  SEQ CHAPTER \h \r 1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION

MEMORANDUM

DATE:  	04/14/2014

SUBJECT:	Trifloxystrobin.  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for Uses on Dry Peas, Chickpeas, and Lentils.

PC Code: 129112	DP Barcode: D413712

Decision No.: 478982	Registration No.: 264-1055

Petition No.: 3F8180	Regulatory Action: Section 3 Registration

Risk Assessment Type: Single Chemical/Aggregate	Case No.: NA

TXR No.: NA	CAS No.: 141517-21-7

MRID No.: NA	40 CFR: 180.555

FROM:	Meheret Negussie, Chemist

	Risk Assessment Branch III (RAB3)

	Health Effects Division (HED; 7509P)

THROUGH:	William Cutchin, Chemist

		Ideliz Negrón-Encarnación, Ph. D. Chemist

	Dietary Exposure Science Advisory Council (DESAC)

		and

	Christine Olinger, Branch Chief

	RAB3/HED (7509P)

TO:		Nancy Tsaur, Chemist/Risk Assessor

		RAB3/HED (7509P)

			and

Tony Kish, RM 22

				Fungicide Branch

				Registration Division (7505P)

Executive Summary

Acute and Chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16.  This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  The analyses were conducted in support of a human health risk assessment for the proposed Section 3 requests on dry peas, chickpeas, and lentils.  This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Acute Dietary Results and Characterization

There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population; therefore, a dose and endpoint were not identified.  An acute endpoint was identified for females 13-49 years old.  Therefore, an acute dietary assessment was conducted for this population subgroup.

An acute dietary assessment was conducted assuming tolerance level residues and 100% crop treated (%CT).  DEEM version 7.81 default processing factors were assumed except for where tolerances were established for processed commodities.  For the dietary assessment, a value of 0.20 ppm was added for the metabolite L7a in addition to the recommended tolerance level for liver.  The acute drinking water estimate of 427 µg/L, provided by the Environmental Fate and Effects Division (EFED) was directly incorporated into the acute assessment.

The results of the acute dietary (food and drinking water) analysis indicate that exposure and risk does not exceed HED’s level of concern (LOC) for females 13-49 years old.  The dietary exposure for food and water at the 95th percentile of exposure distribution is estimated at 1% of the acute Population Adjusted Dose (aPAD) for the females 13-49 years old.

Chronic Dietary Results and Characterization

A chronic dietary assessment was conducted assuming tolerance level residues for all commodities except grapes, apples, oranges, and pears which used anticipated residues (ARs).  For the dietary assessment, a value of 0.20 ppm was added to account for the Metabolite L7a in addition to the recommended tolerance level for liver.  For all crops, it was assumed that 100%CT was treated.  DEEM version 7.81 default processing factors were assumed except for where tolerances were established for processed commodities.  The chronic drinking water estimate of 365 µg/L, provided by EFED was directly incorporated into the chronic assessment.

The results of the chronic dietary (food and drinking water) analysis indicate that exposure and risk does not exceed HED’s LOC for the U.S. population and all population subgroups.  The dietary exposure for food and water is estimated at 32% of the chronic Population Adjusted Dose (cPAD) for the general U.S. population and 78% for all infants, the most highly exposed population subgroup. Drinking water is the major contributor to the chronic dietary assessment.

Cancer Dietary Exposure

The Cancer Assessment Review Committee (CARC) classified zoxamide as “not likely to be carcinogenic to humans;” therefore, a cancer assessment was not performed.

I. 	 Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for trifloxystrobin was conducted by Nancy Tsaur (DP#387201, 07/13/2011).

II.	Residue Information

Tolerances:  Permanent tolerances for residues of trifloxystrobin are listed in 40 CFR §180.555 and are expressed in terms of combined residues of trifloxystrobin and the free form of its acid metabolite CGA-321113, in or on a variety of plant commodities.

Residue of Concern:  HED has concluded that both trifloxystrobin and CGA-321113 are of concern for both regulatory and risk assessment purposes in both plant and livestock commodities (DP#257835, F. Ives, 07/13/1999).  HED also determined that for livestock commodities, the metabolite L7a (taurine conjugate of trifloxystrobin) in liver should be included in the risk assessment.  Drinking water estimates used in this memo include combined residues of parent and the major metabolite CGA-321113.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010.  In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use.  To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and physicochemical properties.  In 2008, PDP analyzed 552 samples of catfish for trifloxystrobin residues.  None of the samples contained detectable residues.  As a result, residues in fish were not included in the assessment.

For the proposed new uses for dry peas, chickpeas, and lentils, the recommended tolerances are presented in Table 1 (DP# D413711, M. Negussie, 04/14/2014).

Table 1. 	Tolerance Summary for Trifloxystrobin.

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments; Correct Commodity Definition

Pea, dry, seed	0.06	0.06

Residue Data used for Acute and Chronic Assessments:

The acute assessment was based on the assumption of tolerance level residues for all commodities while the chronic assessment incorporated some ARs.  Both assessments assumed 100 %CT.  For the dietary assessments, a value of 0.20 ppm was added for the Metabolite L7a in addition to the recommended tolerance level for liver; therefore, meat byproducts and liver of cattle, goats, horses, and sheep were assessed in the dietary assessments at 0.3 ppm.  The maximum theoretical dietary burden was lower for pork, except for pork liver, than for these other commodities.  Therefore, pork was included in the DEEM at the established tolerance level of 0.05 ppm; pork, liver was included at 0.16 ppm (DP# D267787, L. Cheng, 01/17/2002).  A separate tolerance was set for grape, raisin; therefore, the processing factor for this commodity was set at 1.  For all other processed commodities, DEEM 7.81 default processing factors were used.  Residue reduction data on strawberries from a single trial were previously provided which demonstrated that residues of trifloxystrobin and CGA-321113 declined in/on strawberries after washing and cooking.  The default processing factor of 1 was retained since the exposure estimates are below HED’s LOC.

The chronic dietary assessment was refined by using ARs for apple, grape, orange, and pear commodities (see Table 2).  ARs were provided by ARIA (email, D. Rate, 09/11/2007) and calculated by averaging the residue values of over the entire field trial and using the LOQ for non-detect samples.

Table 2.	Calculated Anticipated Residues for Use in Trifloxystrobin Chronic Dietary Analysis.

Commodity	Field Trial Average a

ppm	Recommended Anticipated Residue to Use in DEEM

ppm

Grape	0.374875	0.4

Apple	0.187285	0.2

Orange	0.12052	0.15

Pear	0.168	0.2

a  non-detect = LOQ

III.   Percent Crop Treated Information

100% CT was assumed for all crops.

IV.   Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) and incorporated directly into this dietary assessment (DP#413801, M. Biscoe, 01/28/2014).  Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

The currently registered turf use continues to have the highest annual use rate (1.33 lb a.i./acre) of all the proposed and existing uses of trifloxystrobin.

esidues in groundwater is 427 μg/L, and the highest estimated (chronic) concentration in groundwater is 365 μg/L.

Table 3.     Maximum Estimated Drinking Water Concentrations (EDWCs) of Total Toxic Residues of Trifloxystrobin.

	Drinking water source (model)	Model Scenario & Application Method	Acute Chronic	Cancer

Units: μ/L

Surface Water 1 (PRZM-EXAMS)	Pennsylvania Turf scenario

Aerial Application	Peak

1-in-10 Year	Chronic

1-in-10 Year	30-year Annual Average

29 ppb	23 ppb	19 ppb

Groundwater

(PRZM-GW 30-year simulation)	Wisconsin Corn scenario

Ground Application	Peak	Post-Breakthrough Average

427 ppb2	365 ppb2

1Drinking Water Assessment for Tolerance Petition for New Uses of Trifloxystrobin in Trifloxystrobin Flowable Fungicide [EPA Reg. No. 264-989].  D378919

2 The highest estimated concentration is bolded.

V.  DEEM-FCID Program and Consumption Information

Trifloxystrobin acute and chronic dietary exposure assessments were conducted using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s NHANES/WWEIA.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  However, for acute exposure assessment, consumption data are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

VI.   Toxicological Information

HED previously evaluated the toxicology data base for trifloxystrobin, established Reference Doses (RfDs), and selected the toxicological endpoints for dietary exposure risk assessments.  No acute dietary endpoint was identified for the general population or other population subgroup aside from females 13-49 (i.e. females of childbearing age).  The FQPA SF was reduced to 1X based on toxicological considerations by the FQPA SF Committee (HED Doc. No. 013545, B. Tarplee, 01/07/1999).  The doses relevant to dietary exposure are summarized in Table 4.

Table 4.	Summary of Toxicological Doses and Endpoints for Trifloxystrobin for Use in Dietary Risk Assessments.

Exposure/

Scenario	Dose Used in Risk

Assessment/UF

	Hazard and Exposure Based Special FQPA Safety Factor	Study and Toxicological Effects

Acute Dietary (Females 13-49 only)	NOAEL = 250 mg/kg/day

UF = 100X

Acute RfD = 2.5 mg/kg/day

	FQPA SF=1X

aPAD = aRfD ÷ FQPA SF = 2.5 mg/kg/day 	Developmental Toxicity-Rat

LOAEL = 500 mg/kg/day, based upon increased fetal skeletal anomalies.

Acute Dietary

(General Population including infants and children)	There were no appropriate toxicological effects attributable to a single exposure (dose) observed in oral toxicity studies including maternal effects in developmental studies in rats and rabbits.  Therefore, a dose and endpoint were not identified for this risk assessment.

Chronic Dietary (All Populations)	Parental

NOAEL= 3.8 mg/kg/day

UF = 100X

Chronic RfD = 0.038 mg/kg/day

	FQPA SF=1X

cPAD = cRfD ÷ FQPA SF = 0.038 mg/kg/day	Two-Generation reproduction study-Rat

LOAEL = 55.3 mg/kg/day, based upon decreases in body weight, body weight gains, reduced food consumption and histopathological lesions in the liver, kidneys and spleen.

Cancer (oral, dermal, inhalation)	Trifloxystrobin is classified as “Not Likely Human Carcinogen” based on the lack of evidence of carcinogenicity in mouse and rat cancer studies.

NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.   FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.  N/A = not applicable.

