PAGE INTENTIONALLY LEFT BLANK William C. Herz Director of Scientific Programs M E M O R A N D U M TO: Product Testing Recipient FROM: William C. Herz, Director, Scientific Programs SUBJECT: Ammonium Phosphate Sulfate Product Testing Dossier DATE: March 15, 2003 It is with great pleasure that The Fertilizer Institute ( TFI) announces the completion and distribution of the final product testing dossier for Ammonium Phosphate Sulfate ( CAS # 12593 60 1).

As you are aware, TFI sponsored this four   year program to develop and summarize screeninglevel hazard information for high production volume ( HPV) chemicals. The data elements generated represent a broad overview of human health and ecological parameters. These include a physical  chemical characterization, environmental fate, mammalian toxicity and ecotoxicity. A health and environmental safety data summary dossier was prepared for each of the 23 materials. It summarizes the available literature data, new testing data, category description and read across data as well as provides a conclusion regarding the inherent hazards of the material.

Upon receipt of this data a 90 calendar day regulatory trigger starts within which you must update your material safety data sheets ( MS DS). Upon first product shipment you must also notify your distributors and employers once the MS DS has been updated. These regulatory requirements are detailed in 29 CFR 1910.1200( g)( 5) and 29 CFR 1910.1200( g)( 6)( i). The requirements are found in the Occupational Safety and Health Administration " Hazard Communication Standard" ( 29 CFR 1910.1200).

Please note that by receipt of this data; you agree not to distribute or sell this data beyond your own company. PAGE INTENTIONALLY LEFT BLANK HEALTH & ENVIRONMENTAL SAFETY DATA SUMMARY DOCUMENT AMMONIUM PHOSPHATE SULFATE CAS NO. 12593 60 1 Prepared for:

THE FERTILIZER INSTITUTE January 27, 2003 THE WEINBERG GROUP INC. 1220 Nineteenth St, NW, Suite 300 Washington, DC 20036 2400 e mail science@ weinberggroup. com WASHINGTON NEW YORK SAN FRANCISCO BRUSSELS PARIS PAGE INTENTIONALLY LEFT BLANK Ammonium Phosphate Sulfate CAS # 12593 60 1 TABLE OF CONTENTS Page EXECUTIVE OVERVIEW................................................................................................... 1 SIDS DATA PROFILE.......................................................................................................... 8 SIDS DATA SUMMARY..................................................................................................... 9 1. GENERAL INFORMATION.................................................................................... 11 2. PHYSICAL CHEMICAL DATA.............................................................................. 13 3. ENVIRONMENTAL FATE AND PATHWAYS..................................................... 15 4. ECOTOXICITY......................................................................................................... 17 5. TOXICITY................................................................................................................. 20 6. REFERENCES .......................................................................................................... 23 APPENDICES Appendix A SIDS Data Availability Summary Appendix B SIDS Data Summaries for the Ammonia Compounds Category: Ammonia, Aqua Ammonia, Nitrogen Solutions ( UAN), Urea, Ammonium Nitrate, Ammonium Phosphate Sulfate, Ammonium Sulfate, Ammonium Thiosulfate, Diammonium Phosphate, and Monoammonium Phosphate ACRONYMS AND ABBREVIATIONS BCF Bioconcentration Factor bw Body Weight DAP Diammonium Phosphate DOT Department of Transportation FDA U. S. Food and Drug Administration g/ L Grams per Liter GLP Good Laboratory Practices GTSP Granular Triple Super Phosphate g/ mL Grams per Milliliter HSDB Hazardous Substance Data Bank IPCS International Programme for Chemical Safety KNO3 Potassium Nitrate Koc Organic Carbon Partition Coefficient Kow Octanol/ Water Partition Coefficient LC50 Median Lethal Concentration LD50 Median Lethal Dose LOAEL Lowest Observable Adverse Effect Level LOEC Lowest Observable Effect Concentration LOEL Lowest Observable Effect Level Ammonium Phosphate Sulfate CAS # 12593 60 1 M Molar MAP Monoammonium Phosphate mg/ kg Milligrams per Kilogram mg/ kg/ day Milligrams per Kilogram per Day mg/ L Milligrams per Liter MHb Methyl Hemoglobin mm Hg Millimeters of Mercury mmol/ L Millimoles per Liter NaNo3 Sodium Nitrate NFPA National Fire Prevention Association ( NH4) 2NO3 Ammonium Nitrate NIOSH National Institute for Occupational Safety and Health NO3 Nitrate NOAEL No Observable Adverse Effect Level NOEC No Observable Effect Concentration NOEL No Observable Effect Level OECD Organisation for Economic Co operation and Development Pa Pascal ppm Parts per Million SCAS Semi Continuous Activated Sludge SIDS Screening Information Data Set SSP Single Super Phosphate TLm Median Toxicity Level TLV Threshold Limit Value TFI The Fertilizer Institute UAN Urea Ammonia Nitrogen 1 Ammonium Phosphate Sulfate CAS # 12593 60 1 EXECUTIVE OVERVIEW I. Introduction The Fertilizer Institute, on behalf of its member companies, initiated a Product Testing Project to collect, review, summarize, and where necessary develop additional health and environmental safety data for 23 of its high production volume inorganic fertilizer materials. These data and summaries provide valuable information that can be used to update Material Safety Data Sheets, answer customers' questions, and support product stewardship efforts. The chemical industry is also participating in a voluntary program of comparable scope for high production volume organic chemicals. 1 The 23 fertilizer materials were divided into five categories ( i. e., ammonia compounds, nitrate compounds, phosphate compounds, salts and acids) based on their primary constituents as shown in Table 1. The use of categories is a recognized and accepted method that allows health and environmental safety data from one chemical in the category to be used to represent one or more other related chemicals in the category ( USEPA 1999). The key is to find similar, or at least predictable, patterns and trends among the chemicals in a category. In this way, data can be pooled, resources are optimized, and fewer animals are used in testing, all without losing the ability to evaluate the hazards and safety of the individual chemicals. Note that some of the materials fall into more than one category ( e. g., diammonium phosphate [ DAP] is in both the phosphate and ammonia categories).

Searches were conducted using on line databases, standard scientific data compendia, and other published sources for toxicity, ecotoxicity, environmental fate, and physicalchemical properties. The collected data were reviewed for quality and acceptability and then summarized according to the Organization for Economic Cooperation and Development ( OECD) Screening Information Data Set ( SIDS) dossier format ( OECD 1997). The OECD countries ( including the United States) have agreed on a set of tests and on types of data that are generally necessary to characterize the chemical behavior and potential hazards of chemicals released into the environment. The OECD SIDS dossier was chosen as a standard format for the TFI Product Testing Project in order that it would be scientifically defensible, broadly applicable and easily understandable to a wide range of stakeholders.

The following sections of this Executive Overview provide: the rationale for development of the Ammonia Compounds category ( Section II); a synopsis of the available data related to the physical chemical properties, environmental fate, ecotoxicity and toxicity of ammonium phosphate sulfate ( Section III); and a conclusion regarding the adequacy of the data to sufficiently characterize the category and the need for additional testing ( Section IV).

The data for ammonium phosphate sulfate are summarized in the Chemical Profile and Data Summary tables. Because the evaluation of data adequacy relies on a category 1 HPV Chemical Challenge Program; USEPA 1999 ( http:// www. epa. gov/ opptintr/ chemrtk/ volchall. htm) 2 Ammonium Phosphate Sulfate CAS # 12593 60 1 approach, the Data Summary table references Appendix B when data are available for one or more of the other materials in the category for those data elements where no data specific to ammonium phosphate sulfate are available. Appendix B provides a summary of the data for all of the ammonia compounds in the category. The individual studies for ammonium phosphate sulfate itself are presented in subsequent pages of this document. Separate data summary documents are available for each of the ammonia compounds in the category. Special attention should be given to the summary documents for MAP, DAP, and ammonium sulfate.

II. Rationale for the Ammonia Compounds Category The ammonia compounds category for fertilizer materials includes anhydrous ammonia, aqua ammonia, nitrogen solutions, several ammonium salts, di and monoammonium phosphates, and urea. These compounds are grouped because of chemical composition similarities and the dissociation into un ionized ammonia ( NH3) and/ or the ammonium ion ( NH4 +). The compounds have similar and generally predictable patterns of behavior in the environment as well as toxicological properties. The toxicity of ammonia to aquatic organisms is highly dependent on physicochemical factors, most notably pH because of its importance in chemical speciation ( Clement Associates, Inc. 1990). The acute toxicity of ammonia is also influenced to a lesser degree by temperature, carbon dioxide, dissolved oxygen, and salinity. In aqueous solution, ammonia exists primarily in two forms, un ionized ammonia ( NH3) and the ammonium ion ( NH4 +), which are in equilibrium with each other according to the following established relationship:

NH3( aq) + H2O   NH4 + + OH

In general, as pH increases, the fraction of the total ammonia which is un ionized increases. It is this un ionized ammonia which is generally considered to be the primary cause of toxicity in aquatic systems ( Clement Associates, Inc. 1990). Un ionized ammonia is more toxic to aquatic organisms than the ammonium ion because the unionized form is readily soluble in the lipid of the cell membrane and is rapidly absorbed by the gill. In contrast, the charged ion is not easily passed through the charged line hydrophobic space in the membrane. U. S. Environmental Protection Agency ( USEPA) studies indicate that un ionized ammonia is 190 times more toxic to guppies than ammonium ion ( USEPA 1985; 1998).

