0.02
                                     0.01
Blood
24 h
                                     0.08
                                     0.07
                                     0.07
                                     0.08
                                     0.08
                                     0.01
Spleen
24 h
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.00
Liver
24 h
                                     1.30
                                     1.38
                                     1.29
                                     1.12
                                     1.27
                                     0.11
Kidney
24 h
                                     0.18
                                     0.20
                                     0.22
                                     0.17
                                     0.19
                                     0.02
Heart
24 h
                                     0.04
                                     0.03
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Lung
24 h
                                     0.10
                                     0.11
                                     0.12
                                     0.09
                                     0.10
                                     0.01
Brain
24 h
                                     0.06
                                     0.04
                                     0.04
                                     0.05
                                     0.05
                                     0.01
Femur
24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Testes
24 h
                                     0.11
                                     0.11
                                     0.10
                                     0.09
                                     0.10
                                     0.01
Stomach
24 h
                                     0.08
                                     0.08
                                     0.10
                                     0.07
                                     0.08
                                     0.01
Small Intestine
24 h
                                     0.49
                                     0.66
                                     0.53
                                     0.47
                                     0.54
                                     0.09
Cecum+Lg Int+Rect
24 h
                                     0.19
                                     0.24
                                     0.17
                                     0.20
                                     0.20
                                     0.03
Stomach Contents
24 h
                                     0.01
                                     0.01
                                     N.S.
                                     0.01
                                     0.00
                                     0.00
Small Intestine Cont
24 h
                                     0.21
                                     0.18
                                     0.32
                                      0.2
                                     0.23
                                     0.06
Lg Int + Cecum Cont
24 h
                                     0.34
                                     0.28
                                     0.35
                                     0.32
                                     0.32
                                     0.03
Carcass Digest
24 h
                                     7.33
                                     8.17
                                     8.82
                                     7.25
                                     7.89
                                     0.75

Subtotal
                                     11.43
                                     13.10
                                     15.46
                                     10.85
                                     12.71
                                     2.06

Total
                                    100.00
                                    100.00
                                    100.01
                                    100.00
                                    100.00
                                     0.00
*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample
Table 9.  Concentration of DIPE equivalents (ug/g) in Tissues Following Inhalation Exposure of Male F344 Rats to 600 ppm (Group 1)
Sample
                                  Time point
                                     1-01
                                     1-02
                                     1-03
                                     1-04
                                     Mean
                                      SD
Adipose subcutaneous
                                      24h
                                     6.59
                                      5.6
                                     16.7
                                     3.93
                                     8.21
                                     5.77
Adip (Abdominal)
                                     24 h
                                     10.1
                                     17.5
                                     16.3
                                     10.2
                                     13.5
                                     3.93
Muscle Gastrocnemius
                                     24 h
                                     5.28
                                     4.69
                                     5.59
                                     4.94
                                     5.13
                                     0.393
Skin (neck)
                                     24 h
                                     8.78
                                     13.2
                                     19.9
                                     13.7
                                     13.9
                                     4.57
Blood
                                     24 h
                                     5.87
                                     5.39
                                     5.95
                                     6.12
                                     5.83
                                     0.313
Spleen
                                     24 h
                                      17
                                     15.8
                                     16.6
                                     14.6
                                      16
                                     1.06
Liver
                                     24 h
                                     25.6
                                     25.9
                                      27
                                     23.4
                                     25.5
                                     1.51
Kidney
                                     24 h
                                     21.1
                                     19.7
                                     22.8
                                     17.1
                                     20.2
                                     2.41
Heart
                                     24 h
                                      7.7
                                     6.47
                                     7.91
                                     6.92
                                     7.25
                                     0.672
Lung
                                     24 h
                                     16.4
                                     17.1
                                     21.1
                                     15.4
                                     17.5
                                      2.5
Brain
                                     24 h
                                     5.47
                                      4.3
                                     4.19
                                     4.44
                                      4.6
                                     0.589
Femur
                                     24 h
                                     12.1
                                     10.5
                                     12.2
                                     10.4
                                     11.3
                                     0.983
Testes
                                     24 h
                                     6.93
                                     6.27
                                     6.43
                                     5.67
                                     6.33
                                     0.519
Stomach
                                     24 h
                                     11.9
                                     12.1
                                     12.2
                                     11.3
                                     11.9
                                     0.403
Small Intestine
                                     24 h
                                     24.8
                                      26
                                     27.5
                                     21.5
                                      25
                                     2.55
Cecum+Lg Int+Rect
                                     24 h
                                      17
                                     19.5
                                     18.9
                                     16.7
                                      18
                                     1.38
Stomach Contents
                                     24 h
                                     3.45
                                     0.58
                                     N.S.
                                     2.29
                                     1.58
                                     1.58
Small Intestine Cont
                                     24 h
                                     16.7
                                     10.9
                                     19.4
                                     13.7
                                     15.2
                                     3.68
Lg Int + Cecum Cont
                                     24 h
                                     9.51
                                     8.68
                                     9.66
                                     9.75
                                      9.4
                                     0.49
Carcass Digest
                                     24 h
                                     8.04
                                     8.29
                                     9.66
                                     7.71
                                     8.42
                                     0.857

Table 10.  Disposition of Radioactivity (% of Recovered Radioactivity) Following Inhalation Exposure of Female F344 Rats to 600 ppm [2-[14]C]DIPE  (Group 2).
Sample
Time point
                                     2-01
                                     2-02
                                     2-03
                                     2-04
                                     Mean
                                      SD
Urine
24 h
                                     4.65
                                     5.78
                                     4.70
                                     1.86
                                     4.25
                                     1.67

Subtotal
                                     4.65
                                     5.78
                                     4.70
                                     1.86
                                     4.25
                                     1.67
Feces
24 h
                                     0.41
                                     0.35
                                     0.43
                                     0.73
                                     0.48
                                     0.17

Subtotal
                                     0.41
                                     0.35
                                     0.43
                                     0.73
                                     0.48
                                     0.17
CO2 Trap 1
1 h
                                     3.54
                                     2.02
                                     2.55
                                     3.14
                                     2.81
                                     0.67
CO2 Trap 1
3 h
                                     13.80
                                     11.28
                                     11.75
                                     13.94
                                     12.69
                                     1.38
CO2 Trap 1
6 h
                                     19.67
                                     19.34
                                     21.38
                                     18.42
                                     19.70
                                     1.24
CO2 Trap 1
24 h
                                     5.57
                                     7.18
                                     6.51
                                     4.75
                                     6.00
                                     1.06