VII.		Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 5 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

The results of the acute dietary (food and drinking water) analysis indicate that exposure and risk does not exceed HED’s LOC for females 13-49 years old.  The dietary exposure for food and water at the 95th percentile of exposure distribution is estimated at 1% of the aPAD for females 13-49 years old.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary (food and drinking water) analysis indicate that exposure and risk does not exceed HED’s LOC for the U.S. population and all population subgroups.  The dietary exposure for food and water is estimated at 32% of the cPAD for the general U.S. population and 78% for all infants, the most highly exposed population subgroup.

Drinking water is the major contributor to the dietary assessment.  The dietary exposure for food only was estimated at 26% for all infants, the most highly exposed population subgroup.

Table 5.	Summary of Dietary (Food and Drinking Water) Exposure and Risk for Trifloxystrobin. 1

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary

	Dietary Exposure mg/kg/day	% aPAD	Dietary Exposure

mg/kg/day	% cPAD

General U.S. Population	NA 2	0.012139	32

All Infants (< 1 year old)

0.029751	78

Children 1-2 years old

0.026545	70

Children 3-5 years old

0.020721	54

Children 6-12 years old

0.012755	34

Youth 13-19 years old

0.008879	23

Adults 20-49 years old

0.011282	30

Adults 50-99 years old

0.010870	29

Females 13-49 years old	0.032259	1.3	0.010893	29

1 Values for the population with the highest risk for each type of risk assessment are bolded.

2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups.

3 The highest estimated concentration is bolded.

VIII.		Characterization of Inputs/Outputs

The dietary exposure and risk estimates are highly conservative since they assume tolerance level residues, anticipated residues for some crops, 100 %CT, and include mainly default processing factors.  Additional refinements may be implemented such as the use of additional ARs, incorporation of %CT data, inclusion of empirical processing factors, and/or monitoring data that better reflect residues at the time of consumption.  Drinking water is the major contributor to the dietary assessment. Since risk estimates are below HED’s level of concern, a more highly refined analysis is not needed at this time.

IX.		Conclusions

Based on the conservative assumptions noted above, acute and chronic dietary risk estimates for trifloxystrobin do not exceed HED’s level of concern for the general U.S. population, or any of the population subgroups, including infants and children.  The exposure estimates are likely to overestimate any actual dietary exposures to trifloxystrobin.

X.	List of Attachments

Acute Food Plus Water Residue Input File

Acute Results File

Chronic Food Plus Water Residue Input File

Chronic Results File

Chronic Food Only Results File

Attachment 1:  Acute Food plus Water Residue Input File

Filename: C:\Users\mnegussi\Documents\DEEM Version 3.16\Trifloxystrobin\ACUTE_FoodWater2013.R08

Chemical: Trifloxystrobin

RfD(Chronic): .038 mg/kg bw/day  NOEL(Chronic): 3.8 mg/kg bw/day

RfD(Acute): 2.5 mg/kg bw/day  NOEL(Acute):  250 mg/kg bw/day

Date created/last modified: 05-20-2014/15:22:05       Program ver. 3.16, 03-08-d

Comment: PP#0E7789 (Acute Dietary for Females 13-49 Only)

------------------------------------------------------------------------ -----------

   EPA     Crop                                   Def Res     Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2

---------- ---- -------------------------------  ----------  ------ ------  -------

0101050000 1AB  Beet, garden, roots                0.100000   1.000  1.000

0101050001 1AB  Beet, garden, roots-babyfood       0.100000   1.000  1.000

0101052000 1A   Beet, sugar                        0.100000   1.000  1.000

0101052001 1A   Beet, sugar-babyfood               0.100000   1.000  1.000

0101053000 1A   Beet, sugar, molasses              0.200000   1.000  1.000

0101053001 1A   Beet, sugar, molasses-babyfood     0.200000   1.000  1.000

0101067000 1AB  Burdock                            0.100000   1.000  1.000

0101078000 1AB  Carrot                             0.100000   1.000  1.000

0101078001 1AB  Carrot-babyfood                    0.100000   1.000  1.000

0101079000 1AB  Carrot, juice                      0.100000   1.000  1.000

0101084000 1AB  Celeriac                           0.100000   1.000  1.000

0101100000 1AB  Chicory, roots                     0.100000   1.000  1.000

0101168000 1AB  Ginseng, dried                     0.100000   1.000  1.000

0101190000 1AB  Horseradish                        0.100000   1.000  1.000

0101250000 1AB  Parsley, turnip rooted             0.100000   1.000  1.000

0101251000 1AB  Parsnip                            0.100000   1.000  1.000

0101251001 1AB  Parsnip-babyfood                   0.100000   1.000  1.000

0101314000 1AB  Radish, roots                      0.100000   1.000  1.000  6E7088

0101316000 1AB  Radish, Oriental, roots            0.100000   1.000  1.000  6E7088

0101327000 1AB  Rutabaga                           0.100000   1.000  1.000

0101331000 1AB  Salsify, roots                     0.100000   1.000  1.000

0101388000 1AB  Turnip, roots                      0.100000   1.000  1.000

0103296000 1C   Potato, chips                      0.040000   1.000  1.000  8F7464

0103297000 1C   Potato, dry (granules/ flakes)     0.040000   6.500  1.000  8F7464

0103297001 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500  1.000  8F7464

0103298000 1C   Potato, flour                      0.040000   6.500  1.000  8F7464

0103298001 1C   Potato, flour-babyfood             0.040000   6.500  1.000  8F7464

0103299000 1C   Potato, tuber, w/peel              0.040000   1.000  1.000  8F7464

0103299001 1C   Potato, tuber, w/peel-babyfood     0.040000   1.000  1.000  8F7464

0103300000 1C   Potato, tuber, w/o peel            0.040000   1.000  1.000  8F7464

0103300001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000  1.000  8F7464

0200051000 2    Beet, garden, tops                 4.000000   1.000  1.000

0200315000 2    Radish, tops                      10.000000   1.000  1.000  6E7088

0200317000 2    Radish, Oriental, tops            10.000000   1.000  1.000  6E7088

0402076000 4B   Cardoon                            3.500000   1.000  1.000  8F7464

0402085000 4B   Celery                             3.500000   1.000  1.000  8F7464

0402085001 4B   Celery-babyfood                    3.500000   1.000  1.000  8F7464

0402086000 4B   Celery, juice                      3.500000   1.000  1.000  8F7464

0402087000 4B   Celtuce                            3.500000   1.000  1.000  8F7464

0402152000 4B   Fennel, Florence                   3.500000   1.000  1.000  8F7464

0402322000 4B   Rhubarb                            3.500000   1.000  1.000  8F7464

0402367000 4B   Swiss chard                        3.500000   1.000  1.000  8F7464

0600347000 6    Soybean, seed                      0.080000   1.000  1.000  5F6956

0600349000 6    Soybean, soy milk                  0.080000   1.000  1.000  5F6956

0600349001 6    Soybean, soy milk-babyfood or in   0.080000   1.000  1.000  5F6956

0600350000 6    Soybean, oil                       0.080000   1.000  1.000  5F6956

0600350001 6    Soybean, oil-babyfood              0.080000   1.000  1.000  5F6956

0601349500 6AB  Soybean, vegetable                 0.080000   1.000  1.000

0603098000 6C   Chickpea, seed                     0.060000   1.000  1.000

0603098001 6C   Chickpea, seed-babyfood            0.060000   1.000  1.000

0603099000 6C   Chickpea, flour                    0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603203000 6C   Lentil, seed                       0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603256000 6C   Pea, dry                           0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603256001 6C   Pea, dry-babyfood                  0.060000   1.000  1.000

0603258000 6C   Pea, pigeon, seed                  0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603348000 6C   Soybean, flour                     0.080000   1.000  1.000  5F6956

0603348001 6C   Soybean, flour-babyfood            0.080000   1.000  1.000  5F6956

0801374000 8A   Tomatillo                          0.500000   1.000  1.000

0801375000 8A   Tomato                             0.500000   1.000  1.000

0801375001 8A   Tomato-babyfood                    0.500000   1.000  1.000

0801376000 8A   Tomato, paste                      0.500000   5.400  1.000

0801376001 8A   Tomato, paste-babyfood             0.500000   5.400  1.000

0801377000 8A   Tomato, puree                      0.500000   3.300  1.000

0801377001 8A   Tomato, puree-babyfood             0.500000   3.300  1.000

0801378000 8A   Tomato, dried                      0.500000  14.300  1.000

0801378001 8A   Tomato, dried-babyfood             0.500000  14.300  1.000

0801379000 8A   Tomato, juice                      0.500000   1.500  1.000

0801380000 8A   Tomato, Tree                       0.500000   1.000  1.000

0802148000 8BC  Eggplant                           0.500000   1.000  1.000

0802234000 8BC  Okra                               0.500000   1.000  1.000  8F7464

0802270000 8B   Pepper, bell                       0.500000   1.000  1.000

0802270001 8B   Pepper, bell-babyfood              0.500000   1.000  1.000

0802271000 8B   Pepper, bell, dried                0.500000   1.000  1.000

0802271001 8B   Pepper, bell, dried-babyfood       0.500000   1.000  1.000

0802272000 8BC  Pepper, nonbell                    0.500000   1.000  1.000

0802272001 8BC  Pepper, nonbell-babyfood           0.500000   1.000  1.000

0802273000 8BC  Pepper, nonbell, dried             0.500000   1.000  1.000

0901075000 9A   Cantaloupe                         0.500000   1.000  1.000

0901187000 9A   Honeydew melon                     0.500000   1.000  1.000

0901399000 9A   Watermelon                         0.500000   1.000  1.000

0901400000 9A   Watermelon, juice                  0.500000   1.000  1.000

0902021000 9B   Balsam pear                        0.500000   1.000  1.000

0902088000 9B   Chayote, fruit                     0.500000   1.000  1.000

0902102000 9B   Chinese waxgourd                   0.500000   1.000  1.000

0902135000 9B   Cucumber                           0.500000   1.000  1.000

0902308000 9B   Pumpkin                            0.500000   1.000  1.000

0902309000 9B   Pumpkin, seed                      0.500000   1.000  1.000

0902356000 9B   Squash, summer                     0.500000   1.000  1.000

0902356001 9B   Squash, summer-babyfood            0.500000   1.000  1.000

0902357000 9B   Squash, winter                     0.500000   1.000  1.000

0902357001 9B   Squash, winter-babyfood            0.500000   1.000  1.000

1001106000 10A  Citron                             0.600000   1.000  1.000  0F6121