Multiple EPA studies in aquatic systems have shown that over the pH range of 6.5 9.0, the toxicity of un ionized ammonia increases as the pH decreases ( Clement Associates, Inc. 1990). At lower pH values, this can be attributed to either the increased hydrogen ion concentration increasing the toxicity of un ionized ammonia or that the ammonium ion is exerting some level of toxicity at the lower pH ( Clement Associates, Inc. 1990). However, it would be an oversimplification to attribute the toxic action to only the ammonium ion at low pH and to only un ionized ammonium at high pH because most likely both forms participate when total ammonia concentration is high enough to cause toxicity symptoms ( Clement Associates, Inc. 1990). To incorporate this, a joint toxicity model has been proposed, with ammonium causing most toxicity at high pH values and 3 Ammonium Phosphate Sulfate CAS # 12593 60 1 ammonium ion also contributing to toxicity at lower pH values ( Erickson 1985; Ankley et al. 1995). This is supported through studies demonstrating that at low pH a new inward flux of ammonium ion can occur across the gills of aquatic species ( Evans and Cameron 1986; Ankley et al. 1995). Still, under most environmental conditions, the unionized ammonia concentration is the primary driver of toxicity.

In mammalian systems, the un ionized ammonia again is the primary toxic agent, based on the pH dependency of its distribution ( i. e., NH3 diffuses more easily than NH4+). It should be noted that due to the pH of most biological systems, ammonia typically exists in the ionized form in the body. Nitrate ( NO2, a microbial degradate of NH3) however, can play a more important role in toxicity in mammalian systems than in aquatic systems.

III. Summary of Data Available for the Ammonia Compounds Category Detailed data summaries for ammonium phosphate sulfate are included in subsequent sections of this Health and Environmental Safety Data Summary Document for Ammonium Phosphate Sulfate. These data are briefly summarized here. While ammonia compounds may exist as gases ( e. g., anhydrous ammonia), much of the aquatic testing must, by necessity, be conducted on ammonia compounds in the form of a liquid ( e. g., NH4Cl is commonly used in aquatic testing). Gaseous ammonia was used for inhalation testing of mammals, with ammonia salts ( e. g., NH4OCOCH3) often used for testing by other routes.

Physical Chemical Data The density of gaseous ammonia is 0.696 g/ L at 20 º C and therefore is lighter than air. Liquid ammonia is lighter than water, with a density of 682 g/ L as reported in Constable et al. ( 1999). With solubility values ranging from around 510 to 1,920 g/ L, ammonia compounds are readily soluble in water, where they ionize to form NH4 + under most environmental conditions. Aqueous and anhydrous ammonia are volatile, as shown by their high vapor pressures ( 2,159 and 7,600 mm Hg at 25 ° C, respectively). The salts of ammonia are less volatile.

Environmental Fate and Pathway Because of its high volatility, anhydrous and aqua ammonia are more likely to be present in the atmosphere or used by biological organisms. Of the fraction not taken up by row crops, most of the ammonia released from fertilizer goes to the air rather than to surface or ground water. The high solubility of the other ammonia compounds suggests that at the pH of most biological systems ammonia exists predominantly in the ionized form ( NH4 +). The fate of ammonia is driven by its important role in the nitrogen cycle, including relatively rapid assimilation and degradation by living organisms. The nitrogen cell is well known ( e. g., see www. geog. ouc. bc. ca/ physgeog/ contents/ 9s. html). 4 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ecotoxicity Acute 96 hour LC50 values for fish from the literature range from 0.08 3.51 mg unionized NH3/ L, and from about 13 to over 500 mg total NH3/ L. 1 Numerous differences between studies easily account for the variability observed in acute toxicity, among them test species, age of test subjects, test type ( static or flow through), temperature, and most notably, pH. In addition to these literature values, acute fish studies were conducted under Good Laboratory Practice ( GLP) conditions on nitrogen solutions ( as UAN), ammonium phosphate sulfate, and monoammonium phosphate ( MAP). No lethal or sublethal effects were observed in any of these studies at nominal concentrations up to 100 mg total NH3/ L ( measured concentrations of 85 107 mg total NH3/ L), which were the highest concentrations tested. A similar range of literature values was found with Daphnia and other aquatic invertebrates ( EC50 = 0.19 22.84 mg un ionized NH3/ L). Algae can tolerate relatively high aqueous ammonia concentrations, as they readily assimilate the nitrogen, and phosphorus in the case of MAP and DAP. Response of aquatic organisms to chronic exposures of ammonia compounds is similar to the acute effects. Based on the standard Federal Insecticide Fungicide and Rodenticide Act ( FIFRA) acute toxicity ratings for fish and Daphnia ( below), the compounds in this category may be very highly toxic to aquatic organisms.

EC/ LC50 ( mg/ L) Toxicity Description < 0.1 Very Highly Toxic 0.1 1 Highly Toxic 1 10 Moderately Toxic 10 100 Slightly Toxic > 100 Practically Non Toxic In addition, high concentrations of ammonia affects photosynthetic and respiratory pathways in terrestrial plants and may result in foliar necrosis.

Mammalian Toxicity Acute toxicity The oral route is not an applicable route of exposure for anhydrous ammonia ( a gas). Reported acute oral LD50 values for ammonia compounds ranged from 350 14,300 mg/ kg body weight ( bw), primarily in rats and mice, with ammonium sulfate having the most variability. Inhalation toxicity data are available for anhydrous ammonia and several ammonium salts, and indicate a lack of systemic toxicity by this route of exposure. Dermal studies are available for ammonium sulfate and ammonium nitrate and report acute LD50 values of > 2,000 and > 5000 mg/ kg bw, respectively. To supplement the acute studies available in the literature for members of the ammonia category, additional 1 Ammonia toxicity values may be reported as " un ionized NH3/ L" ( i. e., concentration based on the molecular weight of the compound), as " un ionized NH3 N/ L" ( i. e., concentration based on the molecular weight of only the nitrogen portion of the compound), or as " total NH3/ L" ( i. e., concentration based on the molecular weight of both the un ionized and ionized compounds). 5 Ammonium Phosphate Sulfate CAS # 12593 60 1 acute studies were conducted with ammonium nitrate ( dermal), ammonium phosphate sulfate ( oral), DAP ( oral and dermal), and MAP ( oral and dermal). All of these studies, which were conducted using OECD protocols under GLP conditions, resulted in no signs of lethal or sublethal toxicity at doses equal to 2000 mg/ kg bw ( for the oral studies) and 5000 mg/ kg bw ( for the dermal studies). Based on the standard FIFRA acute toxicity ratings for mammals ( below), the compounds in this category are considered to be of low to very low toxicity ( 40 CFR 156.62).

Toxicity Category I II III IV Toxicity Rating High Moderate Low Very Low Oral LD50   50 mg/ kg > 50 500 mg/ kg > 500 5000 mg/ kg > 5000 mg/ kg Dermal LC50   200 mg/ kg > 200 2000 mg/ kg > 2000 20,000 mg/ kg > 20,000 mg/ kg Inhalation LC50   0.2 mg/ L > 0.2 2 mg/ L > 2 20 mg/ L > 20 mg/ L Genotoxicity Literature data for anhydrous ammonia and ammonium sulfate indicated no evidence for mutagenicity. Additional, bacterial ( Ames test) and non bacterial ( CHO chromosome aberration test) in vitro genotoxicity studies were conducted on ammonium thiosulfate and DAP under GLP conditions. In all cases the results were negative, indicating no evidence of genotoxicity for ammonia compounds.

Repeated dose and developmental toxicity No mortality was observed in repeat dose inhalation studies in rats, guinea pigs, rabbits, dogs and monkeys at anhydrous ammonia concentrations up to 770 mg total NH3/ m3, although reported sublethal effects included nasal, eye and skin irritation and inflammation. A one generation reproduction study in which pigs were exposed to ammonia from manure pits resulted in no significant effects on onset of puberty or litter size. Repeat dose studies on ammonium nitrate and urea indicate low acute toxicity. Reproductive and developmental toxicity studies conducted on these two compounds and urea indicate no toxic effects to rats, mice and hamsters. In addition, a combined protocol ( OECD 422) study that evaluates repeat dose exposures as well as reproductive and developmental endpoints was conducted on DAP under GLP conditions. Results show no mortality in rats given doses by gavage up to 1,500 mg/ kg bw d. Some treatment related effects on haematology were evident, and bodyweight gain was temporarily reduced in the high dose group, after which they regained normal weight gain levels. No treatment related deaths or signs of clinical toxicity were observed. Mating performance, fertility, and offspring all were unaffected by parental exposure to DAP. 6 Ammonium Phosphate Sulfate CAS # 12593 60 1 IV. Conclusion for the Ammonia Compounds Category Several of the compounds in the ammonia category have been extensively studied. Most notably, anhydrous ammonia has an essentially complete database that includes several published reviews ( e. g., ATSDR 1990; Constable et al. 1999; Clement 1990; Ecological Analysts, Inc. 1981; NRC 1979; USEPA 1985 and 1998; and WHO 1986). The database for ammonium nitrate is also largely complete. A SIDS dossier for urea has been accepted as final by the OECD. Furthermore, additional studies have been conducted under GLP conditions to address key endpoints for all of the ammonia category compounds. Consequently, sufficient data are available to characterize the physicalchemical properties, environmental fate, ecotoxicity and toxicity of the ammonia category. Therefore, additional testing is not needed to assess the hazards of these chemicals. 7 Ammonium Phosphate Sulfate CAS # 12593 60 1 TABLE 1: CATEGORIES FOR PRODUCT TESTING PROJECT CATEGORY COMPOUND CAS NUMBER Ammonia Compounds Anhydrous ammonia Aqua ammonia Ammonium nitrate Ammonium sulfate Ammonium thiosulfate Nitrogen solutions ( UAN) Ammonium phosphate sulfate Diammonium phosphate ( DAP) Monoammonium phosphate ( MAP) Urea 7664 41 7 1336 21 6 6484 52 2 7783 20 2 7783 18 8 15978 77 5 12593 60 1 7783 28 0 7722 76 1 57 13 6 Nitrate Compounds Sodium nitrate Ammonium nitrate Potassium nitrate Potassium sodium nitrate Nitrogen solutions ( UAN) 7631 99 4 6484 52 2 7757 79 1 7757 79 1/ 7631 99 4 15978 77 5 Phosphate Compounds Diammonium phosphate ( DAP) Monoammonium phosphate ( MAP) Liquid polyphosphate Single superphosphate** Granular triple superphosphate** 7783 28 0 7722 76 1  8011 76 5 65996 95 4 Salts Potassium chloride Potassium magnesium sulfate Potassium nitrate Potassium sodium nitrate Potassium sulfate Calcium sulfate 7447 40 7 14168 73 1 7757 79 1 7757 79 1/ 7631 99 4 7778 80 5 7778 18 9 Acids Phosphoric acid Nitric acid Sulfuric acid 7664 38 2 7697 37 2 7664 93 9 * = Nitrogen solutions are represented largely by Urea Ammonia Nitrogen ( UAN; 15978 77 5) ** = Single superphosphate and granular triple superphosphate are combined into a single dossier.  = No CAS number readily available 8 Ammonium Phosphate Sulfate CAS # 12593 60 1 V. REFERENCES CITED 40 CFR 156.62. Toxicity Category.