Subtotal
                                     42.57
                                     39.81
                                     42.19
                                     40.25
                                     41.21
                                     1.38
CO2 Trap 2
1 h
                                     *0.02
                                    **0.02
                                     *0.03
                                    **0.02
                                     0.02
                                     0.00
CO2 Trap 2
3 h
                                     *0.02
                                     *0.02
                                    **0.02
                                    **0.01
                                     0.02
                                     0.00
CO2 Trap 2
6 h
                                     *0.06
                                     *0.04
                                    **0.02
                                     *0.02
                                     0.03
                                     0.02
CO2 Trap 2
24 h
                                     *0.07
                                    **0.01
                                     *0.01
                                     *0.02
                                     0.03
                                     0.03

Subtotal
                                     0.17
                                     0.08
                                     0.07
                                     0.08
                                     0.10
                                     0.05
Exhaled VOC Trap 1
1 h
                                     22.65
                                     17.27
                                     20.11
                                     24.21
                                     21.06
                                     3.04
Exhaled VOC Trap 1
3 h
                                     13.83
                                     16.45
                                     15.33
                                     15.27
                                     15.22
                                     1.07
Exhaled VOC Trap 1
6 h
                                     2.71
                                     5.70
                                     4.76
                                     2.78
                                     3.99
                                     1.48
Exhaled VOC Trap 1
24 h
                                     0.27
                                     0.59
                                     0.41
                                     1.03
                                     0.57
                                     0.33

Subtotal
                                     39.46
                                     40.01
                                     40.61
                                     43.29
                                     40.84
                                     1.70
Exhaled VOC Trap 2
1 h
                                     0.02
                                     0.03
                                     0.01
                                     *0.01
                                     0.02
                                     0.01
Exhaled VOC Trap 2
3 h
                                     0.04
                                     0.02
                                     0.03
                                     0.02
                                     0.02
                                     0.01
Exhaled VOC Trap 2
6 h
                                     0.01
                                     0.01
                                     0.02
                                     0.01
                                     0.01
                                     0.00
Exhaled VOC Trap 2
24 h
                                     *0.00
                                    **0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.00

Subtotal
                                     0.06
                                     0.06
                                     0.07
                                     0.03
                                     0.05
                                     0.02
Cage Rinse
24 h
                                     0.60
                                     0.36
                                     0.57
                                     0.53
                                     0.51
                                     0.11
NO Tube Contents
24 h
                                      0.8
                                     1.12
                                     0.32
                                     1.00
                                     0.81
                                     0.36
Adipose subcutaneous
24 h
                                     0.01
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Adip (Abdominal)
24 h
                                     0.01
                                     0.02
                                     0.05
                                     0.01
                                     0.02
                                     0.02
Muscle Gastrocnemius
24 h
                                     0.01
                                     0.01
                                     0.02
                                     0.01
                                     0.01
                                     0.00
Skin (neck)
24 h
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
Blood
24 h
                                     0.13
                                     0.11
                                     0.14
                                     0.06
                                     0.11
                                     0.04
Spleen
24 h
                                     0.06
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.00
Liver
24 h
                                     1.16
                                     1.57
                                     1.19
                                     1.30
                                     1.31
                                     0.18
Kidney
24 h
                                     0.19
                                     0.18
                                     0.18
                                     0.17
                                     0.18
                                     0.01
Heart
24 h
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.00
Lung
24 h
                                     0.13
                                     0.15
                                     0.14
                                     0.14
                                     0.14
                                     0.01
Brain
24 h
                                     0.07
                                     0.05
                                     0.07
                                     0.07
                                     0.07
                                     0.01
Femur
24 h
                                     0.03
                                     0.03
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Ovaries and Uterus
24 h
                                     0.04
                                     0.04
                                     0.04
                                     0.03
                                     0.04
                                     0.00
Stomach
24 h
                                     0.09
                                     0.10
                                     0.09
                                     0.09
                                     0.09
                                     0.01
Small Intestine
24 h
                                     0.56
                                     0.66
                                     0.45
                                     0.60
                                     0.57
                                     0.09
Cecum+Lg Int+Rect
24 h
                                     0.21
                                     0.25
                                     0.21
                                     0.22
                                     0.22
                                     0.02
Stomach Contents
24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Small Intestine Cont
24 h
                                     0.32
                                     0.33
                                     0.41
                                     0.29
                                     0.34
                                     0.05
Lg Int + Cecum Cont
24 h
                                     0.41
                                     0.41
                                     0.34
                                     0.24
                                     0.35
                                     0.08
Carcass Digest
24 h
                                     7.78
                                     8.38
                                     7.57
                                     8.87
                                     8.15
                                     0.59

Subtotal
                                     12.68
                                     13.91
                                     11.93
                                     13.76
                                     13.07
                                     0.94

Total
                                      100
                                      100
                                      100
                                      100
                                      100
                                     0.00
*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample
Table 11.  Concentration of DIPE equivalents (ug/g) in Tissues Following Inhalation Exposure of Female F344 Rats to 600 ppm [2-[14]C]DIPE  (Group 2).
Sample
Time point
                                     2-01
                                     2-02
                                     2-03
                                     2-04
                                     Mean
                                      SD
Adipose subcutaneous
                                     24 h
                                     6.87
                                     10.4
                                     5.83
                                     7.27
                                     7.59
                                     1.97
Adip (Abdominal)
                                     24 h
                                     7.21
                                     27.1
                                     9.24
                                     6.96
                                     12.6
                                      9.7
Muscle Gastrocnemius
                                     24 h
                                     5.54
                                     4.77
                                     5.92
                                     4.84
                                     5.27
                                     0.557
Skin (neck)
                                     24 h
                                     10.4
                                     6.35
                                     7.43
                                     11.0
                                     8.80
                                     2.26
Blood
                                     24 h
                                     6.50
                                     5.57
                                     6.57
                                     5.89
                                     6.13
                                     0.484
Spleen
                                     24 h
                                     16.5
                                     16.3
                                     18.8
                                     16.3
                                     17.0
                                     1.22
Liver
                                     24 h
                                     23.1
                                     31.0
                                     30.0
                                     27.9
                                     28.0
                                     3.51
Kidney
                                     24 h
                                     16.5
                                     16.3
                                     18.9
                                     16.4
                                     17.0
                                     1.25
Heart
                                     24 h
                                     7.37
                                     7.08
                                     8.17
                                     9.04
                                     7.92
                                     0.88
Lung
                                     24 h
                                     17.3
                                     17.9
                                     20.8
                                     15.7
                                     17.9
                                     2.13
Brain
                                     24 h
                                     4.51
                                     3.38
                                     4.14
                                     4.00
                                     4.01
                                     0.47
Femur
                                     24 h
                                      11
                                     10.8
                                     12.8
                                     11.9
                                     11.6
                                     0.918
Ovaries and Uterus
                                     24 h
                                     13.1
                                     15.6
                                     10.5
                                     14.5
                                     13.4
                                      2.2
Stomach
                                     24 h
                                     12.3
                                     11.4
                                     13.8
                                     11.3
                                     12.2
                                     1.16
Small Intestine
                                     24 h
                                     22.9
                                     24.0
                                     27.4
                                     22.7
                                     24.3
                                     2.18
Cecum+Lg Int+Rect
                                     24 h
                                     16.5
                                     16.3
                                     18.0
                                     16.1
                                     16.7
                                     0.866
Stomach Contents
                                     24 h
                                     0.64
                                     1.11
                                     4.87
                                     1.45
                                     2.02
                                     1.93
Small Intestine Cont
                                     24 h
                                     15.0
                                     15.7
                                     22.4
                                     15.4
                                     17.1
                                     3.53
Lg Int + Cecum Cont
                                     24 h
                                     9.76
                                     8.94
                                     11.4
                                     7.18
                                     9.32
                                     1.76
Carcass Digest
                                     24 h
                                     8.03
                                     8.39
                                     8.67
                                     9.19
                                     8.57
                                     0.489