1001107000 10A  Citrus hybrids                     0.600000   1.000  1.000  0F6121

1001108000 10A  Citrus, oil                       38.000000   1.000  1.000  0F6121

1001240000 10A  Orange                             0.600000   1.000  1.000  0F6121

1001241000 10A  Orange, juice                      0.600000   1.800  1.000  0F6121

1001241001 10A  Orange, juice-babyfood             0.600000   1.800  1.000  0F6121

1001242000 10A  Orange, peel                       0.600000   1.000  1.000  0F6121

1001369000 10A  Tangerine                          0.600000   1.000  1.000  0F6121

1001370000 10A  Tangerine, juice                   0.600000   2.300  1.000  0F6121

1002197000 10B  Kumquat                            0.600000   1.000  1.000

1002199000 10B  Lemon                              0.600000   1.000  1.000  0F6121

1002200000 10B  Lemon, juice                       0.600000   2.000  1.000  0F6121

1002200001 10B  Lemon, juice-babyfood              0.600000   2.000  1.000  0F6121

1002201000 10B  Lemon, peel                        0.600000   1.000  1.000  0F6121

1002206000 10B  Lime                               0.600000   1.000  1.000  0F6121

1002207000 10B  Lime, juice                        0.600000   2.000  1.000  0F6121

1002207001 10B  Lime, juice-babyfood               0.600000   2.000  1.000  0F6121

1003180000 10C  Grapefruit                         0.600000   1.000  1.000  0F6121

1003181000 10C  Grapefruit, juice                  0.600000   2.100  1.000  0F6121

1003307000 10C  Pummelo                            0.600000   1.000  1.000

1100007000 11   Apple, fruit with peel             0.500000   1.000  1.000

1100008000 11   Apple, peeled fruit                0.500000   1.000  1.000

1100008001 11   Apple, peeled fruit-babyfood       0.500000   1.000  1.000

1100009000 11   Apple, dried                       0.500000   8.000  1.000

1100009001 11   Apple, dried-babyfood              0.500000   8.000  1.000

1100010000 11   Apple, juice                       0.500000   1.300  1.000

1100010001 11   Apple, juice-babyfood              0.500000   1.300  1.000

1100011000 11   Apple, sauce                       0.500000   1.000  1.000

1100011001 11   Apple, sauce-babyfood              0.500000   1.000  1.000

1100129000 11   Crabapple                          0.500000   1.000  1.000

1100173500 11   Goji berry                         0.500000   1.000  1.000

1100210000 11   Loquat                             0.500000   1.000  1.000

1100266000 11   Pear                               0.500000   1.000  1.000

1100266001 11   Pear-babyfood                      0.500000   1.000  1.000

1100267000 11   Pear, dried                        0.500000   6.250  1.000

1100268000 11   Pear, juice                        0.500000   1.000  1.000

1100268001 11   Pear, juice-babyfood               0.500000   1.000  1.000

1100310000 11   Quince                             0.500000   1.000  1.000

1201090000 12A  Cherry                             2.000000   1.000  1.000  0F6121

1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000  0F6121

1201091000 12A  Cherry, juice                      2.000000   1.500  1.000  0F6121

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000  0F6121

1202012000 12B  Apricot                            2.000000   1.000  1.000  0F6121

1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000  0F6121

1202013000 12B  Apricot, dried                     2.000000   6.000  1.000  0F6121

1202014000 12B  Apricot, juice                     2.000000   1.000  1.000  0F6121

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000  0F6121

1202230000 12B  Nectarine                          2.000000   1.000  1.000  0F6121

1202260000 12B  Peach                              2.000000   1.000  1.000  0F6121

1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000  0F6121

1202261000 12B  Peach, dried                       2.000000   7.000  1.000  0F6121

1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000  0F6121

1202262000 12B  Peach, juice                       2.000000   1.000  1.000

1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000

1203285000 12C  Plum                               2.000000   1.000  1.000  0F6121

1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000  0F6121

1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000  0F6121

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000  0F6121

1203287000 12C  Plum, prune, dried                 2.000000   5.000  1.000  0F6121

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000  1.000  0F6121

1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000  0F6121

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000  0F6121

1304175000 13D  Grape                              2.000000   1.000  1.000

1304176000 13D  Grape, juice                       2.000000   1.200  1.000

1304176001 13D  Grape, juice-babyfood              2.000000   1.200  1.000

1304179000 13D  Grape, wine and sherry             2.000000   1.000  1.000

1307359000 13G  Strawberry                         1.100000   1.000  1.000  8F7464

1307359001 13G  Strawberry-babyfood                1.100000   1.000  1.000  8F7464

1307360000 13G  Strawberry, juice                  1.100000   1.000  1.000  8F7464

1307360001 13G  Strawberry, juice-babyfood         1.100000   1.000  1.000  8F7464

1400003000 14   Almond                             0.040000   1.000  1.000

1400003001 14   Almond-babyfood                    0.040000   1.000  1.000

1400004000 14   Almond, oil                        0.040000   1.000  1.000

1400004001 14   Almond, oil-babyfood               0.040000   1.000  1.000

1400059000 14   Brazil nut                         0.040000   1.000  1.000  0F6121

1400068000 14   Butternut                          0.040000   1.000  1.000

1400081000 14   Cashew                             0.040000   1.000  1.000  0F6121

1400092000 14   Chestnut                           0.040000   1.000  1.000  0F6121

1400155000 14   Hazelnut                           0.040000   1.000  1.000  0F6121

1400156000 14   Hazelnut, oil                      0.040000   1.000  1.000

1400185000 14   Hickory nut                        0.040000   1.000  1.000

1400213000 14   Macadamia nut                      0.040000   1.000  1.000  0F6121

1400269000 14   Pecan                              0.040000   1.000  1.000  0F6121

1400278000 14   Pine nut                           0.040000   1.000  1.000

1400282000 14   Pistachio                          0.040000   1.000  1.000  0F6121

1400391000 14   Walnut                             0.040000   1.000  1.000  0F6121

1500025000 15   Barley, pearled barley             0.050000   1.000  1.000

1500025001 15   Barley, pearled barley-babyfood    0.050000   1.000  1.000

1500026000 15   Barley, flour                      0.050000   1.000  1.000

1500026001 15   Barley, flour-babyfood             0.050000   1.000  1.000

1500027000 15   Barley, bran                       0.050000   1.000  1.000

1500065000 15   Buckwheat                          0.050000   1.000  1.000

1500066000 15   Buckwheat, flour                   0.050000   1.000  1.000

1500120000 15   Corn, field, flour                 0.050000   1.000  1.000  0F6121

1500120001 15   Corn, field, flour-babyfood        0.050000   1.000  1.000  0F6121

1500121000 15   Corn, field, meal                  0.050000   1.000  1.000  0F6121

1500121001 15   Corn, field, meal-babyfood         0.050000   1.000  1.000  0F6121

1500122000 15   Corn, field, bran                  0.050000   1.000  1.000  0F6121

1500123000 15   Corn, field, starch                0.050000   1.000  1.000  0F6121

1500123001 15   Corn, field, starch-babyfood       0.050000   1.000  1.000  0F6121

1500124000 15   Corn, field, syrup                 0.050000   1.500  1.000  0F6121

1500124001 15   Corn, field, syrup-babyfood        0.050000   1.500  1.000  0F6121

1500125000 15   Corn, field, oil                   0.100000   1.000  1.000  0F6121

1500125001 15   Corn, field, oil-babyfood          0.100000   1.000  1.000  0F6121

1500126000 15   Corn, pop                          0.050000   1.000  1.000  0F6121

1500127000 15   Corn, sweet                        0.040000   1.000  1.000

1500127001 15   Corn, sweet-babyfood               0.040000   1.000  1.000

1500231000 15   Oat, bran                          0.050000   1.000  1.000

1500232000 15   Oat, flour                         0.050000   1.000  1.000

1500232001 15   Oat, flour-babyfood                0.050000   1.000  1.000

1500233000 15   Oat, groats/rolled oats            0.050000   1.000  1.000

1500233001 15   Oat, groats/rolled oats-babyfood   0.050000   1.000  1.000

1500323000 15   Rice, white                        3.500000   1.000  1.000  0F6121

1500323001 15   Rice, white-babyfood               3.500000   1.000  1.000  0F6121

1500324000 15   Rice, brown                        3.500000   1.000  1.000  0F6121

1500324001 15   Rice, brown-babyfood               3.500000   1.000  1.000  0F6121

1500325000 15   Rice, flour                        3.500000   1.000  1.000  0F6121

1500325001 15   Rice, flour-babyfood               3.500000   1.000  1.000  0F6121

1500326000 15   Rice, bran                         3.500000   1.000  1.000  0F6121

1500326001 15   Rice, bran-babyfood                3.500000   1.000  1.000  0F6121

1500381000 15   Triticale, flour                   0.050000   1.000  1.000

1500381001 15   Triticale, flour-babyfood          0.050000   1.000  1.000

1500401000 15   Wheat, grain                       0.050000   1.000  1.000

1500401001 15   Wheat, grain-babyfood              0.050000   1.000  1.000

1500402000 15   Wheat, flour                       0.050000   1.000  1.000

1500402001 15   Wheat, flour-babyfood              0.050000   1.000  1.000

1500403000 15   Wheat, germ                        0.050000   1.000  1.000

1500404000 15   Wheat, bran                        0.150000   1.000  1.000

1500405000 15   Wild rice                          3.500000   1.000  1.000

3100044000 31   Beef, meat                         0.100000   1.000  1.000

3100044001 31   Beef, meat-babyfood                0.100000   1.000  1.000

3100045000 31   Beef, meat, dried                  0.100000   1.920  1.000

3100046000 31   Beef, meat byproducts              0.300000   1.000  1.000

3100046001 31   Beef, meat byproducts-babyfood     0.300000   1.000  1.000

3100047000 31   Beef, fat                          0.100000   1.000  1.000

3100047001 31   Beef, fat-babyfood                 0.100000   1.000  1.000

3100048000 31   Beef, kidney                       0.100000   1.000  1.000

3100049000 31   Beef, liver                        0.300000   1.000  1.000  0F6121

