                                                                        0.03221

                                       r

* Excluded from standard curve.

Table 81.  Sample Analysis for DIPE in blood from female rats exposed to 3600 ppm DIPE.

                                   Peak Area

Animal I.D.
                                  Time point
                                     DIPE
                                     MTBE
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                               Sample weight (g)
Corrected Conc. (ug/ml)
                                     16-01
                                    Predose
                                       0
                                    6271920
                                       0
                                   below LOQ
                                    0.1588
                                      n/a

                                     5 min
                                    3861610
                                    5740539
                                     0.673
                                     12.4
                                    0.2065
                                     6.00

                                    10 min
                                    4952923
                                    5436869
                                     0.911
                                     16.4
                                    0.1858
                                     8.81

                                    15 min
                                   34674870
                                    5066482
                                     6.84
                                      116
                                    0.2625
                                     44.0

                                    30 min
                                    5074208
                                    5012705
                                     1.01
                                     18.1
                                    0.1941
                                     9.31

                                     1 hr
                                    8465141
                                    4876695
                                     1.74
                                     30.2
                                    0.1446
                                     20.9

                                     2 hr
                                   10910320
                                    4675384
                                     2.33
                                     40.2
                                    0.1916
                                     21.0

                                      4hr
                                    8900883
                                    4547193
                                     1.96
                                     33.9
                                    0.1742
                                     19.4

                                     6 hr
                                   20093412
                                    4220503
                                     4.76
                                     80.7
                                    0.1913
                                     42.2
                                     16-02
                                    Predose
                                       0
                                    6302373
                                       0
                                   below LOQ
                                    0.1925
                                      n/a

                                     5 min
                                   35406096
                                    5749483
                                     6.16
                                      104
                                    0.2565
                                     40.6

                                    10 min
                                   33113832
                                    5561582
                                     5.95
                                      101
                                    0.2148
                                     46.9

                                    15 min
                                   27418367
                                    5007453
                                     5.48
                                     92.7
                                    0.1919
                                     48.3

                                    30 min
                                   29452782
                                    4963051
                                     5.93
                                      100
                                     0.169
                                     59.4

                                     1 hr
                                   42733338
                                    4675939
                                     9.14
                                      154
                                    0.2063
                                     74.6

                                     2 hr
                                   40011386
                                    4700649
                                     8.51
                                      143
                                    0.1914
                                     75.0

                                      4hr
                                   41115401
                                    4432323
                                     9.28
                                      156
                                    0.1908
                                     81.9

                                     6 hr
                                   37245963
                                    4250567
                                     8.76
                                      148
                                    0.1855
                                     79.6
                                     16-03
                                    Predose
                                       0
                                    6279767
                                     0.00
                                   below LOQ
                                    0.1562
                                      n/a

                                     5 min
                                   22884909
                                    5870253
                                     3.90
                                     66.3
                                    0.1699
                                     39.0

                                    10 min
                                   20855893
                                    5276919
                                     3.95
                                     67.2
                                    0.1747
                                     38.5

                                    15 min
                                   30722438
                                    5000080
                                     6.14
                                      104
                                    0.1749
                                     59.4

                                    30 min
                                   31009830
                                    4843397
                                     6.40
                                      108
                                     0.176
                                     61.5

                                     1 hr
                                   24969780
                                    4771734
                                     5.23
                                     88.6
                                    0.1302
                                     68.1

                                     2 hr
                                   28437864
                                    4484792
                                     6.34
                                      107
                                    0.1723
                                     62.2

                                      4hr
                                   44984445
                                    4520708
                                     9.95
                                      168
                                    0.1889
                                     88.7

                                     6 hr
                                   41309035
                                    4307161
                                     9.59
                                      162
                                    0.1469
                                      110
                                     16-05
                                    Predose
                                       0
                                    6127744
                                       0
                                   below LOQ
                                    0.1315
                                      n/a

                                   6.25 min
                                   10585444
                                    4679671
                                     2.26
                                     39.0
                                    0.1597
                                     24.4

                                    6.5 min
                                    6232616
                                    4284236
                                     1.45
                                     25.5
                                     0.16
                                     15.9

                                     7 min
                                    5489289
                                    4010810
                                     1.37
                                     24.0
                                    0.2715
                                     8.85