Table 12.  Disposition of Radioactivity (% of Recovered Radioactivity) Following Inhalation Exposure of Male F344 Rats to 3600 ppm [2-[14]C]DIPE  (Group 3)
Sample
Time point
                                     3-01
                                     3-02
                                     3-03
                                     3-04
                                     Mean
                                      SD
Urine
24 h
                                     3.49
                                     3.65
                                     5.06
                                     4.63
                                     4.21
                                     0.76

Subtotal
                                     3.49
                                     3.65
                                     5.06
                                     4.63
                                     4.21
                                     0.76
Feces
24 h
                                     0.33
                                     0.49
                                     0.51
                                     0.45
                                     0.44
                                     0.08

Subtotal
                                     0.33
                                     0.49
                                     0.51
                                     0.45
                                     0.44
                                     0.08
CO2 Trap 1
1 h
                                     0.31
                                     0.39
                                     0.37
                                     0.34
                                     0.35
                                     0.04
CO2 Trap 1
3 h
                                     0.97
                                     1.16
                                     1.18
                                     1.17
                                     1.12
                                      0.1
CO2 Trap 1
6 h
                                     2.98
                                     2.53
                                     3.35
                                     3.62
                                     3.12
                                     0.47
CO2 Trap 1
24 h
                                     14.69
                                     10.94
                                     18.73
                                     19.31
                                     15.92
                                      3.9

Subtotal
                                     18.95
                                     15.03
                                     23.63
                                     24.45
                                     20.51
                                     4.39
CO2 Trap 2
1 h
                                     *0.01
                                     *0.02
                                     *0.02
                                     *0.01
                                     0.01
                                     0.00
CO2 Trap 2
3 h
                                     *0.01
                                     *0.01
                                     *0.01
                                     *0.01
                                     0.01
                                     0.00
CO2 Trap 2
6 h
                                     *0.01
                                    **0.01
                                     *0.01
                                     *0.02
                                     0.01
                                     0.00
CO2 Trap 2
24 h
                                     2.15
                                      1.1
                                      2.3
                                     0.71
                                     1.57
                                     0.78

Subtotal
                                     2.19
                                     1.14
                                     2.34
                                     0.75
                                     1.61
                                     0.78
Exhaled VOC Trap 1
1 h
                                     29.23
                                     36.84
                                     26.6
                                     26.17
                                     29.71
                                     4.94
Exhaled VOC Trap 1
3 h
                                     17.80
                                     10.81
                                     8.48
                                     10.48
                                     11.89
                                     4.07
Exhaled VOC Trap 1
6 h
                                     14.04
                                     14.23
                                     14.35
                                     16.89
                                     14.88
                                     1.34
Exhaled VOC Trap 1
24 h
                                     1.67
                                     2.34
                                     2.24
                                     1.43
                                     1.92
                                     0.44

Subtotal
                                     62.74
                                     64.22
                                     51.67
                                     54.96
                                     58.4
                                     6.05
Exhaled VOC Trap 2
1 h
                                    **0.00
                                    **0.00
                                    **0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
3 h
                                    **0.00
                                    **0.00
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
6 h
                                     *0.00
                                     *0.00
                                     *0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
24 h
                                     4.62
                                     6.18
                                      6.4
                                     3.66
                                     5.22
                                     1.31

Subtotal
                                     4.63
                                     6.19
                                     6.41
                                     3.67
                                     5.22
                                      1.3
NO Tube Contents
0 m
                                     0.61
                                     1.74
                                      1.8
                                     1.41
                                     1.39
                                     0.55

Subtotal
                                     0.61
                                     1.74
                                      1.8
                                     1.41
                                     1.39
                                     0.55
Cage Rinse
24 h
                                     0.55
                                     0.57
                                     0.43
                                     0.63
                                     0.54
                                     0.08
Adipose subcutaneous
24 h
                                     0.00
                                     0.00
                                     0.01
                                     0.00
                                     0.00
                                     0.00
Adip (Abdominal)
24 h
                                     0.00
                                     00.00
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Muscle Gastrocnemius
24 h
                                     0.00
                                     0.01
                                     0.00
                                     0.01
                                     0.01
                                     0.00
Skin (neck)
24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Blood
24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.06
                                     0.05
                                     0.00
Spleen
24 h
                                     0.02
                                     0.03
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Liver
24 h
                                     0.77
                                     0.84
                                     1.24
                                     1.31
                                     1.04
                                     0.28
Kidney
24 h
                                     0.10
                                     0.11
                                     0.14
                                     0.13
                                     0.12
                                     0.02
Heart
24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Lung
24 h
                                     0.06
                                     0.06
                                     0.08
                                     0.08
                                     0.07
                                     0.01
Brain
24 h
                                     0.03
                                     0.03
                                     0.02
                                     0.03
                                     0.03
                                     0.00
Femur
24 h
                                     0.01
                                     0.02
                                     0.01
                                     0.02
                                     0.01
                                     0.00
Testes
24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.06
                                     0.05
                                     0.00
Stomach
24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.06
                                     0.05
                                     0.01
Small Intestine
24 h
                                     0.28
                                     0.42
                                     0.35
                                     0.45
                                     0.38
                                     0.08
Cecum+Lg Int+Rect
24 h
                                      0.1
                                     0.14
                                     0.13
                                     0.17
                                     0.13
                                     0.03
Stomach Contents
24 h
                                     N.S.
                                     0.01
                                     0.01
                                     N.S.
                                     0.00
                                     0.00
Small Intestine Cont
24 h
                                     0.16
                                     0.26
                                     0.21
                                     0.21
                                     0.21
                                     0.04
Lg Int + Cecum Cont
24 h
                                     0.26
                                     0.25
                                     0.32
                                     0.38
                                      0.3
                                     0.06
Carcass Digest
24 h
                                     4.54
                                     4.63
                                     5.42
                                     6.00
                                     5.15
                                     0.69