3100049001 31   Beef, liver-babyfood               0.300000   1.000  1.000  0F6121

3200169000 32   Goat, meat                         0.100000   1.000  1.000

3200170000 32   Goat, meat byproducts              0.300000   1.000  1.000

3200171000 32   Goat, fat                          0.100000   1.000  1.000

3200172000 32   Goat, kidney                       0.100000   1.000  1.000

3200173000 32   Goat, liver                        0.300000   1.000  1.000

3300189000 33   Horse, meat                        0.100000   1.000  1.000

3400290000 34   Pork, meat                         0.050000   1.000  1.000

3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000

3400291000 34   Pork, skin                         0.050000   1.000  1.000

3400292000 34   Pork, meat byproducts              0.050000   1.000  1.000

3400292001 34   Pork, meat byproducts-babyfood     0.050000   1.000  1.000

3400293000 34   Pork, fat                          0.050000   1.000  1.000

3400293001 34   Pork, fat-babyfood                 0.050000   1.000  1.000  0F6121

3400294000 34   Pork, kidney                       0.050000   1.000  1.000  0F6121

3400295000 34   Pork, liver                        0.160000   1.000  1.000  0F6121

3500339000 35   Sheep, meat                        0.100000   1.000  1.000

3500339001 35   Sheep, meat-babyfood               0.100000   1.000  1.000

3500340000 35   Sheep, meat byproducts             0.300000   1.000  1.000

3500341000 35   Sheep, fat                         0.100000   1.000  1.000

3500341001 35   Sheep, fat-babyfood                0.100000   1.000  1.000

3500342000 35   Sheep, kidney                      0.100000   1.000  1.000

3500343000 35   Sheep, liver                       0.300000   1.000  1.000

3600222000 36   Milk, fat                          0.020000   1.000  1.000

3600222001 36   Milk, fat-baby food/infant formu   0.020000   1.000  1.000

3600223000 36   Milk, nonfat solids                0.020000   1.000  1.000

3600223001 36   Milk, nonfat solids-baby food/in   0.020000   1.000  1.000

3600224000 36   Milk, water                        0.020000   1.000  1.000

3600224001 36   Milk, water-babyfood/infant form   0.020000   1.000  1.000

3600225001 36   Milk, sugar (lactose)-baby food/   0.020000   1.000  1.000

4000093000 40   Chicken, meat                      0.040000   1.000  1.000  0F6121

4000093001 40   Chicken, meat-babyfood             0.040000   1.000  1.000  0F6121

4000094000 40   Chicken, liver                     0.040000   1.000  1.000  0F6121

4000095000 40   Chicken, meat byproducts           0.040000   1.000  1.000  0F6121

4000095001 40   Chicken, meat byproducts-babyfoo   0.040000   1.000  1.000  0F6121

4000096000 40   Chicken, fat                       0.040000   1.000  1.000  0F6121

4000096001 40   Chicken, fat-babyfood              0.040000   1.000  1.000  0F6121

4000097000 40   Chicken, skin                      0.040000   1.000  1.000  0F6121

4000097001 40   Chicken, skin-babyfood             0.040000   1.000  1.000  0F6121

5000382000 50   Turkey, meat                       0.040000   1.000  1.000  0F6121

5000382001 50   Turkey, meat-babyfood              0.040000   1.000  1.000  0F6121

5000383000 50   Turkey, liver                      0.040000   1.000  1.000  0F6121

5000383001 50   Turkey, liver-babyfood             0.040000   1.000  1.000  0F6121

5000384000 50   Turkey, meat byproducts            0.040000   1.000  1.000  0F6121

5000384001 50   Turkey, meat byproducts-babyfood   0.040000   1.000  1.000  0F6121

5000385000 50   Turkey, fat                        0.040000   1.000  1.000  0F6121

5000385001 50   Turkey, fat-babyfood               0.040000   1.000  1.000  0F6121

5000386000 50   Turkey, skin                       0.040000   1.000  1.000  0F6121

5000386001 50   Turkey, skin-babyfood              0.040000   1.000  1.000  0F6121

6000301000 60   Poultry, other, meat               0.040000   1.000  1.000  0F6121

6000302000 60   Poultry, other, liver              0.040000   1.000  1.000  0F6121

6000303000 60   Poultry, other, meat byproducts    0.040000   1.000  1.000  0F6121

6000304000 60   Poultry, other, fat                0.040000   1.000  1.000  0F6121

6000305000 60   Poultry, other, skin               0.040000   1.000  1.000  0F6121

7000145000 70   Egg, whole                         0.040000   1.000  1.000  0F6121

7000145001 70   Egg, whole-babyfood                0.040000   1.000  1.000  0F6121

7000146000 70   Egg, white                         0.040000   1.000  1.000  0F6121

7000146001 70   Egg, white (solids)-babyfood       0.040000   1.000  1.000  0F6121

7000147000 70   Egg, yolk                          0.040000   1.000  1.000  0F6121

7000147001 70   Egg, yolk-babyfood                 0.040000   1.000  1.000  0F6121

8601000000 86A  Water, direct, all sources         0.427000   1.000  1.000  8F7487

8602000000 86B  Water, indirect, all sources       0.427000   1.000  1.000  8F7487

9500016000 O    Artichoke, globe                   1.000000   1.000  1.000  8F7464

9500019000 O    Asparagus                          0.070000   1.000  1.000  6E7088

9500023000 O    Banana                             0.100000   1.000  1.000

9500023001 O    Banana-babyfood                    0.100000   1.000  1.000

9500024000 O    Banana, dried                      0.100000   3.900  1.000

9500024001 O    Banana, dried-babyfood             0.100000   3.900  1.000

9500074000 O    Canistel                           0.700000   1.000  1.000

9500115000 O    Coffee, roasted bean               0.020000   1.000  1.000  0E7789

9500116000 O    Coffee, instant                    0.020000   1.000  1.000  0E7789

9500177000 O    Grape, leaves                      2.000000   1.000  1.000

9500178000 O    Grape, raisin                      5.000000   1.000  1.000  8F7464

9500188000 O    Hop                               11.000000   1.000  1.000

9500215000 O    Mango                              0.700000   1.000  1.000  6E7088

9500215001 O    Mango-babyfood                     0.700000   1.000  1.000  6E7088

9500216000 O    Mango, dried                       0.700000   1.000  1.000  6E7088

9500217000 O    Mango, juice                       0.700000   1.000  1.000  6E7088

9500217001 O    Mango, juice-babyfood              0.700000   1.000  1.000  6E7088

9500245000 O    Papaya                             0.700000   1.000  1.000  6E7088

9500245001 O    Papaya-babyfood                    0.700000   1.000  1.000  6E7088

9500246000 O    Papaya, dried                      0.700000   1.800  1.000  6E7088

9500247000 O    Papaya, juice                      0.700000   1.500  1.000  6E7088

9500263000 O    Peanut                             0.050000   1.000  1.000

9500264000 O    Peanut, butter                     0.050000   1.890  1.000

9500265000 O    Peanut, oil                        0.050000   1.000  1.000

9500283000 O    Plantain                           0.100000   1.000  1.000

9500284000 O    Plantain, dried                    0.100000   3.900  1.000

9500333000 O    Sapote, Mamey                      0.700000   1.000  1.000  6E7088

Attachment 2:  Acute Results File

U.S. EPA                                                    Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for TRIFLOXYSTROBIN             NHANES 2003-2008 2-Day

Residue file: ACUTE_FoodWater2013.R08             Adjustment factor #2 NOT used.

Analysis Date: 05-21-2014/10:39:23    Residue file dated: 05-20-2014/15:22:05

NOEL (Acute) = 250.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "PP#0E7789 (Acute Dietary for Females 13-49 Only)"

======================================================================== =======

Summary calculations--per capita:

---   95th Percentile----   ---   99th Percentile----     ---99.9th Percentile----

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  % aRfD     MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

  0.032259    1.29    7749    0.045068    1.80    5547    0.059044    2.36    4234

Attachment 3:  Chronic Food plus Water Residue Input File

Filename: C:\Users\mnegussi\Documents\DEEM Version 3.16\Trifloxystrobin\CHRONIC_FoodWater2013.R08

Chemical: Trifloxystrobin

RfD(Chronic): .038 mg/kg bw/day  NOEL(Chronic): 3.8 mg/kg bw/day

RfD(Acute): 2.5 mg/kg bw/day  NOEL(Acute):  250 mg/kg bw/day

Date created/last modified: 05-20-2014/15:20:22       Program ver. 3.16, 03-08-d

Comment: PP#0F7789 (Acute Dietary Females 13-49 Only) water GW 365 ppb

------------------------------------------------------------------------ -----------

   EPA     Crop                                   Def Res     Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2

---------- ---- -------------------------------  ----------  ------ ------  -------

0101050000 1AB  Beet, garden, roots                0.100000   1.000  1.000

0101050001 1AB  Beet, garden, roots-babyfood       0.100000   1.000  1.000

0101052000 1A   Beet, sugar                        0.100000   1.000  1.000

0101052001 1A   Beet, sugar-babyfood               0.100000   1.000  1.000

0101053000 1A   Beet, sugar, molasses              0.200000   1.000  1.000

0101053001 1A   Beet, sugar, molasses-babyfood     0.200000   1.000  1.000

0101067000 1AB  Burdock                            0.100000   1.000  1.000

0101078000 1AB  Carrot                             0.100000   1.000  1.000

0101078001 1AB  Carrot-babyfood                    0.100000   1.000  1.000

0101079000 1AB  Carrot, juice                      0.100000   1.000  1.000

0101084000 1AB  Celeriac                           0.100000   1.000  1.000

0101100000 1AB  Chicory, roots                     0.100000   1.000  1.000

0101168000 1AB  Ginseng, dried                     0.100000   1.000  1.000

0101190000 1AB  Horseradish                        0.100000   1.000  1.000

0101250000 1AB  Parsley, turnip rooted             0.100000   1.000  1.000

0101251000 1AB  Parsnip                            0.100000   1.000  1.000

0101251001 1AB  Parsnip-babyfood                   0.100000   1.000  1.000

0101314000 1AB  Radish, roots                      0.100000   1.000  1.000  6E7088