                                   7.33 min
                                    1621694
                                    3969380
                                     0.409
                                     7.98
                                    0.1743
                                     4.58

                                     8  hr
                                    1251384
                                    3956153
                                     0.316
                                     6.43
                                    0.1849
                                     3.48

                                     10 hr
                                    282819
                                    3821254
                                    0.0740
                                     1.48
                                     0.186
                                     0.796

                                     16 hr
                                     22056
                                    4300079
                                    0.00513
                                   below LOQ
                                    0.2096
                                      n/a

                                     24 hr
                                       0
                                    4022996
                                       0
                                   below LOQ
                                    0.1885
                                      n/a
                                     16-06
                                    Predose
                                       0
                                    6159429
                                       0
                                   below LOQ
                                    0.1505
                                      n/a

                                   6.25 min
                                   14731630
                                    4500807
                                     3.27
                                     55.9
                                    0.1675
                                     33.4

                                    6.5 min
                                    9911988
                                    4281562
                                     2.32
                                     39.9
                                    0.1942
                                     20.5

                                     7 min
                                    4215814
                                    4079433
                                     1.03
                                     18.4
                                    0.1963
                                     9.39

                                   7.33 min
                                    2636567
                                    3887642
                                     0.678
                                     12.5
                                    0.1955
                                     6.39

                                     8  hr
                                    1319290
                                    3852917
                                     0.342
                                     6.87
                                    0.1699
                                     4.04

                                     10 hr
                                    557827
                                    3723419
                                     0.150
                                     3.00
                                    0.1973
                                     1.52

                                     16 hr
                                     14604
                                    4351623
                                    0.00336
                                   below LOQ
                                    0.1675
                                      n/a

                                     24 hr
                                     5039
                                    4115558
                                    0.00122
                                   below LOQ
                                    0.1868
                                      n/a
                                     16-07
                                    Predose
                                       0
                                    5950118
                                       0
                                   below LOQ
                                    0.1816
                                      n/a

                                   6.25 min
                                   14260947
                                    4580646
                                     3.11
                                     53.2
                                    0.1729
                                     30.8

                                    6.5 min
                                    9698944
                                    4286395
                                     2.26
                                     39.0
                                    0.1898
                                     20.5

                                     7 min
                                    3664677
                                    3960905
                                     0.925
                                     16.6
                                    0.1537
                                     10.8

                                   7.33 min
                                    2662116
                                    3864868
                                     0.689
                                     12.7
                                     0.178
                                     7.11

                                     8  hr
                                    1478497
                                    3729255
                                     0.396
                                     7.77
                                    0.1864
                                     4.17

                                     10 hr
                                    393306
                                    3749899
                                     0.105
                                     2.10
                                    0.1826
                                     1.15

                                     16 hr
                                     49688
                                    4357311
                                    0.0114
                                     0.222
                                    0.1754
                                      n/a

                                     24 hr
                                     8529
                                    4135663
                                    0.00206
                                   below LOQ
                                     0.178
                                      n/a

                                  a   INTERCEPT
                                                                      0.0003471
                                                                       -0.06854

                                  b     SLOPE
                                                                        0.04976
                                                                        0.05981

Table 82.  Sample Analysis for Isopropanol in blood from male rats exposed to 3600 ppm DIPE.

                                   Peak Area

Animal I.D.
                                  Time point
                                  isopropanol
                                  1-propanol
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                               Sample weight (g)
Corrected Conc. (ug/ml)
                                     15-01
                                    Predose
                                     17503
                                    3587647
                                    0.00488
                                  below  LOQ
                                    0.1399
                                      n/a

                                     5 min
                                    193892
                                    2711318
                                    0.0715
                                     2.80
                                    0.2034
                                     1.38

                                    10 min
                                    356827
                                    2216477
                                     0.161
                                     4.37
                                    0.2459
                                     1.78

                                    15 min
                                    159043
                                    1859332
                                    0.0855
                                     2.00
                                     0.228
                                     0.876

                                    30 min
                                    1002751
                                    2037825
                                     0.492
                                     10.2
                                    0.2318
                                     4.39

                                     1 hr
                                    2020605
                                    2420508
                                     0.835
                                     16.2
                                    0.1897
                                     8.52