Subtotal
                                     7.06
                                     7.54
                                     8.58
                                     9.67
                                     8.21
                                     1.16

Total
                                      100
                                      100
                                      100
                                      100
                                      100
                                     0.00
*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample
Table 13.  Concentration of DIPE equivalents (ug/g) in Tissues Following Inhalation Exposure of Male F344 Rats to 3600 ppm [2-[14]C]DIPE  (Group 3).
Sample
                                  TIME POINT
                                     3-01
                                     3-02
                                     3-03
                                     3-04
                                     Mean
                                      SD
Adipose subcutaneous
                                     24 h
                                     12.4
                                     10.5
                                     21.0
                                     13.8
                                     14.4
                                     4.59
Adip (Abdominal)
                                     24 h
                                     8.83
                                     15.8
                                     38.0
                                     38.7
                                     25.3
                                     15.3
Muscle Gastrocnemius
                                     24 h
                                     11.2
                                     8.42
                                     10.1
                                     10.0
                                     9.93
                                     1.14
Skin (neck)
                                     24 h
                                     30.5
                                     23.8
                                     36.3
                                     45.5
                                     34.0
                                      9.2
Blood
                                     24 h
                                     14.7
                                     14.1
                                     14.1
                                     16.1
                                     14.8
                                     0.943
Spleen
                                     24 h
                                     40.4
                                     38.2
                                     39.6
                                     45.2
                                     40.8
                                     3.04
Liver
                                     24 h
                                     68.4
                                     64.4
                                     88.6
                                     95.2
                                     79.2
                                     15.1
Kidney
                                     24 h
                                     45.7
                                     44.5
                                     53.6
                                     52.9
                                     49.2
                                     4.74
Heart
                                     24 h
                                     17.2
                                     15.1
                                     19.1
                                     18.4
                                     17.5
                                     1.75
Lung
                                     24 h
                                     45.8
                                     41.9
                                     51.9
                                     55.4
                                     48.8
                                     6.05
Brain
                                     24 h
                                     9.74
                                     8.55
                                     8.35
                                     10.0
                                     9.16
                                     0.831
Femur
                                     24 h
                                      22
                                     17.6
                                     19.7
                                     28.0
                                     21.8
                                     4.49
Testes
                                     24 h
                                     15.2
                                     12.2
                                     12.8
                                     13.5
                                     13.4
                                      1.3
Stomach
                                     24 h
                                     32.4
                                     28.5
                                     32.9
                                     36.4
                                     32.6
                                     3.23
Small Intestine
                                     24 h
                                     66.1
                                     62.4
                                     70.1
                                     82.7
                                     70.3
                                     8.83
Cecum+Lg Int+Rect
                                     24 h
                                     44.9
                                     43.9
                                     46.5
                                     52.3
                                     46.9
                                     3.76
Stomach Contents
                                     24 h
                                     N.S.
                                     5.32
                                     8.39
                                     N.S.
                                     3.43
                                     4.15
Small Intestine Cont
                                     24 h
                                     42.5
                                     89.8
                                     37.3
                                     68.2
                                     59.5
                                     24.3
Lg Int + Cecum Cont
                                     24 h
                                     35.8
                                     33.6
                                     29.4
                                     36.1
                                     33.7
                                     3.09
Carcass Digest
                                     24 h
                                     19.4
                                     17.6
                                     21.2
                                     23.4
                                     20.4
                                     2.48

Table 14.  Disposition of Radioactivity (% of recovered radioactivity) Following Inhalation Exposure of Female F344 Rats to 3600 ppm [2-[14]C]DIPE  (Group 4)
Sample
Time point
                                     4-01
                                     4-02
                                     4-03
                                     4-04
                                     Mean
                                      SD
Urine
24 h
                                     3.48
                                     3.92
                                     3.50
                                     3.30
                                     3.55
                                     0.26

Subtotal
                                     3.48
                                     3.92
                                     3.50
                                     3.30
                                     3.55
                                     0.26
Feces
24 h
                                     0.22
                                     0.33
                                     0.41
                                     0.15
                                     0.28
                                     0.12

Subtotal
                                     0.22
                                     0.33
                                     0.41
                                     0.15
                                     0.28
                                     0.12
CO2 Trap 1
1 h
                                     0.41
                                     0.27
                                     0.47
                                     0.30
                                     0.36
                                     0.09
CO2 Trap 1
3 h
                                     1.85
                                     1.07
                                     1.65
                                     1.24
                                     1.45
                                     0.36
CO2 Trap 1
6 h
                                      5.2
                                     4.33
                                     5.15
                                     3.93
                                     4.65
                                     0.63
CO2 Trap 1
24 h
                                     10.96
                                     13.52
                                     10.41
                                     10.21
                                     11.28
                                     1.53

Subtotal
                                     18.42
                                     19.19
                                     17.68
                                     15.67
                                     17.74
                                     1.51
CO2 Trap 2
1 h
                                     *0.02
                                     *0.02
                                     *0.01
                                     *0.02
                                     0.02
                                     0.01
CO2 Trap 2
3 h
                                     *0.01
                                     *0.02
                                     *0.02
                                     *0.02
                                     0.02
                                     0.01
CO2 Trap 2
6 h
                                     *0.01
                                     *0.02
                                     *0.03
                                     *0.02
                                     0.02
                                     0.01
CO2 Trap 2
24 h
                                     1.07
                                     *0.03
                                     0.72
                                     0.14
                                     0.49
                                     0.49