0101316000 1AB  Radish, Oriental, roots            0.100000   1.000  1.000  6E7088

0101327000 1AB  Rutabaga                           0.100000   1.000  1.000

0101331000 1AB  Salsify, roots                     0.100000   1.000  1.000

0101388000 1AB  Turnip, roots                      0.100000   1.000  1.000

0103296000 1C   Potato, chips                      0.040000   1.000  1.000

0103297000 1C   Potato, dry (granules/ flakes)     0.040000   6.500  1.000

0103297001 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500  1.000

0103298000 1C   Potato, flour                      0.040000   6.500  1.000

0103298001 1C   Potato, flour-babyfood             0.040000   6.500  1.000

0103299000 1C   Potato, tuber, w/peel              0.040000   1.000  1.000

0103299001 1C   Potato, tuber, w/peel-babyfood     0.040000   1.000  1.000

0103300000 1C   Potato, tuber, w/o peel            0.040000   1.000  1.000

0103300001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000  1.000

0200051000 2    Beet, garden, tops                 4.000000   1.000  1.000

0200315000 2    Radish, tops                      10.000000   1.000  1.000  6E7088

0200317000 2    Radish, Oriental, tops            10.000000   1.000  1.000  6E7088

0402076000 4B   Cardoon                            3.500000   1.000  1.000  8F7464

0402085000 4B   Celery                             3.500000   1.000  1.000  8F7464

0402085001 4B   Celery-babyfood                    3.500000   1.000  1.000  8F7464

0402086000 4B   Celery, juice                      3.500000   1.000  1.000  8F7464

0402087000 4B   Celtuce                            3.500000   1.000  1.000  8F7464

0402152000 4B   Fennel, Florence                   3.500000   1.000  1.000  8F7464

0402322000 4B   Rhubarb                            3.500000   1.000  1.000  8F7464

0402367000 4B   Swiss chard                        3.500000   1.000  1.000  8F7464

0600347000 6    Soybean, seed                      0.080000   1.000  1.000  5F6956

0600349000 6    Soybean, soy milk                  0.080000   1.000  1.000  5F6956

0600349001 6    Soybean, soy milk-babyfood or in   0.080000   1.000  1.000  5F6956

0600350000 6    Soybean, oil                       0.080000   1.000  1.000  5F6956

0600350001 6    Soybean, oil-babyfood              0.080000   1.000  1.000  5F6956

0601349500 6AB  Soybean, vegetable                 0.080000   1.000  1.000

0603098000 6C   Chickpea, seed                     0.060000   1.000  1.000

0603098001 6C   Chickpea, seed-babyfood            0.060000   1.000  1.000

0603099000 6C   Chickpea, flour                    0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603203000 6C   Lentil, seed                       0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603256000 6C   Pea, dry                           0.060000   1.000  1.000

0603256001 6C   Pea, dry-babyfood                  0.060000   1.000  1.000

0603258000 6C   Pea, pigeon, seed                  0.060000   1.000  1.000  3F8180

            Full comment: 3F8180 DP# 413711

0603348000 6C   Soybean, flour                     0.080000   1.000  1.000  5F6956

0603348001 6C   Soybean, flour-babyfood            0.080000   1.000  1.000  5F6956

0801374000 8A   Tomatillo                          0.500000   1.000  1.000

0801375000 8A   Tomato                             0.500000   1.000  1.000

0801375001 8A   Tomato-babyfood                    0.500000   1.000  1.000

0801376000 8A   Tomato, paste                      0.500000   5.400  1.000

0801376001 8A   Tomato, paste-babyfood             0.500000   5.400  1.000

0801377000 8A   Tomato, puree                      0.500000   3.300  1.000

0801377001 8A   Tomato, puree-babyfood             0.500000   3.300  1.000

0801378000 8A   Tomato, dried                      0.500000  14.300  1.000

0801378001 8A   Tomato, dried-babyfood             0.500000  14.300  1.000

0801379000 8A   Tomato, juice                      0.500000   1.500  1.000

0801380000 8A   Tomato, Tree                       0.500000   1.000  1.000

0802148000 8BC  Eggplant                           0.500000   1.000  1.000

0802234000 8BC  Okra                               0.500000   1.000  1.000  8F7464

0802270000 8B   Pepper, bell                       0.500000   1.000  1.000

0802270001 8B   Pepper, bell-babyfood              0.500000   1.000  1.000

0802271000 8B   Pepper, bell, dried                0.500000   1.000  1.000

0802271001 8B   Pepper, bell, dried-babyfood       0.500000   1.000  1.000

0802272000 8BC  Pepper, nonbell                    0.500000   1.000  1.000

0802272001 8BC  Pepper, nonbell-babyfood           0.500000   1.000  1.000

0802273000 8BC  Pepper, nonbell, dried             0.500000   1.000  1.000

0901075000 9A   Cantaloupe                         0.500000   1.000  1.000

0901187000 9A   Honeydew melon                     0.500000   1.000  1.000

0901399000 9A   Watermelon                         0.500000   1.000  1.000

0901400000 9A   Watermelon, juice                  0.500000   1.000  1.000

0902021000 9B   Balsam pear                        0.500000   1.000  1.000

0902088000 9B   Chayote, fruit                     0.500000   1.000  1.000

0902102000 9B   Chinese waxgourd                   0.500000   1.000  1.000

0902135000 9B   Cucumber                           0.500000   1.000  1.000

0902308000 9B   Pumpkin                            0.500000   1.000  1.000

0902309000 9B   Pumpkin, seed                      0.500000   1.000  1.000

0902356000 9B   Squash, summer                     0.500000   1.000  1.000

0902356001 9B   Squash, summer-babyfood            0.500000   1.000  1.000

0902357000 9B   Squash, winter                     0.500000   1.000  1.000

0902357001 9B   Squash, winter-babyfood            0.500000   1.000  1.000

1001106000 10A  Citron                             0.600000   1.000  1.000  0F6121

1001107000 10A  Citrus hybrids                     0.600000   1.000  1.000  0F6121

1001108000 10A  Citrus, oil                       38.000000   1.000  1.000  0F6121

1001240000 10A  Orange                             0.150000   1.000  1.000  0F6121

1001241000 10A  Orange, juice                      0.150000   1.800  1.000  0F6121

1001241001 10A  Orange, juice-babyfood             0.150000   1.800  1.000  0F6121

1001242000 10A  Orange, peel                       0.150000   1.000  1.000  0F6121

1001369000 10A  Tangerine                          0.600000   1.000  1.000  0F6121

1001370000 10A  Tangerine, juice                   0.600000   2.300  1.000  0F6121

1002197000 10B  Kumquat                            0.600000   1.000  1.000

1002199000 10B  Lemon                              0.600000   1.000  1.000  0F6121

1002200000 10B  Lemon, juice                       0.600000   2.000  1.000  0F6121

1002200001 10B  Lemon, juice-babyfood              0.600000   2.000  1.000  0F6121

1002201000 10B  Lemon, peel                        0.600000   1.000  1.000  0F6121

1002206000 10B  Lime                               0.600000   1.000  1.000  0F6121

1002207000 10B  Lime, juice                        0.600000   2.000  1.000  0F6121

1002207001 10B  Lime, juice-babyfood               0.600000   2.000  1.000  0F6121

1003180000 10C  Grapefruit                         0.600000   1.000  1.000  0F6121

1003181000 10C  Grapefruit, juice                  0.600000   2.100  1.000  0F6121

1003307000 10C  Pummelo                            0.600000   1.000  1.000

1100007000 11   Apple, fruit with peel             0.200000   1.000  1.000

1100008000 11   Apple, peeled fruit                0.200000   1.000  1.000

1100008001 11   Apple, peeled fruit-babyfood       0.200000   1.000  1.000

1100009000 11   Apple, dried                       0.200000   8.000  1.000

1100009001 11   Apple, dried-babyfood              0.200000   8.000  1.000

1100010000 11   Apple, juice                       0.200000   1.300  1.000

1100010001 11   Apple, juice-babyfood              0.200000   1.300  1.000

1100011000 11   Apple, sauce                       0.200000   1.000  1.000

1100011001 11   Apple, sauce-babyfood              0.200000   1.000  1.000

1100129000 11   Crabapple                          0.200000   1.000  1.000

1100173500 11   Goji berry                         0.500000   1.000  1.000

1100210000 11   Loquat                             0.200000   1.000  1.000

1100266000 11   Pear                               0.200000   1.000  1.000

1100266001 11   Pear-babyfood                      0.200000   1.000  1.000

1100267000 11   Pear, dried                        0.200000   6.250  1.000

1100268000 11   Pear, juice                        0.200000   1.000  1.000

1100268001 11   Pear, juice-babyfood               0.200000   1.000  1.000

1100310000 11   Quince                             0.200000   1.000  1.000

1201090000 12A  Cherry                             2.000000   1.000  1.000  0F6121

1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000  0F6121

1201091000 12A  Cherry, juice                      2.000000   1.500  1.000  0F6121

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000  0F6121

1202012000 12B  Apricot                            2.000000   1.000  1.000  0F6121

1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000  0F6121

1202013000 12B  Apricot, dried                     2.000000   6.000  1.000  0F6121

1202014000 12B  Apricot, juice                     2.000000   1.000  1.000  0F6121

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000  0F6121

1202230000 12B  Nectarine                          2.000000   1.000  1.000  0F6121

1202260000 12B  Peach                              2.000000   1.000  1.000  0F6121

1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000  0F6121

1202261000 12B  Peach, dried                       2.000000   7.000  1.000  0F6121

1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000  0F6121

1202262000 12B  Peach, juice                       2.000000   1.000  1.000

1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000

1203285000 12C  Plum                               2.000000   1.000  1.000  0F6121

1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000  0F6121

1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000  0F6121

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000  0F6121

1203287000 12C  Plum, prune, dried                 2.000000   5.000  1.000  0F6121

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000  1.000  0F6121

1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000  0F6121

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000  0F6121

1304175000 13D  Grape                              0.400000   1.000  1.000

1304176000 13D  Grape, juice                       0.400000   1.200  1.000

1304176001 13D  Grape, juice-babyfood              0.400000   1.200  1.000

1304179000 13D  Grape, wine and sherry             0.400000   1.000  1.000

1307359000 13G  Strawberry                         1.100000   1.000  1.000  8F7464