                                     2 hr
                                    3902066
                                    2335320
                                     1.67
                                     30.8
                                    0.1835
                                     16.8

                                      4hr
                                    8595656
                                    1641466
                                     5.24
                                     93.3
                                    0.2473
                                     37.7

                                     6 hr
                                   11572361
                                    2325605
                                     4.98
                                     88.7
                                    0.1556
                                     57.0
                                     15-02
                                    Predose
                                     18949
                                    3535317
                                    0.0054
                                    0.0985
                                    0.1537
                                      n/a

                                     5 min
                                    196852
                                    3027526
                                    0.0650
                                     1.51
                                    0.1818
                                     0.831

                                    10 min
                                    334446
                                    2721818
                                     0.123
                                     2.88
                                    0.1928
                                     1.49

                                    15 min
                                    291100
                                    2552166
                                     0.114
                                     2.67
                                    0.1879
                                     1.42

                                    30 min
                                    856127
                                    2352299
                                     0.364
                                     7.92
                                    0.2025
                                     3.91

                                     1 hr
                                    1735178
                                    2894843
                                     0.599
                                     12.0
                                    0.1518
                                     7.93

                                     2 hr
                                    3396156
                                    2321086
                                     1.46
                                     27.2
                                    0.1871
                                     14.5

                                      4hr
                                    5771860
                                    1850229
                                     3.12
                                     56.2
                                    0.2055
                                     27.3

                                     6 hr
                                   10174692
                                    1761510
                                     5.78
                                      103
                                    0.2101
                                     48.9
                                     15-03
                                   Predose*
                                     21179
                                     6847
                                    3.0932
                                      n/a
                                    0.1886
                                      n/a

                                     5 min
                                    166814
                                    2795076
                                    0.0597
                                     1.38
                                    0.1921
                                     0.721

                                    10 min
                                    302470
                                    2370926
                                     0.128
                                     2.99
                                    0.2225
                                     1.34

                                    15 min
                                    288860
                                    2708798
                                     0.107
                                     2.50
                                    0.2155
                                     1.16

                                    30 min
                                    734711
                                    2449628
                                     0.300
                                     6.80
                                    0.1908
                                     3.56

                                     1 hr
                                    1598429
                                    2386313
                                     0.670
                                     13.3
                                    0.1819
                                     7.30

                                     2 hr
                                    2867298
                                    2752473
                                     1.04
                                     19.8
                                    0.1519
                                     13.0

                                      4hr
                                    5351124
                                    2234717
                                     2.39
                                     43.5
                                    0.1703
                                     25.5

                                     6 hr
                                    9676010
                                    2161584
                                     4.48
                                     79.9
                                    0.1672
                                     47.8
                                     15-05
                                    Predose
                                     11810
                                    3452124
                                    0.00342
                                  below  LOQ
                                    0.1549
                                      n/a

                                   6.25 min
                                   11743396
                                    2030000
                                     5.78
                                      103
                                    0.1917
                                     53.7

                                    6.5 min
                                   10378423
                                    2097487
                                     4.95
                                     88.2
                                    0.1761
                                     50.1

                                     7 min
                                    8627390
                                    2162076
                                     3.99
                                     71.4
                                     0.173
                                     41.3

                                   7.33 min
                                    8266777
                                    2215928
                                     3.73
                                     66.9
                                     0.183
                                     36.5

                                     8  hr
                                    5818517
                                    1618660
                                     3.59
                                     64.5
                                    0.2564
                                     25.2

                                     10 hr
                                    1422311
                                    1573032
                                     0.904
                                     17.4
                                    0.2521
                                     6.89

                                     16 hr
                                     65328
                                    1811760
                                    0.0361
                                     0.825
                                    0.1792
                                     0.461

                                     24 hr
                                     8379
                                    1509014
                                    0.00555
                                     0.103
                                    0.2012
                                      n/a
                                     15-06
                                    Predose
                                     11546
                                    2869650
                                    0.00402
                                  below  LOQ
                                    0.1874
                                      n/a

                                   6.25 min
                                   12028495
                                    2070979
                                     5.81
                                      103
                                    0.1848
                                     55.9

                                    6.5 min
                                    8675322
                                    3374040
                                     2.57
                                     46.6
                                    0.0962
                                     48.4

                                     7 min
                                    9210108
                                    1914243
                                     4.81
                                     85.8
                                    0.1973
                                     43.5