Agency for Toxic Substances and Disease Registry ( ATSDR). 1990. Toxicological Profile for Ammonia.

Ankley, G. T., Schubauer Berigan, and Monson, P. D. 1995. Influence of pH and hardness on toxicity of ammonia to the amphipod Hyalella azteca. Can. J. Fish. Aquat. Sci. 52: 2078 2083.

Clement Associates, Inc. 1990. Health Effects Assessment for Ammonia. Prepared for The Fertilizer Institute, Washington, D. C.

Constable, M., Jensen, F., McLeron, J. Craig, G., and Moore, D. 1999. Canadian Environmental Protection Act, Priority Substances List II: Supporting Document for Ammonia in the Aquatic Environment. Draft, Unpublished Version. Government of Canada, Environment Canada.

Ecological Analysts, Inc. 1981. The Sources, Chemistry, Fate, and Effects of Ammonia in Aquatic Environments. Washington, D. C. American Petroleum Institute.

Erickson, R. J. 1985. An evaluation of mathematical models for the effects of pH and temperature on ammonia toxicity to aquatic organisms. Water Res. 19: 1047 1058.

Evans, D. E. and Cameron, J. N. 1986. Gill ammonia transport. J. Exp. Zool. 239: 17 23.

National Research Council ( NRC). 1979. Ammonia. Subcommittee on Ammonia. Committee on Medical and Biologic Effects of Environmental Pollutants. Division of Medical Sciences, Assembly of Life Sciences. National Research Council. Baltimore: University Park Press. NTIS No. PB 278 027.

OECD. 1997. SIDS Manual. OECD Secretariat, 3rd Revision, July 1997.

U. S. Environmental Protection Agency ( USEPA). 1985. Ambient Water Quality Criteria for Ammonia   1984. Office of Water Regulations and Standards, Criteria and Standards Division. Washington, D. C. EPA 504/ 5 85 006.

U. S. Environmental Protection Agency ( USEPA). 1998. 1998 Update of Ambient Water Quality Criteria for Ammonia. Office of Water, Washington, D. C. EPA 822 R 98 008.

USEPA. 1999. Development of Chemical Categories in the HPV Challenge Program. www. epa. gove/ chemrtk/ catdoc29. pdf.

World Health Organization ( WHO). 1986. Ammonia   Environmental Health Criteria 54. Geneva" International Programme on Chemical Safety. 9 Ammonium Phosphate Sulfate CAS # 12593 60 1 SIDS DATA PROFILE Date: January 27, 2003 1.01 A. CAS No. 12593 60 1 1.01 C. CHEMICAL NAME ( OECD NAME) Ammonium Phosphate Sulfate 1.01 D CAS DESCRIPTOR Ammonium Phosphate Sulfate 1.01 G STRUCTURAL FORMULA (( NH4) 2( H2PO4)( HSO4)) OTHER CHEMICAL IDENTITY INFORMATION None 1.5 QUANTITY No data available 1.7 USE PATTERN Ammonium phosphate sulfate is used exclusively as a fertilizer.

1.9 SOURCES AND LEVELS OF EXPOSURE Low human exposure is expected because ammonium phosphate sulfate is manufactured in closed systems. Exposure to dusts and direct contact with the material is possible during fertilizer application. ISSUES FOR DISCUSSION The data for ammonium phosphate sulfate should be evaluated in combination with the other materials in the ammonia category. Data for mono and di ammonium phosphate and for ammonium sulfate may also be applicable. 10 Ammonium Phosphate Sulfate CAS # 12593 60 1 SIDS DATA SUMMARY Date: January 27, 2003 AMMONIUM PHOSPHATE SULFATE ( CAS NO. 12593 60 1) SPECIES PROTOCOL RESULTS PHYSICAL CHEMICAL DATA 2.1 Melting Point See Appendix B results* 2.2 Boiling Point See Appendix B results* 2.3 Density See Appendix B results* 2.4 Vapor Pressure See Appendix B results* 2.5 Octanol/ Water Partition Coefficient See Appendix B results* 2.6A Water Solubility See Appendix B results* 2.6B pH value See Appendix B results* 2.7 Flash Point See Appendix B results* 2.8 Auto Flammability See Appendix B results* 2.9 Flammability See Appendix B results* 2.10 Explosive Properties See Appendix B results* 2.11 Oxidizing Properties See Appendix B results* 2.12 Oxidation: Reduction Potential See Appendix B results* 2.13A Additional data See Appendix B results* ENVIRONMENTAL FATE and PATHWAY 3.1.1 Photodegradation See Appendix B results* 3.1.2 Stability in Water See Appendix B results* 3.1.3 Stability in Soil See Appendix B results* 3.3.2 Distribution See Appendix B results* 3.5 Biodegradation See Appendix B results* 3.7 Bioaccumulation See Appendix B results* ECOTOXICITY 4.1 Acute Toxicity to Fish Oncorhynchus mykiss 96 hrs LC50 > 107 mg/ L 4.2 Acute Toxicity to Aquatic Invertebrates See Appendix B results* 4.3 Toxicity to Aquatic Plants ( Algae) See Appendix B results* 4.4 Toxicity to Bacteria See Appendix B results* 4.5.1 Chronic Toxicity to Fish See Appendix B results* 4.5.2 Chronic Toxicity to Aquatic Invertebrates See Appendix B results* 4.6.2 Toxicity to Terrestrial Plants See Appendix B results* 4.6.3 Toxicity to Other Non Mammalian Terrestrial Species See Appendix B results*

* See Appendix B results for data on other chemicals in the ammonia category. 11 Ammonium Phosphate Sulfate CAS # 12593 60 1 AMMONIUM PHOSPHATE SULFATE ( CAS NO. 12593 60 1) SPECIES PROTOCOL RESULTS TOXICITY 5.1.1 Acute Oral Toxicity Rat OECD 425 LD50 > 2000 mg/ kg bw 5.1.2 Acute Inhalation Toxicity See Appendix B results* 5.1.3 Acute Dermal Toxicity See Appendix B results* 5.1.4 Acute Toxicity, Other Routes See Appendix B results* 5.2.1 Skin Irritation/ Corrosion See Appendix B results* 5.2.2 Eye Irritation/ Corrosion See Appendix B results* 5.3 Skin Sensitization See Appendix B results* 5.4 Repeated Dose Toxicity See Appendix B results* 5.5 Genetic Toxicity in vitro See Appendix B results* 5.6 Genetic Toxicity in vivo See Appendix B results* 5.7 Carcinogenicity See Appendix B results* 5.8 Toxicity to Reproduction See Appendix B results* 5.9 Developmental Toxicity/ Teratogenicity See Appendix B results* 5.10 Additional Information See Appendix B results* 5.11 Human Experience See Appendix B results* 1.8 Occupational Exposure Limits No TLV established * See Appendix B results for data on other chemicals in the ammonia category. 12 Ammonium Phosphate Sulfate CAS # 12593 60 1 1. GENERAL INFORMATION 1.01 SUBSTANCE INFORMATION A. CAS number 12593 60 1 B. Name ( IUPAC name) Ammonium Phosphate Sulfate C. Name ( OECD name) Ammonium Phosphate Sulfate D. CAS Descriptor The most common form of Ammonium Phosphate Sulfate essentially consists of monoammonium phosphate ( MAP) and ammonium sulfate.