Subtotal
                                     1.12
                                     0.09
                                     0.78
                                      0.2
                                     0.55
                                     0.49
Exhaled VOC Trap 1
1 h
                                     21.43
                                     21.09
                                     31.04
                                     32.04
                                     26.4
                                     5.95
Exhaled VOC Trap 1
3 h
                                     29.81
                                     27.75
                                     23.05
                                     24.45
                                     26.26
                                     3.08
Exhaled VOC Trap 1
6 h
                                     13.60
                                     14.66
                                     12.20
                                     13.57
                                     13.51
                                     1.01
Exhaled VOC Trap 1
24 h
                                     2.57
                                     6.05
                                     1.21
                                     2.58
                                     3.10
                                     2.07

Subtotal
                                     67.41
                                     69.55
                                     67.5
                                     72.63
                                     69.27
                                     2.45
Exhaled VOC Trap 2
1 h
                                    **0.00
                                    **0.00
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
3 h
                                    **0.00
                                    **0.00
                                     *0.01
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
6 h
                                    **0.00
                                     *0.00
                                     *0.00
                                     *0.01
                                     0.00
                                     0.00
Exhaled VOC Trap 2
24 h
                                     1.89
                                     0.02
                                     0.91
                                     2.20
                                     1.26
                                     0.99

Subtotal
                                     1.89
                                     0.02
                                     0.92
                                     2.21
                                     1.26
                                     0.99
NO Tube Contents
0 m
                                     0.45
                                     0.75
                                     1.07
                                     0.15
                                      0.6
                                     0.39

Subtotal
                                     0.45
                                     0.75
                                     1.07
                                     0.15
                                      0.6
                                     0.39
Cage Rinse
24 h
                                     0.52
                                     0.33
                                     0.34
                                     0.27
                                     0.36
                                     0.11
Adipose subcutaneous
24 h
                                     0.00
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Adip (Abdominal)
24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Muscle Gastrocnemius
24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Skin (neck)
24 h
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.01
                                     0.00
Blood
24 h
                                     0.07
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.01
Spleen
24 h
                                     0.04
                                     0.03
                                     0.03
                                     0.02
                                     0.03
                                     0.01
Liver
24 h
                                     0.91
                                     0.84
                                      1.2
                                     0.97
                                     0.98
                                     0.16
Kidney
24 h
                                     0.11
                                     0.09
                                     0.11
                                     0.07
                                     0.09
                                     0.02
Heart
24 h
                                     0.03
                                     0.02
                                     0.02
                                     0.01
                                     0.02
                                     0.01
Lung
24 h
                                     0.08
                                     0.06
                                      0.1
                                     0.07
                                     0.08
                                     0.02
Brain
24 h
                                     0.03
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Femur
24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Ovaries and Uterus
24 h
                                     0.02
                                     0.04
                                     0.03
                                     0.02
                                     0.03
                                     0.01
Stomach
24 h
                                     0.05
                                     0.05
                                     0.06
                                     0.05
                                     0.05
                                     0.01
Small Intestine
24 h
                                     0.31
                                     0.31
                                     0.33
                                     0.27
                                     0.31
                                     0.02
Cecum+Lg Int+Rect
24 h
                                     0.12
                                     0.11
                                     0.12
                                     0.11
                                     0.11
                                     0.00
Stomach Contents
24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Small Intestine Cont
24 h
                                     0.22
                                     0.14
                                     0.23
                                     0.14
                                     0.18
                                     0.05
Lg Int + Cecum Cont
24 h
                                     0.23
                                     0.24
                                     0.28
                                     0.24
                                     0.25
                                     0.02
Carcass Digest
24 h
                                     4.24
                                     3.79
                                     5.16
                                     3.31
                                     4.13
                                     0.79

Subtotal
                                     7.01
                                     6.15
                                     8.14
                                     5.68
                                     6.74
                                     1.08

Total
                                      100
                                      100
                                      100
                                      100
                                      100
                                     0.00
*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample
Table 15.  Concentration of DIPE equivalents (ug/g) in Tissues Following Inhalation Exposure of Female F344 Rats to 3600 ppm [2-[14]C]DIPE  (Group 4).
Sample
                                  TIME POINT
                                     4-01
                                     4-02
                                     4-03
                                     4-04
                                     MEAN
                                      SD
Adipose subcutaneous
                                     24 h
                                     11.6
                                     7.97
                                     17.8
                                     15.5
                                     13.2
                                     4.33
Adip (Abdominal)
                                     24 h
                                     8.37
                                     23.3
                                     23.2
                                     43.4
                                     24.6
                                     14.4
Muscle Gastrocnemius
                                     24 h
                                     8.43
                                     5.92
                                     7.86
                                     6.65
                                     7.22
                                     1.14
Skin (neck)
                                     24 h
                                     13.5
                                     21.8
                                     12.8
                                      27
                                     18.8
                                     6.84
Blood
                                     24 h
                                     12.4
                                     10.4
                                     10.4
                                     12.4
                                     11.4
                                     1.15
Spleen
                                     24 h
                                     34.8
                                     34.6
                                     35.1
                                     31.4
                                     34.0
                                     1.73
Liver
                                     24 h
                                     54.3
                                     72.7
                                     79.7
                                     79.7
                                     71.6
                                      12
Kidney
                                     24 h
                                     34.9
                                     36.0
                                          39.0
                                     31.6
                                     35.4
                                     3.06
Heart
                                     24 h
                                     17.8
                                     13.8
                                     16.4
                                     13.2
                                     15.3
                                     2.17
Lung
                                     24 h
                                     39.9
                                     41.9
                                     50.0
                                     40.0
                                     43.0
                                     4.79
Brain
                                     24 h
                                     6.08
                                     6.02
                                     5.55
                                     4.84
                                     5.62
                                     0.573
Femur
                                     24 h
                                     20.0
                                     16.6
                                     18.6
                                     14.2
                                     17.4
                                     2.52
Ovaries and Uterus
                                     24 h
                                     23.7
                                     33.1
                                     23.6
                                     24.1
                                     26.1
                                     4.66
Stomach
                                     24 h
                                     25.7
                                     28.0
                                     28.6
                                     25.9
                                     27.1
                                     1.47
Small Intestine
                                     24 h
                                     53.1
                                     56.6
                                     56.3
                                     49.3
                                     53.8
                                     3.41
Cecum+Lg Int+Rect
                                     24 h
                                     29.9
                                     35.6
                                     33.7
                                     31.4
                                     32.7
                                     2.51
Stomach Contents
                                     24 h
                                     1.93
                                     3.54
                                     3.33
                                     2.33
                                     2.78
                                     0.776
Small Intestine Cont
                                     24 h
                                     33.7
                                     32.0
                                     40.2
                                     32.4
                                     34.6
                                     3.82
Lg Int + Cecum Cont
                                     24 h
                                     21.8
                                     22.4
                                     21.0
                                     17.4
                                     20.7
                                     2.24
Carcass Digest
                                     24 h
                                     14.6
                                     15.3
                                     18.5
                                     13.1
                                     15.4
                                     2.28