1307359001 13G  Strawberry-babyfood                1.100000   1.000  1.000  8F7464

1307360000 13G  Strawberry, juice                  1.100000   1.000  1.000  8F7464

1307360001 13G  Strawberry, juice-babyfood         1.100000   1.000  1.000  8F7464

1400003000 14   Almond                             0.040000   1.000  1.000

1400003001 14   Almond-babyfood                    0.040000   1.000  1.000

1400004000 14   Almond, oil                        0.040000   1.000  1.000

1400004001 14   Almond, oil-babyfood               0.040000   1.000  1.000

1400059000 14   Brazil nut                         0.040000   1.000  1.000  0F6121

1400068000 14   Butternut                          0.040000   1.000  1.000

1400081000 14   Cashew                             0.040000   1.000  1.000  0F6121

1400092000 14   Chestnut                           0.040000   1.000  1.000  0F6121

1400155000 14   Hazelnut                           0.040000   1.000  1.000  0F6121

1400156000 14   Hazelnut, oil                      0.040000   1.000  1.000  0F6121

1400185000 14   Hickory nut                        0.040000   1.000  1.000

1400213000 14   Macadamia nut                      0.040000   1.000  1.000  0F6121

1400269000 14   Pecan                              0.040000   1.000  1.000  0F6121

1400278000 14   Pine nut                           0.040000   1.000  1.000

1400282000 14   Pistachio                          0.040000   1.000  1.000  0F6121

1400391000 14   Walnut                             0.040000   1.000  1.000  0F6121

1500025000 15   Barley, pearled barley             0.050000   1.000  1.000

1500025001 15   Barley, pearled barley-babyfood    0.050000   1.000  1.000

1500026000 15   Barley, flour                      0.050000   1.000  1.000

1500026001 15   Barley, flour-babyfood             0.050000   1.000  1.000

1500027000 15   Barley, bran                       0.050000   1.000  1.000

1500065000 15   Buckwheat                          0.050000   1.000  1.000

1500066000 15   Buckwheat, flour                   0.050000   1.000  1.000

1500120000 15   Corn, field, flour                 0.050000   1.000  1.000  0F6121

1500120001 15   Corn, field, flour-babyfood        0.050000   1.000  1.000  0F6121

1500121000 15   Corn, field, meal                  0.050000   1.000  1.000  0F6121

1500121001 15   Corn, field, meal-babyfood         0.050000   1.000  1.000  0F6121

1500122000 15   Corn, field, bran                  0.050000   1.000  1.000  0F6121

1500123000 15   Corn, field, starch                0.050000   1.000  1.000  0F6121

1500123001 15   Corn, field, starch-babyfood       0.050000   1.000  1.000  0F6121

1500124000 15   Corn, field, syrup                 0.050000   1.500  1.000  0F6121

1500124001 15   Corn, field, syrup-babyfood        0.050000   1.500  1.000  0F6121

1500125000 15   Corn, field, oil                   0.100000   1.000  1.000  0F6121

1500125001 15   Corn, field, oil-babyfood          0.100000   1.000  1.000  0F6121

1500126000 15   Corn, pop                          0.050000   1.000  1.000  0F6121

1500127000 15   Corn, sweet                        0.040000   1.000  1.000

1500127001 15   Corn, sweet-babyfood               0.040000   1.000  1.000

1500231000 15   Oat, bran                          0.050000   1.000  1.000

1500232000 15   Oat, flour                         0.050000   1.000  1.000

1500232001 15   Oat, flour-babyfood                0.050000   1.000  1.000

1500233000 15   Oat, groats/rolled oats            0.050000   1.000  1.000

1500233001 15   Oat, groats/rolled oats-babyfood   0.050000   1.000  1.000

1500323000 15   Rice, white                        3.500000   1.000  1.000  0F6121

1500323001 15   Rice, white-babyfood               3.500000   1.000  1.000  0F6121

1500324000 15   Rice, brown                        3.500000   1.000  1.000  0F6121

1500324001 15   Rice, brown-babyfood               3.500000   1.000  1.000  0F6121

1500325000 15   Rice, flour                        3.500000   1.000  1.000  0F6121

1500325001 15   Rice, flour-babyfood               3.500000   1.000  1.000  0F6121

1500326000 15   Rice, bran                         3.500000   1.000  1.000  0F6121

1500326001 15   Rice, bran-babyfood                3.500000   1.000  1.000  0F6121

1500381000 15   Triticale, flour                   0.050000   1.000  1.000

1500381001 15   Triticale, flour-babyfood          0.050000   1.000  1.000

1500401000 15   Wheat, grain                       0.050000   1.000  1.000

1500401001 15   Wheat, grain-babyfood              0.050000   1.000  1.000

1500402000 15   Wheat, flour                       0.050000   1.000  1.000

1500402001 15   Wheat, flour-babyfood              0.050000   1.000  1.000

1500403000 15   Wheat, germ                        0.050000   1.000  1.000

1500404000 15   Wheat, bran                        0.150000   1.000  1.000

1500405000 15   Wild rice                          3.500000   1.000  1.000

3100044000 31   Beef, meat                         0.100000   1.000  1.000

3100044001 31   Beef, meat-babyfood                0.100000   1.000  1.000

3100045000 31   Beef, meat, dried                  0.100000   1.920  1.000

3100046000 31   Beef, meat byproducts              0.300000   1.000  1.000

3100046001 31   Beef, meat byproducts-babyfood     0.300000   1.000  1.000

3100047000 31   Beef, fat                          0.100000   1.000  1.000

3100047001 31   Beef, fat-babyfood                 0.100000   1.000  1.000

3100048000 31   Beef, kidney                       0.100000   1.000  1.000

3100049000 31   Beef, liver                        0.300000   1.000  1.000  0F6121

3100049001 31   Beef, liver-babyfood               0.300000   1.000  1.000  0F6121

3200169000 32   Goat, meat                         0.100000   1.000  1.000

3200170000 32   Goat, meat byproducts              0.300000   1.000  1.000

3200171000 32   Goat, fat                          0.100000   1.000  1.000

3200172000 32   Goat, kidney                       0.100000   1.000  1.000

3200173000 32   Goat, liver                        0.300000   1.000  1.000

3300189000 33   Horse, meat                        0.100000   1.000  1.000

3400290000 34   Pork, meat                         0.050000   1.000  1.000

3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000

3400291000 34   Pork, skin                         0.050000   1.000  1.000

3400292000 34   Pork, meat byproducts              0.050000   1.000  1.000

3400292001 34   Pork, meat byproducts-babyfood     0.050000   1.000  1.000

3400293000 34   Pork, fat                          0.050000   1.000  1.000

3400293001 34   Pork, fat-babyfood                 0.050000   1.000  1.000  0F6121

3400294000 34   Pork, kidney                       0.050000   1.000  1.000  0F6121

3400295000 34   Pork, liver                        0.160000   1.000  1.000  0F6121

3500339000 35   Sheep, meat                        0.100000   1.000  1.000

3500339001 35   Sheep, meat-babyfood               0.100000   1.000  1.000

3500340000 35   Sheep, meat byproducts             0.300000   1.000  1.000

3500341000 35   Sheep, fat                         0.100000   1.000  1.000

3500341001 35   Sheep, fat-babyfood                0.100000   1.000  1.000

3500342000 35   Sheep, kidney                      0.100000   1.000  1.000

3500343000 35   Sheep, liver                       0.300000   1.000  1.000

3600222000 36   Milk, fat                          0.020000   1.000  1.000

3600222001 36   Milk, fat-baby food/infant formu   0.020000   1.000  1.000

3600223000 36   Milk, nonfat solids                0.020000   1.000  1.000

3600223001 36   Milk, nonfat solids-baby food/in   0.020000   1.000  1.000

3600224000 36   Milk, water                        0.020000   1.000  1.000

3600224001 36   Milk, water-babyfood/infant form   0.020000   1.000  1.000

3600225001 36   Milk, sugar (lactose)-baby food/   0.020000   1.000  1.000

4000093000 40   Chicken, meat                      0.040000   1.000  1.000  0F6121

4000093001 40   Chicken, meat-babyfood             0.040000   1.000  1.000  0F6121

4000094000 40   Chicken, liver                     0.040000   1.000  1.000  0F6121

4000095000 40   Chicken, meat byproducts           0.040000   1.000  1.000  0F6121

4000095001 40   Chicken, meat byproducts-babyfoo   0.040000   1.000  1.000  0F6121

4000096000 40   Chicken, fat                       0.040000   1.000  1.000  0F6121

4000096001 40   Chicken, fat-babyfood              0.040000   1.000  1.000  0F6121

4000097000 40   Chicken, skin                      0.040000   1.000  1.000  0F6121

4000097001 40   Chicken, skin-babyfood             0.040000   1.000  1.000  0F6121

5000382000 50   Turkey, meat                       0.040000   1.000  1.000  0F6121

5000382001 50   Turkey, meat-babyfood              0.040000   1.000  1.000  0F6121

5000383000 50   Turkey, liver                      0.040000   1.000  1.000  0F6121

5000383001 50   Turkey, liver-babyfood             0.040000   1.000  1.000  0F6121

5000384000 50   Turkey, meat byproducts            0.040000   1.000  1.000  0F6121

5000384001 50   Turkey, meat byproducts-babyfood   0.040000   1.000  1.000  0F6121

5000385000 50   Turkey, fat                        0.040000   1.000  1.000  0F6121

5000385001 50   Turkey, fat-babyfood               0.040000   1.000  1.000  0F6121

5000386000 50   Turkey, skin                       0.040000   1.000  1.000  0F6121

5000386001 50   Turkey, skin-babyfood              0.040000   1.000  1.000  0F6121

6000301000 60   Poultry, other, meat               0.040000   1.000  1.000  0F6121

6000302000 60   Poultry, other, liver              0.040000   1.000  1.000  0F6121

6000303000 60   Poultry, other, meat byproducts    0.040000   1.000  1.000  0F6121

6000304000 60   Poultry, other, fat                0.040000   1.000  1.000  0F6121

6000305000 60   Poultry, other, skin               0.040000   1.000  1.000  0F6121

7000145000 70   Egg, whole                         0.040000   1.000  1.000  0F6121

7000145001 70   Egg, whole-babyfood                0.040000   1.000  1.000  0F6121