E. EINECS Number 235 712 2 F. Molecular Formula H11N2O8PS G. Structural Formula (( NH4) 2( H2PO4)( HSO4))

H. Substance Group Not applicable I. Substance Remark Not applicable J. Molecular Weight 230 1.02 OECD INFORMATION A. Sponsor Country Not applicable B. Lead Organization Not applicable C. Name of Responder Name: Mr. William C. Herz, Director of Scientific Programs Address/ Phones: The Fertilizer Institute Union Center Plaza 820 First Street, NE, Suite 430 Washington, DC 20002 USA Tel: ( 202) 962 0490 Fax: ( 202) 962 0577 13 Ammonium Phosphate Sulfate CAS # 12593 60 1 1.1 GENERAL SUBSTANCE INFORMATION A. Type of Substance element [ ]; inorganic [ X]; natural substance [ ]; organic [ ]; organometallic [ ]; petroleum product [ ]

B. Physical State ( at 20 ° C and 1.013 hPa)

gaseous [ ]; liquid [ ]; solid [ X]

1.2 SYNONYMS Diammonium Phosphate Sulfate 1.3 IMPURITIES None identified 1.4 ADDITIVES None identified 1.5 QUANTITY Remarks: No data available 1.6 LABELING AND CLASSIFICATION Remarks: No specific labeling established 1.7 USE PATTERN A. General Type of Use: Category:

( a) main Wide dispersive use industrial Agricultural industry use Fertilizers Remarks: ( a) Ammonium phosphate sulfate fertilizers have been popular for many years and are still popular in many areas.

Reference: United Nations Industrial Development Organization ( UNIDO) and International Fertilizer Development Center ( IFDC). 1998. Fertilizer Manual. Kluwer Academic Publishers, The Netherlands.

B. Uses in Consumer Products Remarks: No consumer product uses. 14 Ammonium Phosphate Sulfate CAS # 12593 60 1 1.8 OCCUPATIONAL EXPOSURE LIMIT VALUE Remarks: No specific limit values established.

1.9 SOURCES OF EXPOSURE Remarks: Ammonium phosphate sulfate can be absorbed into the body by inhalation of its aerosol and by ingestion, although significant human and environmental exposures during manufacture are unlikely if the process is well managed. Engineering controls such as mechanical ventilation, process or personnel enclosure, control of process conditions, and process modifications significantly reduce exposure. Local exhaust ( ventilation) control as close to the point of generation is both the most economical and safest method to minimize personnel exposure to airborne concentrations. Personal protective equipment includes neoprene or nitrile gloves, dusk masks or fume hoods as appropriate, chemical safety goggles, and impervious apron, sleeves and boots. Field exposure to workers is possible when handling and using on farms as a fertilizer. However, fertilizers are applied by mechanical spreaders, which reduces contact exposure. Environmental releases are controlled at the manufacturing plant. Gaseous emissions are low due to use of scrubbers and liquid effluent is recovered as much as possible. Exposure to environmental receptors is dependent on the amount used as fertilizer on fields, the climatic conditions, and the hydrological conditions of the area of application.

1.10 ADDITIONAL REMARKS Remarks: Ammonium phosphate sulfate must be disposed of in accordance with federal, state and local environmental control regulations.

2. PHYSICAL CHEMICAL DATA 2.1 MELTING POINT Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 15 Ammonium Phosphate Sulfate CAS # 12593 60 1 2.2 BOILING POINT Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.3 DENSITY ( Relative Density)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.4 VAPOR PRESSURE Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.5 PARTITION COEFFICIENT logPow Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.6 WATER SOLUBILITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.7 FLASH POINT ( liquids)

Remarks: Not applicable 2.8 AUTO FLAMMABILITY ( solid/ gases)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 16 Ammonium Phosphate Sulfate CAS # 12593 60 1 2.9 FLAMMABILITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.10 EXPLOSIVE PROPERTIES Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.11 OXIDIZING PROPERTIES Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.12 OXIDATION: REDUCTION POTENTIAL Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

2.13 ADDITIONAL DATA Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3. ENVIRONMENTAL FATE AND PATHWAYS 3.1 STABILITY 3.1.1 PHOTODEGRADATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 17 Ammonium Phosphate Sulfate CAS # 12593 60 1 3.1.2 STABILITY IN WATER Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.1.3 STABILITY IN SOIL Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.2 MONITORING DATA ( ENVIRONMENTAL)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.3 TRANSPORT AND DISTRIBUTION BETWEEN ENVIRONMENTAL COMPARTMENTS INCLUDING ESTIMATED ENVIRONMENTAL CONCENTRATIONS AND DISTRIBUTION PATHWAYS 3.3.1 TRANSPORT Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.3.2 THEORETICAL DISTRIBUTION ( FUGACITY CALCULATION)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.4 IDENTIFICATION OF MAIN MODE OF DEGRADABILITY IN ACTUAL USE Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 18 Ammonium Phosphate Sulfate CAS # 12593 60 1 3.5 BIODEGRADATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.6 BOD5, COD OR RATIO BOD5/ COD Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.7 BIOACCUMULATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

3.8 ADDITIONAL REMARKS Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4. ECOTOXICITY 4.1 ACUTE/ PROLONGED TOXICITY TO FISH Type of test: Static [ X ]; Semi static [ ]; Flow through [ ]; Opensystem [ X ]; Closed system [ ] Species: Oncorhynchus mykiss ( Rainbow trout) Exposure period: 96 hours Results: No mortality or sublethal effects LC50 ( 96 h) > 107 mg/ L NOEC = 107 mg/ L Analytical monitoring: Yes [ X ]; No [ ]; ? [ ] Method: OECD 203, 1992. GLP: Yes [ X ] No [ ] ? [ ] Test substance: Ammonium phosphate sulfate Remarks: No lethal or sublethal effects were observed at the highest concentration tested. Ammonium phosphate sulfate concentrations were calculated from total sulfate 19 Ammonium Phosphate Sulfate CAS # 12593 60 1 measurements. Measured total ammonium concentration at the highest concentration tested were 24 and 28 mg/ L at test initiation and completion, respectively. Measured un ionized ammonium concentration at the highest concentration tested were 0.18 and 0.27 mg/ L at test initiation and completion, respectively. References: Madsen, T. J. and Bussard, J. B. 2000. Acute toxicity of Ammonium Phosphate Sulfate to the rainbow trout, Oncorhynchus mykiss, determined under static test conditions. ABC Labs Study No. 46203.

4.2 ACUTE TOXICITY TO AQUATIC INVERTEBRATES Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.3 TOXICITY TO AQUATIC PLANTS, e. g. algae Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.4 TOXICITY TO BACTERIA Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.5 CHRONIC TOXICITY TO AQUATIC ORGANISMS 4.5.1 CHRONIC TOXICITY TO FISH Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 20 Ammonium Phosphate Sulfate CAS # 12593 60 1 4.5.2 CHRONIC TOXICITY TO AQUATIC INVERTEBRATES Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.6 TOXICITY TO TERRESTRIAL ORGANISMS 4.6.1 TOXICITY TO SOIL DWELLING ORGANISMS Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.6.2 TOXICITY TO TERRESTRIAL PLANTS Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.6.3 TOXICITY TO OTHER NON MAMMALIAN TERRESTRIAL SPECIES ( INCLUDING AVIAN)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.7 BIOLOGICAL EFFECTS MONITORING ( INCLUDING BIOMAGNIFICATION)

Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

4.8 BIOTRANSFORMATION AND KINETICS Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 21 Ammonium Phosphate Sulfate CAS # 12593 60 1 4.9 ADDITIONAL REMARKS Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5. TOXICITY 5.1 ACUTE TOXICITY 5.1.1 ACUTE ORAL TOXICITY Type: LD0 [ ]; LD100 [ ]; LD50 [ X ]; LDL0 [ ]; Other [ ] Species/ strain: Sprague Dawley rat Value: > 2,000 mg/ kg bw Method: OECD 425, " Up and Down Protocol" An initial dose of two thousand milligrams of the test substance per kilogram of bodyweight was administered to one healthy female rat by oral gavage. Due to the absence of mortality in this animal, a second female received the same dose level. Following the completion of dosing and 100% survival in a total of three females, a group of three males was tested ( simultaneously) at the above dose level. All animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days after dosing. Bodyweights were recorded prior to administration and again on days 7 and 14 ( termination) after dosing. Necropsies were performed on all animals at terminal sacrifice. GLP: Yes [ X ] No [ ] ? [ ] Test substance: Ammonium phosphate sulfate ( light gray granules) Remarks: The ground test substance was administered by gavage as a 60% w/ w suspension in distilled water and was kept on a magnetic stirrer during dosing. All animals survived, gained weight and appeared active and healthy throughout the test. No signs of toxicity were observed. References: Merkel, D. J. 2000. Acute oral toxicity: Up and down procedure in rats limit test. Product Safety Labs study number 9732. 22 Ammonium Phosphate Sulfate CAS # 12593 60 1 5.1.2 ACUTE INHALATION TOXICITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.1.3 ACUTE DERMAL TOXICITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.1.4 ACUTE TOXICITY BY OTHER ROUTES OF ADMINISTRATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.2 CORROSIVENESS/ IRRITATION 5.2.1 SKIN IRRITATION/ CORROSION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.2.2 EYE IRRITATION/ CORROSION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.3 SKIN SENSITIZATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 23 Ammonium Phosphate Sulfate CAS # 12593 60 1 5.4 REPEATED DOSE TOXICITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.5 GENETIC TOXICITY IN VITRO Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.6 GENETIC TOXICITY IN VIVO Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.7 CARCINOGENICITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.8 TOXICITY TO REPRODUCTION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.9 DEVELOPMENTAL TOXICITY/ TERATOGENICITY Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information. 24 Ammonium Phosphate Sulfate CAS # 12593 60 1 5.10 OTHER RELEVANT INFORMATION Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

5.11 EXPERIENCE WITH HUMAN EXPOSURE Remarks: No specific data available for this material. Refer to the Health and Environmental Safety Data Summaries of Mono and Di Ammonium Phosphate and Ammonium Sulfate for further information.