Table 16.  Disposition of Radioactivity (Percent of recovered radioactivity) Following Repeat Inhalation Exposure of Male F344 Rats to 3600 ppm DIPE with [2-[14]C]DIPE Exposure on Last Day (Group 5)
                                    Sample
                                  Time point
                                     5-01
                                     5-02
                                     5-03
                                     5-04
                                     Mean
                                      SD
Urine
                                     24 h
                                     8.73
                                     9.78
                                     8.20
                                     7.46
                                     8.54
                                     0.98

                                                                       Subtotal
                                     8.73
                                     9.78
                                     8.20
                                     7.46
                                     8.54
                                     0.98
Feces
                                     24 h
                                     1.03
                                     0.92
                                     0.73
                                     1.02
                                     0.93
                                     0.14

                                                                       Subtotal
                                     1.03
                                     0.92
                                     0.73
                                     1.02
                                     0.93
                                     0.14
CO2 Trap 1
                                      1 h
                                     0.54
                                     0.45
                                     0.58
                                     0.47
                                     0.51
                                     0.06
CO2 Trap 1
                                      3 h
                                     1.12
                                     1.17
                                     1.21
                                     1.18
                                     1.17
                                     0.04
CO2 Trap 1
                                      6 h
                                     2.85
                                     2.97
                                     3.01
                                     3.18
                                     3.00
                                     0.14
CO2 Trap 1
                                     24 h
                                     23.0
                                     2.94
                                     26.6
                                     24.7
                                     19.3
                                     11.0

                                                                       Subtotal
                                     27.5
                                     7.53
                                     31.4
                                     29.5
                                     24.0
                                     11.1
CO2 Trap 2
                                      1 h
                                     *0.00
                                    **0.00
                                     *0.01
                                    **0.00
                                     0.00
                                     0.01
CO2 Trap 2
                                      3 h
                                     *0.01
                                    **0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.01
CO2 Trap 2
                                      6 h
                                     *0.01
                                    **0.00
                                     *0.01
                                     *0.01
                                     0.01
                                     0.01
CO2 Trap 2
                                     24 h
                                     4.93
                                     25.4
                                     5.01
                                     3.72
                                     9.76
                                     10.4

                                                                       Subtotal
                                     4.95
                                     25.4
                                     5.03
                                     3.73
                                     9.78
                                     10.4
Exhaled VOC Trap 1
                                      1 h
                                     16.0
                                     13.8
                                     14.7
                                     17.5
                                     15.5
                                     1.61
Exhaled VOC Trap 1
                                      3 h
                                     11.3
                                     11.9
                                     10.3
                                     10.9
                                     11.1
                                     0.67
Exhaled VOC Trap 1
                                      6 h
                                     14.6
                                     14.1
                                     13.2
                                     14.2
                                     14.0
                                     0.59
Exhaled VOC Trap 1
                                     24 h
                                     1.39
                                     1.43
                                     0.96
                                     1.07
                                     1.21
                                     0.23

                                                                       Subtotal
                                     43.3
                                     41.2
                                     39.2
                                     43.7
                                     41.9
                                     2.08
Exhaled VOC Trap 2
                                      1 h
                                     0.00
                                     0.00
                                     0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      3 h
                                     0.00
                                     0.00
                                     0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      6 h
                                     0.01
                                     0.00
                                     0.10
                                     0.00
                                     0.03
                                     0.05
Exhaled VOC Trap 2
                                     24 h
                                     3.20
                                     4.28
                                     2.25
                                     2.76
                                     3.12
                                     0.86

                                                                       Subtotal
                                     3.21
                                     4.28
                                     2.35
                                     2.76
                                     3.15
                                     0.83
NO Tube Contents
                                      0 m
                                     N.S.
                                     0.53
                                     0.60
                                     0.05
                                     0.30
                                     0.31

                                                                       Subtotal
                                     0.00
                                     0.53
                                     0.60
                                     0.05
                                     0.30
                                     0.31
Cage Rinse
                                     24 h
                                     0.64
                                     0.51
                                     1.01
                                     0.47
                                     0.66
                                     0.25
Adipose subcutaneous
                                     24 h
                                     0.02
                                     0.05
                                     0.03
                                     0.05
                                     0.04
                                     0.02
Adip (Abdominal)
                                     24 h
                                     0.04
                                     0.05
                                     0.04
                                     0.04
                                     0.04
                                     0.01
Muscle Gastrocnemius
                                     24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
Skin (neck)
                                     24 h
                                     0.00
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.01
Blood
                                     24 h
                                     0.07
                                     0.06
                                     0.07
                                     0.09
                                     0.07
                                     0.01
Spleen
                                     24 h
                                     0.03
                                     0.03
                                     0.03
                                     0.04
                                     0.03
                                     0.01
Liver
                                     24 h
                                     1.60
                                     1.86
                                     2.18
                                     1.89
                                     1.88
                                     0.24
Kidney
                                     24 h
                                     0.18
                                     0.14
                                     0.17
                                     0.14
                                     0.16
                                     0.02
Heart
                                     24 h
                                     0.03
                                     0.02
                                     0.03
                                     0.02
                                     0.03
                                     0.01
Lung
                                     24 h
                                     0.10
                                     0.11
                                     0.10
                                     0.10
                                     0.10
                                     0.01
Brain
                                     24 h
                                     0.03
                                     0.03
                                     0.03
                                     0.02
                                     0.03
                                     0.01
Femur
                                     24 h
                                     0.02
                                     0.02
                                     0.03
                                     0.02
                                     0.02
                                     0.01
Testes
                                     24 h
                                     0.06
                                     0.06
                                     0.06
                                     0.06
                                     0.06
                                     0.00
Stomach
                                     24 h
                                     0.07
                                     0.06
                                     0.08
                                     0.08
                                     0.07
                                     0.01
Small Intestine
                                     24 h
                                     0.47
                                     0.52
                                     0.44
                                     0.43
                                     0.47
                                     0.04
Cecum+Lg Int+Rect
                                     24 h
                                     0.17
                                     0.17
                                     0.18
                                     0.19
                                     0.18
                                     0.01
Stomach Contents
                                     24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.01
Small Intestine Cont
                                     24 h
                                     0.26
                                     0.17
                                     0.31
                                     0.22
                                     0.24
                                     0.06
Lg Int + Cecum Cont
                                     24 h
                                     0.34
                                     0.26
                                     0.33
                                     0.25
                                     0.30
                                     0.05
Carcass Digest
                                     24 h
                                     7.09
                                     6.21
                                     7.37
                                     7.71
                                     7.10
                                     0.64