                                   7.33 min
                                    9062042
                                    2112542
                                     4.29
                                     76.7
                                    0.1957
                                     39.2

                                     8  hr
                                    5920543
                                    1592317
                                     3.72
                                     66.7
                                    0.2484
                                     26.8

                                     10 hr
                                    1434289
                                    2049841
                                     0.700
                                     13.8
                                    0.1891
                                     7.30

                                     16 hr
                                     20075
                                    1864840
                                    0.0108
                                     0.226
                                    0.1589
                                     0.143

                                     24 hr
                                     5867
                                    1794053
                                    0.00327
                                  below  LOQ
                                    0.2059
                                      n/a
                                     15-07
                                    Predose
                                     10621
                                    3390613
                                    0.00313
                                  below  LOQ
                                    0.1597
                                      n/a

                                   6.25 min
                                   12109066
                                    2100180
                                     5.77
                                      103
                                    0.1797
                                     57.1

                                    6.5 min
                                   11092949
                                    2066352
                                     5.37
                                     95.6
                                    0.1727
                                     55.3

                                     7 min
                                    9712830
                                    1997866
                                     4.86
                                     86.7
                                    0.1938
                                     44.7

                                   7.33 min
                                    9256352
                                    2379772
                                     3.89
                                     69.7
                                    0.1728
                                     40.3

                                     8  hr
                                    6118977
                                    1764639
                                     3.47
                                     62.3
                                    0.2108
                                     29.5

                                     10 hr
                                    1629996
                                    1818544
                                     0.896
                                     17.2
                                    0.2172
                                     7.94

                                     16 hr
                                     66513
                                    2079336
                                    0.0320
                                     0.729
                                    0.1559
                                     0.468

                                     24 hr
                                     4872
                                    1497163
                                    0.00325
                                  below  LOQ
                                    0.2005
                                      n/a

                                  a   INTERCEPT
                                                                      0.0011996
                                                                       -0.08833

                                  b     SLOPE
                                                                        0.04224
                                                                         0.0571

* ISTD not added into this sample

Table 83.  Sample Analysis for Isopropanol in blood from female rats exposed to 3600 ppm DIPE.

                                   Peak Area

Animal I.D.
                                  Time point
                                  isopropanol
                                  1-propanol
                                Peak Area Ratio
                              Cal. Conc. (ug/ml)
                               Sample weight (g)
Corrected Conc. (ug/ml)
                                     16-01
                                    Predose
                                     12668
                                    3401232
                                    0.00372
                                  below  LOQ
                                    0.1588
                                      n/a

                                     5 min
                                     71967
                                    2584945
                                    0.0278
                                     0.631
                                    0.2065
                                     0.305

                                    10 min
                                    117882
                                    2722579
                                    0.0433
                                     0.997
                                    0.1858
                                     0.536

                                    15 min
                                    481787
                                    2143468
                                     0.225
                                     5.48
                                    0.2625
                                     2.09

                                    30 min
                                    189956
                                    2370068
                                    0.0801
                                     1.87
                                    0.1941
                                     0.96

                                     1 hr
                                    311799
                                    2835557
                                     0.110
                                     2.57
                                    0.1446
                                     1.78

                                     2 hr
                                    656845
                                    2202889
                                     0.298
                                     6.77
                                    0.1916
                                     3.53

                                      4hr
                                    1198967
                                    2053527
                                     0.584
                                     11.8
                                    0.1742
                                     6.76

                                     6 hr
                                    2783157
                                    1823322
                                     1.53
                                     28.3
                                    0.1913
                                     14.8
                                     16-02
                                    Predose
                                     15731
                                    2881445
                                    0.00546
                                     0.101
                                    0.1925
                                    0.0524

                                     5 min
                                    147742
                                    2161856
                                    0.0683
                                     1.59
                                    0.2565
                                     0.620

                                    10 min
                                    220994
                                    2336543
                                    0.0946
                                     2.21
                                    0.2148
                                     1.03

                                    15 min
                                    420873
                                    2622038
                                     0.161
                                     3.77
                                    0.1919
                                     1.97

                                    30 min
                                    395489
                                    2706033
                                     0.146
                                     3.43
                                     0.169
                                     2.03