6. REFERENCES Madsen, T. J. and Bussard, J. B. 2000. Acute toxicity of Ammonium Phosphate Sulfate to the rainbow trout, Oncorhynchus mykiss, determined under static test conditions. ABC Labs Study No. 46203.

Merkel, D. J. 2000. Acute oral toxicity: Up and down procedure in rats limit test. Product Safety Labs study number 9732.

United Nations Industrial Development Organization ( UNIDO) and International Fertilizer Development Center ( IFDC). 1998. Fertilizer Manual. Kluwer Academic Publishers, The Netherlands. Ammonium Phosphate Sulfate CAS # 12593 60 1 APPENDIX A   SIDS Data Availability Summary Ammonium Phosphate Sulfate CAS # 12593 60 1 Explanation of Appendix A Appendix A is a SIDS Data Summary table that provides an overview of availability and quality of the data used in this Health and Environmental Safety Data Summary for Ammonium Phosphate Sulfate. Y ( Yes) and N ( No) designations indicate whether data are available that meet the criteria for each column. The columns are described as:

Information: Data exist that were useful for describing the data element. These data may be from standard laboratory tests or from generally recognized published sources or professional experience.

OECD Study: The data were developed using standard OECD or essentially similar ( e. g., EPA harmonized protocols) guidelines.

GLP: The data were developed under standard Good Laboratory Practice provisions. These generally represent the highest quality data.

Other Study: Studies were conducted that could not be definitively identified as following OECD or GLP protocols. These studies were included when they were determined to be of adequate quality and provided relevant information to the characterization of the compound.

Estimation Method: In some cases, data may be estimated using established structure activity relationships. These methods are common for physical chemical parameters such as octanolwater partition coefficients and water solubility.

Acceptable: This column indicates whether the data are deemed acceptable by standard acceptability criteria and professional judgment. Only the data meeting adequacy standards are included in this summary document.

SIDS Testing Recommended: This column indicates whether additional testing is recommended based on an evaluation of the available data summarized in this document. It is generally not necessary to fill all of the apparent data gaps in order to adequately characterize the inherent hazard of chemicals. Information from other data elements and from other chemicals in the category, along with professional judgment, are useful in the final determination of the need for further testing. Ammonium Phosphate Sulfate CAS # 12593 60 1 SIDS DATA AVAILABILITY SUMMARY DATE: January 27, 2003 Ammonium Phosphate Sulfate CAS No: 12593 60 1 Information OECD Study GLP Other Study Estimated Method Acceptable SIDS Testing Recommended STUDY Y/ N Y/ N Y/ N Y/ N Y/ N Y/ N Y/ N PHYSICAL CHEMICAL DATA 2.1 2.2 2.3 2.4 2.5 2.6 2.12 Melting Point Boiling Point Density Vapor Pressure Partition Coefficient Water Solubility pH and pKa Values Oxidation: Reduction Potential N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N         N N N N N N N N OTHER P/ C STUDIES RECEIVED N N N N N  N ENVIRONMENTAL FATE and PATHWAY 3.1.1 3.1.2 3.2 3.3 3.5 Photodegradation Stability in Water Monitoring Data Transport and Distribution Biodegradation N N N N N N N N N N N N N N N N Y N N N N N N N N      N N N N N OTHER ENV FATE STUDIES RECEIVED N N N N N  N ECOTOXICITY 4.1 4.2 4.3 4.5.1 4.5.2 4.6.1 4.6.2 4.6.3 Acute Toxicity to Fish Acute Toxicity to Daphnia Toxicity to Algae Chronic Toxicity to Fish Chronic Toxicity to Daphnia Toxicity to Soil Dwelling Organisms Toxicity to Terrestrial Plants Toxicity to Birds Y N N N N N N N Y N N N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N Y        N N N N N N N N OTHER ECOTOXICITY STUDIES RECEIVED N N N N N  N TOXICITY 5.1.1 5.1.2 5.1.3 5.4 5.5 5.6 5.8 5.9 5.11 Acute Oral Acute Inhalation Acute Dermal Repeated Dose Genetic Toxicity in vitro . Gene mutation . Chromosomal aberration Genetic Toxicity in vivo Reproduction Toxicity Development/ Teratogenicity Human Experience Y N N N N N N N N N Y N N N N N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Y

      N N N N N N N N N N OTHER TOXICITY STUDIES RECEIVED N N N N N  N Ammonium Phosphate Sulfate CAS # 12593 60 1 APPENDIX B   SIDS Data Summaries for the Ammonia Compounds Category: Ammonia, Aqua Ammonia, Nitrogen Solutions ( UAN), Urea, Ammonium Nitrate, Ammonium Phosphate Sulfate, Ammonium Sulfate, Ammonium Thiosulfate, Diammonium Phosphate, and Monoammonium Phosphate SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonia Aqua Ammonia Nitrogen Solutions ( UAN)

DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS PHYSICAL CHEMICAL DATA 2.1 Melting Point Decomposition  78oC  77oC 2.2 Boiling Point  33oC at 1 atm 36oC 2.3 Density 0.696 g/ L at 20oC 0.9 g/ mL 2.4 Vapor Pressure 7,600 mm Hg at 25oC 2.159 x 103 mm Hg 2.5 Octanol/ Water Partition Coefficient OECD 107  1.14 at 25oC 2.6A Water Solubility 510 530 g/ L at 20oC Miscible 2.6B pH and pKa values pH: 10.6 in 0.01%

aqueous solution at 25oC pKa: 9.25 at 25oC 4.75 at 25oC 2.7 Flash Point Not flammable 2.8 Auto Flammability DIN 51 794 651oC at 1 atm Not applicable 2.9 Flammability Not flammable Not flammable 2.10 Explosive Properties Not explosive 2.11 Oxidizing Properties Not an oxidizer 2.12 Oxidation:

Reduction Potential 1.275 V 1.275 V 2.13A Additional Data Soil sorption ,

Reaction cylinder Similar to first order reaction See text 2.13B Henry's Law Constant 1.6 x 10 5 atm m3/ mol 2.13B Specific Gravity 0.6818 at  33.35oC and 1 atm 2.13B Viscosity 0.00982 cP at 20oC 2.13B Critical Temperature 132 133oC 2.13B Critical Pressure 111 atm 2.13B Critical Density 0.2362 g/ ml SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonia Aqua Ammonia Nitrogen Solutions ( UAN)

DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ENVIRONMENTAL FATE and PATHWAY 3.1.1 Photodegradation Undergoes photolytic degradation 3.12 Stability in Water Field study in Lake St.

George,

Canada Ke = 25.6 47.3 cm/ h at 15.2

15.0oC Removed from aquatic systems 3.1.3 Stability in Soil Laboratory soil columns Mean sorptions:

sand: 19%

loam: 28%

clay, clay loam,

and silt loam: 38%

3.3.1 Transport 3.3.2 Distribution Calculated,

Fugacity Level I 99.98% to air,

<. 1% each to water, soil, biota,

and sediment Miscible in water 3.5 Biodegradation Rapidly biodegraded Miscible in water and readily degrades 3.7 Bioaccumulation Rapidly assimilated by animals and plants Does not bioaccumulate SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonia Aqua Ammonia Nitrogen Solutions ( UAN)

DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ECOTOXICITY 4.1 Acute toxicity to Fish Many species Mostly 96 hr LC50 = 0.09 3.51 mg un ionized NH3/ L Cyprinus carpio 48 hr semistatic LC50 = 1.34 1.70 mg un ionized NH3/ L Oncorhynchus mykiss 96 hrs LC50 > 103 mg/ L Pimephalas promelas 96 hrs LC50 between 100 and 500 mg/ L 4.2 Acute Toxicity to Aquatic Invertebrates Daphnia magna 48 hr, ASTM E 729 80 LC50 = 2.94 mg un ionized NH3

N/ L Daphnia magna 48 hr static LC50 = 32 mg HN4OH/ L 4.3 Toxicity to Aquatic Plants ( Algae) Benthic diatoms Up to 25 days LOEC = 0.5 1.0 mg N/ L See text Chlorella vulgaris 21 days LOEC = 500 mg N/ L 4.4 Toxicity to Bacteria Photobacterium phosphoreum 5 min, tested for bioluminescence EC50 = 1.49 mg un ionized NH3/ L 4.5.1 Chronic Toxicity to Fish Many species Various ( 12 d 5 yrs) NOEC = 0.025 1.2 mg un ionized NH3/ L Many species See text Ictalurus punctatus 8 days LC50 = 37.5 ppm total ammonia 4.5.2 Chronic Toxicity to Aquatic Invertebrates D. magna &

others 21 d 76 weeks NOEC = 0.163

0.42 mg unionized NH3/ L See text 4.6.1 Toxicity to Soil Dwelling Organisms 4.6.2 Toxicity to Terrestrial Plants Many species Various ( 4 mins 16 hrs) LOEC = 3 250 ppm Can cause inhibition of photosynthesis 4.6.3 Toxicity to Other Non Mammalian Terrestrial Species G. domesticus 1 hr injections LD50 = 2.72 mM SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonia Aqua Ammonia Nitrogen Solutions ( UAN)

DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS TOXICITY 5.1.1 Acute Oral Toxicity Rat LD50 = 350 mg/ kg bw Rat OECD 425 LD50 > 2,000 mg/ kg bw Cat LD50 = 750 mg/ kg bw 5.1.2 Acute Inhalation Rat, mouse 1 hr LC50 = 4,230

19,960 total NH3/ m3 5.1.3 Acute Dermal Toxicity 5.1.4 Acute Toxicity,

Other Routes Rat, mouse 1 hr intravenous LC50 = 45.5 195.1 mg total NH3/ kg bw Rabbit i. v. LDLo = 10 mg/ kg bw 5.2.1 Skin Irritation/

Corrosion Corrosive to skin Rabbit Corrosive at 20%

but not 10%

5.2.2 Eye Irritation/

Corrosion Subacute and chronic exposure to 200 1,000 ppm produced eye damage. 100 200 ppm produced moderate to severe eye irritation. Rabbit Irritating 5.3 Skin Sensitization 5.4 Repeated Dose Rats, guinea pigs, rabbits,

monkeys,

beagle dogs Inhalation, up to 770 mg/ m3 No mortality SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonia Aqua Ammonia Nitrogen Solutions ( UAN)

DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS 5.5 Genetic Toxicity in vitro . Gene mutation Salmonella typhimurium,

Saccharomyces E. coli Bacterial gene mutation assay Negative E. coli Negative . Chromosomal aberration Chick fibroblasts Cytogenetic assay Induced chromosomal clumping, polyploidy, and arrested spindle formation. No data showing that ammonia is mutagenic in mammals.

5.6 Genetic Toxicity in vivo Drosophila melanogaster Drosophila mutagenicity test No evidence for mutagenicity No evidence for mutagenicity 5.7 Carcinogenicity No carcinogenic effects Not carcinogenic 5.8 Toxicity to Reproduction Pig One generation study Temporarily depressed mean daily gain at 35 mg/ kg in gilts 5.9 Development Toxicity/ Teratogenicity 51.0 Additional Information 5.11 Human Experience Inhalation;

human volunteers Nasal and pulmonary irritation at concentrations of about 100 ppm and higher See text 1.8 Occupational Exposure Limits 8 hr TWA TLV 50 ppm ( 35 mg/ m3) TLV 24 mg/ m3 24 mg/ m3 15 min STELTLV 35 ppm ( 27 mg/ m3) SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Urea Ammonium Nitrate Ammonium Phosphate Sulfate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS PHYSICAL CHEMICAL DATA 2.1 Melting Point 133oC 169.6oC 2.2 Boiling Point 135oC ( at 101 kPa)

( decomposes) 210oC 2.3 Density 750 kg/ m3 1.725 g/ mL at 25oC 2.4 Vapor Pressure Calculated 80 Pa at 20oC 15 hPa at 20oC 2.5 Octanol/ Water Partition Coefficient  1.59 at 20 25oC OECD 107  3.1 at 25oC 2.6A Water Solubility 1,193 g/ L at 25oC 1,920 g/ L at 20oC 2.6B pH and pKa values pH = 7.2 ( 100 g/ L) pH = 5.43 in aqueous solution 2.7 Flash Point Not applicable 2.8 Auto Flammability Not flammable 2.9 Flammability Not flammable 2.10 Explosive Properties May explode under high temperature or strong shocks 2.11 Oxidizing Properties Strong oxidizer 2.12 Oxidation:

Reduction Potential 2.13A Additional Data See text SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Urea Ammonium Nitrate Ammonium Phosphate Sulfate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ENVIRONMENTAL FATE and PATHWAY 3.1.1 Photodegradation Does not photodegrade 3.1.2 Stability in Water Calculated t1/ 2 > 1 year Stable 3.1.3 Stability in Soil Binds to clay particles 3.3.1 Transport 3.3.2 Distribution Calculated ( Fugacity Level I) 0.16% to air 99.84% to water Calculated,

Fugacity Level III 0.251% to air 45.4% to water 54.2% to soil 0.757% to sediment 3.5 Biodegradation OECD 302B SCAS 24 hr Ultimately biodegradable 93 98% Readily biodegraded 3.7 Bioaccumulation Does not bioaccumulate SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Urea Ammonium Nitrate Ammonium Phosphate Sulfate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ECOTOXICITY 4.1 Acute toxicity to Fish Barillius barna 96 hrs LC50 > 9,100 mg/ L Cyprinus carpio L. 48 hrs LC50 = 1.15 1.72 mg un ionized NH3/ L Oncorhynchus mykiss OECD 203 LC50 > 107 mg/ L Chinook salmon, rainbow trout, bluegill 96 hrs LC50 = 420 1,360 mg NO3/ L 4.2 Acute Toxicity to Aquatic Invertebrates Daphnia magna DIN 38412 Part II; 24 hrs EC50 > 10,000 mg/ L Daphnia magna EC50 = 555 mg/ L 4.3 Toxicity to Aquatic Plants ( Algae) Scenedesmus quadricauda 192 hr cell multiplication inhibition test TT > 10,000 mg/ L Scenedesmus quadricauda EC50 = 83 mg/ L 4.5.1 Chronic Toxicity to Fish 4.5.2 Chronic Toxicity to Aquatic Invertebrates Bullia digitalis Up to 7 days NOEC = 300 mg/ L 4.6.1 Toxicity to Soil Dwelling Organisms Applications of nitrogenous fertilizers to grassland for long period may have deleterious effects on earthworms in the absence of liming.

4.6.2 Toxicity to Terrestrial Plant Glycine max ( L.) Merr. 7 days exposure to 9 mg urea/ leaf Leaf tip necrosis See text 4.6.3 Toxicity to Other Non Mammalian Terrestrial Species Pigeon Subcutaneous LDLo = 16,000 mg/ kg SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Urea Ammonium Nitrate Ammonium Phosphate Sulfate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS TOXICITY 5.1.1 Acute Oral Toxicity Rat LD50 = 14,300

15,000 mg/ kg Rat OECD 401 LD50 = 2,800 mg/ kg bw Rat OECD 425 LD50 > 2,000 mg/ kg bw Mouse LD50 = 11,500

13,000 mg/ kg Rat OECD 401 LD50 = 2,462 mg/ kg bw Cattle LD50 = 510 mg/ kg Rat OECD 401 LD50 = 2,950 mg/ kg bw Rat LD50 = 4,500 mg/ kg bw 5.1.2 Acute Inhalation Rat 4 hrs LC50 > 88.8 mg/ L 5.1.3 Acute Dermal Toxicity Rat 4 hrs LC50 > 5,000 mg/ kg 5.1.4 Acute Toxicity,

Other Routes White rat Injected; 3 hrs Minimum lethal dose = 0.065 mg NH4NO3 N 5.2.1 Skin Irritation/

Corrosion Mouse 10% solution Not irritating Rabbit Moderately irritating Rabbit 50% solution Not irritating Rabbit Not irritating 5.2.2 Eye Irritation/

Corrosion 5.3 Skin Sensitization 5.4 Repeated Dose Rat 24 weeks;

dermal NOAEL = 40% in ointment Rat Inhalation; 2 weeks NOAEL = 185 mg/ m3 Rat Inhalation; 4 weeks NOAEL = 1 mg/ m3 5.5 Genetic Toxicity in vitro . Gene mutation Salmonella typhimurium Bacterial reverse mutation assay Negative Salmonella typhimurium Bacterial reverse mutation assay Negative . Chromosomal aberration Chinese hamster Mouse Chromosomal aberration test Mouse lymphoma TK locus assay Positive ( very high dose) Positive ( very high dose) SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Urea Ammonium Nitrate Ammonium Phosphate Sulfate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS 5.6 Genetic Toxicity in vivo Mouse Bone marrow cytogenetic test Positive ( extremely high dose)

5.7 Carcinogenicity Mouse Rat 12 month diet 12 month diet Not carcinogenic Not carcinogenic 5.8 Toxicity to Reproduction Mouse 12 month carcinogenicity screening No toxic effects in gonads reported Rat 12 month carcinogenicity No toxic effects in gonads reported 5.9 Development Toxicity/ Teratogenicity Rat 2 doses/ day x 14 days gavage Not teratogenic Rat NOAEL > 57 mg/ kg/ day 5.10 Metabolism and Toxicokinetics No sensory irritation 5.11 Human Experience Despite extensive medical use, no significant side effects on humans have been noted See text 1.8 Occupational Exposure Limits No TLV established TLV as inert dust 15 mg/ m3 No TLV established SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS PHYSICAL CHEMICAL DATA 2.1 Melting Point 235 512oC 150oC 155 ° C 2.2 Boiling Point 872oC Decomposes 2.3 Density 1.77 g/ mL 0.7 1.679 g/ mL 0.93 1.619 g/ mL at 20oC 2.4 Vapor Pressure < 100 Pa at 20 ° C 2.5 Octanol/ Water Partition Coefficient OECD 107  5.1 2.6A Water Solubility 7.5 x 105 mg/ L at 20oC 1,800 g/ L at 20oC 588 g/ L at 20 ° C 2.6B pH and pKa values 5.0 200 g/ L 6.5 7.2 ~ 8 2.7 Flash Point Not applicable Not applicable Not applicable 2.8 Auto Flammability Not flammable Not flammable 2.9 Flammability Not flammable Not flammable 2.10 Explosive Properties May explode if mixed with oxidizers May explode when mixed with chlorate Not explosive 2.11 Oxidizing Properties Not an oxidizer Not an oxidizer 2.12 Oxidation:

Reduction Potential 2.13A Additional Data See text SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ENVIRONMENTAL FATE and PATHWAY 3.1.1 Photodegradation Not a significant dissipation mechanism 3.1.2 Stability in Water Stable 3.1.3 Stability in Soil Stable 3.3.2 Distribution Calculated,

fugacity level III 0.0156% to air 44.1% to water 55.8% to soil 0.0754% to sediment Calculated,

fugacity level III 0.151% to air 49.9% to water 49.8% to soil 0.0893% to sediment Calculated,

Fugacity Level III 6.5 x 10 15% to air 45.3% to water 54.6% to soil 0.0755% to sediment 3.5 Biodegradation 3.7 Bioaccumulation Does not bioaccumulate Does not bioaccumulate SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ECOTOXICITY 4.1 Acute toxicity to Fish Coho salmon, Rainbow trout, Large mouth bass,

Fathead minnow, etc. 24 96 hrs LC50 = 90 to > 1,500 mg/ L Guppy DIN 38412 LC50 > 200 mg/ L Coho salmon, Chinook salmon, Rainbow trout, Bluegill,

Large mouth bass, Tilapia, Fathead minnow 96 hrs LC50 = 90 1,875 mg/ L 4.2 Acute Toxicity to Aquatic Invertebrates Daphnia magna 50 96 hrs EC50 > 433 mg/ L Amphipod 96 hrs LC50 = 40 52 mg/ L Amphipod 96 hrs LC50 = 40 62 mg/ L Snail, Worm 96 hrs LC50 = 1,005

2,472 mg/ L Snails, worm 48 96 hrs LC50 = > 100 700 mg/ L 4.3 Toxicity to Aquatic Plants ( Algae) Chlorella vulgaris 21 days NOEC = 250 mg N/ L Selenastrum capricornutum 72 hrs NOEC ( toxicity)

= 97.1 mg DAP/ L NOEC ( stimulation) =

3.57 mg DAP/ L Various 17 days NOEC = 50 µ g NH4 N/ L 4.4 Toxicity to Bacteria Photobacterium phosphoreum Microtox EC50 = 1.49 mg un ionized NH3/ L Anaerobic bacteria ETAD fermentation tube EC50 = 3,000 mg/ L SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS 4.5.1 Chronic Toxicity to Fish Rainbow trout 12 & 35 days LC50 = 0.26 0.68 mg un ionized NH3/ L Pink salmon 21, 40 & 61 days NOEC = 1.2 mg un ionized NH3/ L Channel catfish 6 months LOEC = 100 500 mg/ L 4.5.2 Chronic Toxicity to Aquatic Invertebrates 4.6.1 Toxicity to Soil Dwelling Organisms 4.6.2 Toxicity to Terrestrial Plants 4.6.3 Toxicity to Other Non Mammalian Terrestrial Species SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS TOXICITY 5.1.1 Acute Oral Toxicity Rat LD50 = > 2,000

4,250 mg/ kg bw Rat LD50 = 1,950

2,890 mg/ kg bw Rat OECD 425 LD50 > 2,000 mg/ kg bw Mouse LD50 = 640 mg/ kg bw Mouse LD50 = 2,100  >

3,000 mg/ kg bw Goat LD50 = 3,500 mg/ kg bw Guinea pig LD50 = 1,100 mg/ kg bw 5.1.2 Acute Inhalation Rabbit 1 hr LD50 > 2,200 µ g/ m3 Rat 4 hrs LC50 > 2,260 mg/ m3 Mouse 4 hrs LC50 > 1,800 mg/ m3 5.1.3 Acute Dermal Toxicity Rat, mouse LD50 > 2,000 mg/ kg bw Rat OECD 402 LD50 > 5,000 mg/ kg bw 5.1.4 Acute Toxicity,

Other Routes Rat injected; 3 hrs MLD = 0.094 mg ( NH4) 2SO4 N Mouse i. p. LD50 = 610 mg/ kg bw 5.2.1 Skin Irritation/

Corrosion Rabbit Not irritating Rabbit OECD 404 Not irritating 5.2.2 Eye Irritation/

Corrosion Rabbit Not irritating Rabbit OECD 405 Not irritating 5.3 Skin Sensitization 5.4 Repeated Dose Rat 8 months; 5 hrs/ day; 5 days/ wk; inhalation Mild & transient effects at 0.5 mg/ m3. See text Rat Oral; 45 90 days LOAEL = 300 mg/ kg/ day Rat OECD 422 NOAEL = 250 mg/ kg/ day Rat Inhalation; 2 or 4 months LOAEL = 26.77 mg/ m3 Rat Dermal; 20 days LOAEL = 45%

( NH4) 2S2O3 SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Ammonium Sulfate Ammonium Thiosulfate Diammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS 5.5 Genetic Toxicity in vitro . Gene mutation Salmonella typhimurium OECD 471 Negative Salmonella typhimurium OECD 471 Negative Salmonella typhimurium OECD 471 Negative . Chromosomal aberration Chinese hamster ovaries Negative Chinese hamster ovaries Negative Chinese hamster ovaries OECD 473 Negative 5.6 Genetic Toxicity in vivo Rat, mouse Oral single dose NOAEL = 5,000 mg/ kg bw 5.7 Carcinogenicity Rat, hamster Not carcinogenic 5.8 Toxicity to Reproduction Rat OECD 422 NOAEL = 1,500 mg/ kg/ day 5.9 Development Toxicity/ Teratogenicity Chicken eggs NOAEL > 10 mg/ egg Rat, mouse,

hamster Oral NOAEL > 550 mg/ kg/ day Rat OECD 422 NOAEL = 1,500 mg/ kg/ day 5.10 Metabolism and Toxicokinetics See text 5.11 Human Experience See text 1 2g See text See text 1.8 Occupational Exposure Limits TLV as inert dust 15 mg/ m3 TLV as inert dust 15 mg/ m3 TLV as inert dust 15 mg/ m3 SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Monammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS PHYSICAL CHEMICAL DATA 2.1 Melting Point 190 ° C 2.2 Boiling Point Decomposes 2.3 Density 1.83 g/ mL at 25oC 2.4 Vapor Pressure < 100 Pa at 20 ° C 2.5 Octanol/ Water Partition Coefficient 2.6A Water Solubility 328 g/ L at 20 ° C 2.6B pH and pKa values 4.2 in 0.2M aqueous solution 2.7 Flash Point Not applicable 2.8 Auto Flammability Not flammable 2.9 Flammability Not flammable 2.10 Explosive Properties Not explosive 2.11 Oxidizing Properties Not an oxidizer 2.12 Oxidation:

Reduction Potential 2.13A Additional Data SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Monammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ENVIRONMENTAL FATE and PATHWAY 3.1.1 Photodegradation 3.1.2 Stability in Water Stable 3.1.3 Stability in Soil Stable 3.3.2 Distribution Calculated,

Fugacity Level III 3.98 x 10 12% to air 45.3% to water 54.6% to soil 0.0755% to sediment 3.5 Biodegradation 3.7 Bioaccumulation Does not bioaccumulate SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Monammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS ECOTOXICITY 4.1 Acute toxicity to Fish Oncorhynchus mykiss 96 hrs LC50 > 85.9 mg/ L 4.2 Acute Toxicity to Aquatic Invertebrates 4.3 Toxicity to Aquatic Plants ( Algae)

4.4 Toxicity to Bacteria 4.5.1 Chronic Toxicity to Fish 4.5.2 Chronic Toxicity to Aquatic Invertebrates 4.6.1 Toxicity to Soil Dwelling Organisms 4.6.2 Toxicity to Terrestrial Plants 4.6.3 Toxicity to Other Non Mammalian Terrestrial Species SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1 Monammonium Phosphate DATA ELEMENTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS SPECIES PROTOCOL RESULTS TOXICITY 5.1.1 Acute Oral Toxicity Rat OECD 425 LD50 > 2,000 mg/ kg bw 5.1.2 Acute Inhalation 5.1.3 Acute Dermal Toxicity Rat OECD 402 LD50 > 5,000 mg/ kg bw 5.1.4 Acute Toxicity,

Other Routes 5.2.1 Skin Irritation/

Corrosion 5.2.2 Eye Irritation/

Corrosion 5.3 Skin Sensitization 5.4 Repeated Dose 5.5 Genetic Toxicity in vitro . Gene mutation . Chromosomal aberration 5.6 Genetic Toxicity in vivo 5.7 Carcinogenicity 5.8 Toxicity to Reproduction 5.9 Development Toxicity/ Teratogenicity 5.10 Metabolism and Toxicokinetics See text 5.11 Human Experience See text 1.8 Occupational Exposure Limits TLV as inert dust 15 mg/ m3 SIDS DATA SUMMARIES FOR THE AMMONIA CATEGORY Date: January 27, 2003 Ammonium Phosphate Sulfate CAS # 12593 60 1


[Federal Register Volume 80, Number 155 (Wednesday, August 12, 2015)]
[Notices]
[Pages 48415-48416]
[FR Doc No: 2015-19751]

-----------------------------------------------------------------------

DEPARTMENT OF TRANSPORTATION

Federal Railroad Administration

[Docket No. FRA-2015-0007-N-20]

Proposed Agency Information Collection Activities; Comment
Request

AGENCY: Federal Railroad Administration (FRA), Department of
Transportation (DOT).