                                   Subtotal
                                     11.2
                                     10.4
                                     12.5
                                     11.8
                                     11.5
                                     0.89

                                     Total
                                     99.9
                                     100.
                                     100.
                                     100.
                                     100.
                                     0.05
*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample

Table 17.  Concentration of DIPE equivalents (ug/g) in Tissues Following Repeat Inhalation Exposure of Male F344 Rats to 3600 ppm DIPE with [2-[14]C]DIPE Exposure on Last Day (Group 5)

                                    Sample
                                  Time point
                                     5-01
                                     5-02
                                     5-03
                                     5-04
                                     Mean
                                      SD
                             Adipose subcutaneous
                                     24 h
                                                                            140
                                                                            146
                                                                            199
                                                                            204
                                                                            172
                                                                           33.9
                               Adip (Abdominal)
                                     24 h
                                                                            297
                                                                            210
                                                                            389
                                                                            309
                                                                            301
                                                                           73.3
                             Muscle Gastrocnemius
                                     24 h
                                                                           18.7
                                                                           19.6
                                                                           19.5
                                                                           18.8
                                                                           19.2
                                                                            0.5
                                  Skin (neck)
                                     24 h
                                                                           34.7
                                                                           68.9
                                                                           46.0
                                                                           94.8
                                                                           61.1
                                                                           26.6
                                     Blood
                                     24 h
                                                                           34.8
                                                                           29.0
                                                                           30.4
                                                                           36.1
                                                                           32.6
                                                                            3.4
                                    Spleen
                                     24 h
                                                                           97.7
                                                                           86.0
                                                                           95.0
                                                                           88.8
                                                                           91.9
                                                                            5.4
                                     Liver
                                     24 h
                                                                            181
                                                                            214
                                                                            242
                                                                            200
                                                                            209
                                                                           25.7
                                    Kidney
                                     24 h
                                                                            118
                                                                           92.2
                                                                            124
                                                                           94.1
                                                                            107
                                                                           16.3
                                     Heart
                                     24 h
                                                                           39.8
                                                                           32.8
                                                                           38.8
                                                                           31.5
                                                                           35.7
                                                                            4.2
                                     Lung
                                     24 h
                                                                            118
                                                                            109
                                                                            111
                                                                            107
                                                                            111
                                                                            4.8
                                     Brain
                                     24 h
                                                                           17.3
                                                                           15.9
                                                                           15.8
                                                                           13.5
                                                                           15.6
                                                                            1.6
                                     Femur
                                     24 h
                                                                           56.8
                                                                           46.6
                                                                           59.7
                                                                           48.3
                                                                           52.9
                                                                            6.4
                                    Testes
                                     24 h
                                                                           26.7
                                                                           23.8
                                                                           24.7
                                                                           21.5
                                                                           24.2
                                                                            2.2
                                    Stomach
                                     24 h
                                                                           66.8
                                                                           61.1
                                                                           81.7
                                                                           66.5
                                                                           69.0
                                                                            8.9
                                Small Intestine
                                     24 h
                                                                            151
                                                                            146
                                                                            163
                                                                            138
                                                                            150
                                                                           10.5
                               Cecum+Lg Int+Rect
                                     24 h
                                                                           99.7
                                                                           88.0
                                                                            106
                                                                           95.5
                                                                           97.3
                                                                            7.6
                               Stomach Contents
                                     24 h
                                                                           12.0
                                                                           13.1
                                                                           14.5
                                                                            2.9
                                                                           10.6
                                                                            5.3
                             Small Intestine Cont
                                     24 h
                                                                           81.3
                                                                           64.5
                                                                           84.9
                                                                           53.6
                                                                           71.1
                                                                           14.7
                              Lg Int + Cecum Cont
                                     24 h
                                                                           44.6
                                                                           43.5
                                                                           46.7
                                                                           37.3
                                                                           43.0
                                                                            4.0
                                Carcass Digest
                                     24 h
                                                                           51.2
                                                                           47.6
                                                                           55.2
                                                                           56.9
                                                                           52.7
                                                                            4.2

Table 18.  Disposition of Radioactivity (% of Recovered Radioactivity) Following Repeat Inhalation Exposure of Female F344 Rats to 3600 ppm DIPE with [2-[14]C]DIPE Exposure on Last Day (Group 6)

                                    Sample
                                  Time point
                                     6-01
                                     6-02
                                     6-03
                                     6-04
                                     Mean
                                      SD
                                     Urine
                                     24 h
                                                                           7.41
                                                                           6.91
                                                                           6.85
                                                                           6.18
                                                                           6.84
                                                                           0.51

                                                                       Subtotal
                                                                           7.41
                                                                           6.91
                                                                           6.85
                                                                           6.18
                                                                           6.84
                                                                           0.51
                                     Feces
                                     24 h
                                                                           0.75
                                                                           1.14
                                                                           0.42
                                                                           0.98
                                                                           0.82
                                                                           0.31

                                                                       Subtotal
                                                                           0.75
                                                                           1.14
                                                                           0.42
                                                                           0.98
                                                                           0.82
                                                                           0.31
                                  CO2 Trap 1
                                      1 h
                                                                           0.56
                                                                           0.40
                                                                           0.61
                                                                           0.40
                                                                           0.49
                                                                           0.11
                                  CO2 Trap 1
                                      3 h
                                                                           1.16
                                                                           1.12
                                                                           1.53
                                                                           1.69
                                                                           1.38
                                                                           0.28
                                  CO2 Trap 1
                                      6 h
                                                                           3.34
                                                                           2.88
                                                                           4.05
                                                                           5.96
                                                                           4.06
                                                                           1.36
                                  CO2 Trap 1
                                     24 h
                                                                           18.3
                                                                           21.2
                                                                           20.1
                                                                           16.8
                                                                           19.0
                                                                           1.94