                                     1 hr
                                    798304
                                    2150198
                                     0.371
                                     8.05
                                    0.2063
                                     3.90

                                     2 hr
                                    1466387
                                    2225090
                                     0.659
                                     13.1
                                    0.1914
                                     6.84

                                      4hr
                                    2808889
                                    1921345
                                     1.46
                                     27.2
                                    0.1908
                                     14.2

                                     6 hr
                                    4137643
                                    1880529
                                     2.20
                                     40.1
                                    0.1855
                                     21.6
                                     16-03
                                    Predose
                                     10537
                                    3181719
                                    0.00331
                                  below  LOQ
                                    0.1562
                                      n/a

                                     5 min
                                    245185
                                    3059864
                                    0.0801
                                     1.87
                                    0.1699
                                     1.10

                                    10 min
                                    229919
                                    2828798
                                    0.0813
                                     1.90
                                    0.1747
                                     1.09

                                    15 min
                                    369667
                                    2223328
                                     0.166
                                     3.91
                                    0.1749
                                     2.23

                                    30 min
                                    505525
                                    2543607
                                     0.199
                                     5.03
                                     0.176
                                     2.86

                                     1 hr
                                    864074
                                    3120123
                                     0.277
                                     6.40
                                    0.1302
                                     4.91

                                     2 hr
                                    1791815
                                    2423354
                                     0.739
                                     14.5
                                    0.1723
                                     8.41

                                      4hr
                                    3175357
                                    1942350
                                     1.63
                                     30.2
                                    0.1889
                                     16.0

                                     6 hr
                                    4637021
                                    2331873
                                     1.99
                                     36.4
                                    0.1469
                                     24.8
                                     16-05
                                    Predose
                                     8670
                                    3653222
                                    0.00237
                                  below  LOQ
                                    0.1315
                                      n/a

                                   6.25 min
                                    5663514
                                    2354276
                                     2.41
                                     43.7
                                    0.1597
                                     27.3

                                    6.5 min
                                    5331870
                                    2367607
                                     2.25
                                     41.0
                                     0.16
                                     25.6

                                     7 min
                                    4537498
                                    1368081
                                     3.32
                                     59.6
                                    0.2715
                                     22.0

                                   7.33 min
                                    3553517
                                    2350277
                                     1.51
                                     28.0
                                    0.1743
                                     16.1

                                     8  hr
                                    2117345
                                    2114937
                                     1.00
                                     19.1
                                    0.1849
                                     10.3

                                     10 hr
                                    358188
                                    2010913
                                     0.178
                                     4.19
                                     0.186
                                     2.25

                                     16 hr
                                     5083
                                    1555817
                                    0.00327
                                  below  LOQ
                                    0.2096
                                      n/a

                                     24 hr
                                     3419
                                    1553276
                                    0.00220
                                  below  LOQ
                                    0.1885
                                      n/a
                                     16-06
                                    Predose
                                     9787
                                    3307224
                                    0.00296
                                  below  LOQ
                                    0.1505
                                      n/a

                                   6.25 min
                                    4962981
                                    2284002
                                     2.17
                                     39.6
                                    0.1675
                                     23.6

                                    6.5 min
                                    4952597
                                    1943701
                                     2.55
                                     46.2
                                    0.1942
                                     23.8

                                     7 min
                                    4375815
                                    2090444
                                     2.09
                                     38.2
                                    0.1963
                                     19.5

                                   7.33 min
                                    3729877
                                    2107637
                                     1.77
                                     32.5
                                    0.1955
                                     16.6

                                     8  hr
                                    2326888
                                    2244358
                                     1.04
                                     19.7
                                    0.1699
                                     11.6

                                     10 hr
                                    763502
                                    1991761
                                     0.383
                                     8.26
                                    0.1973
                                     4.19

                                     16 hr
                                     66258
                                    2079747
                                    0.0319
                                     0.73
                                    0.1675
                                      n/a

                                     24 hr
                                     3428
                                    1548949
                                    0.00221
                                  below  LOQ
                                    0.1868
                                      n/a
                                     16-07
                                    Predose
                                     8738
                                    2944834
                                    0.00297
                                  below  LOQ
                                    0.1816
                                      n/a

                                   6.25 min
                                    4799592
                                    2264700
                                     2.12
                                     38.7