7000146000 70   Egg, white                         0.040000   1.000  1.000  0F6121

7000146001 70   Egg, white (solids)-babyfood       0.040000   1.000  1.000  0F6121

7000147000 70   Egg, yolk                          0.040000   1.000  1.000  0F6121

7000147001 70   Egg, yolk-babyfood                 0.040000   1.000  1.000  0F6121

8601000000 86A  Water, direct, all sources         0.365000   1.000  1.000  8F7487

8602000000 86B  Water, indirect, all sources       0.365000   1.000  1.000  8F7487

9500016000 O    Artichoke, globe                   1.000000   1.000  1.000  8F7464

9500019000 O    Asparagus                          0.070000   1.000  1.000  6E7088

9500023000 O    Banana                             0.100000   1.000  1.000

9500023001 O    Banana-babyfood                    0.100000   1.000  1.000

9500024000 O    Banana, dried                      0.100000   3.900  1.000

9500024001 O    Banana, dried-babyfood             0.100000   3.900  1.000

9500074000 O    Canistel                           0.700000   1.000  1.000

9500115000 O    Coffee, roasted bean               0.020000   1.000  1.000  0E7789

9500116000 O    Coffee, instant                    0.020000   1.000  1.000  0E7789

9500177000 O    Grape, leaves                      0.400000   1.000  1.000

9500178000 O    Grape, raisin                      5.000000   1.000  1.000  8F7464

9500188000 O    Hop                               11.000000   1.000  1.000

9500215000 O    Mango                              0.700000   1.000  1.000  6E7088

9500215001 O    Mango-babyfood                     0.700000   1.000  1.000  6E7088

9500216000 O    Mango, dried                       0.700000   1.000  1.000  6E7088

9500217000 O    Mango, juice                       0.700000   1.000  1.000  6E7088

9500217001 O    Mango, juice-babyfood              0.700000   1.000  1.000  6E7088

9500245000 O    Papaya                             0.700000   1.000  1.000  6E7088

9500245001 O    Papaya-babyfood                    0.700000   1.000  1.000  6E7088

9500246000 O    Papaya, dried                      0.700000   1.800  1.000  6E7088

9500247000 O    Papaya, juice                      0.700000   1.500  1.000  6E7088

9500263000 O    Peanut                             0.050000   1.000  1.000

9500264000 O    Peanut, butter                     0.050000   1.890  1.000

9500265000 O    Peanut, oil                        0.050000   1.000  1.000

9500283000 O    Plantain                           0.100000   1.000  1.000

9500284000 O    Plantain, dried                    0.100000   3.900  1.000

9500333000 O    Sapote, Mamey                      0.700000   1.000  1.000  6E7088

Attachment 4:  Chronic Food and Water Results File

U.S. EPA                                                        Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for TRIFLOXYSTROBIN             NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 3.16\Trifloxystrobin\CHRONIC_FoodWater2013.R08

                                                 Adjustment factor #2 NOT used.

Analysis Date 05-21-2014/10:36:43     Residue file dated: 05-20-2014/15:20:22

Reference dose (RfD, Chronic) = .038 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ----------------

Total US Population                         0.012139                31.9%

Hispanic                                    0.012815                33.7%

Non-Hisp-White                              0.012049                31.7%

Non-Hisp-Black                              0.010498                27.6%

Non-Hisp-Other                              0.015487                40.8%

Nursing Infants                             0.013417                35.3%

Non-Nursing Infants                         0.037045                97.5%

Female 13+ PREG                             0.011279                29.7%

Children 1-6                                0.022181                58.4%

Children 7-12                               0.011998                31.6%

Male 13-19                                  0.008623                22.7%

Female 13-19/NP                             0.009141                24.1%

Male 20+                                    0.010888                28.7%

Female 20+/NP                               0.011299                29.7%

Seniors 55+                                 0.010686                28.1%

All Infants                                 0.029751                78.3%

Female 13-50                                0.010893                28.7%

Children 1-2                                0.026545                69.9%

Children 3-5                                0.020721                54.5%

Children 6-12                               0.012755                33.6%

Youth 13-19                                 0.008879                23.4%

Adults 20-49                                0.011282                29.7%

Adults 50-99                                0.010870                28.6%

Female 13-49                                0.010893                28.7%

------------------------------------------------------------------------ -------

Attachment 5:  Chronic Food only Results File

U.S. EPA                                                        Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for TRIFLOXYSTROBIN             NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 3.16\Trifloxystrobin\CHRONIC_Food2013.R08

                                                 Adjustment factor #2 NOT used.

Analysis Date 05-21-2014/10:44:04     Residue file dated: 05-21-2014/10:43:16

Reference dose (RfD, Chronic) = .038 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ----------------

Total US Population                         0.004496                11.8%

Hispanic                                    0.005518                14.5%

Non-Hisp-White                              0.004189                11.0%

Non-Hisp-Black                              0.004191                11.0%

Non-Hisp-Other                              0.006678                17.6%

Nursing Infants                             0.006503                17.1%

Non-Nursing Infants                         0.011625                30.6%

Female 13+ PREG                             0.004082                10.7%

Children 1-6                                0.012392                32.6%

Children 7-12                               0.005626                14.8%

Male 13-19                                  0.003369                 8.9%

Female 13-19/NP                             0.003254                 8.6%

Male 20+                                    0.003767                 9.9%

Female 20+/NP                               0.003272                 8.6%

Seniors 55+                                 0.003296                 8.7%

All Infants                                 0.010044                26.4%

Female 13-50                                0.003287                 8.6%

Children 1-2                                0.015520                40.8%

Children 3-5                                0.011432                30.1%

Children 6-12                               0.006056                15.9%

Youth 13-19                                 0.003306                 8.7%

Adults 20-49                                0.003657                 9.6%

Adults 50-99                                0.003331                 8.8%

Female 13-49                                0.003295                 8.7%

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Trifloxystrobin	Dietary Exposure and Risk Assessment	DP Number: 413712

PC Code:  129112

Page   PAGE  1  of   NUMPAGES   21


? Need to return call by / at/ between and . Signature: Project No.: 0<IP_ADDRESS>   DISTRIBUTION Page ___ of _

Project Name: 304( m)

TELEPHONE CALL RECORD Outgoing Call Date: 1/ 28/ 05 Time: 2: 15 pm Company Name: Kimberly Clark Worldwide Inc. Contact Name: Jim Ketchum Phone No.: ( 425) 259 7308 e mail: Jketchum@ kcc. com Name: TJ Finseth Eastern Research Group GENERAL SUBJECT : Kimberly Clark Everett WA Dioxin releases in TRI 2002 TOPICS DISCUSSED AND ACTION TAKEN On Wednesday January 19, 2005 at 2: 00 pm, I left a message on Mr. Scott Helker's machine requesting him to call me back.

On Thursday January 20, 2005 at 10: 00 am, I was contacted by a woman at the EPA Region 3 office in response to my call to Mr. Helker, to confirm my affiliation with the EPA.

On Thursday January 20, 2005 at 5: 15 pm, Mr. Jim Ketchum left a message on my machine requesting me to contact him with my questions about Kimberly Clark Everett's TRI dioxin releases via e mail.

On Friday January 21, 2005 at 9: 00 am, I sent Mr. Ketchum the questions I had for him.

On Friday January 28, 2005 at 10: 15 am, I sent Mr. Ketchum an e mail letting him know that I was still waiting for his response.

On Friday January 28, 2005 at 1: 40 pm, Mr. Ketchum sent me an e mail letting me know that his answers to my questions were still under review.

On Friday January 28, 2005 at 2: 15 pm, Mr. Ketchum sent me the answers to my questions about Kimberly Clark Everett's dioxin releases.

The questions I asked and Mr. Ketchum's response is attached to this telecon, along with all correspondence between the two of us.

It was determined from Mr. Ketchum's response that Kimberly Clark Everett, created emission factors from mill specific data collected over a 5 year period for their bleach plant and wood waste boiler, which are the sources of dioxin. The facility then calculated stream partition factors to determine the path of the dioxins after exiting the ? Need to return call by / at/ between and . Signature: two sources.

The facility did analyze their wastewater using 24 hour composites. There did detect dioxins for the full congener spectrum and for 2,3,7,8 TCDF, but 2,3,7,8 TCDD was a not detected. The concentrations can be seen in the attached correspondence.

Mr. Ketchum wrote that the wood waste boiler ash is the primary source of dioxins in the facility.


[Federal Register Volume 77, Number 129 (Thursday, July 5, 2012)]
[Notices]
[Pages 39779-39781]
[FR Doc No: 2012-16469]

-----------------------------------------------------------------------

SECURITIES AND EXCHANGE COMMISSION

[Release No. 34-67302; File No. SR-CBOE-2012-061]

Self-Regulatory Organizations; Chicago Board Options Exchange,
Incorporated; Notice of Filing and Immediate Effectiveness of a
Proposed Rule Change Relating to the Exchange's Automated Improvement
Mechanism

June 28, 2012.
    Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934
(the ``Act''),\1\ and Rule 19b-4 thereunder,\2\ notice is hereby given
that on June 26, 2012, the Chicago Board Options Exchange, Incorporated
(``Exchange'' or ``CBOE'') filed with the Securities and Exchange
Commission (``Commission'') the proposed rule change as described in
Items I and II below, which Items have been prepared by the Exchange.
The Exchange filed the proposal as a ``non-controversial'' proposed
rule change pursuant to Section 19(b)(3)(A)(iii) of the Act \3\ and
Rule 19b-4(f)(6) thereunder,\4\ which renders the proposed rule change
effective upon filing with the Commission. The Commission is publishing
this notice to solicit comments on the proposed rule change from
interested persons.
---------------------------------------------------------------------------

    \1\ 15 U.S.C. 78s(b)(1).
    \2\ 17 CFR 240.19b-4.
    \3\ 15 U.S.C. 78s(b)(3)(A)(iii).
    \4\ 17 CFR 240.19b-4(f)(6).
---------------------------------------------------------------------------

I. Self-Regulatory Organization's Statement of the Terms of Substance
of the Proposed Rule Change

    The Exchange proposes to amend its rules related to its Automated
Improvement Mechanism (``AIM''). The text of the proposed rule change
is available on the Exchange's Web site (http://www.cboe.com/AboutCBOE/CBOELegalRegulatoryHome.aspx), at the Exchange's Office of the
Secretary, and at the Commission's Public Reference Room.