                                                                       Subtotal
                                                                           23.4
                                                                           25.0
                                                                           26.3
                                                                           24.9
                                                                           25.1
                                                                           1.24
                                  CO2 Trap 2
                                      1 h
                                                                         **0.00
                                                                         **0.00
                                                                         **0.00
                                                                          *0.01
                                                                           0.00
                                                                           0.01
                                  CO2 Trap 2
                                      3 h
                                                                         **0.00
                                                                          *0.01
                                                                          *0.01
                                                                          *0.01
                                                                           0.01
                                                                           0.01
                                  CO2 Trap 2
                                      6 h
                                                                          *0.01
                                                                         **0.00
                                                                          *0.02
                                                                         **0.01
                                                                           0.01
                                                                           0.01
                                  CO2 Trap 2
                                     24 h
                                                                           3.13
                                                                           0.31
                                                                           0.28
                                                                           1.30
                                                                           1.25
                                                                           1.34

                                                                       Subtotal
                                                                           3.14
                                                                           0.32
                                                                           0.31
                                                                           1.33
                                                                           1.27
                                                                           1.33
                              Exhaled VOC Trap 1
                                      1 h
                                                                           21.7
                                                                           15.2
                                                                           25.2
                                                                           27.4
                                                                           22.4
                                                                           5.33
                              Exhaled VOC Trap 1
                                      3 h
                                                                           13.1
                                                                           12.3
                                                                           10.3
                                                                           16.0
                                                                           13.0
                                                                           2.54
                              Exhaled VOC Trap 1
                                      6 h
                                                                           12.1
                                                                           13.9
                                                                           11.6
                                                                           10.3
                                                                           12.0
                                                                           1.49
                              Exhaled VOC Trap 1
                                     24 h
                                                                           1.28
                                                                           3.63
                                                                           1.67
                                                                           0.83
                                                                           1.85
                                                                           1.23

                                                                       Subtotal
                                                                           48.2
                                                                           45.0
                                                                           48.8
                                                                           54.9
                                                                           49.0
                                                                           4.13
                              Exhaled VOC Trap 2
                                      1 h
                                                                           0.01
                                                                           0.00
                                                                           0.00
                                                                           0.00
                                                                           0.00
                                                                           0.01
                              Exhaled VOC Trap 2
                                      3 h
                                                                           0.00
                                                                           0.00
                                                                           0.00
                                                                           0.00
                                                                           0.00
                                                                           0.00
                              Exhaled VOC Trap 2
                                      6 h
                                                                           0.02
                                                                           0.00
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.01
                              Exhaled VOC Trap 2
                                     24 h
                                                                           3.26
                                                                           6.92
                                                                           3.55
                                                                           1.50
                                                                           3.81
                                                                           2.26

                                                                       Subtotal
                                                                           3.29
                                                                           6.92
                                                                           3.56
                                                                           1.51
                                                                           3.82
                                                                           2.26
                               NO Tube Contents
                                      0 m
                                                                           0.72
                                                                           0.63
                                                                           0.66
                                                                           0.42
                                                                           0.61
                                                                           0.13

                                                                       Subtotal
                                                                           0.72
                                                                           0.63
                                                                           0.66
                                                                           0.42
                                                                           0.61
                                                                           0.13
                                  Cage Rinse
                                     24 h
                                                                           0.45
                                                                           0.57
                                                                           0.66
                                                                           0.30
                                                                           0.50
                                                                           0.16
                             Adipose subcutaneous
                                     24 h
                                                                           0.04
                                                                           0.05
                                                                           0.04
                                                                           0.03
                                                                           0.04
                                                                           0.01
                               Adip (Abdominal)
                                     24 h
                                                                           0.12
                                                                           0.03
                                                                           0.06
                                                                           0.05
                                                                           0.07
                                                                           0.04
                             Muscle Gastrocnemius
                                     24 h
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.00
                                  Skin (neck)
                                     24 h
                                                                           0.01
                                                                           0.03
                                                                           0.01
                                                                           0.01
                                                                           0.02
                                                                           0.01
                                     Blood
                                     24 h
                                                                           0.07
                                                                           0.09
                                                                           0.11
                                                                           0.12
                                                                           0.10
                                                                           0.02
                                    Spleen
                                     24 h
                                                                           0.03
                                                                           0.04
                                                                           0.05
                                                                           0.06
                                                                           0.05
                                                                           0.01
                                     Liver
                                     24 h
                                                                           1.39
                                                                           1.90
                                                                           1.64
                                                                           1.37
                                                                           1.58
                                                                           0.25
                                    Kidney
                                     24 h
                                                                           0.20
                                                                           0.17
                                                                           0.18
                                                                           0.11
                                                                           0.17
                                                                           0.04
                                     Heart
                                     24 h
                                                                           0.05
                                                                           0.03
                                                                           0.04
                                                                           0.03
                                                                           0.04
                                                                           0.01
                                     Lung
                                     24 h
                                                                           0.13
                                                                           0.13
                                                                           0.14
                                                                           0.09
                                                                           0.12
                                                                           0.02
                                     Brain
                                     24 h
                                                                           0.02
                                                                           0.03
                                                                           0.03
                                                                           0.02
                                                                           0.03
                                                                           0.01
                                     Femur
                                     24 h
                                                                           0.02
                                                                           0.03
                                                                           0.02
                                                                           0.02
                                                                           0.02
                                                                           0.01
                              Ovaries and Uterus
                                     24 h
                                                                           0.05
                                                                           0.02
                                                                           0.04
                                                                           0.02
                                                                           0.03
                                                                           0.02
                                    Stomach
                                     24 h
                                                                           0.08
                                                                           0.09
                                                                           0.08
                                                                           0.07
                                                                           0.08
                                                                           0.01
                                Small Intestine
                                     24 h
                                                                           0.42
                                                                           0.65
                                                                           0.53
                                                                           0.42
                                                                           0.51
                                                                           0.11
                               Cecum+Lg Int+Rect
                                     24 h
                                                                           0.21
                                                                           0.19
                                                                           0.17
                                                                           0.15
                                                                           0.18
                                                                           0.03
                               Stomach Contents
                                     24 h
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.01
                                                                           0.00
                             Small Intestine Cont
                                     24 h
                                                                           0.30
                                                                           0.27
                                                                           0.25
                                                                           0.26
                                                                           0.27
                                                                           0.02
                              Lg Int + Cecum Cont
                                     24 h
                                                                           0.31
                                                                           0.37
                                                                           0.52
                                                                           0.28
                                                                           0.37
                                                                           0.11
                                Carcass Digest
                                     24 h
                                                                           9.16
                                                                           8.79
                                                                           8.42
                                                                           6.34
                                                                           8.18
                                                                           1.26

                                   Subtotal
                                                                           13.1
                                                                           13.5
                                                                           13.0
                                                                           9.77