ACTION: Notice and request for comments.

-----------------------------------------------------------------------

SUMMARY: In compliance with the Paperwork Reduction Act of 1995, this
notice announces that FRA is forwarding the modified Information
Collection Request (ICR) abstracted below to the Office of Management
and Budget (OMB) for review and comment. The ICR describes the nature
of the information collection and its expected burden. The Federal
Register notice with a 60-day comment period soliciting comments on the
collection of information was published on April 24, 2015 (80 FR
23069).

DATES: Comments must be submitted on or before September 11, 2015.

FOR FURTHER INFORMATION CONTACT: Mr. Robert Brogan, Safety Regulatory
Analysis Division, RRS-21, U.S. Department of Transportation, Federal
Railroad Administration, 1200 New Jersey Ave. SE., Mail Stop 25,
Washington, DC 20590 (Telephone:<PHONE_NUMBER>), or Ms. Kebo Chen,
Staff Director, Railroad Safety Information Management Division, RRS-
22, U.S. Department of Transportation, Federal Railroad Administration,
1200 New Jersey Ave. SE., Mail Stop 25, Washington, DC 20590
(Telephone:<PHONE_NUMBER>). (These telephone numbers are not toll-
free.)

SUPPLEMENTARY INFORMATION: The Paperwork Reduction Act of 1995 (PRA),
Public Law 104-13, sec. 2, 109 Stat. 163 (1995) (codified as revised at
44 U.S.C. 3501-3520), and its implementing regulations, 5 CFR part
1320, require Federal agencies to issue two notices seeking public
comment on information collection activities before OMB may approve
paperwork packages. 44 U.S.C. 3506, 3507; 5 CFR 1320.5, 1320.8(d)(1),
and 1320.12. On April 24, 2015, FRA published a 60-day notice in the
Federal Register soliciting comment on an ICR that the agency is
seeking OMB approval. See 80 FR 23069. In its ICR, FRA proposed to
utilize Form FRA 6180.54's Special Study Block 49b (SSB) to collect
specific information concerning rail cars carrying petroleum crude oil
(crude oil) in trains involved in FRA reportable accidents.
    FRA received two comments in response to the notice, from the U.S.
Department of Commerce's Bureau of Economic Analysis (BEA) and an
article titled ``DOT Takes Additional Actions on Crude Oil Trains--
Incident Report ICR,'' originally posted on the blog Chemical Facility
Security News by Peter Coyle on April 20, 2015. The substance of both
comments, along with FRA's responses to those comments is discussed
below. You may also review the full text of the comments online at
www.regulations.gov in docket number FRA-2015-0007.
    BEA's comment generally expresses support for the information
collection activities associated with FRA's accident/incident reporting
regulations, and references specific FRA forms that the BEA uses in its
analysis that are different than the form this ICR covers. FRA
appreciates BEA's comment, but notes that the comment relates to FRA
forms that are outside the scope of this ICR. This ICR is limited to
modifying the existing instructions on Form FRA F 6180.54 titled ``Rail
Equipment Accident/Incident Report'' and does not impact FRA's
information collection activities under other FRA accident/incident
reporting forms.
    In his comment, Mr. Coyle asserts that FRA's proposed collection of
information related to crude oil train accidents is of limited
usefulness and ``will provide almost nothing in the way of information
that can be used for analytical purposes.'' Mr. Coyle suggests that FRA
design a new report ``specifically for rail accidents and incidents
involving damaged and leaking rail cars containing crude oil.'' Mr.
Coyle also asserts that combining the number of cars loaded with crude
oil and crude oil residue cars in the data collection will ``about
double the number of cars involved in accidents and damaged in
accidents since most

railcars in crude oil service are not cleaned before being returned for
refilling.'' Further, Mr. Coyle asserts that ``since there is no effort
being made to determine what types of tank cars are actually in use and
the rate of failure (measured by leaks) for each type of tank car, the
FRA will not be able to adequately describe how the continuing change
of the makeup of the crude oil tank car fleet will affect the failure
rate of the fleet.''
    In response to Mr. Coyle's concern that the proposed information
collection will not provide useful information for analytical purposes,
FRA acknowledges that the proposed modifications will not capture all
information about an accident that FRA needs to fully analyze an
accident. FRA believes these simple modifications will, however, make
this data more readily accessible to FRA and help to capture more
specific information on the behavior of tank cars transporting crude
oil in accident conditions. As Mr. Coyle suggests FRA should do, FRA
intends to continue considering other options for gathering additional
information concerning rail cars carrying crude oil (and other
hazardous materials) involved in reportable accidents. However,
implementation of any significant changes by FRA (such as the
development of a new form) will necessitate a notice and comment
rulemaking, a time consuming process. FRA does not want to wait for the
completion of a rulemaking proceeding to begin making changes to
improve the existing data collection. FRA believes that utilizing the
existing SSB in the short term is the most efficient and expeditious
method of improving FRA's information collection activity. FRA will,
however, continue to evaluate additional, more comprehensive, methods
of improving the agency's overall information collection activities
related to the transportation of hazardous materials by railroad.
    In response to Mr. Coyle's assertion that combining the number of
cars loaded with crude oil and crude oil residue cars in the data
collection will double the number of cars reported to be in accidents
and damaged in accidents, FRA notes that residue cars, including cars
carrying residue amounts of crude oil, are already included in the
counts of all hazardous materials cars in blocks 8, 9, and 10 of FRA
Form 6180.54. These current counts will not change as a result of the
additional information collection in the SSB of Form FRA F 6180.54.
Thus, FRA believes Mr. Coyle's assertion is incorrect.
    Finally, Mr. Coyle asserts that ``since there is no effort being
made to determine what types of tank cars are actually in use and the
rate of failure (measured by leaks) for each type of tank car, the FRA
will not be able to adequately describe how the continuing change of
the makeup of the crude oil tank car fleet will affect the failure rate
of the fleet.'' However, FRA again notes that the agency intends for
the SSB as described in FRA's April 24, 2015 notice to be a short term
method of obtaining some additional information on the number and
behavior of tank cars transporting crude oil involved in FRA reportable
accidents. FRA will continue to evaluate whether it needs more data as
part of a comprehensive, long-term improvement in its information
collection activities for the rail transportation of crude oil and the
rail transportation of hazardous materials in general.
    FRA received no other comments. After careful consideration of each
of the comments discussed above, FRA reevaluated and certified this
information collection activity under 5 CFR 1320.5(a), and is now
forwarding this ICR to OMB for review and approval under 5 CFR
1320.12(c).
    Before OMB decides whether to approve this proposed collection of
information, it must provide 30 days for public comment. 44 U.S.C.
3507(b); 5 CFR 1320.12(d). Federal law requires OMB to approve or
disapprove paperwork packages between 30 and 60 days after the 30 day
notice is published. 44 U.S.C. 3507 (b)-(c); 5 CFR 1320.12(d); see also
60 FR 44978, 44983, Aug. 29, 1995. OMB believes that the 30 day notice
informs the regulated community to file relevant comments and affords
the agency adequate time to digest public comments before it renders a
decision. 60 FR 44983, Aug. 29, 1995. Therefore, respondents should
submit their respective comments to OMB within 30 days of publication
to best ensure having their full effect. 5 CFR 1320.12(c); see also 60
FR 44983, Aug. 29, 1995.
    The summary below describes the nature of the ICR and the expected
burden. FRA is submitting the proposed revisions to OMB for clearance
as the PRA requires.
    Title: Accident Incident Reporting and Recordkeeping.
    OMB Control Number: 2130-0500.
    Abstract: The collection of information arises from FRA's accident
reporting regulations set forth in 49 CFR part 225. Part 225 requires
railroads to submit monthly reports summarizing collisions,
derailments, and certain other accidents/incidents involving damages
above a certain dollar threshold, as well as certain injuries to
passengers, employees, and other persons on railroad property
(including those which are railroad work-related). Because the
reporting requirements and information needed regarding each category
are unique, a different form is used for each category. FRA is
modifying the instructions for one of the three referenced agency forms
to request that the SSB of Form FRA F 6180.54 be used to capture (with
coded letters) information pertaining to accidents that involve rail
cars transporting crude oil.
    Type of Request: Revision of a Currently Approved Information
Collection.
    Affected Public: Businesses (Railroads).
    Form(s): FRA F 6180.54.
    Annual Estimated Burden: 39,058 hours.
    Addressee: Send comments regarding these information collections to
the Office of Information and Regulatory Affairs, Office of Management
and Budget, 725 Seventeenth Street NW., Washington, DC, 20503,
Attention: FRA Desk Officer. Comments may also be sent via email to OMB
at the following address<EMAIL_ADDRESS>    Comments are invited on the following: Whether the proposed
collection of information is necessary for the proper performance of
the functions of the Department, including whether the information will
have practical utility; the accuracy of the Department's estimates of
the burden of the proposed information collection; ways to enhance the
quality, utility, and clarity of the information to be collected; and
ways to minimize the burden of the collection of information on
respondents, including the use of automated collection techniques or
other forms of information technology.
    A comment to OMB is best assured of having its full effect if OMB
receives it within 30 days of publication of this notice in the Federal
Register.

    Authority:  44 U.S.C. 3501-3520.

    Issued in Washington, DC, on August 6, 2015.
Patrick Warren,
Deputy Associate Administrator for Safety Compliance and Program
Implementation.
[FR Doc. 2015-19751 Filed 8-11-15; 8:45 am]
 BILLING CODE 4910-06-P