II. Self-Regulatory Organization's Statement of the Purpose of, and
Statutory Basis for, the Proposed Rule Change

    In its filing with the Commission, the Exchange included statements
concerning the purpose of and basis for the proposed rule change and
discussed any comments it received on the proposed rule change. The
text of these statements may be examined at the places specified in
Item IV below. The Exchange has prepared summaries, set forth in
sections A, B, and C below, of the most significant aspects of such
statements.

A. Self-Regulatory Organization's Statement of the Purpose of, and the
Statutory Basis for, the Proposed Rule Change

1. Purpose
    In February 2006, CBOE obtained approval from the Commission to
adopt the AIM auction process.\5\ In March 2012, CBOE obtained approval
from the Commission to adopt a substantially similar AIM auction
process for Flexible Exchange Options (``FLEX Options'').\6\ AIM
exposes certain orders electronically to an auction process to provide
these orders with the opportunity to receive an execution at an
improved price. The AIM auction is available only for orders that an
Exchange Trading Permit Holder represents as agent (``Agency Order'')
and for which a second order of the same size as the Agency Order (and
on the opposite side of the market) is also submitted (effectively
stopping the Agency Order at a given price).
---------------------------------------------------------------------------

    \5\ See Securities Exchange Act Release No. 53222 (February 3,
2006), 71 FR 7089 (February 10, 2006) (SR-CBOE-2005-060).
    \6\ See Securities Exchange Act Release No. 66702 (March 30,
2012), 77 FR 20675 (April 5, 2012) (SR-CBOE-2011-123). FLEX Options
provide investors with the ability to customize basic option
features including size, expiration date, exercise style, and
certain exercise prices. The rules governing the trading of FLEX
Options on the FLEX Request for Quote (RFQ) System platform are
contained in Chapter XXIVA. The rules governing the trading of FLEX
Options on the FLEX Hybrid Trading System platform are contained in
Chapter XXIVB.
---------------------------------------------------------------------------

    With respect to non-FLEX Options, the Commission approved two
components of AIM on a pilot basis: (1) That there is no minimum size
requirement for orders to be eligible for the auction; and (2) that the
auction will conclude prematurely anytime there is a quote lock on the
Exchange pursuant to Rule 6.45A(d).\7\ With respect to FLEX Options,
the Commission approved on a pilot basis the component of AIM that
there is no minimum size requirement for orders to be eligible for the
auction.\8\ In connection with the pilot programs, the Exchange has
submitted to the Commission reports providing detailed AIM auction and
order execution data, and the Exchange will continue to submit to the
Commission these reports. Six one-year extensions to the non-

FLEX pilot programs have previously become effective.\9\ The proposed
rule change merely extends the duration of the non-FLEX and FLEX pilot
programs until July 18, 2013. Extending the pilots for an additional
year will allow the Commission more time to consider the impact of the
pilot programs on AIM order executions.
---------------------------------------------------------------------------

    \7\ A quote lock occurs when a CBOE Market-Maker's quote
interacts with the quote of another CBOE Market-Maker (i.e. when
internal quotes lock).
    \8\ The pilot for the FLEX AIM auction process was modeled after
the existing pilot for non-FLEX Options, and included an expiration
date of July 18, 2012 so that the FLEX pilot would coincide with the
existing non-FLEX pilot.
    \9\ See Securities Exchange Act Release Nos. 54147 (July 14,
2006), 71 FR 41487 (July 21, 2006) (SR-CBOE-2006-064); 56094 (July
18, 2007), 72 FR 40910 (July 25, 2007) (SR-CBOE-2007-080); 58196
(July 18, 2008), 73 FR 43803 (July 28, 2008) (SR-CBOE-2008-076) (in
this filing, the Exchange agreed to provide to the Commission
additional information relating to the AIM auctions each month in
order to aid the Commission in its evaluation of the pilot program,
which the Exchange will continue to do); 60338 (July 17, 2009), 74
FR 36803 (July 24, 2009) (SR-CBOE-2009-051); 62522 (July 16, 2010),
75 FR 43596 (July 26, 2010) (SR-CBOE-2010-067); and 64930 (July 20,
2011), 76 FR 44636 (July 26, 2011) (SR-CBOE-2011-066).
---------------------------------------------------------------------------

2. Statutory Basis
    The Exchange believes the proposed rule change is consistent with
the Act and the rules and regulations thereunder applicable to the
Exchange and, in particular, the requirements of Section 6(b) of the
Act.\10\ Specifically, the Exchange believes the proposed rule change
is consistent with the Section 6(b)(5) \11\ requirements that the rules
of an exchange be designed to promote just and equitable principles of
trade, to prevent fraudulent and manipulative acts, to remove
impediments to and to perfect the mechanism for a free and open market
and a national market system, and, in general, to protect investors and
the public interest.
---------------------------------------------------------------------------

    \10\ 15 U.S.C. 78f(b).
    \11\ 15 U.S.C. 78f(b)(5).
---------------------------------------------------------------------------

    In particular, the proposed rule change protects investors and the
public interest by allowing for an extension of the AIM pilot programs,
and thus allowing additional time for the Commission to evaluate the
AIM pilot programs. The AIM pilot programs will continue to allow (1)
smaller orders to receive the opportunity for price improvement
pursuant to the AIM auction (for non-FLEX and FLEX Options), and (2)
Agency Orders in AIM auctions that are concluded early because of quote
lock on the Exchange to receive the benefit of the lock price (for non-
FLEX Options).

B. Self-Regulatory Organization's Statement on Burden on Competition

    CBOE does not believe that the proposed rule change will impose any
burden on competition that is not necessary or appropriate in
furtherance of the purposes of the Act.

C. Self-Regulatory Organization's Statement on Comments on the Proposed
Rule Change Received From Members, Participants, or Others

    The Exchange neither solicited nor received comments on the
proposed rule change.

III. Date of Effectiveness of the Proposed Rule Change and Timing for
Commission Action

    The Exchange has filed the proposed rule change pursuant to Section
19(b)(3)(A)(iii) of the Act \12\ and Rule 19b-4(f)(6) thereunder.\13\
Because the proposed rule change does not: (i) Significantly affect the
protection of investors or the public interest; (ii) impose any
significant burden on competition; and (iii) by its terms, become
operative prior to 30 days from the date on which it was filed, or such
shorter time as the Commission may designate, if consistent with the
protection of investors and the public interest, the proposed rule
change has become effective upon filing with the Commission pursuant to
Section 19(b)(3)(A) of the Act \14\ and Rule 19b-4(f)(6)(iii)
thereunder.\15\
---------------------------------------------------------------------------

    \12\ 15 U.S.C. 78s(b)(3)(A)(iii).
    \13\ 17 CFR 240.19b-4(f)(6).
    \14\ 15 U.S.C. 78s(b)(3)(A).
    \15\ 17 CFR 240.19b-4(f)(6)(iii). In addition, Rule 19b-
4(f)(6)(iii) requires the Exchange to give the Commission written
notice of the Exchange's intent to file the proposed rule change,
along with a brief description and text of the proposed rule change,
at least five business days prior to the date of filing of the
proposed rule change, or such shorter time as designated by the
Commission. The Exchange has met this requirement.
---------------------------------------------------------------------------

    The Exchange has requested that the Commission waive the 30-day
operative delay period. The Commission believes that waiver of the 30-
day operative delay period is consistent with the protection of
investors and the public interest because such waiver will allow the
AIM pilot programs to continue without interruption. Accordingly, the
Commission designates the proposed rule change operative upon filing
with the Commission.\16\
---------------------------------------------------------------------------

    \16\ For purposes only of waiving the operative delay for this
proposal, the Commission has considered the proposed rule's impact
on efficiency, competition, and capital formation. See 15 U.S.C.
78c(f).
---------------------------------------------------------------------------

    At any time within 60 days of the filing of such proposed rule
change, the Commission summarily may temporarily suspend such rule
change if it appears to the Commission that such action is necessary or
appropriate in the public interest, for the protection of investors, or
otherwise in furtherance of the purposes of the Act. If the Commission
takes such action, the Commission shall institute proceedings to
determine whether the proposed rule should be approved or disapproved.

IV. Solicitation of Comments

    Interested persons are invited to submit written data, views, and
arguments concerning the foregoing, including whether the proposed rule
change is consistent with the Act. Comments may be submitted by any of
the following methods:

Electronic Comments

     Use the Commission's Internet comment form (http://www.sec.gov/rules/sro.shtml); or
     Send an email to<EMAIL_ADDRESS>Please include
File Number SR-CBOE-2012-061 on the subject line.

Paper Comments

     Send paper comments in triplicate to Elizabeth M. Murphy,
Secretary, Securities and Exchange Commission, 100 F Street NE.,
Washington, DC 20549-1090.

All submissions should refer to File Number SR-CBOE-2012-061. This file
number should be included on the subject line if email is used. To help
the Commission process and review your comments more efficiently,
please use only one method. The Commission will post all comments on
the Commission's Internet Web site (http://www.sec.gov/rules/sro.shtml). Copies of the submission, all subsequent amendments, all
written statements with respect to the proposed rule change that are
filed with the Commission, and all written communications relating to
the proposed rule change between the Commission and any person, other
than those that may be withheld from the public in accordance with the
provisions of 5 U.S.C. 552, will be available for Web site viewing and
printing in the Commission's Public Reference Room, 100 F Street NE.,
Washington, DC 20549, on official business days between the hours of 10
a.m. and 3 p.m. Copies of such filing also will be available for
inspection and copying at the principal office of the Exchange. All
comments received will be posted without change; the Commission does
not edit personal identifying information from submissions. You should
submit only information that you wish to make available publicly. All
submissions should refer to File Number SR-CBOE-2012-061 and should be
submitted by July 26, 2012.

    For the Commission, by the Division of Trading and Markets,
pursuant to delegated authority.\17\
---------------------------------------------------------------------------

    \17\ 17 CFR 200.30-3(a)(12).
---------------------------------------------------------------------------

Kevin M. O'Neill,
Deputy Secretary.
[FR Doc. 2012-16469 Filed 7-3-12; 8:45 am]
BILLING CODE 8011-01-P